Retrieval induces adaptive forgetting of competing memories via cortical pattern suppression.

Abstract:

:Remembering a past experience can, surprisingly, cause forgetting. Forgetting arises when other competing traces interfere with retrieval and inhibitory control mechanisms are engaged to suppress the distraction they cause. This form of forgetting is considered to be adaptive because it reduces future interference. The effect of this proposed inhibition process on competing memories has, however, never been observed, as behavioral methods are 'blind' to retrieval dynamics and neuroimaging methods have not isolated retrieval of individual memories. We developed a canonical template tracking method to quantify the activation state of individual target memories and competitors during retrieval. This method revealed that repeatedly retrieving target memories suppressed cortical patterns unique to competitors. Pattern suppression was related to engagement of prefrontal regions that have been implicated in resolving retrieval competition and, critically, predicted later forgetting. Thus, our findings demonstrate a cortical pattern suppression mechanism through which remembering adaptively shapes which aspects of our past remain accessible.

journal_name

Nat Neurosci

journal_title

Nature neuroscience

authors

Wimber M,Alink A,Charest I,Kriegeskorte N,Anderson MC

doi

10.1038/nn.3973

subject

Has Abstract

pub_date

2015-04-01 00:00:00

pages

582-9

issue

4

eissn

1097-6256

issn

1546-1726

pii

nn.3973

journal_volume

18

pub_type

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