Abstract:
:Neuroscientists increasingly analyze the joint activity of multineuron recordings to identify population-level structures believed to be significant and scientifically novel. Claims of significant population structure support hypotheses in many brain areas. However, these claims require first investigating the possibility that the population structure in question is an expected byproduct of simpler features known to exist in data. Classically, this critical examination can be either intuited or addressed with conventional controls. However, these approaches fail when considering population data, raising concerns about the scientific merit of population-level studies. Here we develop a framework to test the novelty of population-level findings against simpler features such as correlations across times, neurons and conditions. We apply this framework to test two recent population findings in prefrontal and motor cortices, providing essential context to those studies. More broadly, the methodologies we introduce provide a general neural population control for many population-level hypotheses.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Elsayed GF,Cunningham JPdoi
10.1038/nn.4617subject
Has Abstractpub_date
2017-09-01 00:00:00pages
1310-1318issue
9eissn
1097-6256issn
1546-1726pii
nn.4617journal_volume
20pub_type
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