Respiratory rhythm generation during gasping depends on persistent sodium current.

abstract：:Many of the behavioral consequences of stress are mediated by the activation of the glucocorticoid receptor by stress-induced high levels of glucocorticoid hormones. To explore the molecular mechanisms of these effects, we combined in vivo and in vitro approaches. We analyzed mice carrying a brain-specific mutation (G...

journal_title：Nature neuroscience

authors： Revest JM,Di Blasi F,Kitchener P,Rougé-Pont F,Desmedt A,Turiault M,Tronche F,Piazza PV

更新日期：2005-05-01 00:00:00

abstract：:Neurons in thalamorecipient layers of sensory cortices integrate thalamocortical and intracortical inputs. Although we know that their functional properties can arise from the convergence of thalamic inputs, intracortical circuits could also be involved in thalamocortical transformations of sensory information. We sil...

journal_title：Nature neuroscience

authors： Li YT,Ibrahim LA,Liu BH,Zhang LI,Tao HW

更新日期：2013-09-01 00:00:00

abstract：:An action may lead to either a reward or a punishment. Therefore, an appropriate action needs to be chosen on the basis of the values of both expected rewards and expected punishments. To understand the underlying neural mechanisms, we conditioned monkeys using a Pavlovian procedure with two distinct contexts: one in ...

journal_title：Nature neuroscience

authors： Matsumoto M,Hikosaka O

更新日期：2009-01-01 00:00:00

abstract：:In this Perspective, we expand the notion of temporal regulation of RNA in the brain and propose that the qualitative nature of RNA and its metabolism, together with RNA abundance, are essential for the molecular mechanisms underlying experience-dependent plasticity. We discuss emerging concepts in the newly burgeonin...

journal_title：Nature neuroscience

authors： Nainar S,Marshall PR,Tyler CR,Spitale RC,Bredy TW

更新日期：2016-09-27 00:00:00

abstract：:Over the last 10 years, optogenetics has become widespread in neuroscience for the study of how specific cell types contribute to brain functions and brain disorder states. The full impact of optogenetics will emerge only when other toolsets mature, including neural connectivity and cell phenotyping tools and neural r...

journal_title：Nature neuroscience

authors： Boyden ES

更新日期：2015-09-01 00:00:00

abstract：:Electrophysiological connectivity patterns in cortex often have a few strong connections, which are sometimes bidirectional, among a lot of weak connections. To explain these connectivity patterns, we created a model of spike timing-dependent plasticity (STDP) in which synaptic changes depend on presynaptic spike arri...

journal_title：Nature neuroscience

authors： Clopath C,Büsing L,Vasilaki E,Gerstner W

更新日期：2010-03-01 00:00:00

abstract：:In mammals, many daily cycles are driven by a central circadian clock, which is based on the cell-autonomous rhythmic expression of clock genes. It is not clear, however, how peripheral cells are able to interpret the rhythmic signals disseminated from this central oscillator. Here we show that cycling expression of t...

journal_title：Nature neuroscience

authors： von Gall C,Garabette ML,Kell CA,Frenzel S,Dehghani F,Schumm-Draeger PM,Weaver DR,Korf HW,Hastings MH,Stehle JH

更新日期：2002-03-01 00:00:00

abstract：:We argue that there will be no single (genetic or cognitive) cause for the diverse symptoms defining autism. We present recent evidence of behavioral fractionation of social impairment, communication difficulties and rigid and repetitive behaviors. Twin data suggest largely nonoverlapping genes acting on each of these...

journal_title：Nature neuroscience

authors： Happé F,Ronald A,Plomin R

更新日期：2006-10-01 00:00:00

abstract：:As the neural network becomes wired, postsynaptic signaling molecules are thought to control the growth of dendrites and synapses. However, how these molecules are coordinated to sculpt postsynaptic structures is less well understood. We find that ephrin-B3, a transmembrane ligand for Eph receptors, functions postsyna...

journal_title：Nature neuroscience

authors： Xu NJ,Sun S,Gibson JR,Henkemeyer M

更新日期：2011-10-02 00:00:00

abstract：:A decade after speech was first decoded from human brain signals, accuracy and speed remain far below that of natural speech. Here we show how to decode the electrocorticogram with high accuracy and at natural-speech rates. Taking a cue from recent advances in machine translation, we train a recurrent neural network t...

journal_title：Nature neuroscience

authors： Makin JG,Moses DA,Chang EF

更新日期：2020-04-01 00:00:00

abstract：:The accessory olfactory bulb (AOB) is a critical olfactory structure that has been implicated in mediating social behavior. It receives input from the vomeronasal organ and projects to targets in the amygdaloid complex. Its anterior and posterior components (aAOB and pAOB) display molecular, connectional and functiona...

journal_title：Nature neuroscience

authors： Huilgol D,Udin S,Shimogori T,Saha B,Roy A,Aizawa S,Hevner RF,Meyer G,Ohshima T,Pleasure SJ,Zhao Y,Tole S

更新日期：2013-02-01 00:00:00

abstract：:Trial-to-trial variability in the blood oxygen level-dependent (BOLD) response of functional magnetic resonance imaging has been shown to be relevant to human perception and behavior, but the sources of this variability remain unknown. We demonstrate that coherent spontaneous fluctuations in human brain activity accou...

journal_title：Nature neuroscience

authors： Fox MD,Snyder AZ,Zacks JM,Raichle ME

更新日期：2006-01-01 00:00:00

abstract：:Although long-term potentiation (LTP) is long-lasting, it is not permanent and decays within weeks after its induction. Little is known about the processes underlying this decay. Here we assessed the contribution of synaptic activity to LTP decay by determining the effect of the competitive NMDA receptor antagonist CP...

journal_title：Nature neuroscience

authors： Villarreal DM,Do V,Haddad E,Derrick BE

更新日期：2002-01-01 00:00:00

abstract：:Phosphoinositide 3 kinase enhancer (PIKE) is a recently identified nuclear GTPase that activates nuclear phosphoinositide 3-kinase (PI3 kinase). We have identified, cloned and characterized a new form of PIKE, designated PIKE-L, which, unlike the nuclear PIKE-S, localizes to both the cytoplasm and the nucleus. We demo...

journal_title：Nature neuroscience

authors： Rong R,Ahn JY,Huang H,Nagata E,Kalman D,Kapp JA,Tu J,Worley PF,Snyder SH,Ye K

更新日期：2003-11-01 00:00:00

abstract：:Autophosphorylation of alpha calcium-calmodulin-dependent kinase II (alphaCaMKII) has been proposed to be the key event in memory storage. We tested this hypothesis with autophosphorylation-deficient mutant mice in hippocampus- and amygdala-dependent learning and memory tasks and found that the autophosphorylation of ...

journal_title：Nature neuroscience

authors： Irvine EE,Vernon J,Giese KP

更新日期：2005-04-01 00:00:00

abstract：:Autism spectrum disorder (ASD) is genetically heterogeneous with convergent symptomatology, suggesting common dysregulated pathways. In this study, we analyzed brain transcriptional changes in five mouse models of Pitt-Hopkins syndrome (PTHS), a syndromic form of ASD caused by mutations in the TCF4 gene, but not the T...

journal_title：Nature neuroscience

authors： Phan BN,Bohlen JF,Davis BA,Ye Z,Chen HY,Mayfield B,Sripathy SR,Cerceo Page S,Campbell MN,Smith HL,Gallop D,Kim H,Thaxton CL,Simon JM,Burke EE,Shin JH,Kennedy AJ,Sweatt JD,Philpot BD,Jaffe AE,Maher BJ

更新日期：2020-03-01 00:00:00

abstract：:Behavior-contingent network oscillations bring about transient, functionally coherent neuronal assemblies in the cerebral cortex, including the hippocampus. Inhibitory input on and close to the soma is believed to phase intrinsic oscillations and output of pyramidal cells, but the function of GABA release to pyramidal...

journal_title：Nature neuroscience

authors： Klausberger T,Márton LF,Baude A,Roberts JD,Magill PJ,Somogyi P

更新日期：2004-01-01 00:00:00

abstract：:During development, the mammalian ventral telencephalon is comprised of three major proliferative zones: the medial (MGE), lateral (LGE) and caudal (CGE) ganglionic eminences. Through gene expression studies, in vitro migration assays, genetic mutant analysis and in vivo fate mapping in mice, we found that the CGE is ...

journal_title：Nature neuroscience

authors： Nery S,Fishell G,Corbin JG

更新日期：2002-12-01 00:00:00

abstract：:Understanding the transcriptional changes that are engaged in stress resilience may reveal novel antidepressant targets. Here we use gene co-expression analysis of RNA-sequencing data from brains of resilient mice to identify a gene network that is unique to resilience. Zfp189, which encodes a previously unstudied zin...

journal_title：Nature neuroscience

authors： Lorsch ZS,Hamilton PJ,Ramakrishnan A,Parise EM,Salery M,Wright WJ,Lepack AE,Mews P,Issler O,McKenzie A,Zhou X,Parise LF,Pirpinias ST,Ortiz Torres I,Kronman HG,Montgomery SE,Loh YE,Labonté B,Conkey A,Symonds AE,Nev

更新日期：2019-09-01 00:00:00

abstract：:The dorsal root ganglia (DRG) contain a variety of mechanoreceptors, but no molecular markers uniquely identify specific mechanoreceptor subtypes. We have used DNA microarrays and subtracted cDNA libraries to isolate genes that are specifically expressed by one type of mouse mechanoreceptor. The T-type calcium channel...

journal_title：Nature neuroscience

authors： Shin JB,Martinez-Salgado C,Heppenstall PA,Lewin GR

更新日期：2003-07-01 00:00:00

abstract：:The neural mechanisms that mediate the transition from a drug-naive state to a state of drug dependence and addiction are not yet known. Here we show that a discrete population of GABA(A) receptors in the mammalian ventral tegmental area (VTA) serves as a potential addiction switching mechanism by gating reward transm...

journal_title：Nature neuroscience

authors： Laviolette SR,Gallegos RA,Henriksen SJ,van der Kooy D

更新日期：2004-02-01 00:00:00

abstract：:Neurons in many species have large receptive fields that are selective for specific optic flow fields. Here, we studied the neural mechanisms underlying flow field selectivity in lobula plate tangential cells (LPTCs) of the blowfly. Among these cells, the H2 cell responds preferentially to visual stimuli approximating...

journal_title：Nature neuroscience

authors： Farrow K,Haag J,Borst A

更新日期：2006-10-01 00:00:00

abstract：:Spillover of glutamate under physiological conditions has only been established as an adjunct to conventional synaptic transmission. Here we describe a pure spillover connection between the climbing fiber and molecular layer interneurons in the rat cerebellar cortex. We show that, instead of acting via conventional sy...

journal_title：Nature neuroscience

authors： Szapiro G,Barbour B

更新日期：2007-06-01 00:00:00

abstract：:Adult expertise in face processing is mediated largely by neural networks in the right hemisphere. Here we evaluate the contribution of early visual input in establishing this neural substrate. We compared visually normal individuals to patients for whom visual input had been restricted mainly to one hemisphere during...

journal_title：Nature neuroscience

authors： Le Grand R,Mondloch CJ,Maurer D,Brent HP

更新日期：2003-10-01 00:00:00

abstract：:The autosomal dominant disorder neurofibromatosis type 2 (NF2) is a hereditary tumor syndrome caused by inactivation of the NF2 tumor suppressor gene, encoding merlin. Apart from tumors affecting the peripheral and central nervous systems, most NF2 patients develop peripheral neuropathies. This peripheral nerve diseas...

journal_title：Nature neuroscience

authors： Schulz A,Baader SL,Niwa-Kawakita M,Jung MJ,Bauer R,Garcia C,Zoch A,Schacke S,Hagel C,Mautner VF,Hanemann CO,Dun XP,Parkinson DB,Weis J,Schröder JM,Gutmann DH,Giovannini M,Morrison H

更新日期：2013-04-01 00:00:00

abstract：:Growing evidence suggests that the recognition of different emotional states involves at least partly separable neural circuits. Here we assessed the discrimination of both anger and happiness in healthy subjects receiving transcranial magnetic stimulation (TMS) over the medial-frontal cortex or over a control site (m...

journal_title：Nature neuroscience

authors： Harmer CJ,Thilo KV,Rothwell JC,Goodwin GM

更新日期：2001-01-01 00:00:00

abstract：:Candidate Drosophila olfactory receptors (ORs) provide molecular tools to investigate how the organization of the Drosophila olfactory system determines the coding of olfactory stimuli. Neurons in the third antennal segment and maxillary palp appear to express different ORs. Individual olfactory neurons send axonal pr...

journal_title：Nature neuroscience

authors： Gao Q,Yuan B,Chess A

更新日期：2000-08-01 00:00:00

abstract：:The brain is the central organ involved in perceiving and adapting to social and physical stressors via multiple interacting mediators, from the cell surface to the cytoskeleton to epigenetic regulation and nongenomic mechanisms. A key result of stress is structural remodeling of neural architecture, which may be a si...

journal_title：Nature neuroscience

authors： McEwen BS,Bowles NP,Gray JD,Hill MN,Hunter RG,Karatsoreos IN,Nasca C

更新日期：2015-10-01 00:00:00

abstract：:Individual behavioral performance during learning is known to be affected by modulatory factors, such as stress and motivation, and by genetic predispositions that influence sensitivity to these factors. Despite numerous studies, no integrative framework is available that could predict how a given animal would perform...

journal_title：Nature neuroscience

authors： Luksys G,Gerstner W,Sandi C

更新日期：2009-09-01 00:00:00

abstract：:GABA interneurons play a critical role in higher brain functions. Astrocytic glial cells interact with synapses throughout the whole brain and are recognized as regulatory elements of excitatory synaptic transmission. However, it is largely unknown how GABAergic interneurons and astrocytes interact and contribute to s...

journal_title：Nature neuroscience

authors： Mederos S,Sánchez-Puelles C,Esparza J,Valero M,Ponomarenko A,Perea G

更新日期：2021-01-01 00:00:00