Elevated levels of Secreted-Frizzled-Related-Protein 1 contribute to Alzheimer's disease pathogenesis.

abstract：:Neuronal migration disorders such as lissencephaly and subcortical band heterotopia are associated with epilepsy and intellectual disability. DCX, PAFAH1B1 and TUBA1A are mutated in these disorders; however, corresponding mouse mutants do not show heterotopic neurons in the neocortex. In contrast, spontaneously arisen...

journal_title：Nature neuroscience

authors： Kielar M,Tuy FP,Bizzotto S,Lebrand C,de Juan Romero C,Poirier K,Oegema R,Mancini GM,Bahi-Buisson N,Olaso R,Le Moing AG,Boutourlinsky K,Boucher D,Carpentier W,Berquin P,Deleuze JF,Belvindrah R,Borrell V,Welker E,Chel

更新日期：2014-07-01 00:00:00

abstract：:The development of neuronal networks in the neocortex depends on control mechanisms for mitosis and migration that allow newborn neurons to find their accurate position. Multiple mitogens, neurotrophic factors, guidance molecules and their corresponding receptors are involved in this process, but the mechanisms by whi...

journal_title：Nature neuroscience

authors： Puehringer D,Orel N,Lüningschrör P,Subramanian N,Herrmann T,Chao MV,Sendtner M

更新日期：2013-04-01 00:00:00

abstract：:Tau protein can transfer between neurons transneuronally and trans-synaptically, which is thought to explain the progressive spread of tauopathy observed in the brain of patients with Alzheimer's disease. Here we show that physiological tau released from donor cells can transfer to recipient cells via the medium, sugg...

journal_title：Nature neuroscience

authors： Wu JW,Hussaini SA,Bastille IM,Rodriguez GA,Mrejeru A,Rilett K,Sanders DW,Cook C,Fu H,Boonen RA,Herman M,Nahmani E,Emrani S,Figueroa YH,Diamond MI,Clelland CL,Wray S,Duff KE

更新日期：2016-08-01 00:00:00

abstract：:The spinal cord is the initial stage that integrates temperature information from peripheral inputs. Here we used molecular genetics and in vivo calcium imaging to investigate the coding of cutaneous temperature in the spinal cord in mice. We found that heating or cooling the skin evoked robust calcium responses in sp...

journal_title：Nature neuroscience

authors： Ran C,Hoon MA,Chen X

更新日期：2016-09-01 00:00:00

abstract：:Neural progenitor cells in the developing neocortex change over time to produce different neurons, a phenomenon that is also observed in other regions of the nervous system. Mouse Numb (also known as m-numb) and Numbl (also known as numblike or Nbl) are redundant but essential in maintaining virtually all progenitor c...

journal_title：Nature neuroscience

authors： Petersen PH,Zou K,Krauss S,Zhong W

更新日期：2004-08-01 00:00:00

abstract：:Cognition can be conceptualized as a set of algorithmic control functions whose real-time deployment determines how an organism stores and uses information to guide thought and action. A subset of these functions is required for goal-directed selection and amplification of sensory signals-broadly referred to as attent...

journal_title：Nature neuroscience

authors： Halassa MM,Kastner S

更新日期：2017-12-01 00:00:00

abstract：:The balance between proliferation and apoptosis is critical for proper development of the nervous system. Yet, little is known about molecules that regulate apoptosis of proliferative neurons. Here we identify a soluble, secreted form of CPG15 expressed in embryonic rat brain regions undergoing rapid proliferation and...

journal_title：Nature neuroscience

authors： Putz U,Harwell C,Nedivi E

更新日期：2005-03-01 00:00:00

abstract：:The amygdala is essential for fear learning and expression. The central amygdala (CeA), once viewed as a passive relay between the amygdala complex and downstream fear effectors, has emerged as an active participant in fear conditioning. However, the mechanism by which CeA contributes to the learning and expression of...

journal_title：Nature neuroscience

authors： Li H,Penzo MA,Taniguchi H,Kopec CD,Huang ZJ,Li B

更新日期：2013-03-01 00:00:00

abstract：:An unknown aspect of behavioral state regulation is how the circadian oscillator of the suprachiasmatic nucleus (SCN) regulates sleep and waking. In this report, we describe the necessary elements for a circuit that provides circadian regulation of arousal. Trans-synaptic retrograde tracing revealed a prominent indire...

journal_title：Nature neuroscience

authors： Aston-Jones G,Chen S,Zhu Y,Oshinsky ML

更新日期：2001-07-01 00:00:00

abstract：:The meaning we derive from our experiences is not a simple static extraction of the elements but is largely based on the order in which those elements occur. Models propose that sequence encoding is supported by interactions between high- and low-frequency oscillations, such that elements within an experience are repr...

journal_title：Nature neuroscience

authors： Heusser AC,Poeppel D,Ezzyat Y,Davachi L

更新日期：2016-10-01 00:00:00

abstract：:Trial-to-trial variability in the blood oxygen level-dependent (BOLD) response of functional magnetic resonance imaging has been shown to be relevant to human perception and behavior, but the sources of this variability remain unknown. We demonstrate that coherent spontaneous fluctuations in human brain activity accou...

journal_title：Nature neuroscience

authors： Fox MD,Snyder AZ,Zacks JM,Raichle ME

更新日期：2006-01-01 00:00:00

abstract：:Radial glial progenitor cells exhibit bidirectional cell cycle-dependent nuclear oscillations. The purpose and underlying mechanism of this unusual 'interkinetic nuclear migration' are poorly understood. We investigated the basis for this behavior by live imaging of nuclei, centrosomes and microtubules in embryonic ra...

journal_title：Nature neuroscience

authors： Tsai JW,Lian WN,Kemal S,Kriegstein AR,Vallee RB

更新日期：2010-12-01 00:00:00

abstract：:The retina of warm-blooded vertebrates is believed to be incapable of neural regeneration. Here we provide evidence that the retina of postnatal chickens has the potential to generate new neurons. In response to acute damage, numerous Müller glia re-entered the cell cycle, and shortly thereafter, expressed CASH-1, Pax...

journal_title：Nature neuroscience

authors： Fischer AJ,Reh TA

更新日期：2001-03-01 00:00:00

abstract：:A brief visual target stimulus may be rendered invisible if it is immediately preceded or followed by another stimulus. This class of illusions, known as visual masking, may allow insights into the neural mechanisms that underlie visual perception. We have therefore explored the temporal characteristics of masking ill...

journal_title：Nature neuroscience

authors： Macknik SL,Livingstone MS

更新日期：1998-06-01 00:00:00

abstract：:We show that a natural behavior, exploration of a novel environment, causes DNA double-strand breaks (DSBs) in neurons of young adult wild-type mice. DSBs occurred in multiple brain regions, were most abundant in the dentate gyrus, which is involved in learning and memory, and were repaired within 24 h. Increasing neu...

journal_title：Nature neuroscience

authors： Suberbielle E,Sanchez PE,Kravitz AV,Wang X,Ho K,Eilertson K,Devidze N,Kreitzer AC,Mucke L

更新日期：2013-05-01 00:00:00

abstract：:Striatal parvalbumin (PV) and cholinergic interneurons (CHIs) are poised to play major roles in behavior by coordinating the networks of medium spiny cells that relay motor output. However, the small numbers and scattered distribution of these cells have hindered direct assessment of their contribution to activity in ...

journal_title：Nature neuroscience

authors： Gritton HJ,Howe WM,Romano MF,DiFeliceantonio AG,Kramer MA,Saligrama V,Bucklin ME,Zemel D,Han X

更新日期：2019-04-01 00:00:00

abstract：:Interleukin 17 (IL-17) is a signature cytokine of Th17 cells. We previously reported that deletion of NF-κB activator 1 (Act1), the key transducer of IL-17 receptor signaling, from the neuroectodermal lineage in mice (neurons, oligodendrocytes and astrocytes) results in attenuated severity of experimental autoimmune e...

journal_title：Nature neuroscience

authors： Kang Z,Wang C,Zepp J,Wu L,Sun K,Zhao J,Chandrasekharan U,DiCorleto PE,Trapp BD,Ransohoff RM,Li X

更新日期：2013-10-01 00:00:00

abstract：:Grid cells in layer II of the medial entorhinal cortex form a principal component of the mammalian neural representation of space. The firing pattern of a single grid cell has been hypothesized to be generated through attractor dynamics in a network with a specific local connectivity including both excitatory and inhi...

journal_title：Nature neuroscience

authors： Couey JJ,Witoelar A,Zhang SJ,Zheng K,Ye J,Dunn B,Czajkowski R,Moser MB,Moser EI,Roudi Y,Witter MP

更新日期：2013-03-01 00:00:00

abstract：:The auditory system encodes sound by decomposing the amplitude signal arriving at the ear into multiple frequency bands whose center frequencies and bandwidths are approximately exponential functions of the distance from the stapes. This organization is thought to result from the adaptation of cochlear mechanisms to t...

journal_title：Nature neuroscience

authors： Lewicki MS

更新日期：2002-04-01 00:00:00

abstract：:Speech and vocal impairments characterize many neurological disorders. However, the neurogenetic mechanisms of these disorders are not well understood, and current animal models do not have the necessary circuitry to recapitulate vocal learning deficits. We developed germline transgenic songbirds, zebra finches (Tanei...

journal_title：Nature neuroscience

authors： Liu WC,Kohn J,Szwed SK,Pariser E,Sepe S,Haripal B,Oshimori N,Marsala M,Miyanohara A,Lee R

更新日期：2015-11-01 00:00:00

abstract：:We report on two brain-damaged subjects who exhibit the uncommon pattern of loss of object color knowledge, but spared color perception and naming. The subject P.C.O., as in previously reported patients, is also impaired in processing other perceptual and functional properties of objects. I.O.C., in contrast, is the f...

journal_title：Nature neuroscience

authors： Miceli G,Fouch E,Capasso R,Shelton JR,Tomaiuolo F,Caramazza A

更新日期：2001-06-01 00:00:00

abstract：:Orchestrating appropriate behavioral responses in the face of competing signals that predict either rewards or threats in the environment is crucial for survival. The basolateral nucleus of the amygdala (BLA) and prelimbic (PL) medial prefrontal cortex have been implicated in reward-seeking and fear-related responses,...

journal_title：Nature neuroscience

authors： Burgos-Robles A,Kimchi EY,Izadmehr EM,Porzenheim MJ,Ramos-Guasp WA,Nieh EH,Felix-Ortiz AC,Namburi P,Leppla CA,Presbrey KN,Anandalingam KK,Pagan-Rivera PA,Anahtar M,Beyeler A,Tye KM

更新日期：2017-06-01 00:00:00

abstract：:Selective serotonin reuptake inhibitors (SSRIs) are widely used antidepressants, but the mechanisms by which they influence behavior are only partially resolved. Adult hippocampal neurogenesis is necessary for some of the responses to SSRIs, but it is not known whether mature dentate gyrus granule cells (DG GCs) also ...

journal_title：Nature neuroscience

authors： Samuels BA,Anacker C,Hu A,Levinstein MR,Pickenhagen A,Tsetsenis T,Madroñal N,Donaldson ZR,Drew LJ,Dranovsky A,Gross CT,Tanaka KF,Hen R

更新日期：2015-11-01 00:00:00

abstract：:High and low spatial frequency information in visual images is processed by distinct neural channels. Using event-related functional magnetic resonance imaging (fMRI) in humans, we show dissociable roles of such visual channels for processing faces and emotional fearful expressions. Neural responses in fusiform cortex...

journal_title：Nature neuroscience

authors： Vuilleumier P,Armony JL,Driver J,Dolan RJ

更新日期：2003-06-01 00:00:00

abstract：:Humans exhibit a remarkable degree of resilience in the face of extreme stress, with most resisting the development of neuropsychiatric disorders. Over the past 5 years, there has been increasing interest in the active, adaptive coping mechanisms of resilience; however, in humans, most published work focuses on correl...

journal_title：Nature neuroscience

authors： Russo SJ,Murrough JW,Han MH,Charney DS,Nestler EJ

更新日期：2012-11-01 00:00:00

abstract：:A long-standing debate in neuroscience is whether classical and operant conditioning are mechanistically similar or distinct. The feeding behavior of Aplysia provides a model system suitable for addressing this question. Here we report that classical and operant conditioning of feeding behavior differentially modify t...

journal_title：Nature neuroscience

authors： Lorenzetti FD,Mozzachiodi R,Baxter DA,Byrne JH

更新日期：2006-01-01 00:00:00

abstract：:Learning and memory are associated with the formation and modification of neuronal assemblies: populations of neurons that encode what has been learned and mediate memory retrieval upon recall. Functional studies of neuronal assemblies have progressed dramatically thanks to recent technological advances. Here we discu...

journal_title：Nature neuroscience

authors： Holtmaat A,Caroni P

更新日期：2016-12-01 00:00:00

abstract：:To investigate how the brain combines knowledge with visual processing to locate eye movement targets, we trained monkeys to search for a target defined by a conjunction of color and shape. On successful trials, neurons in the frontal eye field not only discriminated the target from distractors, but also discriminated...

journal_title：Nature neuroscience

authors： Bichot NP,Schall JD

更新日期：1999-06-01 00:00:00

abstract：:Deciphering the interneuronal circuitry is central to understanding brain functions, yet it remains a challenging task in neurobiology. Using simultaneous quadruple-octuple in vitro and dual in vivo whole-cell recordings, we found two previously unknown interneuronal circuits that link cortical layer 1-3 (L1-3) intern...

journal_title：Nature neuroscience

authors： Jiang X,Wang G,Lee AJ,Stornetta RL,Zhu JJ

更新日期：2013-02-01 00:00:00

abstract：:Humans, and animals, often encounter ambiguous situations that require a decision on whether to take an offense or a defense strategy. Behavioral studies suggest that a strategy decision is frequently made before concrete options are evaluated. It remains enigmatic, however, how a strategy is determined without explor...

journal_title：Nature neuroscience

authors： Wan X,Cheng K,Tanaka K

更新日期：2015-05-01 00:00:00