High frequency, synchronized bursting drives eye-specific segregation of retinogeniculate projections.

Abstract:

:Blockade of retinal waves prevents the segregation of retinogeniculate afferents into eye-specific layers in the visual thalamus. However, the key features of retinal waves that drive this refinement are controversial. Some manipulations of retinal waves lead to normal eye-specific segregation but others do not. By comparing retinal spiking patterns in several mutant mice with differing levels of eye-specific segregation, we show that the presence of high-frequency bursts synchronized across neighboring retinal ganglion cells correlates with robust eye-specific segregation and that the presence of high levels of asynchronous spikes does not inhibit this segregation. These findings provide a possible resolution to previously described discrepancies regarding the role of retinal waves in retinogeniculate segregation.

journal_name

Nat Neurosci

journal_title

Nature neuroscience

authors

Torborg CL,Hansen KA,Feller MB

doi

10.1038/nn1376

subject

Has Abstract

pub_date

2005-01-01 00:00:00

pages

72-8

issue

1

eissn

1097-6256

issn

1546-1726

pii

nn1376

journal_volume

8

pub_type

杂志文章
  • Trajectory events across hippocampal place cells require previous experience.

    abstract::Replay of hippocampal place cell sequences has been proposed as a fundamental mechanism of learning and memory. However, the standard interpretation of replay has been challenged by reports that similar activity is observed before experience ('preplay'). By the preplay account, pre-existing temporal sequences are mapp...

    journal_title:Nature neuroscience

    pub_type: 杂志文章

    doi:10.1038/nn.4151

    authors: Silva D,Feng T,Foster DJ

    更新日期:2015-12-01 00:00:00

  • Differentiation of human pluripotent stem cells into neurons or cortical organoids requires transcriptional co-regulation by UTX and 53BP1.

    abstract::UTX is a chromatin modifier required for development and neural lineage specification, but how it controls these biological processes is unclear. To determine the molecular mechanisms of UTX, we identified novel UTX protein interaction partners. Here we show that UTX and 53BP1 directly interact and co-occupy promoters...

    journal_title:Nature neuroscience

    pub_type: 杂志文章

    doi:10.1038/s41593-018-0328-5

    authors: Yang X,Xu B,Mulvey B,Evans M,Jordan S,Wang YD,Pagala V,Peng J,Fan Y,Patel A,Peng JC

    更新日期:2019-03-01 00:00:00

  • Distinct roles for direct and indirect pathway striatal neurons in reinforcement.

    abstract::Dopamine signaling is implicated in reinforcement learning, but the neural substrates targeted by dopamine are poorly understood. We bypassed dopamine signaling itself and tested how optogenetic activation of dopamine D1 or D2 receptor–expressing striatal projection neurons influenced reinforcement learning in mice. S...

    journal_title:Nature neuroscience

    pub_type: 杂志文章

    doi:10.1038/nn.3100

    authors: Kravitz AV,Tye LD,Kreitzer AC

    更新日期:2012-06-01 00:00:00

  • Intracellular zinc inhibits KCC2 transporter activity.

    abstract::We found that K(+)/Cl(-) co-transporter 2 (KCC2) activity, monitored with wide-field fluorescence, was inhibited by intracellular Zn(2+), a major component of neuronal injury. Zn(2+)-mediated KCC2 inhibition produced a depolarizing shift of GABA(A) reversal potentials in rat cortical neurons. Moreover, oxygen-glucose ...

    journal_title:Nature neuroscience

    pub_type: 杂志文章

    doi:10.1038/nn.2316

    authors: Hershfinkel M,Kandler K,Knoch ME,Dagan-Rabin M,Aras MA,Abramovitch-Dahan C,Sekler I,Aizenman E

    更新日期:2009-06-01 00:00:00

  • Acetylcholinesterase is required for neuronal and muscular development in the zebrafish embryo.

    abstract::The neurotransmitter acetylcholine (ACh) has a crucial role in central and neuromuscular synapses of the cholinergic system. After release into the synaptic cleft, ACh is rapidly degraded by acetylcholinesterase (AChE). We have identified a mutation in the ache gene of the zebrafish, which abolishes ACh hydrolysis in ...

    journal_title:Nature neuroscience

    pub_type: 杂志文章

    doi:10.1038/nn788

    authors: Behra M,Cousin X,Bertrand C,Vonesch JL,Biellmann D,Chatonnet A,Strähle U

    更新日期:2002-02-01 00:00:00

  • Control of synaptic strength and timing by the release-site Ca2+ signal.

    abstract::Transmitter release is triggered by highly localized, transient increases in the presynaptic Ca(2+) concentration ([Ca(2+)]). Rapidly decaying [Ca(2+)] elevations were generated using Ca(2+) uncaging techniques, and [Ca(2+)] was measured with a low-affinity Ca(2+) indicator in a giant presynaptic terminal, the calyx o...

    journal_title:Nature neuroscience

    pub_type: 杂志文章

    doi:10.1038/nn1417

    authors: Bollmann JH,Sakmann B

    更新日期:2005-04-01 00:00:00

  • Medial prefrontal D1 dopamine neurons control food intake.

    abstract::Although the prefrontal cortex influences motivated behavior, its role in food intake remains unclear. Here, we demonstrate a role for D1-type dopamine receptor-expressing neurons in the medial prefrontal cortex (mPFC) in the regulation of feeding. Food intake increases activity in D1 neurons of the mPFC in mice, and ...

    journal_title:Nature neuroscience

    pub_type: 杂志文章

    doi:10.1038/nn.3625

    authors: Land BB,Narayanan NS,Liu RJ,Gianessi CA,Brayton CE,Grimaldi DM,Sarhan M,Guarnieri DJ,Deisseroth K,Aghajanian GK,DiLeone RJ

    更新日期:2014-02-01 00:00:00

  • Author Correction: Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain.

    abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title:Nature neuroscience

    pub_type: 已发布勘误

    doi:10.1038/s41593-020-0595-9

    authors: Marschallinger J,Iram T,Zardeneta M,Lee SE,Lehallier B,Haney MS,Pluvinage JV,Mathur V,Hahn O,Morgens DW,Kim J,Tevini J,Felder TK,Wolinski H,Bertozzi CR,Bassik MC,Aigner L,Wyss-Coray T

    更新日期:2020-02-01 00:00:00

  • New role of delta2-glutamate receptors in AMPA receptor trafficking and cerebellar function.

    abstract::Previous gene knockout studies have shown that the orphan glutamate receptor delta2 (GluRdelta2) is critically involved in synaptogenesis between parallel fibers and Purkinje cells during development. However, the precise function of GluRdelta2 and whether it is functional in the mature cerebellum remain unclear. To a...

    journal_title:Nature neuroscience

    pub_type: 杂志文章

    doi:10.1038/nn1086

    authors: Hirai H,Launey T,Mikawa S,Torashima T,Yanagihara D,Kasaura T,Miyamoto A,Yuzaki M

    更新日期:2003-08-01 00:00:00

  • A GABAergic nigrotectal pathway for coordination of drinking behavior.

    abstract::The contribution of basal ganglia outputs to consummatory behavior remains poorly understood. We recorded from the substantia nigra pars reticulata (SNR), the major basal ganglia output nucleus, during self-initiated drinking in mice. The firing rates of many lateral SNR neurons were time-locked to individual licks. T...

    journal_title:Nature neuroscience

    pub_type: 杂志文章

    doi:10.1038/nn.4285

    authors: Rossi MA,Li HE,Lu D,Kim IH,Bartholomew RA,Gaidis E,Barter JW,Kim N,Cai MT,Soderling SH,Yin HH

    更新日期:2016-05-01 00:00:00

  • COUP-TFI regulates the balance of cortical patterning between frontal/motor and sensory areas.

    abstract::We used cortex-specific deletion of the transcription factor gene COUP-TFI (also known as Nr2f1) in mice to demonstrate previously unknown fundamental roles for it in patterning mammalian neocortex into areas. The highest COUP-TFI expression is observed in the cortical progenitors and progeny in parietal and occipital...

    journal_title:Nature neuroscience

    pub_type: 杂志文章

    doi:10.1038/nn1958

    authors: Armentano M,Chou SJ,Tomassy GS,Leingärtner A,O'Leary DD,Studer M

    更新日期:2007-10-01 00:00:00

  • In vivo intracellular recording and perturbation of persistent activity in a neural integrator.

    abstract::To investigate the mechanisms of persistent neural activity, we obtained in vivo intracellular recordings from neurons in an oculomotor neural integrator of the goldfish during spontaneous saccades and fixations. Persistent changes in firing rate following saccades were associated with step changes in interspike membr...

    journal_title:Nature neuroscience

    pub_type: 杂志文章

    doi:10.1038/84023

    authors: Aksay E,Gamkrelidze G,Seung HS,Baker R,Tank DW

    更新日期:2001-02-01 00:00:00

  • Representation of negative motivational value in the primate lateral habenula.

    abstract::An action may lead to either a reward or a punishment. Therefore, an appropriate action needs to be chosen on the basis of the values of both expected rewards and expected punishments. To understand the underlying neural mechanisms, we conditioned monkeys using a Pavlovian procedure with two distinct contexts: one in ...

    journal_title:Nature neuroscience

    pub_type: 杂志文章

    doi:10.1038/nn.2233

    authors: Matsumoto M,Hikosaka O

    更新日期:2009-01-01 00:00:00

  • Dopaminergic neurons promote hippocampal reactivation and spatial memory persistence.

    abstract::We found that optogenetic burst stimulation of hippocampal dopaminergic fibers from midbrain neurons in mice exploring novel environments enhanced the reactivation of pyramidal cell assemblies during subsequent sleep/rest. When applied during spatial learning of new goal locations, dopaminergic photostimulation improv...

    journal_title:Nature neuroscience

    pub_type: 杂志文章

    doi:10.1038/nn.3843

    authors: McNamara CG,Tejero-Cantero Á,Trouche S,Campo-Urriza N,Dupret D

    更新日期:2014-12-01 00:00:00

  • Episodic sequence memory is supported by a theta-gamma phase code.

    abstract::The meaning we derive from our experiences is not a simple static extraction of the elements but is largely based on the order in which those elements occur. Models propose that sequence encoding is supported by interactions between high- and low-frequency oscillations, such that elements within an experience are repr...

    journal_title:Nature neuroscience

    pub_type: 杂志文章

    doi:10.1038/nn.4374

    authors: Heusser AC,Poeppel D,Ezzyat Y,Davachi L

    更新日期:2016-10-01 00:00:00

  • Sensory and decision-related activity propagate in a cortical feedback loop during touch perception.

    abstract::The brain transforms physical sensory stimuli into meaningful perceptions. In animals making choices about sensory stimuli, neuronal activity in successive cortical stages reflects a progression from sensation to decision. Feedforward and feedback pathways connecting cortical areas are critical for this transformation...

    journal_title:Nature neuroscience

    pub_type: 杂志文章

    doi:10.1038/nn.4356

    authors: Kwon SE,Yang H,Minamisawa G,O'Connor DH

    更新日期:2016-09-01 00:00:00

  • Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance.

    abstract::PICALM is a highly validated genetic risk factor for Alzheimer's disease (AD). We found that reduced expression of PICALM in AD and murine brain endothelium correlated with amyloid-β (Aβ) pathology and cognitive impairment. Moreover, Picalm deficiency diminished Aβ clearance across the murine blood-brain barrier (BBB)...

    journal_title:Nature neuroscience

    pub_type: 杂志文章

    doi:10.1038/nn.4025

    authors: Zhao Z,Sagare AP,Ma Q,Halliday MR,Kong P,Kisler K,Winkler EA,Ramanathan A,Kanekiyo T,Bu G,Owens NC,Rege SV,Si G,Ahuja A,Zhu D,Miller CA,Schneider JA,Maeda M,Maeda T,Sugawara T,Ichida JK,Zlokovic BV

    更新日期:2015-07-01 00:00:00

  • Merlin isoform 2 in neurofibromatosis type 2-associated polyneuropathy.

    abstract::The autosomal dominant disorder neurofibromatosis type 2 (NF2) is a hereditary tumor syndrome caused by inactivation of the NF2 tumor suppressor gene, encoding merlin. Apart from tumors affecting the peripheral and central nervous systems, most NF2 patients develop peripheral neuropathies. This peripheral nerve diseas...

    journal_title:Nature neuroscience

    pub_type: 杂志文章

    doi:10.1038/nn.3348

    authors: Schulz A,Baader SL,Niwa-Kawakita M,Jung MJ,Bauer R,Garcia C,Zoch A,Schacke S,Hagel C,Mautner VF,Hanemann CO,Dun XP,Parkinson DB,Weis J,Schröder JM,Gutmann DH,Giovannini M,Morrison H

    更新日期:2013-04-01 00:00:00

  • Respiratory rhythm generation during gasping depends on persistent sodium current.

    abstract::In severe hypoxia, homeostatic mechanisms maintain function of the brainstem respiratory network. We hypothesized that hypoxia involves a transition from neuronal mechanisms of normal breathing (eupnea) to a rudimentary pattern of inspiratory movements (gasping). We provide evidence for hypoxia-driven transformation w...

    journal_title:Nature neuroscience

    pub_type: 杂志文章

    doi:10.1038/nn1650

    authors: Paton JF,Abdala AP,Koizumi H,Smith JC,St-John WM

    更新日期:2006-03-01 00:00:00

  • Optogenetics and the future of neuroscience.

    abstract::Over the last 10 years, optogenetics has become widespread in neuroscience for the study of how specific cell types contribute to brain functions and brain disorder states. The full impact of optogenetics will emerge only when other toolsets mature, including neural connectivity and cell phenotyping tools and neural r...

    journal_title:Nature neuroscience

    pub_type: 评论,杂志文章

    doi:10.1038/nn.4094

    authors: Boyden ES

    更新日期:2015-09-01 00:00:00

  • An α2-Na/K ATPase/α-adducin complex in astrocytes triggers non-cell autonomous neurodegeneration.

    abstract::Perturbations of astrocytes trigger neurodegeneration in several diseases, but the glial cell-intrinsic mechanisms that induce neurodegeneration remain poorly understood. We found that a protein complex of α2-Na/K ATPase and α-adducin was enriched in astrocytes expressing mutant superoxide dismutase 1 (SOD1), which ca...

    journal_title:Nature neuroscience

    pub_type: 杂志文章

    doi:10.1038/nn.3853

    authors: Gallardo G,Barowski J,Ravits J,Siddique T,Lingrel JB,Robertson J,Steen H,Bonni A

    更新日期:2014-12-01 00:00:00

  • Male pheromone-stimulated neurogenesis in the adult female brain: possible role in mating behavior.

    abstract::The regulation of female reproductive behaviors may involve memories of male pheromone signatures, formed in part by neural circuitry involving the olfactory bulb and hippocampus. These neural structures are the principal sites of adult neurogenesis; however, previous studies point to their independent regulation by s...

    journal_title:Nature neuroscience

    pub_type: 杂志文章

    doi:10.1038/nn1928

    authors: Mak GK,Enwere EK,Gregg C,Pakarainen T,Poutanen M,Huhtaniemi I,Weiss S

    更新日期:2007-08-01 00:00:00

  • Genetic identification of an embryonic parafacial oscillator coupling to the preBötzinger complex.

    abstract::The hindbrain transcription factors Phox2b and Egr2 (also known as Krox20) are linked to the development of the autonomic nervous system and rhombomere-related regulation of breathing, respectively. Mutations in these proteins can lead to abnormal breathing behavior as a result of an alteration in an unidentified neur...

    journal_title:Nature neuroscience

    pub_type: 杂志文章

    doi:10.1038/nn.2354

    authors: Thoby-Brisson M,Karlén M,Wu N,Charnay P,Champagnat J,Fortin G

    更新日期:2009-08-01 00:00:00

  • Neural mechanisms of aggression across species.

    abstract::Aggression is a social behavior essential for securing resources and defending oneself and family. Thanks to its indispensable function in competition and thus survival, aggression exists widely across animal species, including humans. Classical works from Tinbergen and Lorenz concluded that instinctive behaviors incl...

    journal_title:Nature neuroscience

    pub_type: 杂志文章,评审

    doi:10.1038/s41593-020-00715-2

    authors: Lischinsky JE,Lin D

    更新日期:2020-11-01 00:00:00

  • Opposing mechanisms mediate morphine- and cocaine-induced generation of silent synapses.

    abstract::Exposures to cocaine and morphine produce similar adaptations in nucleus accumbens (NAc)-based behaviors, yet produce very different adaptations at NAc excitatory synapses. In an effort to explain this paradox, we found that both drugs induced NMDA receptor-containing, AMPA receptor-silent excitatory synapses, albeit ...

    journal_title:Nature neuroscience

    pub_type: 杂志文章

    doi:10.1038/nn.4313

    authors: Graziane NM,Sun S,Wright WJ,Jang D,Liu Z,Huang YH,Nestler EJ,Wang YT,Schlüter OM,Dong Y

    更新日期:2016-07-01 00:00:00

  • Columnar organization of spatial phase in visual cortex.

    abstract::Images are processed in the primary visual cortex by neurons that encode different stimulus orientations and spatial phases. In primates and carnivores, neighboring cortical neurons share similar orientation preferences, but spatial phases were thought to be randomly distributed. We discovered a columnar organization ...

    journal_title:Nature neuroscience

    pub_type: 杂志文章

    doi:10.1038/nn.3878

    authors: Wang Y,Jin J,Kremkow J,Lashgari R,Komban SJ,Alonso JM

    更新日期:2015-01-01 00:00:00

  • Mesopontine median raphe regulates hippocampal ripple oscillation and memory consolidation.

    abstract::Sharp wave-associated field oscillations (∼200 Hz) of the hippocampus, referred to as ripples, are believed to be important for consolidation of explicit memory. Little is known about how ripples are regulated by other brain regions. We found that the median raphe region (MnR) is important for regulating hippocampal r...

    journal_title:Nature neuroscience

    pub_type: 杂志文章

    doi:10.1038/nn.3998

    authors: Wang DV,Yau HJ,Broker CJ,Tsou JH,Bonci A,Ikemoto S

    更新日期:2015-05-01 00:00:00

  • The P2Y12 receptor regulates microglial activation by extracellular nucleotides.

    abstract::Microglia are primary immune sentinels of the CNS. Following injury, these cells migrate or extend processes toward sites of tissue damage. CNS injury is accompanied by release of nucleotides, serving as signals for microglial activation or chemotaxis. Microglia express several purinoceptors, including a G(i)-coupled ...

    journal_title:Nature neuroscience

    pub_type: 杂志文章

    doi:10.1038/nn1805

    authors: Haynes SE,Hollopeter G,Yang G,Kurpius D,Dailey ME,Gan WB,Julius D

    更新日期:2006-12-01 00:00:00

  • The same synaptic vesicles drive active and spontaneous release.

    abstract::Synaptic vesicles release neurotransmitter both actively (on stimulation) and spontaneously (at rest). It has been assumed that identical vesicles use both modes of release; however, recent evidence has challenged this view. Using several assays (FM dye imaging, pHluorin imaging and antibody-labeling of synaptotagmin)...

    journal_title:Nature neuroscience

    pub_type: 杂志文章

    doi:10.1038/nn.2690

    authors: Wilhelm BG,Groemer TW,Rizzoli SO

    更新日期:2010-12-01 00:00:00

  • Contrast gain control and cortical TrkB signaling shape visual acuity.

    abstract::During development and aging and in amblyopia, visual acuity is far below the limitations set by the retina. Expression of brain-derived neurotrophic factor (BDNF) in the visual cortex is reduced in these situations. We asked whether neurotrophic tyrosine kinase receptor, type 2 (TrkB) regulates cortical visual acuity...

    journal_title:Nature neuroscience

    pub_type: 杂志文章

    doi:10.1038/nn.2534

    authors: Heimel JA,Saiepour MH,Chakravarthy S,Hermans JM,Levelt CN

    更新日期:2010-05-01 00:00:00