Abstract：
:Persistent neural activity in the absence of a stimulus has been identified as a neural correlate of working memory, but how such activity is maintained by neocortical circuits remains unknown. We used a computational approach to show that the inhibitory and excitatory microcircuitry of neocortical memory-storing regions is sufficient to implement a corrective feedback mechanism that enables persistent activity to be maintained stably for prolonged durations. When recurrent excitatory and inhibitory inputs to memory neurons were balanced in strength and offset in time, drifts in activity triggered a corrective signal that counteracted memory decay. Circuits containing this mechanism temporally integrated their inputs, generated the irregular neural firing observed during persistent activity and were robust against common perturbations that severely disrupted previous models of short-term memory storage. These results reveal a mechanism for the accumulation and storage of memories in neocortical circuits based on principles of corrective negative feedback that are widely used in engineering applications.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Lim S,Goldman MSdoi
10.1038/nn.3492subject
Has Abstractpub_date
2013-09-01 00:00:00pages
1306-14issue
9eissn
1097-6256issn
1546-1726pii
nn.3492journal_volume
16pub_type
杂志文章abstract：:Endogenous cannabinoids (eCB) mediate synaptic plasticity in brain regions involved in learning and reward. Here we show that in mice, a single in-vivo exposure to Delta 9-tetrahydrocannabinol (THC) abolishes the retrograde signaling that underlies eCB-mediated synaptic plasticity in both nucleus accumbens (NAc) and h...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1251
更新日期：2004-06-01 00:00:00
abstract：:Striatal parvalbumin (PV) and cholinergic interneurons (CHIs) are poised to play major roles in behavior by coordinating the networks of medium spiny cells that relay motor output. However, the small numbers and scattered distribution of these cells have hindered direct assessment of their contribution to activity in ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-019-0341-3
更新日期：2019-04-01 00:00:00
abstract：:Neuronal migration disorders such as lissencephaly and subcortical band heterotopia are associated with epilepsy and intellectual disability. DCX, PAFAH1B1 and TUBA1A are mutated in these disorders; however, corresponding mouse mutants do not show heterotopic neurons in the neocortex. In contrast, spontaneously arisen...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3729
更新日期：2014-07-01 00:00:00
abstract：:A long-standing debate in neuroscience is whether classical and operant conditioning are mechanistically similar or distinct. The feeding behavior of Aplysia provides a model system suitable for addressing this question. Here we report that classical and operant conditioning of feeding behavior differentially modify t...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1593
更新日期：2006-01-01 00:00:00
abstract：:The retina of warm-blooded vertebrates is believed to be incapable of neural regeneration. Here we provide evidence that the retina of postnatal chickens has the potential to generate new neurons. In response to acute damage, numerous Müller glia re-entered the cell cycle, and shortly thereafter, expressed CASH-1, Pax...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/85090
更新日期：2001-03-01 00:00:00
abstract：:Aggression is a social behavior essential for securing resources and defending oneself and family. Thanks to its indispensable function in competition and thus survival, aggression exists widely across animal species, including humans. Classical works from Tinbergen and Lorenz concluded that instinctive behaviors incl...
journal_title：Nature neuroscience
pub_type： 杂志文章,评审
doi：10.1038/s41593-020-00715-2
更新日期：2020-11-01 00:00:00
abstract：:Neurons in thalamorecipient layers of sensory cortices integrate thalamocortical and intracortical inputs. Although we know that their functional properties can arise from the convergence of thalamic inputs, intracortical circuits could also be involved in thalamocortical transformations of sensory information. We sil...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3494
更新日期：2013-09-01 00:00:00
abstract：:Synaptic cadherin adhesion complexes are known to be key regulators of synapse plasticity. However, the molecular mechanisms that coordinate activity-induced modifications in cadherin localization and adhesion and the subsequent changes in synapse morphology and efficacy remain unknown. We demonstrate that the intrace...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3657
更新日期：2014-04-01 00:00:00
abstract：:Peptides derived from proteolytic processing of the beta-amyloid precursor protein (APP), including the amyloid-beta peptide, are important for the pathogenesis of Alzheimer's dementia. We found that transgenic mice overexpressing APP have a profound and selective impairment in endothelium-dependent regulation of the ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/5715
更新日期：1999-02-01 00:00:00
abstract：:The orbitofrontal cortex plays a central role in good-based economic decisions. When subjects make choices, neurons in this region represent the identities and values of offered and chosen goods. Notably, choices in different behavioral contexts may involve a potentially infinite variety of goods. Thus a fundamental q...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4300
更新日期：2016-06-01 00:00:00
abstract：:Specialization and hierarchy are organizing principles for primate cortex, yet there is little direct evidence for how cortical areas are specialized in the temporal domain. We measured timescales of intrinsic fluctuations in spiking activity across areas and found a hierarchical ordering, with sensory and prefrontal ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3862
更新日期：2014-12-01 00:00:00
abstract：:Rapid eye movement (REM) sleep has been considered important for consolidation of memories, particularly of skills. Contrary to expectations, we found that REM sleep suppression by administration of selective serotonin or norepinephrine re-uptake inhibitors after training did not impair consolidation of skills or word...
journal_title：Nature neuroscience
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1038/nn.2206
更新日期：2009-04-01 00:00:00
abstract：:The CNS, which consists of the brain and spinal cord, is continuously monitored by resident microglia and blood-borne immune cells such as macrophages, dendritic cells and T cells to detect for damaging agents that would disrupt homeostasis and optimal functioning of these vital organs. Further, the CNS must balance b...
journal_title：Nature neuroscience
pub_type： 杂志文章,评审
doi：10.1038/nn.3161
更新日期：2012-07-26 00:00:00
abstract：:Calcium arising through release from intracellular stores and from influx across the plasma membrane is essential for signalling by specific guidance cues and by factors that inhibit axon regeneration. The mediators of calcium influx in these cases are largely unknown. Transient receptor potential channels (TRPCs) bel...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1459
更新日期：2005-06-01 00:00:00
abstract：:Individuals' risk attitudes are known to guide choices about uncertain options. However, in the presence of others' decisions, these choices can be swayed and manifest as riskier or safer behavior than one would express alone. To test the mechanisms underlying effective social 'nudges' in human decision-making, we use...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4022
更新日期：2015-06-01 00:00:00
abstract：:The origin of brain mechanisms that support human language-whether these originated de novo in humans or evolved from a neural substrate that existed in a common ancestor-remains a controversial issue. Although the answer is not provided by the fossil record, it is possible to make inferences by studying living specie...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1741
更新日期：2006-08-01 00:00:00
abstract：:Olfactory representations are shaped by brain state and respiration. The interaction and circuit substrates of these influences are unclear. Granule cells (GCs) in the main olfactory bulb (MOB) are presumed to sculpt activity reaching the cortex via inhibition of mitral/tufted cells (MTs). GCs potentially make ensembl...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3669
更新日期：2014-04-01 00:00:00
abstract：:Although inherently linked, body form and body action may be represented in separate neural substrates. Using repetitive transcranial magnetic stimulation in healthy individuals, we show that interference with the extrastriate body area impairs the discrimination of bodily forms, and interference with the ventral prem...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1815
更新日期：2007-01-01 00:00:00
abstract：:The projections and odor responses of mammalian olfactory receptor neurons, as well as the physiology of the bulb's principal neurons-the mitral cells (MCs)-are known from studies in slices and anesthetized animals. In behaving rats trained to discriminate between two odors associated with different reinforcers, we ex...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/14801
更新日期：1999-11-01 00:00:00
abstract：:Histone deacetylases (HDACs) are major epigenetic regulators. We show that HDAC1 and HDAC2 functions are critical for myelination of the peripheral nervous system. Using mouse genetics, we have ablated Hdac1 and Hdac2 specifically in Schwann cells, resulting in massive Schwann cell loss and virtual absence of myelin i...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2762
更新日期：2011-04-01 00:00:00
abstract：:Information analysis shows that face-selective neurons in inferior temporal cortex encode different stimulus attributes early and late in their response to the same image. ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/13149
更新日期：1999-10-01 00:00:00
abstract：:Growing evidence suggests that the recognition of different emotional states involves at least partly separable neural circuits. Here we assessed the discrimination of both anger and happiness in healthy subjects receiving transcranial magnetic stimulation (TMS) over the medial-frontal cortex or over a control site (m...
journal_title：Nature neuroscience
pub_type： 临床试验,杂志文章
doi：10.1038/82854
更新日期：2001-01-01 00:00:00
abstract：:Independent evidence associates β-amyloid pathology with both non-rapid eye movement (NREM) sleep disruption and memory impairment in older adults. However, whether the influence of β-amyloid pathology on hippocampus-dependent memory is, in part, driven by impairments of NREM slow wave activity (SWA) and associated ov...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4035
更新日期：2015-07-01 00:00:00
abstract：:Brain neural stem cells (radial glial progenitors, RGPs) undergo a mysterious form of cell cycle-entrained interkinetic nuclear migration (INM) that is driven apically by cytoplasmic dynein and basally by the kinesin KIF1A, which has recently been implicated in human brain developmental disease. To understand the cons...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4213
更新日期：2016-02-01 00:00:00
abstract：:The cortical nucleus LMAN (lateral magnocellular nucleus of the anterior nidopallium) provides the output of a basal ganglia pathway that is necessary for vocal learning in juvenile songbirds. The shell subregion of LMAN (LMAN(shell)) gives rise to recurrent loops that may subserve specific learning-related functions....
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2472
更新日期：2010-02-01 00:00:00
abstract：:Continuous, predictable events and spontaneous events may coincide in the visual environment. For a continuously moving object, the brain compensates for delays in transmission between a retinal event and neural responses in higher visual areas. Here we show that it similarly compensated for other smoothly changing fe...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/74865
更新日期：2000-05-01 00:00:00
abstract：:We delineated a heritable phenotype resulting from the self-administration of cocaine in rats. We observed delayed acquisition and reduced maintenance of cocaine self-administration in male, but not female, offspring of sires that self-administered cocaine. Brain-derived neurotrophic factor (Bdnf) mRNA and BDNF protei...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3280
更新日期：2013-01-01 00:00:00
abstract：:Phosphatidylinositol 3-kinase (PI3K) has been shown to enhance native voltage-dependent calcium channel (Ca(v)) currents both in myocytes and in neurons; however, the mechanism(s) responsible for this regulation were not known. Here we show that PI3K promotes the translocation of GFP-tagged Ca(v) channels to the plasm...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1300
更新日期：2004-09-01 00:00:00
abstract：:We examined the contribution of 5-HT1A autoreceptors (with [11C]WAY100635 positron emission tomography) to amygdala reactivity (with blood oxygenation level-dependent functional magnetic resonance imaging) in 20 healthy adult volunteers. We found a significant inverse relationship wherein 5-HT1A autoreceptor density p...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1780
更新日期：2006-11-01 00:00:00
abstract：:Neural activity in visual area V4 is enhanced when attention is directed into neuronal receptive fields. However, the source of this enhancement is unclear, as most physiological studies have manipulated attention by changing the absolute reward associated with a particular location as well as its value relative to ot...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4141
更新日期：2015-11-01 00:00:00
