Abstract:
:Odor stimulation evokes complex spatiotemporal activity in the olfactory bulb, suggesting that both the identity of activated neurons and the timing of their activity convey information about odors. However, whether and how downstream neurons decipher these temporal patterns remains unknown. We addressed this question by measuring the spiking activity of downstream neurons while optogenetically stimulating two foci in the olfactory bulb with varying relative timing in mice. We found that the overall spike rates of piriform cortex neurons (PCNs) were sensitive to the relative timing of activation. Posterior PCNs showed higher sensitivity to relative input times than neurons in the anterior piriform cortex. In contrast, olfactory bulb neurons rarely showed such sensitivity. Thus, the brain can transform a relative time code in the periphery into a firing rate-based representation in central brain areas, providing evidence for the relevance of a relative time-based code in the olfactory bulb.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Haddad R,Lanjuin A,Madisen L,Zeng H,Murthy VN,Uchida Ndoi
10.1038/nn.3407subject
Has Abstractpub_date
2013-07-01 00:00:00pages
949-57issue
7eissn
1097-6256issn
1546-1726pii
nn.3407journal_volume
16pub_type
杂志文章abstract::To investigate the mechanisms of persistent neural activity, we obtained in vivo intracellular recordings from neurons in an oculomotor neural integrator of the goldfish during spontaneous saccades and fixations. Persistent changes in firing rate following saccades were associated with step changes in interspike membr...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/84023
更新日期:2001-02-01 00:00:00
abstract::Mutations in copper/zinc superoxide dismutase 1 (SOD1), primary causes of human amyotrophic lateral sclerosis (ALS), provoke motor neuron death through an unidentified toxic property. The known neurofilament-dependent slowing of axonal transport, combined with the prominent misaccumulation of neurofilaments in ALS, su...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/4553
更新日期:1999-01-01 00:00:00
abstract::Fear renewal, a widely pursued model of post-traumatic stress disorder and phobias, refers to the context-specific relapse of conditioned fear after extinction. However, its molecular mechanisms are largely unknown. We found that renewal-inducing stimuli, generally believed to be insufficient to induce synaptic plasti...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3491
更新日期:2013-10-01 00:00:00
abstract::Trafficking of AMPA receptors (AMPARs) is important for many forms of synaptic plasticity. However, the link between activity and resulting synaptic alterations is not fully understood. We identified a direct interaction between N-ethylmaleimide-sensitive fusion protein (NSF), an ATPase involved in membrane fusion eve...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2624
更新日期:2010-10-01 00:00:00
abstract::Enduring deficits in temporal processing can be induced in the auditory cortex by rearing infant rats in the presence of low frequency-modulated noises. We found that it was possible to restore normal temporal processing, overcoming deficits induced during the critical period, by intensively training developmentally i...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2239
更新日期:2009-01-01 00:00:00
abstract::Microcircuits composed of principal neuron and interneuron dendrites have an important role in shaping the representation of sensory information in the olfactory bulb. Here we establish the physiological features governing synaptic signaling in dendrodendritic microcircuits of olfactory bulb glomeruli. We show that de...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1403
更新日期:2005-03-01 00:00:00
abstract::Hippocampal replay during sharp-wave ripple events (SWRs) is thought to drive memory consolidation in hippocampal and cortical circuits. Changes in neocortical activity can precede SWR events, but whether and how these changes influence the content of replay remains unknown. Here we show that during sleep there is a r...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.4457
更新日期:2017-02-01 00:00:00
abstract::A decade after speech was first decoded from human brain signals, accuracy and speed remain far below that of natural speech. Here we show how to decode the electrocorticogram with high accuracy and at natural-speech rates. Taking a cue from recent advances in machine translation, we train a recurrent neural network t...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/s41593-020-0608-8
更新日期:2020-04-01 00:00:00
abstract::Chondroitinase ABC treatment promotes spinal cord plasticity. We investigated whether chondroitinase-induced plasticity combined with physical rehabilitation promotes recovery of manual dexterity in rats with cervical spinal cord injuries. Rats received a C4 dorsal funiculus cut followed by chondroitinase ABC or penic...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2377
更新日期:2009-09-01 00:00:00
abstract::Psychiatric morbidity is high in cities, so identifying potential modifiable urban protective factors is important. We show that exposure to urban green space improves well-being in naturally behaving male and female city dwellers, particularly in districts with higher psychiatric incidence and fewer green resources. ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/s41593-019-0451-y
更新日期:2019-09-01 00:00:00
abstract::Understanding the transcriptional changes that are engaged in stress resilience may reveal novel antidepressant targets. Here we use gene co-expression analysis of RNA-sequencing data from brains of resilient mice to identify a gene network that is unique to resilience. Zfp189, which encodes a previously unstudied zin...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/s41593-019-0462-8
更新日期:2019-09-01 00:00:00
abstract::Accurate optical reporting of electrical activity in genetically defined neuronal populations is a long-standing goal in neuroscience. We developed Accelerated Sensor of Action Potentials 1 (ASAP1), a voltage sensor design in which a circularly permuted green fluorescent protein is inserted in an extracellular loop of...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3709
更新日期:2014-06-01 00:00:00
abstract::EphB receptor tyrosine kinases control multiple steps in nervous system development. However, it remains unclear whether EphBs regulate these different developmental processes directly or indirectly. In addition, given that EphBs signal through multiple mechanisms, it has been challenging to define which signaling fun...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3249
更新日期:2012-12-01 00:00:00
abstract::We introduce a deceptively simple behavioral task that robustly identifies two qualitatively different groups within the general population. When presented with an isochronous train of random syllables, some listeners are compelled to align their own concurrent syllable production with the perceived rate, whereas othe...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/s41593-019-0353-z
更新日期:2019-04-01 00:00:00
abstract::The deposition of aggregated amyloid-β peptides derived from the pro-amyloidogenic processing of the amyloid precurson protein (APP) into characteristic amyloid plaques (APs) is distinctive to Alzheimer's disease (AD). Alternative APP processing via the metalloprotease ADAM10 prevents amyloid-β formation. We tested wh...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/s41593-019-0432-1
更新日期:2019-08-01 00:00:00
abstract::Intrinsic signal imaging from inferotemporal (IT) cortex, a visual area essential for object perception and recognition, revealed that visually presented objects activated patches in a distributed manner. When visual features of these objects were partially removed, the simplified stimuli activated only a subset of th...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/90547
更新日期:2001-08-01 00:00:00
abstract::A single neurotransmitter elicits diverse physiological responses through activation of multiple receptor subtypes and/or heterosynaptic interactions involving distinct synaptic targets. We found that a typical excitatory transmitter released from the climbing fiber (CF) in the cerebellar cortex not only excited Purki...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/75718
更新日期:2000-06-01 00:00:00
abstract::T cells clear virus from the CNS and dynamically regulate brain functions, including spatial learning, through cytokine signaling. Here we determined whether hippocampal T cells that persist after recovery from infection with West Nile virus (WNV) or Zika virus (ZIKV) impact hippocampal-dependent learning and memory. ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/s41593-019-0427-y
更新日期:2019-08-01 00:00:00
abstract::Medical imaging has enormous potential for early disease prediction, but is impeded by the difficulty and expense of acquiring data sets before symptom onset. UK Biobank aims to address this problem directly by acquiring high-quality, consistently acquired imaging data from 100,000 predominantly healthy participants, ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.4393
更新日期:2016-11-01 00:00:00
abstract::Tumor-associated macrophages (TAMs) play an important role in the immune response to cancer, but the mechanisms by which the tumor microenvironment controls TAMs and T cell immunity are not completely understood. Here we report that kynurenine produced by glioblastoma cells activates aryl hydrocarbon receptor (AHR) in...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/s41593-019-0370-y
更新日期:2019-05-01 00:00:00
abstract::Neural stem and progenitor cells (NSCs/NPCs) give rise to neurons, astrocytes and oligodendrocytes. However, the mechanisms underlying the decision of a stem cell to either self-renew or differentiate are incompletely understood. We demonstrate here that Fbw7 (F-box and WD repeat domain containing-7), the substrate re...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2644
更新日期:2010-11-01 00:00:00
abstract::Axonal injury results in regenerative success or failure, depending on whether the axon lies in the peripheral or the CNS, respectively. The present study addresses whether epigenetic signatures in dorsal root ganglia discriminate between regenerative and non-regenerative axonal injury. Chromatin immunoprecipitation f...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/s41593-019-0490-4
更新日期:2019-11-01 00:00:00
abstract::How different are the neuronal circuits for a given behavior across individual animals? To address this question, we measured multiple cellular and synaptic parameters in individual preparations to see how they correlated with circuit function, using neurons and synapses in the pyloric circuit of the stomatogastric ga...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2404
更新日期:2009-11-01 00:00:00
abstract::Previous studies suggested that MeCP2 competes with linker histone H1, but this hypothesis has never been tested in vivo. Here, we performed chromatin immunoprecipitation followed by sequencing (ChIP-seq) of Flag-tagged-H1.0 in mouse forebrain excitatory neurons. Unexpectedly, Flag-H1.0 and MeCP2 occupied similar geno...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/s41593-018-0155-8
更新日期:2018-06-01 00:00:00
abstract::Over the last 10 years, optogenetics has become widespread in neuroscience for the study of how specific cell types contribute to brain functions and brain disorder states. The full impact of optogenetics will emerge only when other toolsets mature, including neural connectivity and cell phenotyping tools and neural r...
journal_title:Nature neuroscience
pub_type: 评论,杂志文章
doi:10.1038/nn.4094
更新日期:2015-09-01 00:00:00
abstract::In the cat primary visual cortex, neurons are classified into the two main categories of simple cells and complex cells based on their response properties. According to the hierarchical model, complex receptive fields derive from convergent inputs of simple cells with similar orientation preferences. This model receiv...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/1609
更新日期:1998-09-01 00:00:00
abstract::Cuing covert spatial attention can increase spatial resolution. Here we pinpointed the specific locus of this effect using texture segmentation. At the level of visual cortex, texture segmentation theoretically involves passage of visual input through two layers of spatial linear filters separated by a pointwise nonli...
journal_title:Nature neuroscience
pub_type: 临床试验,杂志文章
doi:10.1038/75804
更新日期:2000-06-01 00:00:00
abstract::We used cortex-specific deletion of the transcription factor gene COUP-TFI (also known as Nr2f1) in mice to demonstrate previously unknown fundamental roles for it in patterning mammalian neocortex into areas. The highest COUP-TFI expression is observed in the cortical progenitors and progeny in parietal and occipital...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1958
更新日期:2007-10-01 00:00:00
abstract::Although it has long been known that cultured embryonic stem cells can generate neurons, the lineage relationships with their immediate precursors remain unclear. We report here that selection of highly proliferative stem cells followed by treatment with retinoic acid generated essentially pure precursors that markers...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1301
更新日期:2004-09-01 00:00:00
abstract::Nature Neuroscience presents a special issue of recent advances on shared mechanisms underlying neurodegenerative disease. ...
journal_title:Nature neuroscience
pub_type: 社论
doi:10.1038/s41593-018-0250-x
更新日期:2018-10-01 00:00:00