Abstract:
:Vesicular release of neurotransmitter is the universal output signal of neurons in the brain. It is generally believed that fast transmitter release is restricted to nerve terminals that contact postsynaptic cells in the gray matter. Here we show in the rat brain that the neurotransmitter glutamate is also released at discrete sites along axons in white matter in the absence of neurons and nerve terminals. The propagation of single action potentials along axons leads to rapid vesicular release of glutamate, which is detected by ionotropic glutamate receptors on local oligodendrocyte precursor cells. Axonal release of glutamate is reliable, involves highly localized calcium microdomain signaling and is strongly calcium cooperative, similar to vesicle fusion at synapses. This axonal transmitter release represents a widespread mechanism for high-fidelity, activity-dependent signaling at the axon-glia interface in white matter.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Kukley M,Capetillo-Zarate E,Dietrich Ddoi
10.1038/nn1850subject
Has Abstractpub_date
2007-03-01 00:00:00pages
311-20issue
3eissn
1097-6256issn
1546-1726pii
nn1850journal_volume
10pub_type
杂志文章abstract::Processing of rapidly successive acoustic stimuli can be markedly improved by sensory training. To investigate the cortical mechanisms underlying such temporal plasticity, we trained rats in a 'sound maze' in which navigation using only auditory cues led to a target location paired with food reward. In this task, the ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1293
更新日期:2004-09-01 00:00:00
abstract::A moving grating elicits innate optomotor behavior in zebrafish larvae; they swim in the direction of perceived motion. We took advantage of this behavior, using computer-animated displays, to determine what attributes of motion are extracted by the fish visual system. As in humans, first-order (luminance-defined or F...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/80649
更新日期:2000-11-01 00:00:00
abstract::Economic choice entails assigning values to the available options and is impaired by lesions to the orbitofrontal cortex (OFC). Recent results show that some neurons in the OFC encode the values that monkeys (Macaca mulatta) assign to different goods when they choose between them. A broad and fundamental question is h...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn2020
更新日期:2008-01-01 00:00:00
abstract::Agonists of GABA(B) receptors exert a bi-directional effect on the activity of dopamine (DA) neurons of the ventral tegmental area, which can be explained by the fact that coupling between GABA(B) receptors and G protein-gated inwardly rectifying potassium (GIRK) channels is significantly weaker in DA neurons than in ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn2006
更新日期:2007-12-01 00:00:00
abstract::Modeling of human neuropsychiatric disorders in animals is extremely challenging given the subjective nature of many symptoms, the lack of biomarkers and objective diagnostic tests, and the early state of the relevant neurobiology and genetics. Nonetheless, progress in understanding pathophysiology and in treatment de...
journal_title:Nature neuroscience
pub_type: 杂志文章,评审
doi:10.1038/nn.2647
更新日期:2010-10-01 00:00:00
abstract::Spillover of glutamate under physiological conditions has only been established as an adjunct to conventional synaptic transmission. Here we describe a pure spillover connection between the climbing fiber and molecular layer interneurons in the rat cerebellar cortex. We show that, instead of acting via conventional sy...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1907
更新日期:2007-06-01 00:00:00
abstract::The eyeless animal C. elegans is able to sense light and engages in phototaxis behavior that is mediated by photoreceptor cells. However, the molecular and cellular mechanisms underlying phototransduction in C. elegans remain largely unclear. By recording the photoreceptor neuron ASJ in wild-type and various mutant wo...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2540
更新日期:2010-06-01 00:00:00
abstract::Psychiatric morbidity is high in cities, so identifying potential modifiable urban protective factors is important. We show that exposure to urban green space improves well-being in naturally behaving male and female city dwellers, particularly in districts with higher psychiatric incidence and fewer green resources. ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/s41593-019-0451-y
更新日期:2019-09-01 00:00:00
abstract::Blockade of retinal waves prevents the segregation of retinogeniculate afferents into eye-specific layers in the visual thalamus. However, the key features of retinal waves that drive this refinement are controversial. Some manipulations of retinal waves lead to normal eye-specific segregation but others do not. By co...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1376
更新日期:2005-01-01 00:00:00
abstract::It is widely accepted that D1 dopamine receptor-expressing striatal neurons convey their information directly to the output nuclei of the basal ganglia, whereas D2-expressing neurons do so indirectly via pallidal neurons. Combining optogenetics and electrophysiology, we found that this architecture does not apply to m...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.4068
更新日期:2015-09-01 00:00:00
abstract::Lis1 gene defects impair neuronal migration, causing the severe human brain malformation lissencephaly. Although much is known about its interactions with microtubules, microtubule-binding proteins such as CLIP-170, and with the dynein motor complex, the response of Lis1 to neuronal motility signals has not been eluci...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1619
更新日期:2006-01-01 00:00:00
abstract::Dot patterns sliding transparently across one another are normally perceived as independently moving surfaces. Recordings from direction-selective neurons in area MT of the macaque suggested that this perceptual segregation did not depend on the presence of two peaks in the population activity. Rather, the visual syst...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/72985
更新日期:2000-03-01 00:00:00
abstract::Leptin regulates energy balance. However, knowledge of the critical intracellular transducers of leptin signaling remains incomplete. We found that Rho-kinase 1 (ROCK1) regulates leptin action on body weight homeostasis by activating JAK2, an initial trigger of leptin receptor signaling. Leptin promoted the physical i...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3207
更新日期:2012-10-01 00:00:00
abstract::Human chromosome 16p11.2 microdeletion is the most common gene copy number variation in autism, but the synaptic pathophysiology caused by this mutation is largely unknown. Using a mouse with the same genetic deficiency, we found that metabotropic glutamate receptor 5 (mGluR5)-dependent synaptic plasticity and protein...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3911
更新日期:2015-02-01 00:00:00
abstract::Mutations in copper/zinc superoxide dismutase 1 (SOD1), primary causes of human amyotrophic lateral sclerosis (ALS), provoke motor neuron death through an unidentified toxic property. The known neurofilament-dependent slowing of axonal transport, combined with the prominent misaccumulation of neurofilaments in ALS, su...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/4553
更新日期:1999-01-01 00:00:00
abstract::Humans have ~400 intact odorant receptors, but each individual has a unique set of genetic variations that lead to variation in olfactory perception. We used a heterologous assay to determine how often genetic polymorphisms in odorant receptors alter receptor function. We identified agonists for 18 odorant receptors a...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3598
更新日期:2014-01-01 00:00:00
abstract::Binocular competition is thought to drive eye-specific segregation in the developing visual system, potentially through Hebbian synaptic learning rules that are sensitive to correlations in afferent activity. Altering retinal activity can disrupt eye-specific segregation, but little is known about the temporal feature...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3007
更新日期:2011-11-18 00:00:00
abstract::The identification of distinct cell types in the basal ganglia has been critical to our understanding of basal ganglia function and the treatment of neurological disorders. The external globus pallidus (GPe) is a key contributor to motor suppressing pathways in the basal ganglia, yet its neuronal heterogeneity has rem...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.4559
更新日期:2017-06-01 00:00:00
abstract::Understanding a sensory system implies the ability to predict responses to a variety of inputs from a common model. In the retina, this includes predicting how the integration of signals across visual space shapes the outputs of retinal ganglion cells. Existing models of this process generalize poorly to predict respo...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3225
更新日期:2012-11-01 00:00:00
abstract::Synaptic strength can be altered by a variety of pre- or postsynaptic modifications. Here we test the hypothesis that long-term depression (LTD) involves a decrease in the number of glutamate receptors that are clustered at individual synapses in primary cultures of hippocampal neurons. Similar to a prominent form of ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/8123
更新日期:1999-05-01 00:00:00
abstract::We found that K(+)/Cl(-) co-transporter 2 (KCC2) activity, monitored with wide-field fluorescence, was inhibited by intracellular Zn(2+), a major component of neuronal injury. Zn(2+)-mediated KCC2 inhibition produced a depolarizing shift of GABA(A) reversal potentials in rat cortical neurons. Moreover, oxygen-glucose ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2316
更新日期:2009-06-01 00:00:00
abstract::Lateral and medial parts of entorhinal cortex (EC) convey nonspatial 'what' and spatial 'where' information, respectively, into hippocampal CA1, via both the indirect EC layer 2→ hippocampal dentate gyrus→CA3→CA1 and the direct EC layer 3→CA1 paths. However, it remains elusive how the direct path transfers distinct in...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.4517
更新日期:2017-04-01 00:00:00
abstract::Memory reconsolidation has been demonstrated in various tasks and species, suggesting it is a fundamental process. However, there are experimental parameters that can inhibit reconsolidation from occurring (boundary conditions). These conditions and their mechanisms remain poorly defined. Here, we characterize the abi...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2350
更新日期:2009-07-01 00:00:00
abstract::Though motor neurons selectively degenerate in amyotrophic lateral sclerosis, other cell types are likely involved in this disease. We recently generated rNLS8 mice in which human TDP-43 (hTDP-43) pathology could be reversibly induced in neurons and expected that microglia would contribute to neurodegeneration. Howeve...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/s41593-018-0083-7
更新日期:2018-03-01 00:00:00
abstract::Blood vessels in the nervous system have traditionally been considered neutral bystanders that only passively adapt their structure and function in response to the needs of neural cells. Emerging evidence suggests, however, that vessels and angiogenic molecules actively participate in the pathogenesis of neurological ...
journal_title:Nature neuroscience
pub_type: 杂志文章,评审
doi:10.1038/nn.2947
更新日期:2011-10-26 00:00:00
abstract::In Huntington's disease (HD), expansion of CAG codons in the huntingtin gene (HTT) leads to the aberrant formation of protein aggregates and the differential degeneration of striatal medium spiny neurons (MSNs). Modeling HD using patient-specific MSNs has been challenging, as neurons differentiated from induced plurip...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/s41593-018-0075-7
更新日期:2018-03-01 00:00:00
abstract::Ongoing sensory input is critical for shaping internal representations of the external world. Conversely, a lack of sensory input can profoundly perturb the formation of these representations. The olfactory system is particularly vulnerable to sensory deprivation, owing to the widespread prevalence of allergic, viral ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3186
更新日期:2012-09-01 00:00:00
abstract::In the postnatal subventricular zone (SVZ), local cues or signaling molecules released from neuroblasts limit the proliferation of glial fibrillary acidic protein (GFAP)-expressing progenitors thought to be stem cells. However, signals between SVZ cells have not been identified. We show that depolarization of neurobla...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1522
更新日期:2005-09-01 00:00:00
abstract::The hippocampus is thought to be involved in episodic memory formation by reactivating traces of waking experience during sleep. Indeed, the joint firing of spatially tuned pyramidal cells encoding nearby places recur during sleep. We found that the sleep cofiring of rat CA1 pyramidal cells encoding similar places inc...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn2037
更新日期:2008-02-01 00:00:00
abstract::Peptides derived from proteolytic processing of the beta-amyloid precursor protein (APP), including the amyloid-beta peptide, are important for the pathogenesis of Alzheimer's dementia. We found that transgenic mice overexpressing APP have a profound and selective impairment in endothelium-dependent regulation of the ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/5715
更新日期:1999-02-01 00:00:00