Abstract:
:Learning and memory are associated with the formation and modification of neuronal assemblies: populations of neurons that encode what has been learned and mediate memory retrieval upon recall. Functional studies of neuronal assemblies have progressed dramatically thanks to recent technological advances. Here we discuss how a focus on assembly formation and consolidation has provided a powerful conceptual framework to relate mechanistic studies of synaptic and circuit plasticity to behaviorally relevant aspects of learning and memory. Neurons are likely recruited to particular learning-related assemblies as a function of their relative excitabilities and synaptic activation, followed by selective strengthening of pre-existing synapses, formation of new connections and elimination of outcompeted synapses to ensure memory formation. Mechanistically, these processes involve linking transcription to circuit modification. They include the expression of immediate early genes and specific molecular and cellular events, supported by network-wide activities that are shaped and modulated by local inhibitory microcircuits.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Holtmaat A,Caroni Pdoi
10.1038/nn.4418subject
Has Abstractpub_date
2016-12-01 00:00:00pages
1553-1562issue
12eissn
1097-6256issn
1546-1726pii
nn.4418journal_volume
19pub_type
杂志文章,评审abstract::Protein-coding de novo mutations (DNMs) are significant risk factors in many neurodevelopmental disorders, whereas schizophrenia (SCZ) risk associated with DNMs has thus far been shown to be modest. We analyzed DNMs from 1,695 SCZ-affected trios and 1,077 published SCZ-affected trios to better understand the contribut...
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abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
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更新日期:2016-12-01 00:00:00
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更新日期:2013-05-01 00:00:00
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pub_type: 临床试验,杂志文章
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