Abstract:
:In this Perspective, we expand the notion of temporal regulation of RNA in the brain and propose that the qualitative nature of RNA and its metabolism, together with RNA abundance, are essential for the molecular mechanisms underlying experience-dependent plasticity. We discuss emerging concepts in the newly burgeoning field of epitranscriptomics, which are predicted to be heavily involved in cognitive function. These include activity-induced RNA modifications, RNA editing, dynamic changes in the secondary structure of RNA, and RNA localization. Each is described with an emphasis on its role in regulating the function of both protein-coding genes, as well as various noncoding regulatory RNAs, and how each might influence learning and memory.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Nainar S,Marshall PR,Tyler CR,Spitale RC,Bredy TWdoi
10.1038/nn.4378subject
Has Abstractpub_date
2016-09-27 00:00:00pages
1292-8issue
10eissn
1097-6256issn
1546-1726pii
nn.4378journal_volume
19pub_type
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