Evolving insights into RNA modifications and their functional diversity in the brain.


:In this Perspective, we expand the notion of temporal regulation of RNA in the brain and propose that the qualitative nature of RNA and its metabolism, together with RNA abundance, are essential for the molecular mechanisms underlying experience-dependent plasticity. We discuss emerging concepts in the newly burgeoning field of epitranscriptomics, which are predicted to be heavily involved in cognitive function. These include activity-induced RNA modifications, RNA editing, dynamic changes in the secondary structure of RNA, and RNA localization. Each is described with an emphasis on its role in regulating the function of both protein-coding genes, as well as various noncoding regulatory RNAs, and how each might influence learning and memory.


Nat Neurosci


Nature neuroscience


Nainar S,Marshall PR,Tyler CR,Spitale RC,Bredy TW




Has Abstract


2016-09-27 00:00:00














  • Neurobiology of resilience.

    abstract::Humans exhibit a remarkable degree of resilience in the face of extreme stress, with most resisting the development of neuropsychiatric disorders. Over the past 5 years, there has been increasing interest in the active, adaptive coping mechanisms of resilience; however, in humans, most published work focuses on correl...

    journal_title:Nature neuroscience

    pub_type: 杂志文章,评审


    authors: Russo SJ,Murrough JW,Han MH,Charney DS,Nestler EJ

    更新日期:2012-11-01 00:00:00

  • AlphaCaMKII autophosphorylation contributes to rapid learning but is not necessary for memory.

    abstract::Autophosphorylation of alpha calcium-calmodulin-dependent kinase II (alphaCaMKII) has been proposed to be the key event in memory storage. We tested this hypothesis with autophosphorylation-deficient mutant mice in hippocampus- and amygdala-dependent learning and memory tasks and found that the autophosphorylation of ...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: Irvine EE,Vernon J,Giese KP

    更新日期:2005-04-01 00:00:00

  • Functional connectivity between simple cells and complex cells in cat striate cortex.

    abstract::In the cat primary visual cortex, neurons are classified into the two main categories of simple cells and complex cells based on their response properties. According to the hierarchical model, complex receptive fields derive from convergent inputs of simple cells with similar orientation preferences. This model receiv...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: Alonso JM,Martinez LM

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  • Molecular disruption of hypothalamic nutrient sensing induces obesity.

    abstract::The sensing of circulating nutrients within the mediobasal hypothalamus may be critical for energy homeostasis. To induce a sustained impairment in hypothalamic nutrient sensing, adeno-associated viruses (AAV) expressing malonyl-coenzyme A decarboxylase (MCD; an enzyme involved in the degradation of malonyl coenzyme A...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: He W,Lam TK,Obici S,Rossetti L

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  • Fear conditioning drives profilin into amygdala dendritic spines.

    abstract::Changes in spine morphology may underlie memory formation, but the molecular mechanisms that subserve such alterations are poorly understood. Here we show that fear conditioning in rats leads to the movement of profilin, an actin polymerization-regulatory protein, into dendritic spines in the lateral amygdala and that...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: Lamprecht R,Farb CR,Rodrigues SM,LeDoux JE

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  • Intracellular zinc inhibits KCC2 transporter activity.

    abstract::We found that K(+)/Cl(-) co-transporter 2 (KCC2) activity, monitored with wide-field fluorescence, was inhibited by intracellular Zn(2+), a major component of neuronal injury. Zn(2+)-mediated KCC2 inhibition produced a depolarizing shift of GABA(A) reversal potentials in rat cortical neurons. Moreover, oxygen-glucose ...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: Hershfinkel M,Kandler K,Knoch ME,Dagan-Rabin M,Aras MA,Abramovitch-Dahan C,Sekler I,Aizenman E

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  • Opiate state controls bi-directional reward signaling via GABAA receptors in the ventral tegmental area.

    abstract::The neural mechanisms that mediate the transition from a drug-naive state to a state of drug dependence and addiction are not yet known. Here we show that a discrete population of GABA(A) receptors in the mammalian ventral tegmental area (VTA) serves as a potential addiction switching mechanism by gating reward transm...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: Laviolette SR,Gallegos RA,Henriksen SJ,van der Kooy D

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  • KIF1A inhibition immortalizes brain stem cells but blocks BDNF-mediated neuronal migration.

    abstract::Brain neural stem cells (radial glial progenitors, RGPs) undergo a mysterious form of cell cycle-entrained interkinetic nuclear migration (INM) that is driven apically by cytoplasmic dynein and basally by the kinesin KIF1A, which has recently been implicated in human brain developmental disease. To understand the cons...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


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    更新日期:2016-02-01 00:00:00

  • Octopamine fuels fighting flies.

    abstract::The neural basis of aggression is poorly understood. A study in this issue used genetic scalpels to dissect the circuitry of the fly brain and identified a small cluster of octopaminergic neurons that can make a fly fighting mad. ...

    journal_title:Nature neuroscience

    pub_type: 评论,杂志文章,评审


    authors: Potter CJ,Luo L

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  • Fbw7 controls neural stem cell differentiation and progenitor apoptosis via Notch and c-Jun.

    abstract::Neural stem and progenitor cells (NSCs/NPCs) give rise to neurons, astrocytes and oligodendrocytes. However, the mechanisms underlying the decision of a stem cell to either self-renew or differentiate are incompletely understood. We demonstrate here that Fbw7 (F-box and WD repeat domain containing-7), the substrate re...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: Hoeck JD,Jandke A,Blake SM,Nye E,Spencer-Dene B,Brandner S,Behrens A

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  • Oligodendrocyte precursor cell specification is regulated by bidirectional neural progenitor-endothelial cell crosstalk.

    abstract::Neural-derived signals are crucial regulators of CNS vascularization. However, whether the vasculature responds to these signals by means of elongating and branching or in addition by building a feedback response to modulate neurodevelopmental processes remains unknown. In this study, we identified bidirectional cross...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


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    更新日期:2021-01-28 00:00:00

  • Neuronal correlates of visibility and invisibility in the primate visual system.

    abstract::A brief visual target stimulus may be rendered invisible if it is immediately preceded or followed by another stimulus. This class of illusions, known as visual masking, may allow insights into the neural mechanisms that underlie visual perception. We have therefore explored the temporal characteristics of masking ill...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: Macknik SL,Livingstone MS

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  • Rich cell-type-specific network topology in neocortical microcircuitry.

    abstract::Uncovering structural regularities and architectural topologies of cortical circuitry is vital for understanding neural computations. Recently, an experimentally constrained algorithm generated a dense network reconstruction of a ∼0.3-mm3 volume from juvenile rat somatosensory neocortex, comprising ∼31,000 cells and ∼...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: Gal E,London M,Globerson A,Ramaswamy S,Reimann MW,Muller E,Markram H,Segev I

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  • Complete sparing of high-contrast color input to motion perception in cortical color blindness.

    abstract::It is widely held that color and motion are processed by separate parallel pathways in the visual system, but this view is difficult to reconcile with the fact that motion can be detected in equiluminant stimuli that are defined by color alone. To examine the relationship between color and motion, we tested three pati...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


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  • Author Correction: Microglial immune checkpoint mechanisms.

    abstract::In the version of this article initially published, the annotation accompanying ref. 47 ended with "though the modulation of microglia." The first word of this phrase should have been "through." The error has been corrected in the HTML and PDF versions of the article. ...

    journal_title:Nature neuroscience

    pub_type: 已发布勘误


    authors: Deczkowska A,Amit I,Schwartz M

    更新日期:2018-08-01 00:00:00

  • A dual shaping mechanism for postsynaptic ephrin-B3 as a receptor that sculpts dendrites and synapses.

    abstract::As the neural network becomes wired, postsynaptic signaling molecules are thought to control the growth of dendrites and synapses. However, how these molecules are coordinated to sculpt postsynaptic structures is less well understood. We find that ephrin-B3, a transmembrane ligand for Eph receptors, functions postsyna...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: Xu NJ,Sun S,Gibson JR,Henkemeyer M

    更新日期:2011-10-02 00:00:00

  • Efficient coding of natural sounds.

    abstract::The auditory system encodes sound by decomposing the amplitude signal arriving at the ear into multiple frequency bands whose center frequencies and bandwidths are approximately exponential functions of the distance from the stapes. This organization is thought to result from the adaptation of cochlear mechanisms to t...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: Lewicki MS

    更新日期:2002-04-01 00:00:00

  • Kinesin 3 and cytoplasmic dynein mediate interkinetic nuclear migration in neural stem cells.

    abstract::Radial glial progenitor cells exhibit bidirectional cell cycle-dependent nuclear oscillations. The purpose and underlying mechanism of this unusual 'interkinetic nuclear migration' are poorly understood. We investigated the basis for this behavior by live imaging of nuclei, centrosomes and microtubules in embryonic ra...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: Tsai JW,Lian WN,Kemal S,Kriegstein AR,Vallee RB

    更新日期:2010-12-01 00:00:00

  • Endogenous nicotinic cholinergic activity regulates dopamine release in the striatum.

    abstract::Dopamine is vital for coordinated motion and for association learning linked to behavioral reinforcement. Here we show that the precise overlap of striatal dopaminergic and cholinergic fibers underlies potent control of dopamine release by ongoing nicotinic receptor activity. In mouse striatal slices, nicotinic antago...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: Zhou FM,Liang Y,Dani JA

    更新日期:2001-12-01 00:00:00

  • Neural encoding of opposing strategy values in anterior and posterior cingulate cortex.

    abstract::Humans, and animals, often encounter ambiguous situations that require a decision on whether to take an offense or a defense strategy. Behavioral studies suggest that a strategy decision is frequently made before concrete options are evaluated. It remains enigmatic, however, how a strategy is determined without explor...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: Wan X,Cheng K,Tanaka K

    更新日期:2015-05-01 00:00:00

  • Cocaine inverts rules for synaptic plasticity of glutamate transmission in the ventral tegmental area.

    abstract::The manner in which drug-evoked synaptic plasticity affects reward circuits remains largely elusive. We found that cocaine reduced NMDA receptor excitatory postsynaptic currents and inserted GluA2-lacking AMPA receptors in dopamine neurons of mice. Consequently, a stimulation protocol pairing glutamate release with hy...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: Mameli M,Bellone C,Brown MT,Lüscher C

    更新日期:2011-04-01 00:00:00

  • Temporal structure of motor variability is dynamically regulated and predicts motor learning ability.

    abstract::Individual differences in motor learning ability are widely acknowledged, yet little is known about the factors that underlie them. Here we explore whether movement-to-movement variability in motor output, a ubiquitous if often unwanted characteristic of motor performance, predicts motor learning ability. Surprisingly...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: Wu HG,Miyamoto YR,Gonzalez Castro LN,Ölveczky BP,Smith MA

    更新日期:2014-02-01 00:00:00

  • Columnar organization of spatial phase in visual cortex.

    abstract::Images are processed in the primary visual cortex by neurons that encode different stimulus orientations and spatial phases. In primates and carnivores, neighboring cortical neurons share similar orientation preferences, but spatial phases were thought to be randomly distributed. We discovered a columnar organization ...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: Wang Y,Jin J,Kremkow J,Lashgari R,Komban SJ,Alonso JM

    更新日期:2015-01-01 00:00:00

  • State-related and item-related neural correlates of successful memory encoding.

    abstract::Neuroimaging studies show that the efficacy of long-term memory encoding of a stimulus is indexed by transient neural activity elicited by that stimulus. Here, we show that successful memory encoding is also indexed by neural activity that is tonically maintained throughout a study task. Using functional magnetic reso...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: Otten LJ,Henson RN,Rugg MD

    更新日期:2002-12-01 00:00:00

  • A complexin fusion clamp regulates spontaneous neurotransmitter release and synaptic growth.

    abstract::Neuronal signaling occurs through both action potential-triggered synaptic vesicle fusion and spontaneous release, although the fusion clamp machinery that prevents premature exocytosis of synaptic vesicles in the absence of calcium is unknown. Here we demonstrate that spontaneous release at synapses is regulated by c...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: Huntwork S,Littleton JT

    更新日期:2007-10-01 00:00:00

  • HDAC1 and HDAC2 control the transcriptional program of myelination and the survival of Schwann cells.

    abstract::Histone deacetylases (HDACs) are major epigenetic regulators. We show that HDAC1 and HDAC2 functions are critical for myelination of the peripheral nervous system. Using mouse genetics, we have ablated Hdac1 and Hdac2 specifically in Schwann cells, resulting in massive Schwann cell loss and virtual absence of myelin i...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: Jacob C,Christen CN,Pereira JA,Somandin C,Baggiolini A,Lötscher P,Ozçelik M,Tricaud N,Meijer D,Yamaguchi T,Matthias P,Suter U

    更新日期:2011-04-01 00:00:00

  • Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways.

    abstract::Here we report that synaptic and extrasynaptic NMDA (N-methyl-D-aspartate) receptors have opposite effects on CREB (cAMP response element binding protein) function, gene regulation and neuron survival. Calcium entry through synaptic NMDA receptors induced CREB activity and brain-derived neurotrophic factor (BDNF) gene...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: Hardingham GE,Fukunaga Y,Bading H

    更新日期:2002-05-01 00:00:00

  • Dynamic circuit motifs underlying rhythmic gain control, gating and integration.

    abstract::Brain circuitry processes information by rapidly and selectively engaging functional neuronal networks. The dynamic formation of networks is often evident in rhythmically synchronized neuronal activity and tightly correlates with perceptual, cognitive and motor performances. But how synchronized neuronal activity cont...

    journal_title:Nature neuroscience

    pub_type: 杂志文章,评审


    authors: Womelsdorf T,Valiante TA,Sahin NT,Miller KJ,Tiesinga P

    更新日期:2014-08-01 00:00:00

  • Multiple models to capture the variability in biological neurons and networks.

    abstract::How tightly tuned are the synaptic and intrinsic properties that give rise to neuron and circuit function? Experimental work shows that these properties vary considerably across identified neurons in different animals. Given this variability in experimental data, this review describes some of the complications of buil...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: Marder E,Taylor AL

    更新日期:2011-02-01 00:00:00

  • Sharp emergence of feature-selective sustained activity along the dorsal visual pathway.

    abstract::Sustained activity encoding visual working memory representations has been observed in several cortical areas of primates. Where along the visual pathways this activity emerges remains unknown. Here we show in macaques that sustained spiking activity encoding memorized visual motion directions is absent in direction-s...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: Mendoza-Halliday D,Torres S,Martinez-Trujillo JC

    更新日期:2014-09-01 00:00:00