Abstract：
:Striatal parvalbumin (PV) and cholinergic interneurons (CHIs) are poised to play major roles in behavior by coordinating the networks of medium spiny cells that relay motor output. However, the small numbers and scattered distribution of these cells have hindered direct assessment of their contribution to activity in networks of medium spiny neurons (MSNs) during behavior. Here, we build on recent improvements in single-cell calcium imaging combined with optogenetics to test the capacity of PVs and CHIs to affect MSN activity and behavior in mice engaged in voluntary locomotion. We find that PVs and CHIs have unique effects on MSN activity and dissociable roles in supporting movement. PV cells facilitate movement by refining the activation of MSN networks responsible for movement execution. CHIs, in contrast, synchronize activity within MSN networks to signal the end of a movement bout. These results provide new insights into the striatal network activity that supports movement.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Gritton HJ,Howe WM,Romano MF,DiFeliceantonio AG,Kramer MA,Saligrama V,Bucklin ME,Zemel D,Han Xdoi
10.1038/s41593-019-0341-3subject
Has Abstractpub_date
2019-04-01 00:00:00pages
586-597issue
4eissn
1097-6256issn
1546-1726pii
10.1038/s41593-019-0341-3journal_volume
22pub_type
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