Abstract：
:We used cortex-specific deletion of the transcription factor gene COUP-TFI (also known as Nr2f1) in mice to demonstrate previously unknown fundamental roles for it in patterning mammalian neocortex into areas. The highest COUP-TFI expression is observed in the cortical progenitors and progeny in parietal and occipital cortex that form sensory areas, and the lowest expression was observed in frontal cortex that includes motor areas. Cortical deletion of COUP-TFI resulted in massive expansion of frontal areas, including motor, to occupy most of neocortex, paralleled by marked compression of sensory areas to caudal occipital cortex. These area patterning changes are preceded and paralleled by corresponding changes in molecular markers of area identity and altered axonal projections to maintain patterned area-specific input and output connections. We conclude that COUP-TFI is required for balancing patterning of neocortex into frontal/motor and sensory areas by acting in its expression domain to repress frontal/motor area identities and to specify sensory area identities.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Armentano M,Chou SJ,Tomassy GS,Leingärtner A,O'Leary DD,Studer Mdoi
10.1038/nn1958subject
Has Abstractpub_date
2007-10-01 00:00:00pages
1277-86issue
10eissn
1097-6256issn
1546-1726pii
nn1958journal_volume
10pub_type
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