Abstract：
:Brain neural stem cells (radial glial progenitors, RGPs) undergo a mysterious form of cell cycle-entrained interkinetic nuclear migration (INM) that is driven apically by cytoplasmic dynein and basally by the kinesin KIF1A, which has recently been implicated in human brain developmental disease. To understand the consequences of altered basal INM and the roles of KIF1A in disease, we performed constitutive and conditional RNAi and expressed mutant KIF1A in E16 to P7 rat RGPs and neurons. RGPs inhibited in basal INM still showed normal cell cycle progression, although neurogenic divisions were severely reduced. Postmitotic neuronal migration was independently disrupted at the multipolar stage and accompanied by premature ectopic expression of neuronal differentiation markers. Similar effects were unexpectedly observed throughout the layer of surrounding control cells, mimicked by Bdnf (brain-derived neurotrophic factor) or Dcx RNAi, and rescued by BDNF application. These results identify sequential and independent roles for KIF1A and provide an important new approach for reversing the effects of human disease.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Carabalona A,Hu DJ,Vallee RBdoi
10.1038/nn.4213subject
Has Abstractpub_date
2016-02-01 00:00:00pages
253-62issue
2eissn
1097-6256issn
1546-1726pii
nn.4213journal_volume
19pub_type
杂志文章abstract：:Transformation of mechanical energy into ionic currents is essential for touch, hearing and nociception. Although DEG/ENaC proteins are believed to form sensory mechanotransduction channels, the evidence for this role remains indirect. By recording from C. elegans touch receptor neurons in vivo, we found that external...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1362
更新日期：2005-01-01 00:00:00
abstract：:It is often assumed that all neurons of the same cell type have identical intrinsic properties, both within an animal and between animals. We exploited the large size and small number of unambiguously identifiable neurons in the crab stomatogastric ganglion to test this assumption at the level of channel mRNA expressi...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1639
更新日期：2006-03-01 00:00:00
abstract：:Neuronal signaling occurs through both action potential-triggered synaptic vesicle fusion and spontaneous release, although the fusion clamp machinery that prevents premature exocytosis of synaptic vesicles in the absence of calcium is unknown. Here we demonstrate that spontaneous release at synapses is regulated by c...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1980
更新日期：2007-10-01 00:00:00
abstract：:EphB receptor tyrosine kinases control multiple steps in nervous system development. However, it remains unclear whether EphBs regulate these different developmental processes directly or indirectly. In addition, given that EphBs signal through multiple mechanisms, it has been challenging to define which signaling fun...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3249
更新日期：2012-12-01 00:00:00
abstract：:Nucleus accumbens (NAc) dopamine is widely implicated in mediating the reinforcing effects of drugs of abuse. However, the precise function of the NAc itself in drug self-administration has been difficult to establish. Here we show a neural double-dissociation of the behavioral processes that underlie cocaine self-adm...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1217
更新日期：2004-04-01 00:00:00
abstract：:Epilepsy is a common and refractory neurological disorder, but the neuronal regulatory mechanisms of epileptogenesis remain largely unclear. Activity-dependent transcription of genes for neurotrophins such as brain-derived neurotrophic factor (BDNF) has been shown to promote epileptogenesis; however, little is known a...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3005
更新日期：2011-12-11 00:00:00
abstract：:Using magnetoencephalography (MEG), we compared the processing of sinusoidal tones in the auditory cortex of 12 non-musicians, 12 professional musicians and 13 amateur musicians. We found neurophysiological and anatomical differences between groups. In professional musicians as compared to non-musicians, the activity ...
journal_title：Nature neuroscience
pub_type： 临床试验,杂志文章
doi：10.1038/nn871
更新日期：2002-07-01 00:00:00
abstract：:The hypothalamus contains the highest diversity of neurons in the brain. Many of these neurons can co-release neurotransmitters and neuropeptides in a use-dependent manner. Investigators have hitherto relied on candidate protein-based tools to correlate behavioral, endocrine and gender traits with hypothalamic neuron ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4462
更新日期：2017-02-01 00:00:00
abstract：:Timing is crucial to many aspects of human performance. To better understand its neural underpinnings, we used event-related fMRI to examine the time course of activation associated with different components of a time perception task. We distinguished systems associated with encoding time intervals from those related ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/85191
更新日期：2001-03-01 00:00:00
abstract：:Anatomical studies have led to the assertion that intratelencephalic and pyramidal tract cortical neurons innervate different striatal projection neurons. To test this hypothesis, we measured the responses of mouse striatal neurons to optogenetic activation of intratelencephalic and pyramidal tract axons. Contrary to ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3397
更新日期：2013-06-01 00:00:00
abstract：:Unifying principles of movement have emerged from the computational study of motor control. We review several of these principles and show how they apply to processes such as motor planning, control, estimation, prediction and learning. Our goal is to demonstrate how specific models emerging from the computational app...
journal_title：Nature neuroscience
pub_type： 杂志文章,评审
doi：10.1038/81497
更新日期：2000-11-01 00:00:00
abstract：:Increases in dopamine and glutamate transmission in the nucleus accumbens independently promote the reinstatement of cocaine seeking, an animal model of relapse. Here we have tested whether cocaine reinstatement in rats depends on interactions between accumbal dopamine and glutamate systems that are mediated by Ca(2+)...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn2054
更新日期：2008-03-01 00:00:00
abstract：:Mammalian hearing owes its remarkable sensitivity and frequency selectivity to a local mechanical feedback process within the cochlea. Cochlear outer hair cells (OHCs) function as the key elements in the feedback loop in which the fast somatic motility of OHCs is thought to be the source of cochlear amplification. An ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1509
更新日期：2005-08-01 00:00:00
abstract：:All the higher mental and cognitive functions unique to humans depend on the neocortex ('new' cortex, referring to its relatively recent appearance in evolution), which is divided into discrete areas that subserve distinct functions, such as language, movement and sensation. With a few notable exceptions, all neocorti...
journal_title：Nature neuroscience
pub_type： 杂志文章,评审
doi：10.1038/nn752
更新日期：2001-11-01 00:00:00
abstract：:Active dendritic integration is thought to enrich the computational power of central neurons. However, a direct role of active dendritic processing in the execution of defined neuronal computations in intact neural networks has not been established. Here we used multi-site electrophysiological recording techniques to ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3565
更新日期：2013-12-01 00:00:00
abstract：:In the cat primary visual cortex, neurons are classified into the two main categories of simple cells and complex cells based on their response properties. According to the hierarchical model, complex receptive fields derive from convergent inputs of simple cells with similar orientation preferences. This model receiv...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/1609
更新日期：1998-09-01 00:00:00
abstract：:Axonal injury results in regenerative success or failure, depending on whether the axon lies in the peripheral or the CNS, respectively. The present study addresses whether epigenetic signatures in dorsal root ganglia discriminate between regenerative and non-regenerative axonal injury. Chromatin immunoprecipitation f...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-019-0490-4
更新日期：2019-11-01 00:00:00
abstract：:The sensing of circulating nutrients within the mediobasal hypothalamus may be critical for energy homeostasis. To induce a sustained impairment in hypothalamic nutrient sensing, adeno-associated viruses (AAV) expressing malonyl-coenzyme A decarboxylase (MCD; an enzyme involved in the degradation of malonyl coenzyme A...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1626
更新日期：2006-02-01 00:00:00
abstract：:Fast desensitization is an important regulatory mechanism of neuronal NMDA receptor function. Only recombinant NMDA receptors composed of NR1/NR2A exhibit a fast component of desensitization similar to neuronal NMDA receptors. Here we report that the fast desensitization of NR1/NR2A receptors is caused by ambient zinc...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn0901-894
更新日期：2001-09-01 00:00:00
abstract：:Sensorimotor integration is crucial to perception and motor control. How and where this process takes place in the brain is still largely unknown. Here we analyze the cerebellar contribution to sensorimotor integration in the whisker system of mice. We identify an area in the cerebellum where cortical sensory and moto...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3773
更新日期：2014-09-01 00:00:00
abstract：:Over the past two centuries, prevalent models of energy and glucose homeostasis have emerged from careful anatomical descriptions in tandem with an understanding of cellular physiology. More recent technological advances have culminated in the identification of peripheral and central factors that influence neural circ...
journal_title：Nature neuroscience
pub_type： 杂志文章,评审
doi：10.1038/nn.3217
更新日期：2012-10-01 00:00:00
abstract：:The subunit composition of postsynaptic non-NMDA-type glutamate receptors (GluRs) determines the function and trafficking of the receptor. Changes in GluR composition have been implicated in the homeostasis of neuronal excitability and synaptic plasticity underlying learning. Here, we imaged GluRs in vivo during the f...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2122
更新日期：2008-06-01 00:00:00
abstract：:Fear-inducing memories can be state dependent, meaning that they can best be retrieved if the brain states at encoding and retrieval are similar. Restricted access to such memories can present a risk for psychiatric disorders and hamper their treatment. To better understand the mechanisms underlying state-dependent fe...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4084
更新日期：2015-09-01 00:00:00
abstract：:Lis1 gene defects impair neuronal migration, causing the severe human brain malformation lissencephaly. Although much is known about its interactions with microtubules, microtubule-binding proteins such as CLIP-170, and with the dynein motor complex, the response of Lis1 to neuronal motility signals has not been eluci...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1619
更新日期：2006-01-01 00:00:00
abstract：:The launch of the US BRAIN and European Human Brain Projects coincides with growing international efforts toward transparency and increased access to publicly funded research in the neurosciences. The need for data-sharing standards and neuroinformatics infrastructure is more pressing than ever. However, 'big science'...
journal_title：Nature neuroscience
pub_type： 杂志文章,评审
doi：10.1038/nn.3838
更新日期：2014-11-01 00:00:00
abstract：:Long-term synaptic changes, which are essential for learning and memory, are dependent on homeostatic mechanisms that stabilize neural activity. Homeostatic responses have also been implicated in pathological conditions, including nicotine addiction. Although multiple homeostatic pathways have been described, little i...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2969
更新日期：2011-11-13 00:00:00
abstract：:Chronic morphine exposure upregulates adenylate cyclase signaling and reduces analgesic efficacy, a condition known as opioid tolerance. Nonopioid neurotransmitters can enhance morphine tolerance, but the mechanism for this is poorly understood. We show that morphine tolerance was delayed in mice lacking vasopressin 1...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-018-0144-y
更新日期：2018-06-01 00:00:00
abstract：:Axonal degeneration is important during development but has not been thought to function in the intact mature nervous system. Here, we provide evidence that degeneration of adult axons occurs in the intact rodent brain through a p75 neurotrophin receptor (p75NTR)- and myelin-dependent mechanism. Specifically, we show ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2513
更新日期：2010-05-01 00:00:00
abstract：:The regulation of female reproductive behaviors may involve memories of male pheromone signatures, formed in part by neural circuitry involving the olfactory bulb and hippocampus. These neural structures are the principal sites of adult neurogenesis; however, previous studies point to their independent regulation by s...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1928
更新日期：2007-08-01 00:00:00
abstract：:We argue that there will be no single (genetic or cognitive) cause for the diverse symptoms defining autism. We present recent evidence of behavioral fractionation of social impairment, communication difficulties and rigid and repetitive behaviors. Twin data suggest largely nonoverlapping genes acting on each of these...
journal_title：Nature neuroscience
pub_type： 杂志文章,评审
doi：10.1038/nn1770
更新日期：2006-10-01 00:00:00
