β-amyloid disrupts human NREM slow waves and related hippocampus-dependent memory consolidation.

abstract：:Communication plays an integral role in human social dynamics and is impaired in several neurodevelopmental disorders. Mice are used to study the neurobiology of social behavior; however, the extent to which mouse vocalizations influence social dynamics has remained elusive because it is difficult to identify the voca...

journal_title：Nature neuroscience

authors： Sangiamo DT,Warren MR,Neunuebel JP

更新日期：2020-03-01 00:00:00

abstract：:We examined the contribution of 5-HT1A autoreceptors (with [11C]WAY100635 positron emission tomography) to amygdala reactivity (with blood oxygenation level-dependent functional magnetic resonance imaging) in 20 healthy adult volunteers. We found a significant inverse relationship wherein 5-HT1A autoreceptor density p...

journal_title：Nature neuroscience

authors： Fisher PM,Meltzer CC,Ziolko SK,Price JC,Moses-Kolko EL,Berga SL,Hariri AR

更新日期：2006-11-01 00:00:00

abstract：:Leucine-rich repeat kinase 2 (LRRK2) is enriched in the striatal projection neurons (SPNs). We found that LRRK2 negatively regulates protein kinase A (PKA) activity in the SPNs during synaptogenesis and in response to dopamine receptor Drd1 activation. LRRK2 interacted with PKA regulatory subunit IIβ (PKARIIβ). A lack...

journal_title：Nature neuroscience

authors： Parisiadou L,Yu J,Sgobio C,Xie C,Liu G,Sun L,Gu XL,Lin X,Crowley NA,Lovinger DM,Cai H

更新日期：2014-03-01 00:00:00

abstract：:A fundamental assumption in neuroscience is that brain structure determines function. Accordingly, functionally distinct regions of cortex should be structurally distinct in their connections to other areas. We tested this hypothesis in relation to face selectivity in the fusiform gyrus. By using only structural conne...

journal_title：Nature neuroscience

authors： Saygin ZM,Osher DE,Koldewyn K,Reynolds G,Gabrieli JD,Saxe RR

更新日期：2011-12-25 00:00:00

abstract：:All the higher mental and cognitive functions unique to humans depend on the neocortex ('new' cortex, referring to its relatively recent appearance in evolution), which is divided into discrete areas that subserve distinct functions, such as language, movement and sensation. With a few notable exceptions, all neocorti...

journal_title：Nature neuroscience

authors： Monuki ES,Walsh CA

更新日期：2001-11-01 00:00:00

abstract：:We found that K(+)/Cl(-) co-transporter 2 (KCC2) activity, monitored with wide-field fluorescence, was inhibited by intracellular Zn(2+), a major component of neuronal injury. Zn(2+)-mediated KCC2 inhibition produced a depolarizing shift of GABA(A) reversal potentials in rat cortical neurons. Moreover, oxygen-glucose ...

journal_title：Nature neuroscience

authors： Hershfinkel M,Kandler K,Knoch ME,Dagan-Rabin M,Aras MA,Abramovitch-Dahan C,Sekler I,Aizenman E

更新日期：2009-06-01 00:00:00

abstract：:The control of cell fate in neural progenitor cells is critical for nervous system development. Nevertheless, the processes involved are only partially known. We found that the expression of the tumor suppressor Pml was restricted to neural progenitor cells (NPCs) in the developing neocortex of the mouse. Notably, in ...

journal_title：Nature neuroscience

authors： Regad T,Bellodi C,Nicotera P,Salomoni P

更新日期：2009-02-01 00:00:00

abstract：:Vesicular release of neurotransmitter is the universal output signal of neurons in the brain. It is generally believed that fast transmitter release is restricted to nerve terminals that contact postsynaptic cells in the gray matter. Here we show in the rat brain that the neurotransmitter glutamate is also released at...

journal_title：Nature neuroscience

authors： Kukley M,Capetillo-Zarate E,Dietrich D

更新日期：2007-03-01 00:00:00

abstract：:We introduce a deceptively simple behavioral task that robustly identifies two qualitatively different groups within the general population. When presented with an isochronous train of random syllables, some listeners are compelled to align their own concurrent syllable production with the perceived rate, whereas othe...

journal_title：Nature neuroscience

authors： Assaneo MF,Ripollés P,Orpella J,Lin WM,de Diego-Balaguer R,Poeppel D

更新日期：2019-04-01 00:00:00

abstract：:Neuronal migration disorders such as lissencephaly and subcortical band heterotopia are associated with epilepsy and intellectual disability. DCX, PAFAH1B1 and TUBA1A are mutated in these disorders; however, corresponding mouse mutants do not show heterotopic neurons in the neocortex. In contrast, spontaneously arisen...

journal_title：Nature neuroscience

authors： Kielar M,Tuy FP,Bizzotto S,Lebrand C,de Juan Romero C,Poirier K,Oegema R,Mancini GM,Bahi-Buisson N,Olaso R,Le Moing AG,Boutourlinsky K,Boucher D,Carpentier W,Berquin P,Deleuze JF,Belvindrah R,Borrell V,Welker E,Chel

更新日期：2014-07-01 00:00:00

abstract：:Breathing is a bilaterally synchronous behavior that relies on a respiratory rhythm generator located in the brainstem. An essential component of this generator is the preBötzinger complex (preBötC), which paces inspirations. Little is known about the developmental origin of the interneuronal populations forming the p...

journal_title：Nature neuroscience

authors： Bouvier J,Thoby-Brisson M,Renier N,Dubreuil V,Ericson J,Champagnat J,Pierani A,Chédotal A,Fortin G

更新日期：2010-09-01 00:00:00

abstract：:Here we used magnetoencephalography (MEG) to investigate stages of processing in face perception in humans. We found a face-selective MEG response occurring only 100 ms after stimulus onset (the 'M100'), 70 ms earlier than previously reported. Further, the amplitude of this M100 response was correlated with successful...

journal_title：Nature neuroscience

authors： Liu J,Harris A,Kanwisher N

更新日期：2002-09-01 00:00:00

abstract：:Temporal and quantitative relations between excitatory and inhibitory inputs in the cortex are central to its activity, yet they remain poorly understood. In particular, a controversy exists regarding the extent of correlation between cortical excitation and inhibition. Using simultaneous intracellular recordings in p...

journal_title：Nature neuroscience

authors： Okun M,Lampl I

更新日期：2008-05-01 00:00:00

abstract：:The structure and function of the human brain are highly stereotyped, implying a conserved molecular program responsible for its development, cellular structure and function. We applied a correlation-based metric called differential stability to assess reproducibility of gene expression patterning across 132 structure...

journal_title：Nature neuroscience

authors： Hawrylycz M,Miller JA,Menon V,Feng D,Dolbeare T,Guillozet-Bongaarts AL,Jegga AG,Aronow BJ,Lee CK,Bernard A,Glasser MF,Dierker DL,Menche J,Szafer A,Collman F,Grange P,Berman KA,Mihalas S,Yao Z,Stewart L,Barabási AL

更新日期：2015-12-01 00:00:00

abstract：:Olfaction has often been described as a ‘synthetic’ sense. A study now reveals a surprising capacity to resolve individual odorants in complex mixtures, with implications for how the nervous system recognizes objects. ...

journal_title：Nature neuroscience

authors： Holy TE

更新日期：2014-09-01 00:00:00

abstract：:Neuronal signaling occurs through both action potential-triggered synaptic vesicle fusion and spontaneous release, although the fusion clamp machinery that prevents premature exocytosis of synaptic vesicles in the absence of calcium is unknown. Here we demonstrate that spontaneous release at synapses is regulated by c...

journal_title：Nature neuroscience

authors： Huntwork S,Littleton JT

更新日期：2007-10-01 00:00:00

abstract：:Ability to integrate diverse forms of information in current thought, or working memory, is essential for human reasoning and problem solving. We used functional imaging to identify brain regions preferentially involved in maintaining integrated versus unintegrated information in working memory. For equal amounts of v...

journal_title：Nature neuroscience

authors： Prabhakaran V,Narayanan K,Zhao Z,Gabrieli JD

更新日期：2000-01-01 00:00:00

abstract：:How different are the neuronal circuits for a given behavior across individual animals? To address this question, we measured multiple cellular and synaptic parameters in individual preparations to see how they correlated with circuit function, using neurons and synapses in the pyloric circuit of the stomatogastric ga...

journal_title：Nature neuroscience

authors： Goaillard JM,Taylor AL,Schulz DJ,Marder E

更新日期：2009-11-01 00:00:00

abstract：:Nucleus accumbens (NAc) dopamine is widely implicated in mediating the reinforcing effects of drugs of abuse. However, the precise function of the NAc itself in drug self-administration has been difficult to establish. Here we show a neural double-dissociation of the behavioral processes that underlie cocaine self-adm...

journal_title：Nature neuroscience

authors： Ito R,Robbins TW,Everitt BJ

更新日期：2004-04-01 00:00:00

abstract：:Adult neurogenesis occurs in the hippocampus and the olfactory bulb of the mammalian CNS. Recent studies have demonstrated that newborn granule cells of the adult hippocampus are postsynaptic targets of excitatory and inhibitory neurons, but evidence of synapse formation by the axons of these cells is still lacking. B...

journal_title：Nature neuroscience

authors： Toni N,Laplagne DA,Zhao C,Lombardi G,Ribak CE,Gage FH,Schinder AF

更新日期：2008-08-01 00:00:00

abstract：:The development of neuronal networks in the neocortex depends on control mechanisms for mitosis and migration that allow newborn neurons to find their accurate position. Multiple mitogens, neurotrophic factors, guidance molecules and their corresponding receptors are involved in this process, but the mechanisms by whi...

journal_title：Nature neuroscience

authors： Puehringer D,Orel N,Lüningschrör P,Subramanian N,Herrmann T,Chao MV,Sendtner M

更新日期：2013-04-01 00:00:00

abstract：:Behavior-contingent network oscillations bring about transient, functionally coherent neuronal assemblies in the cerebral cortex, including the hippocampus. Inhibitory input on and close to the soma is believed to phase intrinsic oscillations and output of pyramidal cells, but the function of GABA release to pyramidal...

journal_title：Nature neuroscience

authors： Klausberger T,Márton LF,Baude A,Roberts JD,Magill PJ,Somogyi P

更新日期：2004-01-01 00:00:00

abstract：:Interleukin 17 (IL-17) is a signature cytokine of Th17 cells. We previously reported that deletion of NF-κB activator 1 (Act1), the key transducer of IL-17 receptor signaling, from the neuroectodermal lineage in mice (neurons, oligodendrocytes and astrocytes) results in attenuated severity of experimental autoimmune e...

journal_title：Nature neuroscience

authors： Kang Z,Wang C,Zepp J,Wu L,Sun K,Zhao J,Chandrasekharan U,DiCorleto PE,Trapp BD,Ransohoff RM,Li X

更新日期：2013-10-01 00:00:00

abstract：:Remembering a past experience can, surprisingly, cause forgetting. Forgetting arises when other competing traces interfere with retrieval and inhibitory control mechanisms are engaged to suppress the distraction they cause. This form of forgetting is considered to be adaptive because it reduces future interference. Th...

journal_title：Nature neuroscience

authors： Wimber M,Alink A,Charest I,Kriegeskorte N,Anderson MC

更新日期：2015-04-01 00:00:00

abstract：:Olfactory representations are shaped by brain state and respiration. The interaction and circuit substrates of these influences are unclear. Granule cells (GCs) in the main olfactory bulb (MOB) are presumed to sculpt activity reaching the cortex via inhibition of mitral/tufted cells (MTs). GCs potentially make ensembl...

journal_title：Nature neuroscience

authors： Cazakoff BN,Lau BY,Crump KL,Demmer HS,Shea SD

更新日期：2014-04-01 00:00:00

abstract：:Neuroscientists increasingly analyze the joint activity of multineuron recordings to identify population-level structures believed to be significant and scientifically novel. Claims of significant population structure support hypotheses in many brain areas. However, these claims require first investigating the possibi...

journal_title：Nature neuroscience

authors： Elsayed GF,Cunningham JP

更新日期：2017-09-01 00:00:00

abstract：:Although much learning occurs through direct experience of errors, humans and other animals can learn from the errors of other individuals. The medial frontal cortex (MFC) processes self-generated errors, but the neuronal architecture and mechanisms underlying the monitoring of others' errors are poorly understood. Ex...

journal_title：Nature neuroscience

authors： Yoshida K,Saito N,Iriki A,Isoda M

更新日期：2012-09-01 00:00:00

abstract：:From insects to mammals, olfactory receptor neurons (ORNs) expressing a common olfactory receptor target their axons to specific glomeruli with high precision. Here we show in Drosophila that the POU transcription factor Acj6 controls the axon targeting specificity of a subset of ORN classes, as defined by the olfacto...

journal_title：Nature neuroscience

authors： Komiyama T,Carlson JR,Luo L

更新日期：2004-08-01 00:00:00

abstract：:Electrical stimulation of visual cortex can produce a visual percept (phosphene). We electrically stimulated visual cortex in humans implanted with subdural electrodes while recording from other brain sites. Phosphene perception occurred only if stimulation evoked high-frequency gamma oscillations in the temporopariet...

journal_title：Nature neuroscience

authors： Beauchamp MS,Sun P,Baum SH,Tolias AS,Yoshor D

更新日期：2012-06-03 00:00:00

abstract：:Phasic activation of the dopamine (DA) midbrain system in response to unexpected reward or novelty is critical for adaptive behavioral strategies. This activation of DA midbrain neurons occurs via a synaptically triggered switch from low-frequency background spiking to transient high-frequency burst firing. We found t...

journal_title：Nature neuroscience

authors： Schiemann J,Schlaudraff F,Klose V,Bingmer M,Seino S,Magill PJ,Zaghloul KA,Schneider G,Liss B,Roeper J

更新日期：2012-09-01 00:00:00