Abstract：
:Synaptic stimulation activates signal transduction pathways, producing persistently active protein kinases. PKMzeta is a truncated, persistently active isoform of atypical protein kinase C-zeta (aPKCzeta), which lacks the N-terminal pseudosubstrate regulatory domain. Using a Pavlovian olfactory learning task in Drosophila, we found that induction of the mouse aPKMzeta (MaPKMzeta) transgene enhanced memory. The enhancement required persistent kinase activity and was temporally specific, with optimal induction at 30 minutes after training. Induction also enhanced memory after massed training and corrected the memory defect of radish mutants, but did not improve memory produced by spaced training. The 'M' isoform of the Drosophila homolog of MaPKCzeta (DaPKM) was present and active in fly heads. Chelerythrine, an inhibitor of PKMzeta, and the induction of a dominant-negative MaPKMzeta transgene inhibited memory without affecting learning. Finally, induction of DaPKM after training also enhanced memory. These results show that atypical PKM is sufficient to enhance memory in Drosophila and suggest that it is necessary for normal memory maintenance.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Drier EA,Tello MK,Cowan M,Wu P,Blace N,Sacktor TC,Yin JCdoi
10.1038/nn820subject
Has Abstractpub_date
2002-04-01 00:00:00pages
316-24issue
4eissn
1097-6256issn
1546-1726pii
nn820journal_volume
5pub_type
杂志文章abstract：:Transformation of mechanical energy into ionic currents is essential for touch, hearing and nociception. Although DEG/ENaC proteins are believed to form sensory mechanotransduction channels, the evidence for this role remains indirect. By recording from C. elegans touch receptor neurons in vivo, we found that external...
journal_title：Nature neuroscience
pub_type： 杂志文章
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更新日期：2005-01-01 00:00:00
abstract：:The output of cortical columns is routed to different downstream targets via distinct pathways: cortico-cortical and cortico-subcortical. It is as yet unclear what roles these pathways play in perception, and which cellular and circuit mechanisms regulate their gating. We recently showed that activation of the apical ...
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abstract：:The projections and odor responses of mammalian olfactory receptor neurons, as well as the physiology of the bulb's principal neurons-the mitral cells (MCs)-are known from studies in slices and anesthetized animals. In behaving rats trained to discriminate between two odors associated with different reinforcers, we ex...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/14801
更新日期：1999-11-01 00:00:00
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pub_type： 杂志文章
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journal_title：Nature neuroscience
pub_type： 杂志文章
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更新日期：2005-12-01 00:00:00
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journal_title：Nature neuroscience
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更新日期：2018-07-01 00:00:00
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journal_title：Nature neuroscience
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journal_title：Nature neuroscience
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更新日期：2008-04-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1376
更新日期：2005-01-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章,评审
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更新日期：2013-11-01 00:00:00
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doi：10.1038/nn.3999
更新日期：2015-05-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1928
更新日期：2007-08-01 00:00:00
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journal_title：Nature neuroscience
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doi：10.1038/nn.3161
更新日期：2012-07-26 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1392
更新日期：2005-02-01 00:00:00
abstract：:Amyloid plaques are a hallmark of Alzheimer disease, but their importance in its pathogenesis is controversial. By neuronal labeling and transcranial two-photon imaging, we show in a transgenic mouse model of Alzheimer disease that dendrites passing through or near fibrillar amyloid deposits undergo spine loss and sha...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1335
更新日期：2004-11-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1459
更新日期：2005-06-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
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更新日期：2011-10-30 00:00:00
abstract：:Lis1 gene defects impair neuronal migration, causing the severe human brain malformation lissencephaly. Although much is known about its interactions with microtubules, microtubule-binding proteins such as CLIP-170, and with the dynein motor complex, the response of Lis1 to neuronal motility signals has not been eluci...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1619
更新日期：2006-01-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1150
更新日期：2003-12-01 00:00:00
abstract：:Understanding a sensory system implies the ability to predict responses to a variety of inputs from a common model. In the retina, this includes predicting how the integration of signals across visual space shapes the outputs of retinal ganglion cells. Existing models of this process generalize poorly to predict respo...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3225
更新日期：2012-11-01 00:00:00
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journal_title：Nature neuroscience
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更新日期：2002-03-01 00:00:00
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更新日期：2007-10-01 00:00:00
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journal_title：Nature neuroscience
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更新日期：2006-07-01 00:00:00
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journal_title：Nature neuroscience
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更新日期：2016-04-01 00:00:00
abstract：:Understanding the transcriptional changes that are engaged in stress resilience may reveal novel antidepressant targets. Here we use gene co-expression analysis of RNA-sequencing data from brains of resilient mice to identify a gene network that is unique to resilience. Zfp189, which encodes a previously unstudied zin...
journal_title：Nature neuroscience
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更新日期：2019-09-01 00:00:00
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journal_title：Nature neuroscience
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更新日期：2013-10-01 00:00:00
abstract：:Stimuli that elicit itch are detected by sensory neurons that innervate the skin. This information is processed by the spinal cord; however, the way in which this occurs is still poorly understood. Here we investigated the neuronal pathways for itch neurotransmission, particularly the contribution of the neuropeptide ...
journal_title：Nature neuroscience
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doi：10.1038/s41593-018-0119-z
更新日期：2018-05-01 00:00:00
