Abstract:
:Blockade of retinal waves prevents the segregation of retinogeniculate afferents into eye-specific layers in the visual thalamus. However, the key features of retinal waves that drive this refinement are controversial. Some manipulations of retinal waves lead to normal eye-specific segregation but others do not. By comparing retinal spiking patterns in several mutant mice with differing levels of eye-specific segregation, we show that the presence of high-frequency bursts synchronized across neighboring retinal ganglion cells correlates with robust eye-specific segregation and that the presence of high levels of asynchronous spikes does not inhibit this segregation. These findings provide a possible resolution to previously described discrepancies regarding the role of retinal waves in retinogeniculate segregation.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Torborg CL,Hansen KA,Feller MBdoi
10.1038/nn1376subject
Has Abstractpub_date
2005-01-01 00:00:00pages
72-8issue
1eissn
1097-6256issn
1546-1726pii
nn1376journal_volume
8pub_type
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