Abstract：
:How different are the neuronal circuits for a given behavior across individual animals? To address this question, we measured multiple cellular and synaptic parameters in individual preparations to see how they correlated with circuit function, using neurons and synapses in the pyloric circuit of the stomatogastric ganglion of the crab Cancer borealis. There was considerable preparation-to-preparation variability in the strength of two identified synapses, in the amplitude of a modulator-evoked current and in the expression of six ion channel genes. Nonetheless, we found strong correlations across preparations among these parameters and attributes of circuit performance. These data illustrate the importance of making multidimensional measurements from single preparations for understanding how variability in circuit output is related to the variability of multiple circuit parameters.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Goaillard JM,Taylor AL,Schulz DJ,Marder Edoi
10.1038/nn.2404subject
Has Abstractpub_date
2009-11-01 00:00:00pages
1424-30issue
11eissn
1097-6256issn
1546-1726pii
nn.2404journal_volume
12pub_type
杂志文章abstract：:Uncovering structural regularities and architectural topologies of cortical circuitry is vital for understanding neural computations. Recently, an experimentally constrained algorithm generated a dense network reconstruction of a ∼0.3-mm3 volume from juvenile rat somatosensory neocortex, comprising ∼31,000 cells and ∼...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4576
更新日期：2017-07-01 00:00:00
abstract：:Neuronal signaling occurs through both action potential-triggered synaptic vesicle fusion and spontaneous release, although the fusion clamp machinery that prevents premature exocytosis of synaptic vesicles in the absence of calcium is unknown. Here we demonstrate that spontaneous release at synapses is regulated by c...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1980
更新日期：2007-10-01 00:00:00
abstract：:The precise role of synchronous neuronal firing in signal encoding remains unclear. To examine what kinds of signals can be carried by synchrony, I reproduced a multilayer feedforward network of neurons in an in vitro slice preparation of rat cortex using an iterative procedure. When constant and time-varying frequenc...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1056
更新日期：2003-06-01 00:00:00
abstract：:Blood flow into the brain is dynamically regulated to satisfy the changing metabolic requirements of neurons, but how this is accomplished has remained unclear. Here we demonstrate a central role for capillary endothelial cells in sensing neural activity and communicating it to upstream arterioles in the form of an el...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4533
更新日期：2017-05-01 00:00:00
abstract：:As the neural network becomes wired, postsynaptic signaling molecules are thought to control the growth of dendrites and synapses. However, how these molecules are coordinated to sculpt postsynaptic structures is less well understood. We find that ephrin-B3, a transmembrane ligand for Eph receptors, functions postsyna...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2931
更新日期：2011-10-02 00:00:00
abstract：:Neurotransmitter transporters can affect neuronal excitability indirectly via modulation of neurotransmitter concentrations or directly via transporter currents. A physiological or pathophysiological role for transporter currents has not been described. We found that GABA transporter 1 (GAT-1) cation currents directly...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2940
更新日期：2011-10-30 00:00:00
abstract：:Leptin regulates energy balance. However, knowledge of the critical intracellular transducers of leptin signaling remains incomplete. We found that Rho-kinase 1 (ROCK1) regulates leptin action on body weight homeostasis by activating JAK2, an initial trigger of leptin receptor signaling. Leptin promoted the physical i...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3207
更新日期：2012-10-01 00:00:00
abstract：:Sleep can strengthen memory for emotional information, but whether emotional memories can be specifically targeted and modified during sleep is unknown. In human subjects who underwent olfactory contextual fear conditioning, re-exposure to the odorant context in slow-wave sleep promoted stimulus-specific fear extincti...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3527
更新日期：2013-11-01 00:00:00
abstract：:Synaptic strength can be altered by a variety of pre- or postsynaptic modifications. Here we test the hypothesis that long-term depression (LTD) involves a decrease in the number of glutamate receptors that are clustered at individual synapses in primary cultures of hippocampal neurons. Similar to a prominent form of ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/8123
更新日期：1999-05-01 00:00:00
abstract：:Fear-inducing memories can be state dependent, meaning that they can best be retrieved if the brain states at encoding and retrieval are similar. Restricted access to such memories can present a risk for psychiatric disorders and hamper their treatment. To better understand the mechanisms underlying state-dependent fe...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4084
更新日期：2015-09-01 00:00:00
abstract：:The regulation of female reproductive behaviors may involve memories of male pheromone signatures, formed in part by neural circuitry involving the olfactory bulb and hippocampus. These neural structures are the principal sites of adult neurogenesis; however, previous studies point to their independent regulation by s...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1928
更新日期：2007-08-01 00:00:00
abstract：:Although inherently linked, body form and body action may be represented in separate neural substrates. Using repetitive transcranial magnetic stimulation in healthy individuals, we show that interference with the extrastriate body area impairs the discrimination of bodily forms, and interference with the ventral prem...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1815
更新日期：2007-01-01 00:00:00
abstract：:PICALM is a highly validated genetic risk factor for Alzheimer's disease (AD). We found that reduced expression of PICALM in AD and murine brain endothelium correlated with amyloid-β (Aβ) pathology and cognitive impairment. Moreover, Picalm deficiency diminished Aβ clearance across the murine blood-brain barrier (BBB)...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4025
更新日期：2015-07-01 00:00:00
abstract：:Cell type-specific expression of optogenetic molecules allows temporally precise manipulation of targeted neuronal activity. Here we present a toolbox of four knock-in mouse lines engineered for strong, Cre-dependent expression of channelrhodopsins ChR2-tdTomato and ChR2-EYFP, halorhodopsin eNpHR3.0 and archaerhodopsi...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3078
更新日期：2012-03-25 00:00:00
abstract：:Phosphoinositide 3 kinase enhancer (PIKE) is a recently identified nuclear GTPase that activates nuclear phosphoinositide 3-kinase (PI3 kinase). We have identified, cloned and characterized a new form of PIKE, designated PIKE-L, which, unlike the nuclear PIKE-S, localizes to both the cytoplasm and the nucleus. We demo...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1134
更新日期：2003-11-01 00:00:00
abstract：:Sustained activity encoding visual working memory representations has been observed in several cortical areas of primates. Where along the visual pathways this activity emerges remains unknown. Here we show in macaques that sustained spiking activity encoding memorized visual motion directions is absent in direction-s...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3785
更新日期：2014-09-01 00:00:00
abstract：:Synaptic vesicles release neurotransmitter both actively (on stimulation) and spontaneously (at rest). It has been assumed that identical vesicles use both modes of release; however, recent evidence has challenged this view. Using several assays (FM dye imaging, pHluorin imaging and antibody-labeling of synaptotagmin)...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2690
更新日期：2010-12-01 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Nature neuroscience
pub_type： 已发布勘误
doi：10.1038/s41593-019-0546-5
更新日期：2019-12-01 00:00:00
abstract：:Phasic activation of the dopamine (DA) midbrain system in response to unexpected reward or novelty is critical for adaptive behavioral strategies. This activation of DA midbrain neurons occurs via a synaptically triggered switch from low-frequency background spiking to transient high-frequency burst firing. We found t...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3185
更新日期：2012-09-01 00:00:00
abstract：:Newborn microglia rapidly replenish the whole brain after selective elimination of most microglia (>99%) in adult mice. Previous studies reported that repopulated microglia were largely derived from microglial progenitor cells expressing nestin in the brain. However, the origin of these repopulated microglia has been ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-018-0090-8
更新日期：2018-04-01 00:00:00
abstract：:A hallmark event in neurodegenerative diseases (NDs) is the misfolding, aggregation, and accumulation of proteins, leading to cellular dysfunction, loss of synaptic connections, and brain damage. Despite the involvement of distinct proteins in different NDs, the process of protein misfolding and aggregation is remarka...
journal_title：Nature neuroscience
pub_type： 杂志文章,评审
doi：10.1038/s41593-018-0235-9
更新日期：2018-10-01 00:00:00
abstract：:Nature Neuroscience presents a special issue of recent advances on shared mechanisms underlying neurodegenerative disease. ...
journal_title：Nature neuroscience
pub_type： 社论
doi：10.1038/s41593-018-0250-x
更新日期：2018-10-01 00:00:00
abstract：:Leucine-rich repeat kinase 2 (LRRK2) is enriched in the striatal projection neurons (SPNs). We found that LRRK2 negatively regulates protein kinase A (PKA) activity in the SPNs during synaptogenesis and in response to dopamine receptor Drd1 activation. LRRK2 interacted with PKA regulatory subunit IIβ (PKARIIβ). A lack...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3636
更新日期：2014-03-01 00:00:00
abstract：:The processing of synaptic potentials by neuronal dendrites depends on both their passive cable properties and active voltage-gated channels, which can generate complex effects as a result of their nonlinear properties. We characterized the actions of HCN (hyperpolarization-activated cyclic nucleotide-gated cation) ch...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2307
更新日期：2009-05-01 00:00:00
abstract：:Communication plays an integral role in human social dynamics and is impaired in several neurodevelopmental disorders. Mice are used to study the neurobiology of social behavior; however, the extent to which mouse vocalizations influence social dynamics has remained elusive because it is difficult to identify the voca...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-020-0584-z
更新日期：2020-03-01 00:00:00
abstract：:To investigate the mechanisms of persistent neural activity, we obtained in vivo intracellular recordings from neurons in an oculomotor neural integrator of the goldfish during spontaneous saccades and fixations. Persistent changes in firing rate following saccades were associated with step changes in interspike membr...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/84023
更新日期：2001-02-01 00:00:00
abstract：:Growing evidence suggests that the recognition of different emotional states involves at least partly separable neural circuits. Here we assessed the discrimination of both anger and happiness in healthy subjects receiving transcranial magnetic stimulation (TMS) over the medial-frontal cortex or over a control site (m...
journal_title：Nature neuroscience
pub_type： 临床试验,杂志文章
doi：10.1038/82854
更新日期：2001-01-01 00:00:00
abstract：:Cuing covert spatial attention can increase spatial resolution. Here we pinpointed the specific locus of this effect using texture segmentation. At the level of visual cortex, texture segmentation theoretically involves passage of visual input through two layers of spatial linear filters separated by a pointwise nonli...
journal_title：Nature neuroscience
pub_type： 临床试验,杂志文章
doi：10.1038/75804
更新日期：2000-06-01 00:00:00
abstract：:In mammals, many daily cycles are driven by a central circadian clock, which is based on the cell-autonomous rhythmic expression of clock genes. It is not clear, however, how peripheral cells are able to interpret the rhythmic signals disseminated from this central oscillator. Here we show that cycling expression of t...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn806
更新日期：2002-03-01 00:00:00
abstract：:The manner in which drug-evoked synaptic plasticity affects reward circuits remains largely elusive. We found that cocaine reduced NMDA receptor excitatory postsynaptic currents and inserted GluA2-lacking AMPA receptors in dopamine neurons of mice. Consequently, a stimulation protocol pairing glutamate release with hy...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2763
更新日期：2011-04-01 00:00:00
