Abstract：
:Anatomical studies have led to the assertion that intratelencephalic and pyramidal tract cortical neurons innervate different striatal projection neurons. To test this hypothesis, we measured the responses of mouse striatal neurons to optogenetic activation of intratelencephalic and pyramidal tract axons. Contrary to expectation, direct and indirect pathway striatal spiny projection neurons responded to both intratelencephalic and pyramidal tract activation, arguing that these cortical networks innervate both striatal projection neurons.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Kress GJ,Yamawaki N,Wokosin DL,Wickersham IR,Shepherd GM,Surmeier DJdoi
10.1038/nn.3397subject
Has Abstractpub_date
2013-06-01 00:00:00pages
665-7issue
6eissn
1097-6256issn
1546-1726pii
nn.3397journal_volume
16pub_type
杂志文章abstract：:Sharp wave-ripple (SPW-R) complexes in the hippocampus-entorhinal cortex are believed to be important for transferring labile memories from the hippocampus to the neocortex for long-term storage. We found that selective elimination of SPW-Rs during post-training consolidation periods resulted in performance impairment...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2384
更新日期：2009-10-01 00:00:00
abstract：:Selective attention filters information to limit what is encoded and maintained in working memory. Although the prefrontal cortex (PFC) is central to both selective attention and working memory, the underlying neural processes that link these cognitive abilities remain elusive. Using functional magnetic resonance imag...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2773
更新日期：2011-05-01 00:00:00
abstract：:Here we used magnetoencephalography (MEG) to investigate stages of processing in face perception in humans. We found a face-selective MEG response occurring only 100 ms after stimulus onset (the 'M100'), 70 ms earlier than previously reported. Further, the amplitude of this M100 response was correlated with successful...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn909
更新日期：2002-09-01 00:00:00
abstract：:Transformation of mechanical energy into ionic currents is essential for touch, hearing and nociception. Although DEG/ENaC proteins are believed to form sensory mechanotransduction channels, the evidence for this role remains indirect. By recording from C. elegans touch receptor neurons in vivo, we found that external...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1362
更新日期：2005-01-01 00:00:00
abstract：:Class I histone deacetylases (HDACs) Hdac1 and Hdac2 can associate together in protein complexes with transcriptional factors such as methyl-CpG-binding protein 2 (MeCP2). Given their high degree of sequence identity, we examined whether Hdac1 and Hdac2 were functionally redundant in mature mouse brain. We demonstrate...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4395
更新日期：2016-11-01 00:00:00
abstract：:Vesicular release of neurotransmitter is the universal output signal of neurons in the brain. It is generally believed that fast transmitter release is restricted to nerve terminals that contact postsynaptic cells in the gray matter. Here we show in the rat brain that the neurotransmitter glutamate is also released at...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1850
更新日期：2007-03-01 00:00:00
abstract：:The basis for differences in activity-dependent trafficking of AMPA receptors (AMPARs) and NMDA receptors (NMDARs) remains unclear. Using single-molecule tracking, we found different lateral mobilities for AMPARs and NMDARs: changes in neuronal activity modified AMPAR but not NMDAR mobility, whereas protein kinase C a...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1270
更新日期：2004-07-01 00:00:00
abstract：:The molecular organization of presynaptic active zones is important for the neurotransmitter release that is triggered by depolarization-induced Ca2+ influx. Here, we demonstrate a previously unknown interaction between two components of the presynaptic active zone, RIM1 and voltage-dependent Ca2+ channels (VDCCs), th...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1904
更新日期：2007-06-01 00:00:00
abstract：:To investigate the mechanisms of persistent neural activity, we obtained in vivo intracellular recordings from neurons in an oculomotor neural integrator of the goldfish during spontaneous saccades and fixations. Persistent changes in firing rate following saccades were associated with step changes in interspike membr...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/84023
更新日期：2001-02-01 00:00:00
abstract：:How tightly tuned are the synaptic and intrinsic properties that give rise to neuron and circuit function? Experimental work shows that these properties vary considerably across identified neurons in different animals. Given this variability in experimental data, this review describes some of the complications of buil...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2735
更新日期：2011-02-01 00:00:00
abstract：:Transposable elements, known colloquially as 'jumping genes', constitute approximately 45% of the human genome. Cells utilize epigenetic defenses to limit transposable element jumping, including formation of silencing heterochromatin and generation of piwi-interacting RNAs (piRNAs), small RNAs that facilitate clearanc...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-018-0194-1
更新日期：2018-08-01 00:00:00
abstract：:The hypothalamus contains the highest diversity of neurons in the brain. Many of these neurons can co-release neurotransmitters and neuropeptides in a use-dependent manner. Investigators have hitherto relied on candidate protein-based tools to correlate behavioral, endocrine and gender traits with hypothalamic neuron ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4462
更新日期：2017-02-01 00:00:00
abstract：:Neuroscience seeks to understand how neural circuits lead to behavior. However, the gap between circuits and behavior is too wide. An intermediate level is one of neural computations, which occur in individual neurons and populations of neurons. Some computations seem to be canonical: repeated and combined in differen...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3043
更新日期：2012-03-27 00:00:00
abstract：:Dot patterns sliding transparently across one another are normally perceived as independently moving surfaces. Recordings from direction-selective neurons in area MT of the macaque suggested that this perceptual segregation did not depend on the presence of two peaks in the population activity. Rather, the visual syst...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/72985
更新日期：2000-03-01 00:00:00
abstract：:Rhythmic movements, such as walking, chewing or scratching, are phylogenetically old motor behaviors found in many organisms, ranging from insects to primates. In contrast, discrete movements, such as reaching, grasping or kicking, are behaviors that have reached sophistication primarily in younger species, particular...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1322
更新日期：2004-10-01 00:00:00
abstract：:Items held in working memory can be either attended or not, depending on their current behavioral relevance. It has been suggested that unattended contents might be solely retained in an activity-silent form. Instead, we demonstrate here that encoding unattended contents involves a division of labor. While visual cort...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-018-0094-4
更新日期：2018-04-01 00:00:00
abstract：:In mammals, many daily cycles are driven by a central circadian clock, which is based on the cell-autonomous rhythmic expression of clock genes. It is not clear, however, how peripheral cells are able to interpret the rhythmic signals disseminated from this central oscillator. Here we show that cycling expression of t...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn806
更新日期：2002-03-01 00:00:00
abstract：:Precise apposition of pre- to postsynaptic specializations is required for optimal function of chemical synapses, but little is known about how it is achieved. At the skeletal neuromuscular junction, active zones (transmitter release sites) in the nerve terminal lie directly opposite junctional folds in the postsynapt...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/88414
更新日期：2001-06-01 00:00:00
abstract：:Adult neurogenesis occurs in the hippocampus and the olfactory bulb of the mammalian CNS. Recent studies have demonstrated that newborn granule cells of the adult hippocampus are postsynaptic targets of excitatory and inhibitory neurons, but evidence of synapse formation by the axons of these cells is still lacking. B...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2156
更新日期：2008-08-01 00:00:00
abstract：:Sleep can strengthen memory for emotional information, but whether emotional memories can be specifically targeted and modified during sleep is unknown. In human subjects who underwent olfactory contextual fear conditioning, re-exposure to the odorant context in slow-wave sleep promoted stimulus-specific fear extincti...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3527
更新日期：2013-11-01 00:00:00
abstract：:Exposure to a stressor sensitizes behavioral and hormonal responses to future stressors. Stress-associated release of noradrenaline enhances the capacity of central synapses to show plasticity (metaplasticity). We found noradrenaline-dependent metaplasticity at GABA synapses in the paraventricular nucleus of the hypot...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3373
更新日期：2013-05-01 00:00:00
abstract：:The cortical nucleus LMAN (lateral magnocellular nucleus of the anterior nidopallium) provides the output of a basal ganglia pathway that is necessary for vocal learning in juvenile songbirds. The shell subregion of LMAN (LMAN(shell)) gives rise to recurrent loops that may subserve specific learning-related functions....
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2472
更新日期：2010-02-01 00:00:00
abstract：:A fundamental organizing principle of auditory brain circuits is tonotopy, the orderly representation of the sound frequency to which neurons are most sensitive. Tonotopy arises from the coding of frequency along the cochlea and the topographic organization of auditory pathways. The mechanisms that underlie the establ...
journal_title：Nature neuroscience
pub_type： 杂志文章,评审
doi：10.1038/nn.2332
更新日期：2009-06-01 00:00:00
abstract：:Axon guidance cues contributing to the development of eye-specific visual projections to the lateral geniculate nucleus (LGN) have not previously been identified. Here we show that gradients of ephrin-As and their receptors (EphAs) direct retinal ganglion cell (RGC) axons from the two eyes into their stereotyped patte...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1505
更新日期：2005-08-01 00:00:00
abstract：:It is widely held that color and motion are processed by separate parallel pathways in the visual system, but this view is difficult to reconcile with the fact that motion can be detected in equiluminant stimuli that are defined by color alone. To examine the relationship between color and motion, we tested three pati...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/688
更新日期：1998-07-01 00:00:00
abstract：:Cerebellar abnormalities, particularly in Right Crus I (RCrusI), are consistently reported in autism spectrum disorders (ASD). Although RCrusI is functionally connected with ASD-implicated circuits, the contribution of RCrusI dysfunction to ASD remains unclear. Here neuromodulation of RCrusI in neurotypical humans res...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-017-0004-1
更新日期：2017-12-01 00:00:00
abstract：:The eyeless animal C. elegans is able to sense light and engages in phototaxis behavior that is mediated by photoreceptor cells. However, the molecular and cellular mechanisms underlying phototransduction in C. elegans remain largely unclear. By recording the photoreceptor neuron ASJ in wild-type and various mutant wo...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2540
更新日期：2010-06-01 00:00:00
abstract：:Lateral and medial parts of entorhinal cortex (EC) convey nonspatial 'what' and spatial 'where' information, respectively, into hippocampal CA1, via both the indirect EC layer 2→ hippocampal dentate gyrus→CA3→CA1 and the direct EC layer 3→CA1 paths. However, it remains elusive how the direct path transfers distinct in...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4517
更新日期：2017-04-01 00:00:00
abstract：:Blockade of retinal waves prevents the segregation of retinogeniculate afferents into eye-specific layers in the visual thalamus. However, the key features of retinal waves that drive this refinement are controversial. Some manipulations of retinal waves lead to normal eye-specific segregation but others do not. By co...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1376
更新日期：2005-01-01 00:00:00
abstract：:Huntington's disease (HD) is caused by an expansion of exonic CAG triplet repeats in the gene encoding huntingtin protein (Htt), but the mechanisms by which this mutant protein causes neurodegeneration remain unknown. Here we show that lymphoblast mitochondria from patients with HD have a lower membrane potential and ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn884
更新日期：2002-08-01 00:00:00
