Differential activity-dependent regulation of the lateral mobilities of AMPA and NMDA receptors.

abstract：:Agonists of GABA(B) receptors exert a bi-directional effect on the activity of dopamine (DA) neurons of the ventral tegmental area, which can be explained by the fact that coupling between GABA(B) receptors and G protein-gated inwardly rectifying potassium (GIRK) channels is significantly weaker in DA neurons than in ...

journal_title：Nature neuroscience

authors： Labouèbe G,Lomazzi M,Cruz HG,Creton C,Luján R,Li M,Yanagawa Y,Obata K,Watanabe M,Wickman K,Boyer SB,Slesinger PA,Lüscher C

更新日期：2007-12-01 00:00:00

abstract：:Predatory hunting plays a fundamental role in animal survival. Little is known about the neural circuits that convert sensory cues into neural signals to drive this behavior. Here we identified an excitatory subcortical neural circuit from the superior colliculus to the zona incerta that triggers predatory hunting. Th...

journal_title：Nature neuroscience

authors： Shang C,Liu A,Li D,Xie Z,Chen Z,Huang M,Li Y,Wang Y,Shen WL,Cao P

更新日期：2019-06-01 00:00:00

abstract：:Stimuli that elicit itch are detected by sensory neurons that innervate the skin. This information is processed by the spinal cord; however, the way in which this occurs is still poorly understood. Here we investigated the neuronal pathways for itch neurotransmission, particularly the contribution of the neuropeptide ...

journal_title：Nature neuroscience

authors： Huang J,Polgár E,Solinski HJ,Mishra SK,Tseng PY,Iwagaki N,Boyle KA,Dickie AC,Kriegbaum MC,Wildner H,Zeilhofer HU,Watanabe M,Riddell JS,Todd AJ,Hoon MA

更新日期：2018-05-01 00:00:00

abstract：:Fear-inducing memories can be state dependent, meaning that they can best be retrieved if the brain states at encoding and retrieval are similar. Restricted access to such memories can present a risk for psychiatric disorders and hamper their treatment. To better understand the mechanisms underlying state-dependent fe...

journal_title：Nature neuroscience

authors： Jovasevic V,Corcoran KA,Leaderbrand K,Yamawaki N,Guedea AL,Chen HJ,Shepherd GM,Radulovic J

更新日期：2015-09-01 00:00:00

abstract：:Some individuals maintain high cognitive functioning at older ages. Here we show that mechanisms for long-term depression differ in aged rodents that maintain cognitive performance compared to young adults. Our results imply that cognitive abilities may be sustained in aged individuals by a switch in synaptic plastici...

journal_title：Nature neuroscience

authors： Lee HK,Min SS,Gallagher M,Kirkwood A

更新日期：2005-12-01 00:00:00

abstract：:The sensing of circulating nutrients within the mediobasal hypothalamus may be critical for energy homeostasis. To induce a sustained impairment in hypothalamic nutrient sensing, adeno-associated viruses (AAV) expressing malonyl-coenzyme A decarboxylase (MCD; an enzyme involved in the degradation of malonyl coenzyme A...

journal_title：Nature neuroscience

authors： He W,Lam TK,Obici S,Rossetti L

更新日期：2006-02-01 00:00:00

abstract：:Long-term potentiation (LTP) is thought to be critically involved not only in learning and memory, but also during the activity-dependent developmental phases of neural circuit formation and refinement. Whether the mechanisms underlying LTP change during this phase of postnatal development, however, is unknown. We rep...

journal_title：Nature neuroscience

authors： Yasuda H,Barth AL,Stellwagen D,Malenka RC

更新日期：2003-01-01 00:00:00

abstract：:Oxytocin is an essential hormone for mammalian labor and lactation. Here, we show a new function of oxytocin in causing plastic changes in hippocampal synapses during motherhood. In oxytocin-perfused hippocampal slices, one-train tetanus stimulation induced long-lasting, long-term potentiation (L-LTP) and phosphorylat...

journal_title：Nature neuroscience

authors： Tomizawa K,Iga N,Lu YF,Moriwaki A,Matsushita M,Li ST,Miyamoto O,Itano T,Matsui H

更新日期：2003-04-01 00:00:00

abstract：:The healthy human brain is a mosaic of varied genomes. Long interspersed element-1 (LINE-1 or L1) retrotransposition is known to create mosaicism by inserting L1 sequences into new locations of somatic cell genomes. Using a machine learning-based, single-cell sequencing approach, we discovered that somatic L1-associat...

journal_title：Nature neuroscience

authors： Erwin JA,Paquola AC,Singer T,Gallina I,Novotny M,Quayle C,Bedrosian TA,Alves FI,Butcher CR,Herdy JR,Sarkar A,Lasken RS,Muotri AR,Gage FH

更新日期：2016-12-01 00:00:00

abstract：:Loss of noradrenergic locus coeruleus (LC) neurons is a prominent feature of aging-related neurodegenerative diseases, such as Parkinson's disease (PD). The basis of this vulnerability is not understood. To explore possible physiological determinants, we studied LC neurons using electrophysiological and optical approa...

journal_title：Nature neuroscience

authors： Sanchez-Padilla J,Guzman JN,Ilijic E,Kondapalli J,Galtieri DJ,Yang B,Schieber S,Oertel W,Wokosin D,Schumacker PT,Surmeier DJ

更新日期：2014-06-01 00:00:00

abstract：:Experience-dependent plasticity in adult visual cortex is believed to have important roles in visual coding and perceptual learning. Here we show that repeated stimulation with movies of natural scenes induces a rapid improvement in response reliability in cat visual cortex, whereas stimulation with white noise or fla...

journal_title：Nature neuroscience

authors： Yao H,Shi L,Han F,Gao H,Dan Y

更新日期：2007-06-01 00:00:00

abstract：:Ongoing sensory input is critical for shaping internal representations of the external world. Conversely, a lack of sensory input can profoundly perturb the formation of these representations. The olfactory system is particularly vulnerable to sensory deprivation, owing to the widespread prevalence of allergic, viral ...

journal_title：Nature neuroscience

authors： Wu KN,Tan BK,Howard JD,Conley DB,Gottfried JA

更新日期：2012-09-01 00:00:00

abstract：:An unresolved question in neuroscience relates to the extent to which corticothalamocortical circuits emanating from layer 5B are involved in information transfer through the cortical hierarchy. Using a new form of optical imaging in a brain slice preparation, we found that the corticothalamocortical pathway drove rob...

journal_title：Nature neuroscience

authors： Theyel BB,Llano DA,Sherman SM

更新日期：2010-01-01 00:00:00

abstract：:A moving grating elicits innate optomotor behavior in zebrafish larvae; they swim in the direction of perceived motion. We took advantage of this behavior, using computer-animated displays, to determine what attributes of motion are extracted by the fish visual system. As in humans, first-order (luminance-defined or F...

journal_title：Nature neuroscience

authors： Orger MB,Smear MC,Anstis SM,Baier H

更新日期：2000-11-01 00:00:00

abstract：:We used ultrasound image-guided injections of high-titer retroviral vectors to obtain widespread introduction of genes into the mouse nervous system in utero as early as embryonic day 8.5 (E8.5). The vectors used included internal promoters that substantially improved proviral gene expression in the ventricular zone o...

journal_title：Nature neuroscience

authors： Gaiano N,Kohtz JD,Turnbull DH,Fishell G

更新日期：1999-09-01 00:00:00

abstract：:Neurotransmitters are released continuously at ribbon synapses in the retina and cochlea. Notably, a single ribbon synapse of inner hair cells provides the entire input to each cochlear afferent fiber. We investigated hair cell transmitter release in the postnatal rat cochlea by recording excitatory postsynaptic curre...

journal_title：Nature neuroscience

authors： Glowatzki E,Fuchs PA

更新日期：2002-02-01 00:00:00

abstract：:Emotions operate along the dimension of approach and aversion, and it is reasonable to assume that orienting behavior is intrinsically linked to emotionally involved processes such as preference decisions. Here we describe a gaze 'cascade effect' that was present when human observers were shown pairs of human faces an...

journal_title：Nature neuroscience

authors： Shimojo S,Simion C,Shimojo E,Scheier C

更新日期：2003-12-01 00:00:00

abstract：:It is widely accepted that D1 dopamine receptor-expressing striatal neurons convey their information directly to the output nuclei of the basal ganglia, whereas D2-expressing neurons do so indirectly via pallidal neurons. Combining optogenetics and electrophysiology, we found that this architecture does not apply to m...

journal_title：Nature neuroscience

authors： Kupchik YM,Brown RM,Heinsbroek JA,Lobo MK,Schwartz DJ,Kalivas PW

更新日期：2015-09-01 00:00:00

abstract：:Electrical stimulation of visual cortex can produce a visual percept (phosphene). We electrically stimulated visual cortex in humans implanted with subdural electrodes while recording from other brain sites. Phosphene perception occurred only if stimulation evoked high-frequency gamma oscillations in the temporopariet...

journal_title：Nature neuroscience

authors： Beauchamp MS,Sun P,Baum SH,Tolias AS,Yoshor D

更新日期：2012-06-03 00:00:00

abstract：:Multiple protein kinase C (PKC) isozymes are present in neurons, where they regulate a variety of cellular functions. Due to the lack of specific PKC isozyme inhibitors, it remains unknown how PKC acts on its selective target(s) and achieves its specific actions. Here we show that a PKC binding protein, enigma homolog...

journal_title：Nature neuroscience

authors： Maeno-Hikichi Y,Chang S,Matsumura K,Lai M,Lin H,Nakagawa N,Kuroda S,Zhang JF

更新日期：2003-05-01 00:00:00

abstract：:Lateral and medial parts of entorhinal cortex (EC) convey nonspatial 'what' and spatial 'where' information, respectively, into hippocampal CA1, via both the indirect EC layer 2→ hippocampal dentate gyrus→CA3→CA1 and the direct EC layer 3→CA1 paths. However, it remains elusive how the direct path transfers distinct in...

journal_title：Nature neuroscience

authors： Li Y,Xu J,Liu Y,Zhu J,Liu N,Zeng W,Huang N,Rasch MJ,Jiang H,Gu X,Li X,Luo M,Li C,Teng J,Chen J,Zeng S,Lin L,Zhang X

更新日期：2017-04-01 00:00:00

abstract：:Sustained activity encoding visual working memory representations has been observed in several cortical areas of primates. Where along the visual pathways this activity emerges remains unknown. Here we show in macaques that sustained spiking activity encoding memorized visual motion directions is absent in direction-s...

journal_title：Nature neuroscience

authors： Mendoza-Halliday D,Torres S,Martinez-Trujillo JC

更新日期：2014-09-01 00:00:00

abstract：:Individual differences in motor learning ability are widely acknowledged, yet little is known about the factors that underlie them. Here we explore whether movement-to-movement variability in motor output, a ubiquitous if often unwanted characteristic of motor performance, predicts motor learning ability. Surprisingly...

journal_title：Nature neuroscience

authors： Wu HG,Miyamoto YR,Gonzalez Castro LN,Ölveczky BP,Smith MA

更新日期：2014-02-01 00:00:00

abstract：:Changes in spine morphology may underlie memory formation, but the molecular mechanisms that subserve such alterations are poorly understood. Here we show that fear conditioning in rats leads to the movement of profilin, an actin polymerization-regulatory protein, into dendritic spines in the lateral amygdala and that...

journal_title：Nature neuroscience

authors： Lamprecht R,Farb CR,Rodrigues SM,LeDoux JE

更新日期：2006-04-01 00:00:00

abstract：:The C. elegans SAX-3/Robo receptor acts in anterior-posterior, dorsal-ventral and midline guidance decisions. Here we show that SAX-3 signaling involves the C. elegans Enabled protein UNC-34 and an unexpected Netrin-independent function of the Netrin receptor UNC-40/DCC. Genetic interactions with gain- and loss-of-fun...

journal_title：Nature neuroscience

authors： Yu TW,Hao JC,Lim W,Tessier-Lavigne M,Bargmann CI

更新日期：2002-11-01 00:00:00

abstract：:Neurobiological theories of knowledge processing are biased toward the language-dominant (usually the left) hemisphere. Does the right hemisphere critically contribute to knowledge processing? J.A. is a left-hemisphere language-dominant individual who suffered a lesion confined to the right mid- and anterior fusiform ...

journal_title：Nature neuroscience

authors： Vandenbulcke M,Peeters R,Fannes K,Vandenberghe R

更新日期：2006-07-01 00:00:00

abstract：:The ability to attribute mental states to others, and therefore to predict others' behavior, is particularly advanced in humans. A controversial but untested idea is that this is achieved by simulating the other person's mental processes in one's own mind. If this is the case, then the same neural systems activated by...

journal_title：Nature neuroscience

authors： Ramnani N,Miall RC

更新日期：2004-01-01 00:00:00

abstract：:At glutamatergic synapses, calcium influx through NMDA receptors (NMDARs) is required for long-term potentiation (LTP); this is a proposed cellular mechanism underlying memory and learning. Here we show that in lateral amygdala pyramidal neurons, SK channels are also activated by calcium influx through synaptically ac...

journal_title：Nature neuroscience

authors： Faber ES,Delaney AJ,Sah P

更新日期：2005-05-01 00:00:00

abstract：:Cell type-specific expression of optogenetic molecules allows temporally precise manipulation of targeted neuronal activity. Here we present a toolbox of four knock-in mouse lines engineered for strong, Cre-dependent expression of channelrhodopsins ChR2-tdTomato and ChR2-EYFP, halorhodopsin eNpHR3.0 and archaerhodopsi...

journal_title：Nature neuroscience

authors： Madisen L,Mao T,Koch H,Zhuo JM,Berenyi A,Fujisawa S,Hsu YW,Garcia AJ 3rd,Gu X,Zanella S,Kidney J,Gu H,Mao Y,Hooks BM,Boyden ES,Buzsáki G,Ramirez JM,Jones AR,Svoboda K,Han X,Turner EE,Zeng H

更新日期：2012-03-25 00:00:00

abstract：:A decade after speech was first decoded from human brain signals, accuracy and speed remain far below that of natural speech. Here we show how to decode the electrocorticogram with high accuracy and at natural-speech rates. Taking a cue from recent advances in machine translation, we train a recurrent neural network t...

journal_title：Nature neuroscience

authors： Makin JG,Moses DA,Chang EF

更新日期：2020-04-01 00:00:00