Abstract：
:Transmitter release is triggered by highly localized, transient increases in the presynaptic Ca(2+) concentration ([Ca(2+)]). Rapidly decaying [Ca(2+)] elevations were generated using Ca(2+) uncaging techniques, and [Ca(2+)] was measured with a low-affinity Ca(2+) indicator in a giant presynaptic terminal, the calyx of Held, in rat brain slices. The rise time and amplitude of evoked excitatory postsynaptic currents (EPSCs) depended on the half-width of the fluorescence transient, which was predicted by a five-binding site model of a Ca(2+) sensor having relatively high affinity (K(d) approximately 13 microM). Very fast [Ca(2+)] transients (half-width <0.5 ms) evoked EPSCs similar to those elicited by a single action potential (AP) in the same synapse. Triggering release with dual [Ca(2+)] transients of variable amplitudes demonstrated the supralinear transfer function of the sensor. The sensitivity of release to the time course of the [Ca(2+)] transient may contribute to mechanisms by which the presynaptic AP waveform controls synaptic strength.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Bollmann JH,Sakmann Bdoi
10.1038/nn1417subject
Has Abstractpub_date
2005-04-01 00:00:00pages
426-34issue
4eissn
1097-6256issn
1546-1726pii
nn1417journal_volume
8pub_type
杂志文章abstract：:Neural activity exhibits complex dynamics related to various brain functions, internal states and behaviors. Understanding how neural dynamics explain specific measured behaviors requires dissociating behaviorally relevant and irrelevant dynamics, which is not achieved with current neural dynamic models as they are le...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-020-00733-0
更新日期：2021-01-01 00:00:00
abstract：:Dendritic spines undergo actin-based growth and shrinkage during synaptic plasticity, in which the actin depolymerizing factor (ADF)/cofilin family of actin-associated proteins are important. Elevated ADF/cofilin activities often lead to reduced spine size and immature spine morphology but can also enhance synaptic po...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2634
更新日期：2010-10-01 00:00:00
abstract：:Learning and memory are associated with the formation and modification of neuronal assemblies: populations of neurons that encode what has been learned and mediate memory retrieval upon recall. Functional studies of neuronal assemblies have progressed dramatically thanks to recent technological advances. Here we discu...
journal_title：Nature neuroscience
pub_type： 杂志文章,评审
doi：10.1038/nn.4418
更新日期：2016-12-01 00:00:00
abstract：:Stimuli that elicit itch are detected by sensory neurons that innervate the skin. This information is processed by the spinal cord; however, the way in which this occurs is still poorly understood. Here we investigated the neuronal pathways for itch neurotransmission, particularly the contribution of the neuropeptide ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-018-0119-z
更新日期：2018-05-01 00:00:00
abstract：:Memory reconsolidation has been demonstrated in various tasks and species, suggesting it is a fundamental process. However, there are experimental parameters that can inhibit reconsolidation from occurring (boundary conditions). These conditions and their mechanisms remain poorly defined. Here, we characterize the abi...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2350
更新日期：2009-07-01 00:00:00
abstract：:Previous studies suggested that MeCP2 competes with linker histone H1, but this hypothesis has never been tested in vivo. Here, we performed chromatin immunoprecipitation followed by sequencing (ChIP-seq) of Flag-tagged-H1.0 in mouse forebrain excitatory neurons. Unexpectedly, Flag-H1.0 and MeCP2 occupied similar geno...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-018-0155-8
更新日期：2018-06-01 00:00:00
abstract：:We report two functional magnetic resonance imaging experiments showing enhanced responses in human middle superior temporal sulcus for angry relative to neutral prosody. This emotional enhancement was voice specific, unrelated to isolated acoustic amplitude or frequency cues in angry prosody, and distinct from any co...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1392
更新日期：2005-02-01 00:00:00
abstract：:Neural progenitor cells in the developing neocortex change over time to produce different neurons, a phenomenon that is also observed in other regions of the nervous system. Mouse Numb (also known as m-numb) and Numbl (also known as numblike or Nbl) are redundant but essential in maintaining virtually all progenitor c...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1289
更新日期：2004-08-01 00:00:00
abstract：:Neuregulin 1 type III is processed following regulated intramembrane proteolysis, which allows communication from the plasma membrane to the nucleus. We found that the intracellular domain of neuregulin 1 type III upregulated the prostaglandin D2 synthase (L-pgds, also known as Ptgds) gene, which, together with the G ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3857
更新日期：2014-12-01 00:00:00
abstract：:Many types of neurons can release endocannabinoids that act as retrograde signals to inhibit neurotransmitter release from presynaptic terminals. Little is known, however, about the properties or role of such inhibition under physiological conditions. Here we report that brief bursts of presynaptic activity evoked end...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1126
更新日期：2003-10-01 00:00:00
abstract：:Using multimodal neuroimaging in humans, we demonstrate specific interactions between prefrontal activity and midbrain dopaminergic synthesis. A common V(108/158)M substitution in the gene for catecholamine-O-methyltransferase (COMT), an important enzyme regulating prefrontal dopamine turnover, predicted reduced dopam...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1438
更新日期：2005-05-01 00:00:00
abstract：:Midbrain ventral tegmental neurons project to the prefrontal cortex and modulate cognitive functions. Using viral tracing, optogenetics and electrophysiology, we found that mesocortical neurons in the mouse ventrotegmental area provide fast glutamatergic excitation of GABAergic interneurons in the prefrontal cortex an...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4020
更新日期：2015-06-01 00:00:00
abstract：:T cells clear virus from the CNS and dynamically regulate brain functions, including spatial learning, through cytokine signaling. Here we determined whether hippocampal T cells that persist after recovery from infection with West Nile virus (WNV) or Zika virus (ZIKV) impact hippocampal-dependent learning and memory. ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-019-0427-y
更新日期：2019-08-01 00:00:00
abstract：:The molecular organization of presynaptic active zones is important for the neurotransmitter release that is triggered by depolarization-induced Ca2+ influx. Here, we demonstrate a previously unknown interaction between two components of the presynaptic active zone, RIM1 and voltage-dependent Ca2+ channels (VDCCs), th...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1904
更新日期：2007-06-01 00:00:00
abstract：:In Huntington's disease (HD), whether transneuronal spreading of mutant huntingtin (mHTT) occurs and its contribution to non-cell autonomous damage in brain networks is largely unknown. We found mHTT spreading in three different neural network models: human neurons integrated in the neural network of organotypic brain...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3761
更新日期：2014-08-01 00:00:00
abstract：:The cerebral cortex has the ability to adapt to altered sensory inputs. In the visual cortex, a small lesion to the retina causes the deprived cortical region to become responsive to adjacent parts of the visual field. This extensive topographic remapping is assumed to be mediated by the rewiring of intracortical conn...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2181
更新日期：2008-10-01 00:00:00
abstract：:As we move through the environment, the pattern of visual motion on the retina provides rich information about our movement through the scene. Human subjects can use this information, often termed "optic flow", to accurately estimate their direction of self movement (heading) from relatively sparse displays. Physiolog...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/259
更新日期：1998-05-01 00:00:00
abstract：:Although much learning occurs through direct experience of errors, humans and other animals can learn from the errors of other individuals. The medial frontal cortex (MFC) processes self-generated errors, but the neuronal architecture and mechanisms underlying the monitoring of others' errors are poorly understood. Ex...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3180
更新日期：2012-09-01 00:00:00
abstract：:Attention powerfully influences auditory perception, but little is understood about the mechanisms whereby attention sharpens responses to unattended sounds. We used high-resolution surface mapping techniques (using functional magnetic resonance imaging, fMRI) to examine activity in human auditory cortex during an int...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1256
更新日期：2004-06-01 00:00:00
abstract：:Hippocampal replay during sharp-wave ripple events (SWRs) is thought to drive memory consolidation in hippocampal and cortical circuits. Changes in neocortical activity can precede SWR events, but whether and how these changes influence the content of replay remains unknown. Here we show that during sleep there is a r...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4457
更新日期：2017-02-01 00:00:00
abstract：:Axon guidance cues contributing to the development of eye-specific visual projections to the lateral geniculate nucleus (LGN) have not previously been identified. Here we show that gradients of ephrin-As and their receptors (EphAs) direct retinal ganglion cell (RGC) axons from the two eyes into their stereotyped patte...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1505
更新日期：2005-08-01 00:00:00
abstract：:Cue-triggered recall of learned temporal sequences is an important cognitive function that has been attributed to higher brain areas. Here recordings in both anesthetized and awake rats demonstrate that after repeated stimulation with a moving spot that evoked sequential firing of an ensemble of primary visual cortex ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3036
更新日期：2012-01-22 00:00:00
abstract：:We studied how the posterior parietal cortex combines new information with ongoing activity dynamics as mice accumulate evidence during a virtual navigation task. Using new methods to analyze population activity on single trials, we found that activity transitioned rapidly between different sets of active neurons. Eac...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4403
更新日期：2016-12-01 00:00:00
abstract：:Contrast is computed throughout the nervous system to encode changing inputs efficiently. The retina encodes luminance and contrast over a wide range of visual conditions and must adapt its responses to maintain sensitivity and to avoid saturation. We examined the means by which one type of adaptation allows individua...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2945
更新日期：2011-10-23 00:00:00
abstract：:During development, the mammalian ventral telencephalon is comprised of three major proliferative zones: the medial (MGE), lateral (LGE) and caudal (CGE) ganglionic eminences. Through gene expression studies, in vitro migration assays, genetic mutant analysis and in vivo fate mapping in mice, we found that the CGE is ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn971
更新日期：2002-12-01 00:00:00
abstract：:The identity of specific cell types in the nervous system is defined by the expression of neuron type-specific gene batteries. How the expression of such batteries is initiated during nervous system development has been under intensive study over the past few decades. However, comparatively little is known about how g...
journal_title：Nature neuroscience
pub_type： 杂志文章,评审
doi：10.1038/nn.3731
更新日期：2014-07-01 00:00:00
abstract：:The primate superior colliculus (SC) is a midbrain nucleus crucial for the control of rapid eye movements (saccades). Its neurons are topographically arranged over the rostrocaudal and mediolateral extent of its deeper layers so that saccade metrics (amplitude and direction) are coded in terms of the location of activ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn727
更新日期：2001-10-01 00:00:00
abstract：:The entorhinal cortex has been implicated in the early stages of Alzheimer's disease, which is characterized by changes in the tau protein and in the cleaved fragments of the amyloid precursor protein (APP). We used a high-resolution functional magnetic resonance imaging (fMRI) variant that can map metabolic defects i...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3606
更新日期：2014-02-01 00:00:00
abstract：:Remembering a past experience can, surprisingly, cause forgetting. Forgetting arises when other competing traces interfere with retrieval and inhibitory control mechanisms are engaged to suppress the distraction they cause. This form of forgetting is considered to be adaptive because it reduces future interference. Th...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3973
更新日期：2015-04-01 00:00:00
abstract：:Synaptic cadherin adhesion complexes are known to be key regulators of synapse plasticity. However, the molecular mechanisms that coordinate activity-induced modifications in cadherin localization and adhesion and the subsequent changes in synapse morphology and efficacy remain unknown. We demonstrate that the intrace...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3657
更新日期：2014-04-01 00:00:00
