Abstract:
:Phosphatidylinositol 3-kinase (PI3K) has been shown to enhance native voltage-dependent calcium channel (Ca(v)) currents both in myocytes and in neurons; however, the mechanism(s) responsible for this regulation were not known. Here we show that PI3K promotes the translocation of GFP-tagged Ca(v) channels to the plasma membrane in both COS-7 cells and neurons. We show that the effect of PI3K is mediated by Akt/PKB and specifically requires Ca(v)beta(2) subunits. The mutations S574A and S574E in Ca(v)beta(2a) prevented and mimicked, respectively, the effect of PI3K/Akt-PKB, indicating that phosphorylation of Ser574 on Ca(v)beta(2a) is necessary and sufficient to promote Ca(v) channel trafficking.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Viard P,Butcher AJ,Halet G,Davies A,Nürnberg B,Heblich F,Dolphin ACdoi
10.1038/nn1300subject
Has Abstractpub_date
2004-09-01 00:00:00pages
939-46issue
9eissn
1097-6256issn
1546-1726pii
nn1300journal_volume
7pub_type
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