Time to give up on a single explanation for autism.

abstract：:Axonal injury results in regenerative success or failure, depending on whether the axon lies in the peripheral or the CNS, respectively. The present study addresses whether epigenetic signatures in dorsal root ganglia discriminate between regenerative and non-regenerative axonal injury. Chromatin immunoprecipitation f...

journal_title：Nature neuroscience

authors： Palmisano I,Danzi MC,Hutson TH,Zhou L,McLachlan E,Serger E,Shkura K,Srivastava PK,Hervera A,Neill NO,Liu T,Dhrif H,Wang Z,Kubat M,Wuchty S,Merkenschlager M,Levi L,Elliott E,Bixby JL,Lemmon VP,Di Giovanni S

更新日期：2019-11-01 00:00:00

abstract：:The ventral intraparietal area (VIP) receives converging inputs from visual, somatosensory, auditory and vestibular systems that use diverse reference frames to encode sensory information. A key issue is how VIP combines those inputs together. We mapped the visual and tactile receptive fields of multimodal VIP neurons...

journal_title：Nature neuroscience

authors： Avillac M,Denève S,Olivier E,Pouget A,Duhamel JR

更新日期：2005-07-01 00:00:00

abstract：:Neurotransmitters are released continuously at ribbon synapses in the retina and cochlea. Notably, a single ribbon synapse of inner hair cells provides the entire input to each cochlear afferent fiber. We investigated hair cell transmitter release in the postnatal rat cochlea by recording excitatory postsynaptic curre...

journal_title：Nature neuroscience

authors： Glowatzki E,Fuchs PA

更新日期：2002-02-01 00:00:00

abstract：:Humans exhibit a remarkable degree of resilience in the face of extreme stress, with most resisting the development of neuropsychiatric disorders. Over the past 5 years, there has been increasing interest in the active, adaptive coping mechanisms of resilience; however, in humans, most published work focuses on correl...

journal_title：Nature neuroscience

authors： Russo SJ,Murrough JW,Han MH,Charney DS,Nestler EJ

更新日期：2012-11-01 00:00:00

abstract：:Sharp wave-ripple (SPW-R) complexes in the hippocampus-entorhinal cortex are believed to be important for transferring labile memories from the hippocampus to the neocortex for long-term storage. We found that selective elimination of SPW-Rs during post-training consolidation periods resulted in performance impairment...

journal_title：Nature neuroscience

authors： Girardeau G,Benchenane K,Wiener SI,Buzsáki G,Zugaro MB

更新日期：2009-10-01 00:00:00

abstract：:Intrinsic signal imaging from inferotemporal (IT) cortex, a visual area essential for object perception and recognition, revealed that visually presented objects activated patches in a distributed manner. When visual features of these objects were partially removed, the simplified stimuli activated only a subset of th...

journal_title：Nature neuroscience

authors： Tsunoda K,Yamane Y,Nishizaki M,Tanifuji M

更新日期：2001-08-01 00:00:00

abstract：:The molecular trigger of CNS myelination is unknown. By targeting Pten in cerebellar granule cells and activating the AKT1-mTOR pathway, we increased the caliber of normally unmyelinated axons and the expression of numerous genes encoding regulatory proteins. This led to the expansion of genetically wild-type oligoden...

journal_title：Nature neuroscience

authors： Goebbels S,Wieser GL,Pieper A,Spitzer S,Weege B,Yan K,Edgar JM,Yagensky O,Wichert SP,Agarwal A,Karram K,Renier N,Tessier-Lavigne M,Rossner MJ,Káradóttir RT,Nave KA

更新日期：2017-01-01 00:00:00

abstract：:As we move through the environment, the pattern of visual motion on the retina provides rich information about our movement through the scene. Human subjects can use this information, often termed "optic flow", to accurately estimate their direction of self movement (heading) from relatively sparse displays. Physiolog...

journal_title：Nature neuroscience

authors： Britten KH,van Wezel RJ

更新日期：1998-05-01 00:00:00

abstract：:Communication between glia cells and neurons is crucial for brain functions, but the molecular mechanisms and functional consequences of gliotransmission remain enigmatic. Here we report that astrocytes express synaptobrevin II and cellubrevin as functionally non-overlapping vesicular SNARE proteins on glutamatergic v...

journal_title：Nature neuroscience

authors： Schwarz Y,Zhao N,Kirchhoff F,Bruns D

更新日期：2017-11-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature neuroscience

authors： Mongillo G,Rumpel S,Loewenstein Y

更新日期：2019-12-01 00:00:00

abstract：:GABA interneurons play a critical role in higher brain functions. Astrocytic glial cells interact with synapses throughout the whole brain and are recognized as regulatory elements of excitatory synaptic transmission. However, it is largely unknown how GABAergic interneurons and astrocytes interact and contribute to s...

journal_title：Nature neuroscience

authors： Mederos S,Sánchez-Puelles C,Esparza J,Valero M,Ponomarenko A,Perea G

更新日期：2021-01-01 00:00:00

abstract：:Human behavior is mostly composed of habitual actions that require little conscious control. Such actions may become invalid if the environment changes, at which point individuals need to switch behavior by overcoming habitual actions that are otherwise triggered automatically. It is unknown how the brain controls thi...

journal_title：Nature neuroscience

authors： Isoda M,Hikosaka O

更新日期：2007-02-01 00:00:00

abstract：:Motor function requires that motor axons extend from the spinal cord at regular intervals and that they are myelinated by Schwann cells. Little attention has been given to another cellular structure, the perineurium, which ensheaths the motor nerve, forming a flexible, protective barrier. Consequently, the origin of p...

journal_title：Nature neuroscience

authors： Kucenas S,Takada N,Park HC,Woodruff E,Broadie K,Appel B

更新日期：2008-02-01 00:00:00

abstract：:Selective serotonin reuptake inhibitors (SSRIs) are widely used antidepressants, but the mechanisms by which they influence behavior are only partially resolved. Adult hippocampal neurogenesis is necessary for some of the responses to SSRIs, but it is not known whether mature dentate gyrus granule cells (DG GCs) also ...

journal_title：Nature neuroscience

authors： Samuels BA,Anacker C,Hu A,Levinstein MR,Pickenhagen A,Tsetsenis T,Madroñal N,Donaldson ZR,Drew LJ,Dranovsky A,Gross CT,Tanaka KF,Hen R

更新日期：2015-11-01 00:00:00

abstract：:Cannabis is the most frequently used illicit psychoactive substance worldwide; around one in ten users become dependent. The risk for cannabis use disorder (CUD) has a strong genetic component, with twin heritability estimates ranging from 51 to 70%. Here we performed a genome-wide association study of CUD in 2,387 ca...

journal_title：Nature neuroscience

authors： Demontis D,Rajagopal VM,Thorgeirsson TE,Als TD,Grove J,Leppälä K,Gudbjartsson DF,Pallesen J,Hjorthøj C,Reginsson GW,Tyrfingsson T,Runarsdottir V,Qvist P,Christensen JH,Bybjerg-Grauholm J,Bækvad-Hansen M,Huckins LM,Stahl

更新日期：2019-07-01 00:00:00

abstract：:Olfaction has often been described as a ‘synthetic’ sense. A study now reveals a surprising capacity to resolve individual odorants in complex mixtures, with implications for how the nervous system recognizes objects. ...

journal_title：Nature neuroscience

authors： Holy TE

更新日期：2014-09-01 00:00:00

abstract：:Sensorimotor integration is crucial to perception and motor control. How and where this process takes place in the brain is still largely unknown. Here we analyze the cerebellar contribution to sensorimotor integration in the whisker system of mice. We identify an area in the cerebellum where cortical sensory and moto...

journal_title：Nature neuroscience

authors： Proville RD,Spolidoro M,Guyon N,Dugué GP,Selimi F,Isope P,Popa D,Léna C

更新日期：2014-09-01 00:00:00

abstract：:In Huntington's disease (HD), expansion of CAG codons in the huntingtin gene (HTT) leads to the aberrant formation of protein aggregates and the differential degeneration of striatal medium spiny neurons (MSNs). Modeling HD using patient-specific MSNs has been challenging, as neurons differentiated from induced plurip...

journal_title：Nature neuroscience

authors： Victor MB,Richner M,Olsen HE,Lee SW,Monteys AM,Ma C,Huh CJ,Zhang B,Davidson BL,Yang XW,Yoo AS

更新日期：2018-03-01 00:00:00

abstract：:A hallmark event in neurodegenerative diseases (NDs) is the misfolding, aggregation, and accumulation of proteins, leading to cellular dysfunction, loss of synaptic connections, and brain damage. Despite the involvement of distinct proteins in different NDs, the process of protein misfolding and aggregation is remarka...

journal_title：Nature neuroscience

authors： Soto C,Pritzkow S

更新日期：2018-10-01 00:00:00

abstract：:Every year in the United States, an estimated 500,000 babies are born preterm (before 37 completed weeks of gestation), and this number is rising, along with the recognition of brain injuries due to preterm delivery. A common underlying pathogenesis appears to be perinatal hypoxia induced by immature lung development,...

journal_title：Nature neuroscience

authors： Salmaso N,Jablonska B,Scafidi J,Vaccarino FM,Gallo V

更新日期：2014-03-01 00:00:00

abstract：:To investigate how the brain combines knowledge with visual processing to locate eye movement targets, we trained monkeys to search for a target defined by a conjunction of color and shape. On successful trials, neurons in the frontal eye field not only discriminated the target from distractors, but also discriminated...

journal_title：Nature neuroscience

authors： Bichot NP,Schall JD

更新日期：1999-06-01 00:00:00

abstract：:Stimuli that elicit itch are detected by sensory neurons that innervate the skin. This information is processed by the spinal cord; however, the way in which this occurs is still poorly understood. Here we investigated the neuronal pathways for itch neurotransmission, particularly the contribution of the neuropeptide ...

journal_title：Nature neuroscience

authors： Huang J,Polgár E,Solinski HJ,Mishra SK,Tseng PY,Iwagaki N,Boyle KA,Dickie AC,Kriegbaum MC,Wildner H,Zeilhofer HU,Watanabe M,Riddell JS,Todd AJ,Hoon MA

更新日期：2018-05-01 00:00:00

abstract：:Huntington's disease (HD) is caused by an expansion of exonic CAG triplet repeats in the gene encoding huntingtin protein (Htt), but the mechanisms by which this mutant protein causes neurodegeneration remain unknown. Here we show that lymphoblast mitochondria from patients with HD have a lower membrane potential and ...

journal_title：Nature neuroscience

authors： Panov AV,Gutekunst CA,Leavitt BR,Hayden MR,Burke JR,Strittmatter WJ,Greenamyre JT

更新日期：2002-08-01 00:00:00

abstract：:In this Perspective, we expand the notion of temporal regulation of RNA in the brain and propose that the qualitative nature of RNA and its metabolism, together with RNA abundance, are essential for the molecular mechanisms underlying experience-dependent plasticity. We discuss emerging concepts in the newly burgeonin...

journal_title：Nature neuroscience

authors： Nainar S,Marshall PR,Tyler CR,Spitale RC,Bredy TW

更新日期：2016-09-27 00:00:00

abstract：:Vesicular release of neurotransmitter is the universal output signal of neurons in the brain. It is generally believed that fast transmitter release is restricted to nerve terminals that contact postsynaptic cells in the gray matter. Here we show in the rat brain that the neurotransmitter glutamate is also released at...

journal_title：Nature neuroscience

authors： Kukley M,Capetillo-Zarate E,Dietrich D

更新日期：2007-03-01 00:00:00

abstract：:A fundamental organizing principle of auditory brain circuits is tonotopy, the orderly representation of the sound frequency to which neurons are most sensitive. Tonotopy arises from the coding of frequency along the cochlea and the topographic organization of auditory pathways. The mechanisms that underlie the establ...

journal_title：Nature neuroscience

authors： Kandler K,Clause A,Noh J

更新日期：2009-06-01 00:00:00

abstract：:The precise period when experience shapes neural circuits in the mouse visual system is unknown. We used Arc induction to monitor the functional pattern of ipsilateral eye representation in cortex during normal development and after visual deprivation. After monocular deprivation during the critical period, Arc induct...

journal_title：Nature neuroscience

authors： Tagawa Y,Kanold PO,Majdan M,Shatz CJ

更新日期：2005-03-01 00:00:00

abstract：:How different are the neuronal circuits for a given behavior across individual animals? To address this question, we measured multiple cellular and synaptic parameters in individual preparations to see how they correlated with circuit function, using neurons and synapses in the pyloric circuit of the stomatogastric ga...

journal_title：Nature neuroscience

authors： Goaillard JM,Taylor AL,Schulz DJ,Marder E

更新日期：2009-11-01 00:00:00

abstract：:Neuroligins are postsynaptic cell adhesion molecules that are important for synaptic function through their trans-synaptic interaction with neurexins (NRXNs). The localization and synaptic effects of neuroligin-1 (NL-1, also called NLGN1) are specific to excitatory synapses with the capacity to enhance excitatory syna...

journal_title：Nature neuroscience

authors： Bemben MA,Shipman SL,Hirai T,Herring BE,Li Y,Badger JD 2nd,Nicoll RA,Diamond JS,Roche KW

更新日期：2014-01-01 00:00:00

abstract：:The brain transforms physical sensory stimuli into meaningful perceptions. In animals making choices about sensory stimuli, neuronal activity in successive cortical stages reflects a progression from sensation to decision. Feedforward and feedback pathways connecting cortical areas are critical for this transformation...

journal_title：Nature neuroscience

authors： Kwon SE,Yang H,Minamisawa G,O'Connor DH

更新日期：2016-09-01 00:00:00