Abstract：
:Successfully navigating in physical or semantic space requires a neural representation of allocentric (map-based) vectors to boundaries, objects and goals. Cognitive processes such as path-planning and imagination entail the recall of vector representations, but evidence of neuron-level memory for allocentric vectors has been lacking. Here, we describe a novel neuron type, vector trace cell (VTC), whose firing generates a new vector field when a cue is encountered and a 'trace' version of that field for hours after cue removal. VTCs are concentrated in subiculum, distal to CA1. Compared to non-trace cells, VTCs fire at further distances from cues and exhibit earlier-going shifts in preferred theta phase in response to newly introduced cues, which demonstrates a theta-linked neural substrate for memory encoding. VTCs suggest a vector-based model of computing spatial relationships between an agent and multiple spatial objects, or between different objects, freed from the constraints of direct perception of those objects.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Poulter S,Lee SA,Dachtler J,Wills TJ,Lever Cdoi
10.1038/s41593-020-00761-wsubject
Has Abstractpub_date
2020-12-21 00:00:00eissn
1097-6256issn
1546-1726pii
10.1038/s41593-020-00761-wpub_type
杂志文章abstract：:Neuronal development, plasticity and survival require activity-dependent synapse-to-nucleus signaling. Most studies implicate an activity-dependent regulation of gene expression in this phenomenon. However, little is known about other nuclear functions that are regulated by synaptic activity. Here we show that a newly...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1867
更新日期：2007-04-01 00:00:00
abstract：:Memory is supported by a specific ensemble of neurons distributed in the brain that form a unique memory trace. We previously showed that neurons in the lateral amygdala expressing elevated levels of cAMP response-element binding protein are preferentially recruited into fear memory traces and are necessary for the ex...
journal_title：Nature neuroscience
pub_type： 杂志文章
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更新日期：2014-01-01 00:00:00
abstract：:Pericytes are perivascular mural cells of brain capillaries. They are positioned centrally in the neurovascular unit between endothelial cells, astrocytes and neurons. This position allows them to regulate key neurovascular functions of the brain. The role of pericytes in the regulation of cerebral blood flow (CBF) an...
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pub_type： 杂志文章
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更新日期：2017-03-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
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更新日期：2006-05-01 00:00:00
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pub_type： 杂志文章
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journal_title：Nature neuroscience
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更新日期：2009-07-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2016-02-01 00:00:00
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pub_type： 杂志文章
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更新日期：2007-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：2013-07-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
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更新日期：2002-05-01 00:00:00
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更新日期：2008-02-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
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更新日期：2009-04-01 00:00:00
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pub_type： 杂志文章
doi：10.1038/nn805
更新日期：2002-03-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2582
更新日期：2010-08-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
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更新日期：2009-11-01 00:00:00
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更新日期：2019-11-01 00:00:00
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pub_type： 已发布勘误
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更新日期：2019-12-01 00:00:00
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pub_type： 杂志文章
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更新日期：2000-09-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1492
更新日期：2005-07-01 00:00:00
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doi：10.1038/nn1126
更新日期：2003-10-01 00:00:00
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更新日期：2012-06-17 00:00:00
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更新日期：2004-09-01 00:00:00
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更新日期：2006-03-01 00:00:00
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更新日期：2005-08-01 00:00:00
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