Abstract：
:A hallmark of addiction is the loss of control over drug intake, which is seen in only a fraction of those exposed to stimulant drugs such as cocaine. The cellular mechanisms underlying vulnerability or resistance to compulsive drug use remain unknown. We found that individual variability in the development of highly motivated and perseverative behavior toward cocaine is associated with synaptic plasticity in medium spiny neurons expressing dopamine D2 receptors (D2-MSNs) in the nucleus accumbens (NAc) of mice. Potentiation of glutamatergic inputs onto indirect pathway D2-MSNs was associated with resilience toward compulsive cocaine seeking. Inhibition of D2-MSNs using a chemicogenetic approach enhanced the motivation to obtain cocaine, whereas optogenetic activation of D2-MSNs suppressed cocaine self-administration. These results indicate that recruitment of D2-MSNs in NAc functions to restrain cocaine self-administration and serves as a natural protective mechanism in drug-exposed individuals.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Bock R,Shin JH,Kaplan AR,Dobi A,Markey E,Kramer PF,Gremel CM,Christensen CH,Adrover MF,Alvarez VAdoi
10.1038/nn.3369subject
Has Abstractpub_date
2013-05-01 00:00:00pages
632-8issue
5eissn
1097-6256issn
1546-1726pii
nn.3369journal_volume
16pub_type
杂志文章abstract：:Age-related decreases in neural function result in part from alterations in synapses. To identify molecular defects that lead to such changes, we focused on the outer retina, in which synapses are markedly altered in old rodents and humans. We found that the serine/threonine kinase LKB1 and one of its substrates, AMPK...
journal_title：Nature neuroscience
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doi：10.1038/nn.3772
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abstract：:Forces developed by cochlear outer hair cells (OHCs) are responsible for the sharp tuning that underlies sensitivity and frequency selectivity in the ear. OHCs exhibit a voltage-dependent motility involving a 'motor' protein embedded in the basolateral membrane. The motor has so far resisted molecular identification. ...
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abstract：:Breathing is a bilaterally synchronous behavior that relies on a respiratory rhythm generator located in the brainstem. An essential component of this generator is the preBötzinger complex (preBötC), which paces inspirations. Little is known about the developmental origin of the interneuronal populations forming the p...
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更新日期：2010-09-01 00:00:00
abstract：:By combining computational, morphological, and functional analyses, this study relates latent markers of associative threat learning to overt post-traumatic stress disorder (PTSD) symptoms in combat veterans. Using reversal learning, we found that symptomatic veterans showed greater physiological adjustment to cues th...
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更新日期：2019-03-01 00:00:00
abstract：:Evaluating social others requires processing complex information. Nevertheless, we can rapidly form an opinion of an individual during an initial encounter. Moreover, people can vary in these opinions, even though the same information is provided. We investigated the brain mechanisms that give rise to the impressions ...
journal_title：Nature neuroscience
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更新日期：2009-04-01 00:00:00
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更新日期：2014-07-01 00:00:00
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