Abstract：
:The hippocampus is thought to be involved in episodic memory formation by reactivating traces of waking experience during sleep. Indeed, the joint firing of spatially tuned pyramidal cells encoding nearby places recur during sleep. We found that the sleep cofiring of rat CA1 pyramidal cells encoding similar places increased relative to the sleep session before exploration. This cofiring increase depended on the number of times that cells fired together with short latencies (<50 ms) during exploration, and was strongest between cells representing the most visited places. This is indicative of a Hebbian learning rule in which changes in firing associations between cells are determined by the number of waking coincident firing events. In contrast, cells encoding different locations reduced their cofiring in proportion to the number of times that they fired independently. Together these data indicate that reactivated patterns are shaped by both positive and negative changes in cofiring, which are determined by recent behavior.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
O'Neill J,Senior TJ,Allen K,Huxter JR,Csicsvari Jdoi
10.1038/nn2037subject
Has Abstractpub_date
2008-02-01 00:00:00pages
209-15issue
2eissn
1097-6256issn
1546-1726pii
nn2037journal_volume
11pub_type
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