Abstract:
:Microcircuits composed of principal neuron and interneuron dendrites have an important role in shaping the representation of sensory information in the olfactory bulb. Here we establish the physiological features governing synaptic signaling in dendrodendritic microcircuits of olfactory bulb glomeruli. We show that dendritic gamma-aminobutyric acid (GABA) release from periglomerular neurons mediates inhibition of principal tufted cells, retrograde inhibition of sensory input and lateral signaling onto neighboring periglomerular cells. We find that L-type dendritic Ca(2+) spikes in periglomerular cells underlie dendrodendritic transmission by depolarizing periglomerular dendrites and activating P/Q type channels that trigger GABA release. Ca(2+) spikes in periglomerular cells are evoked by powerful excitatory inputs from a single principal cell, and glutamate release from the dendrites of single principal neurons activates a large ensemble of periglomerular cells.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Murphy GJ,Darcy DP,Isaacson JSdoi
10.1038/nn1403subject
Has Abstractpub_date
2005-03-01 00:00:00pages
354-64issue
3eissn
1097-6256issn
1546-1726pii
nn1403journal_volume
8pub_type
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