Abstract:
:We examined the contribution of 5-HT1A autoreceptors (with [11C]WAY100635 positron emission tomography) to amygdala reactivity (with blood oxygenation level-dependent functional magnetic resonance imaging) in 20 healthy adult volunteers. We found a significant inverse relationship wherein 5-HT1A autoreceptor density predicted a notable 30-44% of the variability in amygdala reactivity. Our data suggest a potential molecular mechanism by which a reduced capacity for negative feedback regulation of 5-HT release is associated with increased amygdala reactivity.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Fisher PM,Meltzer CC,Ziolko SK,Price JC,Moses-Kolko EL,Berga SL,Hariri ARdoi
10.1038/nn1780subject
Has Abstractpub_date
2006-11-01 00:00:00pages
1362-3issue
11eissn
1097-6256issn
1546-1726pii
nn1780journal_volume
9pub_type
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