RGS2 modulates coupling between GABAB receptors and GIRK channels in dopamine neurons of the ventral tegmental area.

abstract：:A central question in the study of human behavior is the origin of willed action. EEG recordings of surface brain activity from human subjects performing a self-initiated movement show that the subjective experience of wanting to move follows, rather than precedes, the 'readiness potential'--an electrophysiological ma...

journal_title：Nature neuroscience

authors： Sirigu A,Daprati E,Ciancia S,Giraux P,Nighoghossian N,Posada A,Haggard P

更新日期：2004-01-01 00:00:00

abstract：:The launch of the US BRAIN and European Human Brain Projects coincides with growing international efforts toward transparency and increased access to publicly funded research in the neurosciences. The need for data-sharing standards and neuroinformatics infrastructure is more pressing than ever. However, 'big science'...

journal_title：Nature neuroscience

authors： Ferguson AR,Nielson JL,Cragin MH,Bandrowski AE,Martone ME

更新日期：2014-11-01 00:00:00

abstract：:The hippocampus is thought to be involved in episodic memory formation by reactivating traces of waking experience during sleep. Indeed, the joint firing of spatially tuned pyramidal cells encoding nearby places recur during sleep. We found that the sleep cofiring of rat CA1 pyramidal cells encoding similar places inc...

journal_title：Nature neuroscience

authors： O'Neill J,Senior TJ,Allen K,Huxter JR,Csicsvari J

更新日期：2008-02-01 00:00:00

abstract：:Brain-derived neurotrophic factor (BDNF) acting through the tyrosine kinase B receptor (TrkB) is thought to be a critical mediator of learning. As there are no available selective antagonists of TrkB, we used a lentivirus encoding a dominant-negative TrkB (TrkB.t1) to antagonize BDNF signaling during extinction of con...

journal_title：Nature neuroscience

authors： Chhatwal JP,Stanek-Rattiner L,Davis M,Ressler KJ

更新日期：2006-07-01 00:00:00

abstract：:The mechanistic target of rapamycin (mTOR) acts as a highly conserved signaling "hub" that integrates neuronal activity and a variety of synaptic inputs. mTOR is found in two functionally distinct complexes, mTORC1 and mTORC2, that crucially control long-term synaptic efficacy and memory storage. Dysregulation of mTOR...

journal_title：Nature neuroscience

authors： Costa-Mattioli M,Monteggia LM

更新日期：2013-11-01 00:00:00

abstract：:Three families of ligand-activated ion channels mediate synaptic communication between excitable cells in mammals. For pentameric channels related to nicotinic acetylcholine receptors and tetrameric channels such as glutamate receptors, the pore-forming and gate regions have been studied extensively. In contrast, litt...

journal_title：Nature neuroscience

authors： Li M,Chang TH,Silberberg SD,Swartz KJ

更新日期：2008-08-01 00:00:00

abstract：:A hallmark of addiction is the loss of control over drug intake, which is seen in only a fraction of those exposed to stimulant drugs such as cocaine. The cellular mechanisms underlying vulnerability or resistance to compulsive drug use remain unknown. We found that individual variability in the development of highly ...

journal_title：Nature neuroscience

authors： Bock R,Shin JH,Kaplan AR,Dobi A,Markey E,Kramer PF,Gremel CM,Christensen CH,Adrover MF,Alvarez VA

更新日期：2013-05-01 00:00:00

abstract：:The distinct electrical properties of axonal and dendritic membranes are largely a result of specific transport of vesicle-bound membrane proteins to each compartment. How this specificity arises is unclear because kinesin motors that transport vesicles cannot autonomously distinguish dendritically projecting microtub...

journal_title：Nature neuroscience

authors： Lewis TL Jr,Mao T,Svoboda K,Arnold DB

更新日期：2009-05-01 00:00:00

abstract：:Oxytocin is an essential hormone for mammalian labor and lactation. Here, we show a new function of oxytocin in causing plastic changes in hippocampal synapses during motherhood. In oxytocin-perfused hippocampal slices, one-train tetanus stimulation induced long-lasting, long-term potentiation (L-LTP) and phosphorylat...

journal_title：Nature neuroscience

authors： Tomizawa K,Iga N,Lu YF,Moriwaki A,Matsushita M,Li ST,Miyamoto O,Itano T,Matsui H

更新日期：2003-04-01 00:00:00

abstract：:Accumulation of abnormally phosphorylated TDP-43 (pTDP-43) is the main pathology in affected neurons of people with amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Morphological diversity and neuroanatomical distribution of pTDP-43 accumulations allowed classification of FTLD cases in...

journal_title：Nature neuroscience

authors： Laferrière F,Maniecka Z,Pérez-Berlanga M,Hruska-Plochan M,Gilhespy L,Hock EM,Wagner U,Afroz T,Boersema PJ,Barmettler G,Foti SC,Asi YT,Isaacs AM,Al-Amoudi A,Lewis A,Stahlberg H,Ravits J,De Giorgi F,Ichas F,Bezard E,

更新日期：2019-01-01 00:00:00

abstract：:We investigated the regulation of T-type channels by Rho-associated kinase (ROCK). Activation of ROCK via the endogenous ligand lysophosphatidic acid (LPA) reversibly inhibited the peak current amplitudes of rat Ca(v)3.1 and Ca(v)3.3 channels without affecting the voltage dependence of activation or inactivation, wher...

journal_title：Nature neuroscience

authors： Iftinca M,Hamid J,Chen L,Varela D,Tadayonnejad R,Altier C,Turner RW,Zamponi GW

更新日期：2007-07-01 00:00:00

abstract：:All the higher mental and cognitive functions unique to humans depend on the neocortex ('new' cortex, referring to its relatively recent appearance in evolution), which is divided into discrete areas that subserve distinct functions, such as language, movement and sensation. With a few notable exceptions, all neocorti...

journal_title：Nature neuroscience

authors： Monuki ES,Walsh CA

更新日期：2001-11-01 00:00:00

abstract：:The sensing of circulating nutrients within the mediobasal hypothalamus may be critical for energy homeostasis. To induce a sustained impairment in hypothalamic nutrient sensing, adeno-associated viruses (AAV) expressing malonyl-coenzyme A decarboxylase (MCD; an enzyme involved in the degradation of malonyl coenzyme A...

journal_title：Nature neuroscience

authors： He W,Lam TK,Obici S,Rossetti L

更新日期：2006-02-01 00:00:00

abstract：:We found that K(+)/Cl(-) co-transporter 2 (KCC2) activity, monitored with wide-field fluorescence, was inhibited by intracellular Zn(2+), a major component of neuronal injury. Zn(2+)-mediated KCC2 inhibition produced a depolarizing shift of GABA(A) reversal potentials in rat cortical neurons. Moreover, oxygen-glucose ...

journal_title：Nature neuroscience

authors： Hershfinkel M,Kandler K,Knoch ME,Dagan-Rabin M,Aras MA,Abramovitch-Dahan C,Sekler I,Aizenman E

更新日期：2009-06-01 00:00:00

abstract：:It is often assumed that all neurons of the same cell type have identical intrinsic properties, both within an animal and between animals. We exploited the large size and small number of unambiguously identifiable neurons in the crab stomatogastric ganglion to test this assumption at the level of channel mRNA expressi...

journal_title：Nature neuroscience

authors： Schulz DJ,Goaillard JM,Marder E

更新日期：2006-03-01 00:00:00

abstract：:Distinct cell lineages established early in development are usually maintained throughout adulthood. Thus, adult stem cells have been thought to generate differentiated cells specific to the tissue in which they reside. This view has been challenged; for example, neural stem cells can generate cells that normally orig...

journal_title：Nature neuroscience

authors： Galli R,Borello U,Gritti A,Minasi MG,Bjornson C,Coletta M,Mora M,De Angelis MG,Fiocco R,Cossu G,Vescovi AL

更新日期：2000-10-01 00:00:00

abstract：:The autosomal dominant disorder neurofibromatosis type 2 (NF2) is a hereditary tumor syndrome caused by inactivation of the NF2 tumor suppressor gene, encoding merlin. Apart from tumors affecting the peripheral and central nervous systems, most NF2 patients develop peripheral neuropathies. This peripheral nerve diseas...

journal_title：Nature neuroscience

authors： Schulz A,Baader SL,Niwa-Kawakita M,Jung MJ,Bauer R,Garcia C,Zoch A,Schacke S,Hagel C,Mautner VF,Hanemann CO,Dun XP,Parkinson DB,Weis J,Schröder JM,Gutmann DH,Giovannini M,Morrison H

更新日期：2013-04-01 00:00:00

abstract：:Though motor neurons selectively degenerate in amyotrophic lateral sclerosis, other cell types are likely involved in this disease. We recently generated rNLS8 mice in which human TDP-43 (hTDP-43) pathology could be reversibly induced in neurons and expected that microglia would contribute to neurodegeneration. Howeve...

journal_title：Nature neuroscience

authors： Spiller KJ,Restrepo CR,Khan T,Dominique MA,Fang TC,Canter RG,Roberts CJ,Miller KR,Ransohoff RM,Trojanowski JQ,Lee VM

更新日期：2018-03-01 00:00:00

abstract：:Transmitter release is triggered by highly localized, transient increases in the presynaptic Ca(2+) concentration ([Ca(2+)]). Rapidly decaying [Ca(2+)] elevations were generated using Ca(2+) uncaging techniques, and [Ca(2+)] was measured with a low-affinity Ca(2+) indicator in a giant presynaptic terminal, the calyx o...

journal_title：Nature neuroscience

authors： Bollmann JH,Sakmann B

更新日期：2005-04-01 00:00:00

abstract：:An afterimage looks larger when one fixates on a distant than on a closer surface. We show that the retinotopic activity in the primary visual cortex (V1) associated with viewing an afterimage is modulated by perceived size, even when the size of the retinal image remains constant. This suggests that V1 has an importa...

journal_title：Nature neuroscience

authors： Sperandio I,Chouinard PA,Goodale MA

更新日期：2012-03-11 00:00:00

abstract：:To define the role of the Raf serine/threonine kinases in nervous system development, we conditionally targeted B-Raf and C-Raf, two of the three known mammalian Raf homologs, using a mouse line expressing Cre recombinase driven by a nestin promoter. Targeting of B-Raf, but not C-Raf, markedly attenuated baseline phos...

journal_title：Nature neuroscience

authors： Zhong J,Li X,McNamee C,Chen AP,Baccarini M,Snider WD

更新日期：2007-05-01 00:00:00

abstract：:The deposition of aggregated amyloid-β peptides derived from the pro-amyloidogenic processing of the amyloid precurson protein (APP) into characteristic amyloid plaques (APs) is distinctive to Alzheimer's disease (AD). Alternative APP processing via the metalloprotease ADAM10 prevents amyloid-β formation. We tested wh...

journal_title：Nature neuroscience

authors： Esteve P,Rueda-Carrasco J,Inés Mateo M,Martin-Bermejo MJ,Draffin J,Pereyra G,Sandonís Á,Crespo I,Moreno I,Aso E,Garcia-Esparcia P,Gomez-Tortosa E,Rábano A,Fortea J,Alcolea D,Lleo A,Heneka MT,Valpuesta JM,Esteban JA,

更新日期：2019-08-01 00:00:00

abstract：:Neuronal signaling occurs through both action potential-triggered synaptic vesicle fusion and spontaneous release, although the fusion clamp machinery that prevents premature exocytosis of synaptic vesicles in the absence of calcium is unknown. Here we demonstrate that spontaneous release at synapses is regulated by c...

journal_title：Nature neuroscience

authors： Huntwork S,Littleton JT

更新日期：2007-10-01 00:00:00

abstract：:The identification of distinct cell types in the basal ganglia has been critical to our understanding of basal ganglia function and the treatment of neurological disorders. The external globus pallidus (GPe) is a key contributor to motor suppressing pathways in the basal ganglia, yet its neuronal heterogeneity has rem...

journal_title：Nature neuroscience

authors： Mastro KJ,Zitelli KT,Willard AM,Leblanc KH,Kravitz AV,Gittis AH

更新日期：2017-06-01 00:00:00

abstract：:Vesicular release of neurotransmitter is the universal output signal of neurons in the brain. It is generally believed that fast transmitter release is restricted to nerve terminals that contact postsynaptic cells in the gray matter. Here we show in the rat brain that the neurotransmitter glutamate is also released at...

journal_title：Nature neuroscience

authors： Kukley M,Capetillo-Zarate E,Dietrich D

更新日期：2007-03-01 00:00:00

abstract：:Neurons in thalamorecipient layers of sensory cortices integrate thalamocortical and intracortical inputs. Although we know that their functional properties can arise from the convergence of thalamic inputs, intracortical circuits could also be involved in thalamocortical transformations of sensory information. We sil...

journal_title：Nature neuroscience

authors： Li YT,Ibrahim LA,Liu BH,Zhang LI,Tao HW

更新日期：2013-09-01 00:00:00

abstract：:Neural activity in visual area V4 is enhanced when attention is directed into neuronal receptive fields. However, the source of this enhancement is unclear, as most physiological studies have manipulated attention by changing the absolute reward associated with a particular location as well as its value relative to ot...

journal_title：Nature neuroscience

authors： Baruni JK,Lau B,Salzman CD

更新日期：2015-11-01 00:00:00

abstract：:Continuous, predictable events and spontaneous events may coincide in the visual environment. For a continuously moving object, the brain compensates for delays in transmission between a retinal event and neural responses in higher visual areas. Here we show that it similarly compensated for other smoothly changing fe...

journal_title：Nature neuroscience

authors： Sheth BR,Nijhawan R,Shimojo S

更新日期：2000-05-01 00:00:00

abstract：:The classic 'size principle' of motor control describes how increasingly forceful movements arise by the recruitment of motoneurons of progressively larger size and force output into the active pool. We explored the activity of pools of spinal interneurons in larval zebrafish and found that increases in swimming speed...

journal_title：Nature neuroscience

authors： McLean DL,Masino MA,Koh IY,Lindquist WB,Fetcho JR

更新日期：2008-12-01 00:00:00

abstract：:In severe hypoxia, homeostatic mechanisms maintain function of the brainstem respiratory network. We hypothesized that hypoxia involves a transition from neuronal mechanisms of normal breathing (eupnea) to a rudimentary pattern of inspiratory movements (gasping). We provide evidence for hypoxia-driven transformation w...

journal_title：Nature neuroscience

authors： Paton JF,Abdala AP,Koizumi H,Smith JC,St-John WM

更新日期：2006-03-01 00:00:00