Abstract:
:The molecular trigger of CNS myelination is unknown. By targeting Pten in cerebellar granule cells and activating the AKT1-mTOR pathway, we increased the caliber of normally unmyelinated axons and the expression of numerous genes encoding regulatory proteins. This led to the expansion of genetically wild-type oligodendrocyte progenitor cells, oligodendrocyte differentiation and de novo myelination of parallel fibers. Thus, a neuronal program dependent on the phosphoinositide PI(3,4,5)P3 is sufficient to trigger all steps of myelination.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Goebbels S,Wieser GL,Pieper A,Spitzer S,Weege B,Yan K,Edgar JM,Yagensky O,Wichert SP,Agarwal A,Karram K,Renier N,Tessier-Lavigne M,Rossner MJ,Káradóttir RT,Nave KAdoi
10.1038/nn.4425subject
Has Abstractpub_date
2017-01-01 00:00:00pages
10-15issue
1eissn
1097-6256issn
1546-1726pii
nn.4425journal_volume
20pub_type
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