Abstract：
:We used high-level configural aftereffects induced by adaptation to realistic faces to investigate visual representations underlying complex pattern perception. We found that exposure to an individual face for a few seconds generated a significant and precise bias in the subsequent perception of face identity. In the context of a computationally derived 'face space,' adaptation specifically shifted perception along a trajectory passing through the adapting and average faces, selectively facilitating recognition of a test face lying on this trajectory and impairing recognition of other faces. The results suggest that the encoding of faces and other complex patterns draws upon contrastive neural mechanisms that reference the central tendency of the stimulus category.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Leopold DA,O'Toole AJ,Vetter T,Blanz Vdoi
10.1038/82947subject
Has Abstractpub_date
2001-01-01 00:00:00pages
89-94issue
1eissn
1097-6256issn
1546-1726journal_volume
4pub_type
临床试验,杂志文章abstract：:Retinal bipolar cells have been assumed to generate purely graded responses to light. To test this idea we imaged the presynaptic calcium transient in live zebrafish. We found that ON, OFF, transient and sustained bipolar cells are all capable of generating fast 'all-or-none' calcium transients modulated by visual sti...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2841
更新日期：2011-06-26 00:00:00
abstract：:The excitability of individual dendritic branches is a plastic property of neurons. We found that experience in an enriched environment increased propagation of dendritic Na(+) spikes in a subset of individual dendritic branches in rat hippocampal CA1 pyramidal neurons and that this effect was mainly mediated by local...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2428
更新日期：2009-12-01 00:00:00
abstract：:Economic choice entails assigning values to the available options and is impaired by lesions to the orbitofrontal cortex (OFC). Recent results show that some neurons in the OFC encode the values that monkeys (Macaca mulatta) assign to different goods when they choose between them. A broad and fundamental question is h...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn2020
更新日期：2008-01-01 00:00:00
abstract：:Transposable elements, known colloquially as 'jumping genes', constitute approximately 45% of the human genome. Cells utilize epigenetic defenses to limit transposable element jumping, including formation of silencing heterochromatin and generation of piwi-interacting RNAs (piRNAs), small RNAs that facilitate clearanc...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-018-0194-1
更新日期：2018-08-01 00:00:00
abstract：:Individual differences in motor learning ability are widely acknowledged, yet little is known about the factors that underlie them. Here we explore whether movement-to-movement variability in motor output, a ubiquitous if often unwanted characteristic of motor performance, predicts motor learning ability. Surprisingly...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3616
更新日期：2014-02-01 00:00:00
abstract：:EphAs and ephrinAs are expressed in multiple areas of the developing brain in overlapping countergradients, notably in the retina and tectum. Here they are involved in targeting retinal axons to their correct topographic position in the tectum. We have used truncated versions of EphA3, single-amino acid point mutants ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1655
更新日期：2006-03-01 00:00:00
abstract：:Phosphatidylinositol 3-kinase (PI3K) has been shown to enhance native voltage-dependent calcium channel (Ca(v)) currents both in myocytes and in neurons; however, the mechanism(s) responsible for this regulation were not known. Here we show that PI3K promotes the translocation of GFP-tagged Ca(v) channels to the plasm...
journal_title：Nature neuroscience
pub_type： 杂志文章
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更新日期：2004-09-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-020-0677-8
更新日期：2020-10-01 00:00:00
abstract：:Autism spectrum disorder (ASD) is genetically heterogeneous with convergent symptomatology, suggesting common dysregulated pathways. In this study, we analyzed brain transcriptional changes in five mouse models of Pitt-Hopkins syndrome (PTHS), a syndromic form of ASD caused by mutations in the TCF4 gene, but not the T...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-019-0578-x
更新日期：2020-03-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 评论,新闻
doi：10.1038/12137
更新日期：1999-09-01 00:00:00
abstract：:Predatory hunting plays a fundamental role in animal survival. Little is known about the neural circuits that convert sensory cues into neural signals to drive this behavior. Here we identified an excitatory subcortical neural circuit from the superior colliculus to the zona incerta that triggers predatory hunting. Th...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-019-0405-4
更新日期：2019-06-01 00:00:00
abstract：:Nature Neuroscience presents a special issue of recent advances on shared mechanisms underlying neurodegenerative disease. ...
journal_title：Nature neuroscience
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更新日期：2018-10-01 00:00:00
abstract：:Head-direction cells have frequently been regarded as an internal 'compass' that can be used for navigation, although there is little evidence showing a link between their activity and spatial behavior. In a navigational task requiring the use of internal cues to return to a home location without vision (path integrat...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3215
更新日期：2012-10-01 00:00:00
abstract：:Previous work has shown that human adolescents may be hypersensitive to rewards, but it is not known which aspect of reward processing is responsible for this. We separated decision value and prediction error signals and found that neural prediction error signals in the striatum peaked in adolescence, whereas neural d...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2558
更新日期：2010-06-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1159
更新日期：2004-01-01 00:00:00
abstract：:The launch of the US BRAIN and European Human Brain Projects coincides with growing international efforts toward transparency and increased access to publicly funded research in the neurosciences. The need for data-sharing standards and neuroinformatics infrastructure is more pressing than ever. However, 'big science'...
journal_title：Nature neuroscience
pub_type： 杂志文章,评审
doi：10.1038/nn.3838
更新日期：2014-11-01 00:00:00
abstract：:An action may lead to either a reward or a punishment. Therefore, an appropriate action needs to be chosen on the basis of the values of both expected rewards and expected punishments. To understand the underlying neural mechanisms, we conditioned monkeys using a Pavlovian procedure with two distinct contexts: one in ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2233
更新日期：2009-01-01 00:00:00
abstract：:Blood flow into the brain is dynamically regulated to satisfy the changing metabolic requirements of neurons, but how this is accomplished has remained unclear. Here we demonstrate a central role for capillary endothelial cells in sensing neural activity and communicating it to upstream arterioles in the form of an el...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4533
更新日期：2017-05-01 00:00:00
abstract：:Oxytocin is an essential hormone for mammalian labor and lactation. Here, we show a new function of oxytocin in causing plastic changes in hippocampal synapses during motherhood. In oxytocin-perfused hippocampal slices, one-train tetanus stimulation induced long-lasting, long-term potentiation (L-LTP) and phosphorylat...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1023
更新日期：2003-04-01 00:00:00
abstract：:Successfully navigating in physical or semantic space requires a neural representation of allocentric (map-based) vectors to boundaries, objects and goals. Cognitive processes such as path-planning and imagination entail the recall of vector representations, but evidence of neuron-level memory for allocentric vectors ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-020-00761-w
更新日期：2020-12-21 00:00:00
abstract：:T cells clear virus from the CNS and dynamically regulate brain functions, including spatial learning, through cytokine signaling. Here we determined whether hippocampal T cells that persist after recovery from infection with West Nile virus (WNV) or Zika virus (ZIKV) impact hippocampal-dependent learning and memory. ...
journal_title：Nature neuroscience
pub_type： 杂志文章
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更新日期：2019-08-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3709
更新日期：2014-06-01 00:00:00
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pub_type： 杂志文章
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更新日期：2010-05-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1672
更新日期：2006-04-01 00:00:00
abstract：:Neuroligins are postsynaptic cell adhesion molecules that are important for synaptic function through their trans-synaptic interaction with neurexins (NRXNs). The localization and synaptic effects of neuroligin-1 (NL-1, also called NLGN1) are specific to excitatory synapses with the capacity to enhance excitatory syna...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3601
更新日期：2014-01-01 00:00:00
abstract：:Distinct cell lineages established early in development are usually maintained throughout adulthood. Thus, adult stem cells have been thought to generate differentiated cells specific to the tissue in which they reside. This view has been challenged; for example, neural stem cells can generate cells that normally orig...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/79924
更新日期：2000-10-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/12186
更新日期：1999-09-01 00:00:00
abstract：:Most advances in addiction treatment to date have addressed the physical dependence and withdrawal that accompany addiction to some drugs of abuse. In contrast, it has proven more difficult to develop medications that effectively treat drug craving and relapse, the core features of addictive disorders. Current efforts...
journal_title：Nature neuroscience
pub_type： 杂志文章,评审
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更新日期：2002-11-01 00:00:00
abstract：:Here we used magnetoencephalography (MEG) to investigate stages of processing in face perception in humans. We found a face-selective MEG response occurring only 100 ms after stimulus onset (the 'M100'), 70 ms earlier than previously reported. Further, the amplitude of this M100 response was correlated with successful...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn909
更新日期：2002-09-01 00:00:00
abstract：:The amygdala is essential for fear learning and expression. The central amygdala (CeA), once viewed as a passive relay between the amygdala complex and downstream fear effectors, has emerged as an active participant in fear conditioning. However, the mechanism by which CeA contributes to the learning and expression of...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3322
更新日期：2013-03-01 00:00:00
