Abstract:
:How tightly tuned are the synaptic and intrinsic properties that give rise to neuron and circuit function? Experimental work shows that these properties vary considerably across identified neurons in different animals. Given this variability in experimental data, this review describes some of the complications of building computational models to aid in understanding how system dynamics arise from the interaction of system components. We argue that instead of trying to build a single model that captures the generic behavior of a neuron or circuit, it is beneficial to construct a population of models that captures the behavior of the population that provided the experimental data. Studying a population of models with different underlying structure and similar behaviors provides opportunities to discover unsuspected compensatory mechanisms that contribute to neuron and network function.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Marder E,Taylor ALdoi
10.1038/nn.2735subject
Has Abstractpub_date
2011-02-01 00:00:00pages
133-8issue
2eissn
1097-6256issn
1546-1726pii
nn.2735journal_volume
14pub_type
杂志文章abstract::Emotions operate along the dimension of approach and aversion, and it is reasonable to assume that orienting behavior is intrinsically linked to emotionally involved processes such as preference decisions. Here we describe a gaze 'cascade effect' that was present when human observers were shown pairs of human faces an...
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