Abstract：
:The distinct electrical properties of axonal and dendritic membranes are largely a result of specific transport of vesicle-bound membrane proteins to each compartment. How this specificity arises is unclear because kinesin motors that transport vesicles cannot autonomously distinguish dendritically projecting microtubules from those projecting axonally. We hypothesized that interaction with a second motor might enable vesicles containing dendritic proteins to preferentially associate with dendritically projecting microtubules and avoid those that project to the axon. Here we show that in rat cortical neurons, localization of several distinct transmembrane proteins to dendrites is dependent on specific myosin motors and an intact actin network. Moreover, fusion with a myosin-binding domain from Melanophilin targeted Channelrhodopsin-2 specifically to the somatodendritic compartment of neurons in mice in vivo. Together, our results suggest that dendritic transmembrane proteins direct the vesicles in which they are transported to avoid the axonal compartment through interaction with myosin motors.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Lewis TL Jr,Mao T,Svoboda K,Arnold DBdoi
10.1038/nn.2318subject
Has Abstractpub_date
2009-05-01 00:00:00pages
568-76issue
5eissn
1097-6256issn
1546-1726pii
nn.2318journal_volume
12pub_type
杂志文章abstract：:The sensing of circulating nutrients within the mediobasal hypothalamus may be critical for energy homeostasis. To induce a sustained impairment in hypothalamic nutrient sensing, adeno-associated viruses (AAV) expressing malonyl-coenzyme A decarboxylase (MCD; an enzyme involved in the degradation of malonyl coenzyme A...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1626
更新日期：2006-02-01 00:00:00
abstract：:In Huntington's disease (HD), whether transneuronal spreading of mutant huntingtin (mHTT) occurs and its contribution to non-cell autonomous damage in brain networks is largely unknown. We found mHTT spreading in three different neural network models: human neurons integrated in the neural network of organotypic brain...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3761
更新日期：2014-08-01 00:00:00
abstract：:Some neurons in auditory cortex respond to recent stimulus history by adapting their response functions to track stimulus statistics directly, as might be expected. In contrast, some neurons respond to loud sounds by adjusting their response functions away from high intensities and consequently remain sensitive to sof...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2201
更新日期：2008-11-01 00:00:00
abstract：:Cognition can be conceptualized as a set of algorithmic control functions whose real-time deployment determines how an organism stores and uses information to guide thought and action. A subset of these functions is required for goal-directed selection and amplification of sensory signals-broadly referred to as attent...
journal_title：Nature neuroscience
pub_type： 杂志文章,评审
doi：10.1038/s41593-017-0020-1
更新日期：2017-12-01 00:00:00
abstract：:By analyzing the whole-exome sequences of 4,264 schizophrenia cases, 9,343 controls and 1,077 trios, we identified a genome-wide significant association between rare loss-of-function (LoF) variants in SETD1A and risk for schizophrenia (P = 3.3 × 10(-9)). We found only two heterozygous LoF variants in 45,376 exomes fro...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4267
更新日期：2016-04-01 00:00:00
abstract：:Mutations in copper/zinc superoxide dismutase 1 (SOD1), primary causes of human amyotrophic lateral sclerosis (ALS), provoke motor neuron death through an unidentified toxic property. The known neurofilament-dependent slowing of axonal transport, combined with the prominent misaccumulation of neurofilaments in ALS, su...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/4553
更新日期：1999-01-01 00:00:00
abstract：:Laboratory models, including animal tissues and live animals, have proven useful for discovery of molecular targets of alcohol action as well as for characterization of genetic and environmental factors that influence alcohol's neural actions. Here we consider strengths and weaknesses of laboratory models used in alco...
journal_title：Nature neuroscience
pub_type： 杂志文章,评审
doi：10.1038/nn1581
更新日期：2005-11-01 00:00:00
abstract：:Uncovering the functional relationship between temporal lobe amnesia and diencephalic amnesia depends on determining the role of the fornix, the major interlinking fiber tract. In this study relating fornix volume with memory, we made magnetic resonance imaging-based volume estimates of 13 brain structures in 38 indiv...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2149
更新日期：2008-07-01 00:00:00
abstract：:Vesicular release of neurotransmitter is the universal output signal of neurons in the brain. It is generally believed that fast transmitter release is restricted to nerve terminals that contact postsynaptic cells in the gray matter. Here we show in the rat brain that the neurotransmitter glutamate is also released at...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1850
更新日期：2007-03-01 00:00:00
abstract：:The identification of distinct cell types in the basal ganglia has been critical to our understanding of basal ganglia function and the treatment of neurological disorders. The external globus pallidus (GPe) is a key contributor to motor suppressing pathways in the basal ganglia, yet its neuronal heterogeneity has rem...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4559
更新日期：2017-06-01 00:00:00
abstract：:Pain is fundamentally unpleasant, a feature that protects the organism by promoting motivation and learning. Relief of aversive states, including pain, is rewarding. The aversiveness of pain, as well as the reward from relief of pain, is encoded by brain reward/motivational mesocorticolimbic circuitry. In this Review,...
journal_title：Nature neuroscience
pub_type： 杂志文章,评审
doi：10.1038/nn.3811
更新日期：2014-10-01 00:00:00
abstract：:Images are processed in the primary visual cortex by neurons that encode different stimulus orientations and spatial phases. In primates and carnivores, neighboring cortical neurons share similar orientation preferences, but spatial phases were thought to be randomly distributed. We discovered a columnar organization ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3878
更新日期：2015-01-01 00:00:00
abstract：:Sensory systems create neural representations of environmental stimuli and these representations can be associated with other stimuli through learning. Are spike patterns the neural representations that get directly associated with reinforcement during conditioning? In the moth Manduca sexta, we found that odor presen...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2192
更新日期：2008-10-01 00:00:00
abstract：:Accumulation of abnormally phosphorylated TDP-43 (pTDP-43) is the main pathology in affected neurons of people with amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Morphological diversity and neuroanatomical distribution of pTDP-43 accumulations allowed classification of FTLD cases in...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-018-0294-y
更新日期：2019-01-01 00:00:00
abstract：:Neurobiological theories of knowledge processing are biased toward the language-dominant (usually the left) hemisphere. Does the right hemisphere critically contribute to knowledge processing? J.A. is a left-hemisphere language-dominant individual who suffered a lesion confined to the right mid- and anterior fusiform ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1721
更新日期：2006-07-01 00:00:00
abstract：:Leucine-rich repeat kinase 2 (LRRK2) is enriched in the striatal projection neurons (SPNs). We found that LRRK2 negatively regulates protein kinase A (PKA) activity in the SPNs during synaptogenesis and in response to dopamine receptor Drd1 activation. LRRK2 interacted with PKA regulatory subunit IIβ (PKARIIβ). A lack...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3636
更新日期：2014-03-01 00:00:00
abstract：:Dopamine (DA) D2 receptors expressed in DA neurons (D2 autoreceptors) exert a negative feedback regulation that reduces DA neuron firing, DA synthesis and DA release. As D2 receptors are mostly expressed in postsynaptic neurons, pharmacological and genetic approaches have been unable to definitively address the in viv...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2862
更新日期：2011-07-10 00:00:00
abstract：:It is unclear how knowledge of one's actions and one's body contribute to the understanding of others' actions. Here we show that two subjects lacking cutaneous touch and sense of movement and position show a selective deficit in interpreting another person's anticipation of weight when seeing him lifting boxes. We su...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1535
更新日期：2005-10-01 00:00:00
abstract：:We demonstrate a form of long-term depression (LTD) in the perirhinal cortex that relies on interaction between different glutamate receptors. Group II metabotropic glutamate (mGlu) receptors facilitated group I mGlu receptor-mediated increases in intracellular calcium. This facilitation plus NMDA receptor activation ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/72093
更新日期：2000-02-01 00:00:00
abstract：:Synaptic stimulation activates signal transduction pathways, producing persistently active protein kinases. PKMzeta is a truncated, persistently active isoform of atypical protein kinase C-zeta (aPKCzeta), which lacks the N-terminal pseudosubstrate regulatory domain. Using a Pavlovian olfactory learning task in Drosop...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn820
更新日期：2002-04-01 00:00:00
abstract：:Aggression is a social behavior essential for securing resources and defending oneself and family. Thanks to its indispensable function in competition and thus survival, aggression exists widely across animal species, including humans. Classical works from Tinbergen and Lorenz concluded that instinctive behaviors incl...
journal_title：Nature neuroscience
pub_type： 杂志文章,评审
doi：10.1038/s41593-020-00715-2
更新日期：2020-11-01 00:00:00
abstract：:We used high-level configural aftereffects induced by adaptation to realistic faces to investigate visual representations underlying complex pattern perception. We found that exposure to an individual face for a few seconds generated a significant and precise bias in the subsequent perception of face identity. In the ...
journal_title：Nature neuroscience
pub_type： 临床试验,杂志文章
doi：10.1038/82947
更新日期：2001-01-01 00:00:00
abstract：:Here, we characterized behavioral abnormalities induced by prolonged social isolation in adult rodents. Social isolation induced both anxiety- and anhedonia-like symptoms and decreased cAMP response element-binding protein (CREB) activity in the nucleus accumbens shell (NAcSh). All of these abnormalities were reversed...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2257
更新日期：2009-02-01 00:00:00
abstract：:Using magnetoencephalography (MEG), we compared the processing of sinusoidal tones in the auditory cortex of 12 non-musicians, 12 professional musicians and 13 amateur musicians. We found neurophysiological and anatomical differences between groups. In professional musicians as compared to non-musicians, the activity ...
journal_title：Nature neuroscience
pub_type： 临床试验,杂志文章
doi：10.1038/nn871
更新日期：2002-07-01 00:00:00
abstract：:Precise apposition of pre- to postsynaptic specializations is required for optimal function of chemical synapses, but little is known about how it is achieved. At the skeletal neuromuscular junction, active zones (transmitter release sites) in the nerve terminal lie directly opposite junctional folds in the postsynapt...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/88414
更新日期：2001-06-01 00:00:00
abstract：:Brain neural stem cells (radial glial progenitors, RGPs) undergo a mysterious form of cell cycle-entrained interkinetic nuclear migration (INM) that is driven apically by cytoplasmic dynein and basally by the kinesin KIF1A, which has recently been implicated in human brain developmental disease. To understand the cons...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4213
更新日期：2016-02-01 00:00:00
abstract：:To investigate how the brain combines knowledge with visual processing to locate eye movement targets, we trained monkeys to search for a target defined by a conjunction of color and shape. On successful trials, neurons in the frontal eye field not only discriminated the target from distractors, but also discriminated...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/9205
更新日期：1999-06-01 00:00:00
abstract：:Fear renewal, a widely pursued model of post-traumatic stress disorder and phobias, refers to the context-specific relapse of conditioned fear after extinction. However, its molecular mechanisms are largely unknown. We found that renewal-inducing stimuli, generally believed to be insufficient to induce synaptic plasti...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3491
更新日期：2013-10-01 00:00:00
abstract：:We used fluorescent in-situ hybridization and confocal microscopy to monitor the subcellular distribution of the immediate-early gene Arc. Arc RNA appeared in discrete intranuclear foci within minutes of neuronal activation and subsequently disappeared from the nucleus and accumulated in the cytoplasm by 30 minutes. T...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/16046
更新日期：1999-12-01 00:00:00
abstract：:Orchestrating appropriate behavioral responses in the face of competing signals that predict either rewards or threats in the environment is crucial for survival. The basolateral nucleus of the amygdala (BLA) and prelimbic (PL) medial prefrontal cortex have been implicated in reward-seeking and fear-related responses,...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4553
更新日期：2017-06-01 00:00:00
