Structure in neural population recordings: an expected byproduct of simpler phenomena?

Abstract:

:Neuroscientists increasingly analyze the joint activity of multineuron recordings to identify population-level structures believed to be significant and scientifically novel. Claims of significant population structure support hypotheses in many brain areas. However, these claims require first investigating the possibility that the population structure in question is an expected byproduct of simpler features known to exist in data. Classically, this critical examination can be either intuited or addressed with conventional controls. However, these approaches fail when considering population data, raising concerns about the scientific merit of population-level studies. Here we develop a framework to test the novelty of population-level findings against simpler features such as correlations across times, neurons and conditions. We apply this framework to test two recent population findings in prefrontal and motor cortices, providing essential context to those studies. More broadly, the methodologies we introduce provide a general neural population control for many population-level hypotheses.

journal_name

Nat Neurosci

journal_title

Nature neuroscience

authors

Elsayed GF,Cunningham JP

doi

10.1038/nn.4617

subject

Has Abstract

pub_date

2017-09-01 00:00:00

pages

1310-1318

issue

9

eissn

1097-6256

issn

1546-1726

pii

nn.4617

journal_volume

20

pub_type

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