Evolving insights into RNA modifications and their functional diversity in the brain.

Abstract:

:In this Perspective, we expand the notion of temporal regulation of RNA in the brain and propose that the qualitative nature of RNA and its metabolism, together with RNA abundance, are essential for the molecular mechanisms underlying experience-dependent plasticity. We discuss emerging concepts in the newly burgeoning field of epitranscriptomics, which are predicted to be heavily involved in cognitive function. These include activity-induced RNA modifications, RNA editing, dynamic changes in the secondary structure of RNA, and RNA localization. Each is described with an emphasis on its role in regulating the function of both protein-coding genes, as well as various noncoding regulatory RNAs, and how each might influence learning and memory.

journal_name

Nat Neurosci

journal_title

Nature neuroscience

authors

Nainar S,Marshall PR,Tyler CR,Spitale RC,Bredy TW

doi

10.1038/nn.4378

subject

Has Abstract

pub_date

2016-09-27 00:00:00

pages

1292-8

issue

10

eissn

1097-6256

issn

1546-1726

pii

nn.4378

journal_volume

19

pub_type

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