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Rapid redistribution of glutamate receptors contributes to long-term depression in hippocampal cultures.

Abstract：

:Synaptic strength can be altered by a variety of pre- or postsynaptic modifications. Here we test the hypothesis that long-term depression (LTD) involves a decrease in the number of glutamate receptors that are clustered at individual synapses in primary cultures of hippocampal neurons. Similar to a prominent form of LTD observed in hippocampal slices, LTD in hippocampal cultures required NMDA receptor activation and was accompanied by a decrease in the amplitude and frequency of miniature excitatory postsynaptic currents. Immunocytochemical analysis revealed that induction of LTD caused a concurrent decrease in the number of AMPA receptors clustered at synapses but had no effect on synaptic NMDA receptor clusters. These results suggest that a subtype-specific redistribution of synaptic glutamate receptors contributes to NMDA receptor-dependent LTD.

journal_name

Nat Neurosci

journal_title

Nature neuroscience

authors

Carroll RC,Lissin DV,von Zastrow M,Nicoll RA,Malenka RC

doi

10.1038/8123

subject

Has Abstract

pub_date

1999-05-01 00:00:00

pages

454-60

issue

5

eissn

1097-6256

issn

1546-1726

journal_volume

2

pub_type

杂志文章

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