Abstract:
:Endogenous cannabinoids (eCB) mediate synaptic plasticity in brain regions involved in learning and reward. Here we show that in mice, a single in-vivo exposure to Delta 9-tetrahydrocannabinol (THC) abolishes the retrograde signaling that underlies eCB-mediated synaptic plasticity in both nucleus accumbens (NAc) and hippocampus in vitro. This effect is reversible within 3 days and is associated with a transient modification in the functional properties of cannabinoid receptors.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Mato S,Chevaleyre V,Robbe D,Pazos A,Castillo PE,Manzoni OJdoi
10.1038/nn1251subject
Has Abstractpub_date
2004-06-01 00:00:00pages
585-6issue
6eissn
1097-6256issn
1546-1726pii
nn1251journal_volume
7pub_type
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