Cocaine inverts rules for synaptic plasticity of glutamate transmission in the ventral tegmental area.


:The manner in which drug-evoked synaptic plasticity affects reward circuits remains largely elusive. We found that cocaine reduced NMDA receptor excitatory postsynaptic currents and inserted GluA2-lacking AMPA receptors in dopamine neurons of mice. Consequently, a stimulation protocol pairing glutamate release with hyperpolarizing current injections further strengthened synapses after cocaine treatment. Our data suggest that early cocaine-evoked plasticity in the ventral tegmental area inverts the rules for activity-dependent plasticity, eventually leading to addictive behavior.


Nat Neurosci


Nature neuroscience


Mameli M,Bellone C,Brown MT,Lüscher C




Has Abstract


2011-04-01 00:00:00














  • Neuronal activity modifies the chromatin accessibility landscape in the adult brain.

    abstract::Neuronal activity-induced gene expression modulates the function and plasticity of the nervous system. It is unknown whether and to what extent neuronal activity may trigger changes in chromatin accessibility, a major mode of epigenetic regulation of gene expression. Here we compared chromatin accessibility landscapes...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: Su Y,Shin J,Zhong C,Wang S,Roychowdhury P,Lim J,Kim D,Ming GL,Song H

    更新日期:2017-03-01 00:00:00

  • The spatial structure of correlated neuronal variability.

    abstract::Shared neural variability is ubiquitous in cortical populations. While this variability is presumed to arise from overlapping synaptic input, its precise relationship to local circuit architecture remains unclear. We combine computational models and in vivo recordings to study the relationship between the spatial stru...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: Rosenbaum R,Smith MA,Kohn A,Rubin JE,Doiron B

    更新日期:2017-01-01 00:00:00

  • Slowly dividing neural progenitors are an embryonic origin of adult neural stem cells.

    abstract::The mechanism by which adult neural stem cells (NSCs) are established during development is unclear. In this study, analysis of cell cycle progression by examining retention of a histone 2B (H2B)-GFP fusion protein revealed that, in a subset of mouse embryonic neural progenitor cells (NPCs), the cell cycle slows betwe...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: Furutachi S,Miya H,Watanabe T,Kawai H,Yamasaki N,Harada Y,Imayoshi I,Nelson M,Nakayama KI,Hirabayashi Y,Gotoh Y

    更新日期:2015-05-01 00:00:00

  • Memory enhancement and formation by atypical PKM activity in Drosophila melanogaster.

    abstract::Synaptic stimulation activates signal transduction pathways, producing persistently active protein kinases. PKMzeta is a truncated, persistently active isoform of atypical protein kinase C-zeta (aPKCzeta), which lacks the N-terminal pseudosubstrate regulatory domain. Using a Pavlovian olfactory learning task in Drosop...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: Drier EA,Tello MK,Cowan M,Wu P,Blace N,Sacktor TC,Yin JC

    更新日期:2002-04-01 00:00:00

  • Direct cortical control of muscle activation in voluntary arm movements: a model.

    abstract::What neural activity in motor cortex represents and how it controls ongoing movement remain unclear. Suggestions that cortex generates low-level muscle control are discredited by correlations with higher-level parameters of hand movement, but no coherent alternative exists. I argue that the view of low-level control i...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: Todorov E

    更新日期:2000-04-01 00:00:00

  • Vector trace cells in the subiculum of the hippocampal formation.

    abstract::Successfully navigating in physical or semantic space requires a neural representation of allocentric (map-based) vectors to boundaries, objects and goals. Cognitive processes such as path-planning and imagination entail the recall of vector representations, but evidence of neuron-level memory for allocentric vectors ...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: Poulter S,Lee SA,Dachtler J,Wills TJ,Lever C

    更新日期:2020-12-21 00:00:00

  • Sharp emergence of feature-selective sustained activity along the dorsal visual pathway.

    abstract::Sustained activity encoding visual working memory representations has been observed in several cortical areas of primates. Where along the visual pathways this activity emerges remains unknown. Here we show in macaques that sustained spiking activity encoding memorized visual motion directions is absent in direction-s...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: Mendoza-Halliday D,Torres S,Martinez-Trujillo JC

    更新日期:2014-09-01 00:00:00

  • Structure in neural population recordings: an expected byproduct of simpler phenomena?

    abstract::Neuroscientists increasingly analyze the joint activity of multineuron recordings to identify population-level structures believed to be significant and scientifically novel. Claims of significant population structure support hypotheses in many brain areas. However, these claims require first investigating the possibi...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: Elsayed GF,Cunningham JP

    更新日期:2017-09-01 00:00:00

  • High-fidelity optical reporting of neuronal electrical activity with an ultrafast fluorescent voltage sensor.

    abstract::Accurate optical reporting of electrical activity in genetically defined neuronal populations is a long-standing goal in neuroscience. We developed Accelerated Sensor of Action Potentials 1 (ASAP1), a voltage sensor design in which a circularly permuted green fluorescent protein is inserted in an extracellular loop of...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: St-Pierre F,Marshall JD,Yang Y,Gong Y,Schnitzer MJ,Lin MZ

    更新日期:2014-06-01 00:00:00

  • The sleeping child outplays the adult's capacity to convert implicit into explicit knowledge.

    abstract::When sleep followed implicit training on a motor sequence, children showed greater gains in explicit sequence knowledge after sleep than adults. This greater explicit knowledge in children was linked to their higher sleep slow-wave activity and to stronger hippocampal activation at explicit knowledge retrieval. Our da...

    journal_title:Nature neuroscience

    pub_type: 杂志文章,随机对照试验


    authors: Wilhelm I,Rose M,Imhof KI,Rasch B,Büchel C,Born J

    更新日期:2013-04-01 00:00:00

  • Anatomical connectivity patterns predict face selectivity in the fusiform gyrus.

    abstract::A fundamental assumption in neuroscience is that brain structure determines function. Accordingly, functionally distinct regions of cortex should be structurally distinct in their connections to other areas. We tested this hypothesis in relation to face selectivity in the fusiform gyrus. By using only structural conne...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: Saygin ZM,Osher DE,Koldewyn K,Reynolds G,Gabrieli JD,Saxe RR

    更新日期:2011-12-25 00:00:00

  • Intracellular zinc inhibits KCC2 transporter activity.

    abstract::We found that K(+)/Cl(-) co-transporter 2 (KCC2) activity, monitored with wide-field fluorescence, was inhibited by intracellular Zn(2+), a major component of neuronal injury. Zn(2+)-mediated KCC2 inhibition produced a depolarizing shift of GABA(A) reversal potentials in rat cortical neurons. Moreover, oxygen-glucose ...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: Hershfinkel M,Kandler K,Knoch ME,Dagan-Rabin M,Aras MA,Abramovitch-Dahan C,Sekler I,Aizenman E

    更新日期:2009-06-01 00:00:00

  • Capacity for 5-HT1A-mediated autoregulation predicts amygdala reactivity.

    abstract::We examined the contribution of 5-HT1A autoreceptors (with [11C]WAY100635 positron emission tomography) to amygdala reactivity (with blood oxygenation level-dependent functional magnetic resonance imaging) in 20 healthy adult volunteers. We found a significant inverse relationship wherein 5-HT1A autoreceptor density p...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: Fisher PM,Meltzer CC,Ziolko SK,Price JC,Moses-Kolko EL,Berga SL,Hariri AR

    更新日期:2006-11-01 00:00:00

  • Mesopontine median raphe regulates hippocampal ripple oscillation and memory consolidation.

    abstract::Sharp wave-associated field oscillations (∼200 Hz) of the hippocampus, referred to as ripples, are believed to be important for consolidation of explicit memory. Little is known about how ripples are regulated by other brain regions. We found that the median raphe region (MnR) is important for regulating hippocampal r...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: Wang DV,Yau HJ,Broker CJ,Tsou JH,Bonci A,Ikemoto S

    更新日期:2015-05-01 00:00:00

  • Silencing of EphA3 through a cis interaction with ephrinA5.

    abstract::EphAs and ephrinAs are expressed in multiple areas of the developing brain in overlapping countergradients, notably in the retina and tectum. Here they are involved in targeting retinal axons to their correct topographic position in the tectum. We have used truncated versions of EphA3, single-amino acid point mutants ...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: Carvalho RF,Beutler M,Marler KJ,Knöll B,Becker-Barroso E,Heintzmann R,Ng T,Drescher U

    更新日期:2006-03-01 00:00:00

  • Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways.

    abstract::Here we report that synaptic and extrasynaptic NMDA (N-methyl-D-aspartate) receptors have opposite effects on CREB (cAMP response element binding protein) function, gene regulation and neuron survival. Calcium entry through synaptic NMDA receptors induced CREB activity and brain-derived neurotrophic factor (BDNF) gene...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: Hardingham GE,Fukunaga Y,Bading H

    更新日期:2002-05-01 00:00:00

  • A PKC epsilon-ENH-channel complex specifically modulates N-type Ca2+ channels.

    abstract::Multiple protein kinase C (PKC) isozymes are present in neurons, where they regulate a variety of cellular functions. Due to the lack of specific PKC isozyme inhibitors, it remains unknown how PKC acts on its selective target(s) and achieves its specific actions. Here we show that a PKC binding protein, enigma homolog...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: Maeno-Hikichi Y,Chang S,Matsumura K,Lai M,Lin H,Nakagawa N,Kuroda S,Zhang JF

    更新日期:2003-05-01 00:00:00

  • cJun integrates calcium activity and tlx3 expression to regulate neurotransmitter specification.

    abstract::Neuronal differentiation is accomplished through cascades of intrinsic genetic factors initiated in neuronal progenitors by external gradients of morphogens. Activity has been thought to be important only late in development, but recent evidence suggests that activity also regulates early neuronal differentiation. Act...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: Marek KW,Kurtz LM,Spitzer NC

    更新日期:2010-08-01 00:00:00

  • Drug-induced GABA transporter currents enhance GABA release to induce opioid withdrawal behaviors.

    abstract::Neurotransmitter transporters can affect neuronal excitability indirectly via modulation of neurotransmitter concentrations or directly via transporter currents. A physiological or pathophysiological role for transporter currents has not been described. We found that GABA transporter 1 (GAT-1) cation currents directly...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: Bagley EE,Hacker J,Chefer VI,Mallet C,McNally GP,Chieng BC,Perroud J,Shippenberg TS,Christie MJ

    更新日期:2011-10-30 00:00:00

  • Modulation of glycine-activated ion channel function by G-protein betagamma subunits.

    abstract::Glycine receptors (GlyRs), together with GABA(A) and nicotinic acetylcholine (ACh) receptors, form part of the ligand-activated ion channel superfamily and regulate the excitability of the mammalian brain stem and spinal cord. Here we report that the ability of the neurotransmitter glycine to gate recombinant and nati...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: Yevenes GE,Peoples RW,Tapia JC,Parodi J,Soto X,Olate J,Aguayo LG

    更新日期:2003-08-01 00:00:00

  • A complexin fusion clamp regulates spontaneous neurotransmitter release and synaptic growth.

    abstract::Neuronal signaling occurs through both action potential-triggered synaptic vesicle fusion and spontaneous release, although the fusion clamp machinery that prevents premature exocytosis of synaptic vesicles in the absence of calcium is unknown. Here we demonstrate that spontaneous release at synapses is regulated by c...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: Huntwork S,Littleton JT

    更新日期:2007-10-01 00:00:00

  • TDP-43 extracted from frontotemporal lobar degeneration subject brains displays distinct aggregate assemblies and neurotoxic effects reflecting disease progression rates.

    abstract::Accumulation of abnormally phosphorylated TDP-43 (pTDP-43) is the main pathology in affected neurons of people with amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Morphological diversity and neuroanatomical distribution of pTDP-43 accumulations allowed classification of FTLD cases in...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: Laferrière F,Maniecka Z,Pérez-Berlanga M,Hruska-Plochan M,Gilhespy L,Hock EM,Wagner U,Afroz T,Boersema PJ,Barmettler G,Foti SC,Asi YT,Isaacs AM,Al-Amoudi A,Lewis A,Stahlberg H,Ravits J,De Giorgi F,Ichas F,Bezard E,

    更新日期:2019-01-01 00:00:00

  • CNS lymphatic drainage and neuroinflammation are regulated by meningeal lymphatic vasculature.

    abstract::Neuroinflammatory diseases, such as multiple sclerosis, are characterized by invasion of the brain by autoreactive T cells. The mechanism for how T cells acquire their encephalitogenic phenotype and trigger disease remains, however, unclear. The existence of lymphatic vessels in the meninges indicates a relevant link ...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: Louveau A,Herz J,Alme MN,Salvador AF,Dong MQ,Viar KE,Herod SG,Knopp J,Setliff JC,Lupi AL,Da Mesquita S,Frost EL,Gaultier A,Harris TH,Cao R,Hu S,Lukens JR,Smirnov I,Overall CC,Oliver G,Kipnis J

    更新日期:2018-10-01 00:00:00

  • Author Correction: PD-L1 inhibits acute and chronic pain by suppressing nociceptive neuron activity via PD-1.

    abstract::In the version of this article initially published, what was originally described as 'conditioned place preference' in a two-chamber mouse experiment could be better described as 'conditioned place avoidance'. ...

    journal_title:Nature neuroscience

    pub_type: 已发布勘误


    authors: Chen G,Kim YH,Li H,Luo H,Liu DL,Zhang ZJ,Lay M,Chang W,Zhang YQ,Ji RR

    更新日期:2019-03-01 00:00:00

  • Cortical specialization for attended versus unattended working memory.

    abstract::Items held in working memory can be either attended or not, depending on their current behavioral relevance. It has been suggested that unattended contents might be solely retained in an activity-silent form. Instead, we demonstrate here that encoding unattended contents involves a division of labor. While visual cort...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: Christophel TB,Iamshchinina P,Yan C,Allefeld C,Haynes JD

    更新日期:2018-04-01 00:00:00

  • The spatial structure of a nonlinear receptive field.

    abstract::Understanding a sensory system implies the ability to predict responses to a variety of inputs from a common model. In the retina, this includes predicting how the integration of signals across visual space shapes the outputs of retinal ganglion cells. Existing models of this process generalize poorly to predict respo...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: Schwartz GW,Okawa H,Dunn FA,Morgan JL,Kerschensteiner D,Wong RO,Rieke F

    更新日期:2012-11-01 00:00:00

  • A critical role for PSD-95/AKAP interactions in endocytosis of synaptic AMPA receptors.

    abstract::The endocytosis of AMPA receptors (AMPARs) underlies several forms of synaptic plasticity, including NMDA receptor (NMDAR)-dependent long-term depression (LTD), but the molecular mechanisms responsible for this trafficking remain unknown. We found that PSD-95, a major postsynaptic density protein, is important for NMD...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: Bhattacharyya S,Biou V,Xu W,Schlüter O,Malenka RC

    更新日期:2009-02-01 00:00:00

  • The coding of cutaneous temperature in the spinal cord.

    abstract::The spinal cord is the initial stage that integrates temperature information from peripheral inputs. Here we used molecular genetics and in vivo calcium imaging to investigate the coding of cutaneous temperature in the spinal cord in mice. We found that heating or cooling the skin evoked robust calcium responses in sp...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: Ran C,Hoon MA,Chen X

    更新日期:2016-09-01 00:00:00

  • RIM1 confers sustained activity and neurotransmitter vesicle anchoring to presynaptic Ca2+ channels.

    abstract::The molecular organization of presynaptic active zones is important for the neurotransmitter release that is triggered by depolarization-induced Ca2+ influx. Here, we demonstrate a previously unknown interaction between two components of the presynaptic active zone, RIM1 and voltage-dependent Ca2+ channels (VDCCs), th...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: Kiyonaka S,Wakamori M,Miki T,Uriu Y,Nonaka M,Bito H,Beedle AM,Mori E,Hara Y,De Waard M,Kanagawa M,Itakura M,Takahashi M,Campbell KP,Mori Y

    更新日期:2007-06-01 00:00:00

  • Multiple models to capture the variability in biological neurons and networks.

    abstract::How tightly tuned are the synaptic and intrinsic properties that give rise to neuron and circuit function? Experimental work shows that these properties vary considerably across identified neurons in different animals. Given this variability in experimental data, this review describes some of the complications of buil...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: Marder E,Taylor AL

    更新日期:2011-02-01 00:00:00