Raf kinase signaling functions in sensory neuron differentiation and axon growth in vivo.

abstract：:It is widely held that color and motion are processed by separate parallel pathways in the visual system, but this view is difficult to reconcile with the fact that motion can be detected in equiluminant stimuli that are defined by color alone. To examine the relationship between color and motion, we tested three pati...

journal_title：Nature neuroscience

authors： Cavanagh P,Hénaff MA,Michel F,Landis T,Troscianko T,Intriligator J

更新日期：1998-07-01 00:00:00

abstract：:A fundamental assumption in neuroscience is that brain structure determines function. Accordingly, functionally distinct regions of cortex should be structurally distinct in their connections to other areas. We tested this hypothesis in relation to face selectivity in the fusiform gyrus. By using only structural conne...

journal_title：Nature neuroscience

authors： Saygin ZM,Osher DE,Koldewyn K,Reynolds G,Gabrieli JD,Saxe RR

更新日期：2011-12-25 00:00:00

abstract：:It is widely accepted that D1 dopamine receptor-expressing striatal neurons convey their information directly to the output nuclei of the basal ganglia, whereas D2-expressing neurons do so indirectly via pallidal neurons. Combining optogenetics and electrophysiology, we found that this architecture does not apply to m...

journal_title：Nature neuroscience

authors： Kupchik YM,Brown RM,Heinsbroek JA,Lobo MK,Schwartz DJ,Kalivas PW

更新日期：2015-09-01 00:00:00

abstract：:We investigated the regulation of T-type channels by Rho-associated kinase (ROCK). Activation of ROCK via the endogenous ligand lysophosphatidic acid (LPA) reversibly inhibited the peak current amplitudes of rat Ca(v)3.1 and Ca(v)3.3 channels without affecting the voltage dependence of activation or inactivation, wher...

journal_title：Nature neuroscience

authors： Iftinca M,Hamid J,Chen L,Varela D,Tadayonnejad R,Altier C,Turner RW,Zamponi GW

更新日期：2007-07-01 00:00:00

abstract：:Basal dendrites receive the majority of synapses that contact neocortical pyramidal neurons, yet our knowledge of synaptic processing in these dendrites has been hampered by their inaccessibility for electrical recordings. A new approach to patch-clamp recordings enabled us to characterize the integrative properties o...

journal_title：Nature neuroscience

authors： Nevian T,Larkum ME,Polsky A,Schiller J

更新日期：2007-02-01 00:00:00

abstract：:Neural progenitor cells in the developing neocortex change over time to produce different neurons, a phenomenon that is also observed in other regions of the nervous system. Mouse Numb (also known as m-numb) and Numbl (also known as numblike or Nbl) are redundant but essential in maintaining virtually all progenitor c...

journal_title：Nature neuroscience

authors： Petersen PH,Zou K,Krauss S,Zhong W

更新日期：2004-08-01 00:00:00

abstract：:An ion channel's function depends largely on its location and density on neurons. Here we used high-resolution immunolocalization to determine the subcellular distribution of the hyperpolarization-activated and cyclic-nucleotide-gated channel subunit 1 (HCN1) in rat brain. Light microscopy revealed graded HCN1 immunor...

journal_title：Nature neuroscience

authors： Lörincz A,Notomi T,Tamás G,Shigemoto R,Nusser Z

更新日期：2002-11-01 00:00:00

abstract：:The development of neuronal networks in the neocortex depends on control mechanisms for mitosis and migration that allow newborn neurons to find their accurate position. Multiple mitogens, neurotrophic factors, guidance molecules and their corresponding receptors are involved in this process, but the mechanisms by whi...

journal_title：Nature neuroscience

authors： Puehringer D,Orel N,Lüningschrör P,Subramanian N,Herrmann T,Chao MV,Sendtner M

更新日期：2013-04-01 00:00:00

abstract：:The projections and odor responses of mammalian olfactory receptor neurons, as well as the physiology of the bulb's principal neurons-the mitral cells (MCs)-are known from studies in slices and anesthetized animals. In behaving rats trained to discriminate between two odors associated with different reinforcers, we ex...

journal_title：Nature neuroscience

authors： Kay LM,Laurent G

更新日期：1999-11-01 00:00:00

abstract：:Phasic activation of the dopamine (DA) midbrain system in response to unexpected reward or novelty is critical for adaptive behavioral strategies. This activation of DA midbrain neurons occurs via a synaptically triggered switch from low-frequency background spiking to transient high-frequency burst firing. We found t...

journal_title：Nature neuroscience

authors： Schiemann J,Schlaudraff F,Klose V,Bingmer M,Seino S,Magill PJ,Zaghloul KA,Schneider G,Liss B,Roeper J

更新日期：2012-09-01 00:00:00

abstract：:Quantifying behavior is crucial for many applications in neuroscience. Videography provides easy methods for the observation and recording of animal behavior in diverse settings, yet extracting particular aspects of a behavior for further analysis can be highly time consuming. In motor control studies, humans or other...

journal_title：Nature neuroscience

authors： Mathis A,Mamidanna P,Cury KM,Abe T,Murthy VN,Mathis MW,Bethge M

更新日期：2018-09-01 00:00:00

abstract：:Oxytocin is an essential hormone for mammalian labor and lactation. Here, we show a new function of oxytocin in causing plastic changes in hippocampal synapses during motherhood. In oxytocin-perfused hippocampal slices, one-train tetanus stimulation induced long-lasting, long-term potentiation (L-LTP) and phosphorylat...

journal_title：Nature neuroscience

authors： Tomizawa K,Iga N,Lu YF,Moriwaki A,Matsushita M,Li ST,Miyamoto O,Itano T,Matsui H

更新日期：2003-04-01 00:00:00

abstract：:Microglia are primary immune sentinels of the CNS. Following injury, these cells migrate or extend processes toward sites of tissue damage. CNS injury is accompanied by release of nucleotides, serving as signals for microglial activation or chemotaxis. Microglia express several purinoceptors, including a G(i)-coupled ...

journal_title：Nature neuroscience

authors： Haynes SE,Hollopeter G,Yang G,Kurpius D,Dailey ME,Gan WB,Julius D

更新日期：2006-12-01 00:00:00

abstract：:The eyeless animal C. elegans is able to sense light and engages in phototaxis behavior that is mediated by photoreceptor cells. However, the molecular and cellular mechanisms underlying phototransduction in C. elegans remain largely unclear. By recording the photoreceptor neuron ASJ in wild-type and various mutant wo...

journal_title：Nature neuroscience

authors： Liu J,Ward A,Gao J,Dong Y,Nishio N,Inada H,Kang L,Yu Y,Ma D,Xu T,Mori I,Xie Z,Xu XZ

更新日期：2010-06-01 00:00:00

abstract：:We examined enhancement of synaptic transmission by neurotrophins at the presynaptic level. In a synaptosomal preparation, brain-derived neurotrophic factor (BDNF) increased mitogen-activated protein (MAP) kinase-dependent synapsin I phosphorylation and acutely facilitated evoked glutamate release. PD98059, used to in...

journal_title：Nature neuroscience

authors： Jovanovic JN,Czernik AJ,Fienberg AA,Greengard P,Sihra TS

更新日期：2000-04-01 00:00:00

abstract：:The control of cell fate in neural progenitor cells is critical for nervous system development. Nevertheless, the processes involved are only partially known. We found that the expression of the tumor suppressor Pml was restricted to neural progenitor cells (NPCs) in the developing neocortex of the mouse. Notably, in ...

journal_title：Nature neuroscience

authors： Regad T,Bellodi C,Nicotera P,Salomoni P

更新日期：2009-02-01 00:00:00

abstract：:Fever is a result of the action of prostaglandin E2 (PGE2) on the brain and appears to require EP3 prostaglandin receptors (EP3Rs), but the specific neurons on which PGE2 acts to produce fever have not been definitively established. Here we report that selective genetic deletion of the EP3Rs in the median preoptic nuc...

journal_title：Nature neuroscience

authors： Lazarus M,Yoshida K,Coppari R,Bass CE,Mochizuki T,Lowell BB,Saper CB

更新日期：2007-09-01 00:00:00

abstract：:Timing is crucial to many aspects of human performance. To better understand its neural underpinnings, we used event-related fMRI to examine the time course of activation associated with different components of a time perception task. We distinguished systems associated with encoding time intervals from those related ...

journal_title：Nature neuroscience

authors： Rao SM,Mayer AR,Harrington DL

更新日期：2001-03-01 00:00:00

abstract：:Learning and memory are associated with the formation and modification of neuronal assemblies: populations of neurons that encode what has been learned and mediate memory retrieval upon recall. Functional studies of neuronal assemblies have progressed dramatically thanks to recent technological advances. Here we discu...

journal_title：Nature neuroscience

authors： Holtmaat A,Caroni P

更新日期：2016-12-01 00:00:00

abstract：:We report two functional magnetic resonance imaging experiments showing enhanced responses in human middle superior temporal sulcus for angry relative to neutral prosody. This emotional enhancement was voice specific, unrelated to isolated acoustic amplitude or frequency cues in angry prosody, and distinct from any co...

journal_title：Nature neuroscience

authors： Grandjean D,Sander D,Pourtois G,Schwartz S,Seghier ML,Scherer KR,Vuilleumier P

更新日期：2005-02-01 00:00:00

abstract：:Mutations in MECP2 cause the neurodevelopmental disorder Rett syndrome (RTT). The RTT missense MECP2R306C mutation prevents MeCP2 from interacting with the NCoR/histone deacetylase 3 (HDAC3) complex; however, the neuronal function of HDAC3 is incompletely understood. We found that neuronal deletion of Hdac3 in mice el...

journal_title：Nature neuroscience

authors： Nott A,Cheng J,Gao F,Lin YT,Gjoneska E,Ko T,Minhas P,Zamudio AV,Meng J,Zhang F,Jin P,Tsai LH

更新日期：2016-11-01 00:00:00

abstract：:Cerebellar abnormalities, particularly in Right Crus I (RCrusI), are consistently reported in autism spectrum disorders (ASD). Although RCrusI is functionally connected with ASD-implicated circuits, the contribution of RCrusI dysfunction to ASD remains unclear. Here neuromodulation of RCrusI in neurotypical humans res...

journal_title：Nature neuroscience

authors： Stoodley CJ,D'Mello AM,Ellegood J,Jakkamsetti V,Liu P,Nebel MB,Gibson JM,Kelly E,Meng F,Cano CA,Pascual JM,Mostofsky SH,Lerch JP,Tsai PT

更新日期：2017-12-01 00:00:00

abstract：:Autophosphorylation of alpha calcium-calmodulin-dependent kinase II (alphaCaMKII) has been proposed to be the key event in memory storage. We tested this hypothesis with autophosphorylation-deficient mutant mice in hippocampus- and amygdala-dependent learning and memory tasks and found that the autophosphorylation of ...

journal_title：Nature neuroscience

authors： Irvine EE,Vernon J,Giese KP

更新日期：2005-04-01 00:00:00

abstract：:Communication between glia cells and neurons is crucial for brain functions, but the molecular mechanisms and functional consequences of gliotransmission remain enigmatic. Here we report that astrocytes express synaptobrevin II and cellubrevin as functionally non-overlapping vesicular SNARE proteins on glutamatergic v...

journal_title：Nature neuroscience

authors： Schwarz Y,Zhao N,Kirchhoff F,Bruns D

更新日期：2017-11-01 00:00:00

abstract：:In Huntington's disease (HD), whether transneuronal spreading of mutant huntingtin (mHTT) occurs and its contribution to non-cell autonomous damage in brain networks is largely unknown. We found mHTT spreading in three different neural network models: human neurons integrated in the neural network of organotypic brain...

journal_title：Nature neuroscience

authors： Pecho-Vrieseling E,Rieker C,Fuchs S,Bleckmann D,Esposito MS,Botta P,Goldstein C,Bernhard M,Galimberti I,Müller M,Lüthi A,Arber S,Bouwmeester T,van der Putten H,Di Giorgio FP

更新日期：2014-08-01 00:00:00

abstract：:Very little is known about how stimuli that are typically not rich in sugars, such as beer, trigger attractive gustatory responses in Drosophila. We identified a member of the gustatory receptor family, Gr64e, as a receptor that is required for feeding preference for beer and other sources that have fermenting yeast. ...

journal_title：Nature neuroscience

authors： Wisotsky Z,Medina A,Freeman E,Dahanukar A

更新日期：2011-11-06 00:00:00

abstract：:The growth of neurites (axon and dendrite) should be appropriately regulated by their interactions in the development of nervous systems where a myriad of neurons and their neurites are tightly packed. We show here that mammalian seven-pass transmembrane cadherins Celsr2 and Celsr3 are activated by their homophilic in...

journal_title：Nature neuroscience

authors： Shima Y,Kawaguchi SY,Kosaka K,Nakayama M,Hoshino M,Nabeshima Y,Hirano T,Uemura T

更新日期：2007-08-01 00:00:00

abstract：:Many cells in retinotopic brain areas increase their activity when saccades (rapid eye movements) are about to bring stimuli into their receptive fields. Although previous work has attempted to look at the functional correlates of such predictive remapping, no study has explicitly tested for better attentional perform...

journal_title：Nature neuroscience

authors： Rolfs M,Jonikaitis D,Deubel H,Cavanagh P

更新日期：2011-02-01 00:00:00

abstract：:Although long-term potentiation (LTP) is long-lasting, it is not permanent and decays within weeks after its induction. Little is known about the processes underlying this decay. Here we assessed the contribution of synaptic activity to LTP decay by determining the effect of the competitive NMDA receptor antagonist CP...

journal_title：Nature neuroscience

authors： Villarreal DM,Do V,Haddad E,Derrick BE

更新日期：2002-01-01 00:00:00

abstract：:Pericytes are perivascular mural cells of brain capillaries. They are positioned centrally in the neurovascular unit between endothelial cells, astrocytes and neurons. This position allows them to regulate key neurovascular functions of the brain. The role of pericytes in the regulation of cerebral blood flow (CBF) an...

journal_title：Nature neuroscience

authors： Kisler K,Nelson AR,Rege SV,Ramanathan A,Wang Y,Ahuja A,Lazic D,Tsai PS,Zhao Z,Zhou Y,Boas DA,Sakadžić S,Zlokovic BV

更新日期：2017-03-01 00:00:00