Vesicular glutamate release from axons in white matter.

Abstract:

:Vesicular release of neurotransmitter is the universal output signal of neurons in the brain. It is generally believed that fast transmitter release is restricted to nerve terminals that contact postsynaptic cells in the gray matter. Here we show in the rat brain that the neurotransmitter glutamate is also released at discrete sites along axons in white matter in the absence of neurons and nerve terminals. The propagation of single action potentials along axons leads to rapid vesicular release of glutamate, which is detected by ionotropic glutamate receptors on local oligodendrocyte precursor cells. Axonal release of glutamate is reliable, involves highly localized calcium microdomain signaling and is strongly calcium cooperative, similar to vesicle fusion at synapses. This axonal transmitter release represents a widespread mechanism for high-fidelity, activity-dependent signaling at the axon-glia interface in white matter.

journal_name

Nat Neurosci

journal_title

Nature neuroscience

authors

Kukley M,Capetillo-Zarate E,Dietrich D

doi

10.1038/nn1850

subject

Has Abstract

pub_date

2007-03-01 00:00:00

pages

311-20

issue

3

eissn

1097-6256

issn

1546-1726

pii

nn1850

journal_volume

10

pub_type

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