Pharmacological REM sleep suppression paradoxically improves rather than impairs skill memory.

abstract：:The hindbrain transcription factors Phox2b and Egr2 (also known as Krox20) are linked to the development of the autonomic nervous system and rhombomere-related regulation of breathing, respectively. Mutations in these proteins can lead to abnormal breathing behavior as a result of an alteration in an unidentified neur...

journal_title：Nature neuroscience

authors： Thoby-Brisson M,Karlén M,Wu N,Charnay P,Champagnat J,Fortin G

更新日期：2009-08-01 00:00:00

abstract：:Axonal injury results in regenerative success or failure, depending on whether the axon lies in the peripheral or the CNS, respectively. The present study addresses whether epigenetic signatures in dorsal root ganglia discriminate between regenerative and non-regenerative axonal injury. Chromatin immunoprecipitation f...

journal_title：Nature neuroscience

authors： Palmisano I,Danzi MC,Hutson TH,Zhou L,McLachlan E,Serger E,Shkura K,Srivastava PK,Hervera A,Neill NO,Liu T,Dhrif H,Wang Z,Kubat M,Wuchty S,Merkenschlager M,Levi L,Elliott E,Bixby JL,Lemmon VP,Di Giovanni S

更新日期：2019-11-01 00:00:00

abstract：:A hallmark of addiction is the loss of control over drug intake, which is seen in only a fraction of those exposed to stimulant drugs such as cocaine. The cellular mechanisms underlying vulnerability or resistance to compulsive drug use remain unknown. We found that individual variability in the development of highly ...

journal_title：Nature neuroscience

authors： Bock R,Shin JH,Kaplan AR,Dobi A,Markey E,Kramer PF,Gremel CM,Christensen CH,Adrover MF,Alvarez VA

更新日期：2013-05-01 00:00:00

abstract：:Neocortical GABAergic neurons have diverse molecular, structural and electrophysiological features, but the functional correlates of this diversity are largely unknown. We found unique membrane potential dynamics of somatostatin-expressing (SOM) neurons in layer 2/3 of the primary somatosensory barrel cortex of awake ...

journal_title：Nature neuroscience

authors： Gentet LJ,Kremer Y,Taniguchi H,Huang ZJ,Staiger JF,Petersen CC

更新日期：2012-02-26 00:00:00

abstract：:Human neurodegenerative disorders are among the most difficult to study. In particular, the inability to readily obtain the faulty cell types most relevant to these diseases has impeded progress for decades. Recent advances in pluripotent stem cell technology now grant access to substantial quantities of disease-perti...

journal_title：Nature neuroscience

authors： Sandoe J,Eggan K

更新日期：2013-07-01 00:00:00

abstract：:The hippocampus is thought to be involved in episodic memory formation by reactivating traces of waking experience during sleep. Indeed, the joint firing of spatially tuned pyramidal cells encoding nearby places recur during sleep. We found that the sleep cofiring of rat CA1 pyramidal cells encoding similar places inc...

journal_title：Nature neuroscience

authors： O'Neill J,Senior TJ,Allen K,Huxter JR,Csicsvari J

更新日期：2008-02-01 00:00:00

abstract：:Bright objects capture our attention by virtue of 'popping out' from their surroundings. This correlates with strong responses in cortical areas thought to be important in attentional allocation. Previous studies have suggested that with the right mindset or training, humans can ignore popout stimuli. We studied the a...

journal_title：Nature neuroscience

authors： Ipata AE,Gee AL,Gottlieb J,Bisley JW,Goldberg ME

更新日期：2006-08-01 00:00:00

abstract：:We used high-level configural aftereffects induced by adaptation to realistic faces to investigate visual representations underlying complex pattern perception. We found that exposure to an individual face for a few seconds generated a significant and precise bias in the subsequent perception of face identity. In the ...

journal_title：Nature neuroscience

authors： Leopold DA,O'Toole AJ,Vetter T,Blanz V

更新日期：2001-01-01 00:00:00

abstract：:Short-term synaptic plasticity is a defining feature of neuronal activity, but the underlying molecular mechanisms are poorly understood. Depression of synaptic activity might be due to limited vesicle availability, whereas facilitation is thought to result from elevated calcium levels. However, it is unclear whether ...

journal_title：Nature neuroscience

authors： Sippy T,Cruz-Martín A,Jeromin A,Schweizer FE

更新日期：2003-10-01 00:00:00

abstract：:Phosphoinositide 3 kinase enhancer (PIKE) is a recently identified nuclear GTPase that activates nuclear phosphoinositide 3-kinase (PI3 kinase). We have identified, cloned and characterized a new form of PIKE, designated PIKE-L, which, unlike the nuclear PIKE-S, localizes to both the cytoplasm and the nucleus. We demo...

journal_title：Nature neuroscience

authors： Rong R,Ahn JY,Huang H,Nagata E,Kalman D,Kapp JA,Tu J,Worley PF,Snyder SH,Ye K

更新日期：2003-11-01 00:00:00

abstract：:Brain tumor initiating cells (BTICs) co-opt the neuronal high affinity glucose transporter, GLUT3, to withstand metabolic stress. We investigated another mechanism critical to brain metabolism, mitochondrial morphology, in BTICs. BTIC mitochondria were fragmented relative to non-BTIC tumor cell mitochondria, suggestin...

journal_title：Nature neuroscience

authors： Xie Q,Wu Q,Horbinski CM,Flavahan WA,Yang K,Zhou W,Dombrowski SM,Huang Z,Fang X,Shi Y,Ferguson AN,Kashatus DF,Bao S,Rich JN

更新日期：2015-04-01 00:00:00

abstract：:Fear renewal, a widely pursued model of post-traumatic stress disorder and phobias, refers to the context-specific relapse of conditioned fear after extinction. However, its molecular mechanisms are largely unknown. We found that renewal-inducing stimuli, generally believed to be insufficient to induce synaptic plasti...

journal_title：Nature neuroscience

authors： Lee S,Song B,Kim J,Park K,Hong I,An B,Song S,Lee J,Park S,Kim J,Park D,Lee CJ,Kim K,Shin KS,Tsien RW,Choi S

更新日期：2013-10-01 00:00:00

abstract：:The excitability of individual dendritic branches is a plastic property of neurons. We found that experience in an enriched environment increased propagation of dendritic Na(+) spikes in a subset of individual dendritic branches in rat hippocampal CA1 pyramidal neurons and that this effect was mainly mediated by local...

journal_title：Nature neuroscience

authors： Makara JK,Losonczy A,Wen Q,Magee JC

更新日期：2009-12-01 00:00:00

abstract：:The contribution of basal ganglia outputs to consummatory behavior remains poorly understood. We recorded from the substantia nigra pars reticulata (SNR), the major basal ganglia output nucleus, during self-initiated drinking in mice. The firing rates of many lateral SNR neurons were time-locked to individual licks. T...

journal_title：Nature neuroscience

authors： Rossi MA,Li HE,Lu D,Kim IH,Bartholomew RA,Gaidis E,Barter JW,Kim N,Cai MT,Soderling SH,Yin HH

更新日期：2016-05-01 00:00:00

abstract：:Although the prefrontal cortex influences motivated behavior, its role in food intake remains unclear. Here, we demonstrate a role for D1-type dopamine receptor-expressing neurons in the medial prefrontal cortex (mPFC) in the regulation of feeding. Food intake increases activity in D1 neurons of the mPFC in mice, and ...

journal_title：Nature neuroscience

authors： Land BB,Narayanan NS,Liu RJ,Gianessi CA,Brayton CE,Grimaldi DM,Sarhan M,Guarnieri DJ,Deisseroth K,Aghajanian GK,DiLeone RJ

更新日期：2014-02-01 00:00:00

abstract：:Replay of hippocampal place cell sequences has been proposed as a fundamental mechanism of learning and memory. However, the standard interpretation of replay has been challenged by reports that similar activity is observed before experience ('preplay'). By the preplay account, pre-existing temporal sequences are mapp...

journal_title：Nature neuroscience

authors： Silva D,Feng T,Foster DJ

更新日期：2015-12-01 00:00:00

abstract：:Quantifying behavior is crucial for many applications in neuroscience. Videography provides easy methods for the observation and recording of animal behavior in diverse settings, yet extracting particular aspects of a behavior for further analysis can be highly time consuming. In motor control studies, humans or other...

journal_title：Nature neuroscience

authors： Mathis A,Mamidanna P,Cury KM,Abe T,Murthy VN,Mathis MW,Bethge M

更新日期：2018-09-01 00:00:00

abstract：:The endocytosis of AMPA receptors (AMPARs) underlies several forms of synaptic plasticity, including NMDA receptor (NMDAR)-dependent long-term depression (LTD), but the molecular mechanisms responsible for this trafficking remain unknown. We found that PSD-95, a major postsynaptic density protein, is important for NMD...

journal_title：Nature neuroscience

authors： Bhattacharyya S,Biou V,Xu W,Schlüter O,Malenka RC

更新日期：2009-02-01 00:00:00

abstract：:Calcium arising through release from intracellular stores and from influx across the plasma membrane is essential for signalling by specific guidance cues and by factors that inhibit axon regeneration. The mediators of calcium influx in these cases are largely unknown. Transient receptor potential channels (TRPCs) bel...

journal_title：Nature neuroscience

authors： Shim S,Goh EL,Ge S,Sailor K,Yuan JP,Roderick HL,Bootman MD,Worley PF,Song H,Ming GL

更新日期：2005-06-01 00:00:00

abstract：:At glutamatergic synapses, calcium influx through NMDA receptors (NMDARs) is required for long-term potentiation (LTP); this is a proposed cellular mechanism underlying memory and learning. Here we show that in lateral amygdala pyramidal neurons, SK channels are also activated by calcium influx through synaptically ac...

journal_title：Nature neuroscience

authors： Faber ES,Delaney AJ,Sah P

更新日期：2005-05-01 00:00:00

abstract：:Despite the numerous examples of anticipatory cognitive processes at micro and macro levels in many animal species, the idea that anticipation of specific words plays an integral role in real-time language processing has been contentious. Here we exploited a phonological regularity of English indefinite articles ('an'...

journal_title：Nature neuroscience

authors： DeLong KA,Urbach TP,Kutas M

更新日期：2005-08-01 00:00:00

abstract：:The output of cortical columns is routed to different downstream targets via distinct pathways: cortico-cortical and cortico-subcortical. It is as yet unclear what roles these pathways play in perception, and which cellular and circuit mechanisms regulate their gating. We recently showed that activation of the apical ...

journal_title：Nature neuroscience

authors： Takahashi N,Ebner C,Sigl-Glöckner J,Moberg S,Nierwetberg S,Larkum ME

更新日期：2020-10-01 00:00:00

abstract：:In the version of this article initially published, the annotation accompanying ref. 47 ended with "though the modulation of microglia." The first word of this phrase should have been "through." The error has been corrected in the HTML and PDF versions of the article. ...

journal_title：Nature neuroscience

authors： Deczkowska A,Amit I,Schwartz M

更新日期：2018-08-01 00:00:00

abstract：:Anatomical studies have led to the assertion that intratelencephalic and pyramidal tract cortical neurons innervate different striatal projection neurons. To test this hypothesis, we measured the responses of mouse striatal neurons to optogenetic activation of intratelencephalic and pyramidal tract axons. Contrary to ...

journal_title：Nature neuroscience

authors： Kress GJ,Yamawaki N,Wokosin DL,Wickersham IR,Shepherd GM,Surmeier DJ

更新日期：2013-06-01 00:00:00

abstract：:We elucidated the intrinsic circuitry of the medial prefrontal cortex and its role in regulating fear extinction, using neuronal tracing and optogenetic stimulation in vitro and in vivo. We show that pyramidal neurons in layer 5/6 of the prelimbic medial prefrontal cortex project to pyramidal cells in layer 5/6 of the...

journal_title：Nature neuroscience

authors： Marek R,Xu L,Sullivan RKP,Sah P

更新日期：2018-05-01 00:00:00

abstract：:Selective serotonin reuptake inhibitors (SSRIs) are widely used antidepressants, but the mechanisms by which they influence behavior are only partially resolved. Adult hippocampal neurogenesis is necessary for some of the responses to SSRIs, but it is not known whether mature dentate gyrus granule cells (DG GCs) also ...

journal_title：Nature neuroscience

authors： Samuels BA,Anacker C,Hu A,Levinstein MR,Pickenhagen A,Tsetsenis T,Madroñal N,Donaldson ZR,Drew LJ,Dranovsky A,Gross CT,Tanaka KF,Hen R

更新日期：2015-11-01 00:00:00

abstract：:Neural-derived signals are crucial regulators of CNS vascularization. However, whether the vasculature responds to these signals by means of elongating and branching or in addition by building a feedback response to modulate neurodevelopmental processes remains unknown. In this study, we identified bidirectional cross...

journal_title：Nature neuroscience

authors： Paredes I,Vieira JR,Shah B,Ramunno CF,Dyckow J,Adler H,Richter M,Schermann G,Giannakouri E,Schirmer L,Augustin HG,Ruiz de Almodóvar C

更新日期：2021-01-28 00:00:00

abstract：:Many of the behavioral consequences of stress are mediated by the activation of the glucocorticoid receptor by stress-induced high levels of glucocorticoid hormones. To explore the molecular mechanisms of these effects, we combined in vivo and in vitro approaches. We analyzed mice carrying a brain-specific mutation (G...

journal_title：Nature neuroscience

authors： Revest JM,Di Blasi F,Kitchener P,Rougé-Pont F,Desmedt A,Turiault M,Tronche F,Piazza PV

更新日期：2005-05-01 00:00:00

abstract：:The amygdala is essential for fear learning and expression. The central amygdala (CeA), once viewed as a passive relay between the amygdala complex and downstream fear effectors, has emerged as an active participant in fear conditioning. However, the mechanism by which CeA contributes to the learning and expression of...

journal_title：Nature neuroscience

authors： Li H,Penzo MA,Taniguchi H,Kopec CD,Huang ZJ,Li B

更新日期：2013-03-01 00:00:00

abstract：:We show that a natural behavior, exploration of a novel environment, causes DNA double-strand breaks (DSBs) in neurons of young adult wild-type mice. DSBs occurred in multiple brain regions, were most abundant in the dentate gyrus, which is involved in learning and memory, and were repaired within 24 h. Increasing neu...

journal_title：Nature neuroscience

authors： Suberbielle E,Sanchez PE,Kravitz AV,Wang X,Ho K,Eilertson K,Devidze N,Kreitzer AC,Mucke L

更新日期：2013-05-01 00:00:00