Reactivation of experience-dependent cell assembly patterns in the hippocampus.


:The hippocampus is thought to be involved in episodic memory formation by reactivating traces of waking experience during sleep. Indeed, the joint firing of spatially tuned pyramidal cells encoding nearby places recur during sleep. We found that the sleep cofiring of rat CA1 pyramidal cells encoding similar places increased relative to the sleep session before exploration. This cofiring increase depended on the number of times that cells fired together with short latencies (<50 ms) during exploration, and was strongest between cells representing the most visited places. This is indicative of a Hebbian learning rule in which changes in firing associations between cells are determined by the number of waking coincident firing events. In contrast, cells encoding different locations reduced their cofiring in proportion to the number of times that they fired independently. Together these data indicate that reactivated patterns are shaped by both positive and negative changes in cofiring, which are determined by recent behavior.


Nat Neurosci


Nature neuroscience


O'Neill J,Senior TJ,Allen K,Huxter JR,Csicsvari J




Has Abstract


2008-02-01 00:00:00














  • Dual origins of the mammalian accessory olfactory bulb revealed by an evolutionarily conserved migratory stream.

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    journal_title:Nature neuroscience

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    authors: Huilgol D,Udin S,Shimogori T,Saha B,Roy A,Aizawa S,Hevner RF,Meyer G,Ohshima T,Pleasure SJ,Zhao Y,Tole S

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  • Medial prefrontal D1 dopamine neurons control food intake.

    abstract::Although the prefrontal cortex influences motivated behavior, its role in food intake remains unclear. Here, we demonstrate a role for D1-type dopamine receptor-expressing neurons in the medial prefrontal cortex (mPFC) in the regulation of feeding. Food intake increases activity in D1 neurons of the mPFC in mice, and ...

    journal_title:Nature neuroscience

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    authors: Land BB,Narayanan NS,Liu RJ,Gianessi CA,Brayton CE,Grimaldi DM,Sarhan M,Guarnieri DJ,Deisseroth K,Aghajanian GK,DiLeone RJ

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  • Feature-based attention modulates feedforward visual processing.

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    authors: Zhang W,Luck SJ

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    authors: Wang DV,Yau HJ,Broker CJ,Tsou JH,Bonci A,Ikemoto S

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    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: Todorov E

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    journal_title:Nature neuroscience

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    authors: Grandjean D,Sander D,Pourtois G,Schwartz S,Seghier ML,Scherer KR,Vuilleumier P

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    authors: Mallamaci A,Muzio L,Chan CH,Parnavelas J,Boncinelli E

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