Abstract：
:Tau protein can transfer between neurons transneuronally and trans-synaptically, which is thought to explain the progressive spread of tauopathy observed in the brain of patients with Alzheimer's disease. Here we show that physiological tau released from donor cells can transfer to recipient cells via the medium, suggesting that at least one mechanism by which tau can transfer is via the extracellular space. Neuronal activity has been shown to regulate tau secretion, but its effect on tau pathology is unknown. Using optogenetic and chemogenetic approaches, we found that increased neuronal activity stimulates the release of tau in vitro and enhances tau pathology in vivo. These data have implications for disease pathogenesis and therapeutic strategies for Alzheimer's disease and other tauopathies.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Wu JW,Hussaini SA,Bastille IM,Rodriguez GA,Mrejeru A,Rilett K,Sanders DW,Cook C,Fu H,Boonen RA,Herman M,Nahmani E,Emrani S,Figueroa YH,Diamond MI,Clelland CL,Wray S,Duff KEdoi
10.1038/nn.4328subject
Has Abstractpub_date
2016-08-01 00:00:00pages
1085-92issue
8eissn
1097-6256issn
1546-1726pii
nn.4328journal_volume
19pub_type
杂志文章abstract：:During development, the mammalian ventral telencephalon is comprised of three major proliferative zones: the medial (MGE), lateral (LGE) and caudal (CGE) ganglionic eminences. Through gene expression studies, in vitro migration assays, genetic mutant analysis and in vivo fate mapping in mice, we found that the CGE is ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn971
更新日期：2002-12-01 00:00:00
abstract：:Speech and vocal impairments characterize many neurological disorders. However, the neurogenetic mechanisms of these disorders are not well understood, and current animal models do not have the necessary circuitry to recapitulate vocal learning deficits. We developed germline transgenic songbirds, zebra finches (Tanei...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4133
更新日期：2015-11-01 00:00:00
abstract：:A brief visual target stimulus may be rendered invisible if it is immediately preceded or followed by another stimulus. This class of illusions, known as visual masking, may allow insights into the neural mechanisms that underlie visual perception. We have therefore explored the temporal characteristics of masking ill...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/393
更新日期：1998-06-01 00:00:00
abstract：:Microglia are primary immune sentinels of the CNS. Following injury, these cells migrate or extend processes toward sites of tissue damage. CNS injury is accompanied by release of nucleotides, serving as signals for microglial activation or chemotaxis. Microglia express several purinoceptors, including a G(i)-coupled ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1805
更新日期：2006-12-01 00:00:00
abstract：:Although much learning occurs through direct experience of errors, humans and other animals can learn from the errors of other individuals. The medial frontal cortex (MFC) processes self-generated errors, but the neuronal architecture and mechanisms underlying the monitoring of others' errors are poorly understood. Ex...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3180
更新日期：2012-09-01 00:00:00
abstract：:Vesicular release of neurotransmitter is the universal output signal of neurons in the brain. It is generally believed that fast transmitter release is restricted to nerve terminals that contact postsynaptic cells in the gray matter. Here we show in the rat brain that the neurotransmitter glutamate is also released at...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1850
更新日期：2007-03-01 00:00:00
abstract：:It is often assumed that all neurons of the same cell type have identical intrinsic properties, both within an animal and between animals. We exploited the large size and small number of unambiguously identifiable neurons in the crab stomatogastric ganglion to test this assumption at the level of channel mRNA expressi...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1639
更新日期：2006-03-01 00:00:00
abstract：:The accessory olfactory bulb (AOB) is a critical olfactory structure that has been implicated in mediating social behavior. It receives input from the vomeronasal organ and projects to targets in the amygdaloid complex. Its anterior and posterior components (aAOB and pAOB) display molecular, connectional and functiona...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3297
更新日期：2013-02-01 00:00:00
abstract：:In the cat primary visual cortex, neurons are classified into the two main categories of simple cells and complex cells based on their response properties. According to the hierarchical model, complex receptive fields derive from convergent inputs of simple cells with similar orientation preferences. This model receiv...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/1609
更新日期：1998-09-01 00:00:00
abstract：:Human neurodegenerative disorders are among the most difficult to study. In particular, the inability to readily obtain the faulty cell types most relevant to these diseases has impeded progress for decades. Recent advances in pluripotent stem cell technology now grant access to substantial quantities of disease-perti...
journal_title：Nature neuroscience
pub_type： 杂志文章,评审
doi：10.1038/nn.3425
更新日期：2013-07-01 00:00:00
abstract：:We report a systematic relationship between sound-frequency tuning and sensitivity to interaural time delays for neurons in the midbrain nucleus of the inferior colliculus; neurons with relatively low best frequencies (BFs) showed response peaks at long delays, whereas neurons with relatively high BFs showed response ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/86049
更新日期：2001-04-01 00:00:00
abstract：:Head-direction cells have frequently been regarded as an internal 'compass' that can be used for navigation, although there is little evidence showing a link between their activity and spatial behavior. In a navigational task requiring the use of internal cues to return to a home location without vision (path integrat...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3215
更新日期：2012-10-01 00:00:00
abstract：:The ventral intraparietal area (VIP) receives converging inputs from visual, somatosensory, auditory and vestibular systems that use diverse reference frames to encode sensory information. A key issue is how VIP combines those inputs together. We mapped the visual and tactile receptive fields of multimodal VIP neurons...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1480
更新日期：2005-07-01 00:00:00
abstract：:Leucine-rich repeat kinase 2 (LRRK2) is enriched in the striatal projection neurons (SPNs). We found that LRRK2 negatively regulates protein kinase A (PKA) activity in the SPNs during synaptogenesis and in response to dopamine receptor Drd1 activation. LRRK2 interacted with PKA regulatory subunit IIβ (PKARIIβ). A lack...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3636
更新日期：2014-03-01 00:00:00
abstract：:In the version of this article initially published, paragraph 8 mentioned intra-accumbens administration of SB334867. This should have read systemic (intraperitoneal) administration. The error has been corrected in the HTML and PDF versions of the article. ...
journal_title：Nature neuroscience
pub_type： 已发布勘误
doi：10.1038/s41593-018-0111-7
更新日期：2018-06-01 00:00:00
abstract：:Continuous, predictable events and spontaneous events may coincide in the visual environment. For a continuously moving object, the brain compensates for delays in transmission between a retinal event and neural responses in higher visual areas. Here we show that it similarly compensated for other smoothly changing fe...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/74865
更新日期：2000-05-01 00:00:00
abstract：:Sleep can strengthen memory for emotional information, but whether emotional memories can be specifically targeted and modified during sleep is unknown. In human subjects who underwent olfactory contextual fear conditioning, re-exposure to the odorant context in slow-wave sleep promoted stimulus-specific fear extincti...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3527
更新日期：2013-11-01 00:00:00
abstract：:Illusions that produce perceptual suppression despite constant retinal input are used to manipulate visual consciousness. Here we report on a powerful variant of existing techniques, continuous flash suppression. Distinct images flashed successively at approximately 10 Hz into one eye reliably suppress an image presen...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1500
更新日期：2005-08-01 00:00:00
abstract：:Trafficking of AMPA receptors (AMPARs) is important for many forms of synaptic plasticity. However, the link between activity and resulting synaptic alterations is not fully understood. We identified a direct interaction between N-ethylmaleimide-sensitive fusion protein (NSF), an ATPase involved in membrane fusion eve...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2624
更新日期：2010-10-01 00:00:00
abstract：:The painful sensations produced by a laceration, freeze, burn, muscle strain or internal injury are readily distinguishable because each is characterized by a particular sensory quality such as sharp, aching, burning or prickling. We propose that there are specific neural correlates of each pain quality, and here we u...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn955
更新日期：2002-11-01 00:00:00
abstract：:Visual information is delivered to the brain by >40 types of retinal ganglion cells (RGCs). Diversity in this representation arises within the inner plexiform layer (IPL), where dendrites of each RGC type are restricted to specific sublaminae, limiting the interneuronal types that can innervate them. How such dendriti...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-018-0127-z
更新日期：2018-05-01 00:00:00
abstract：:In this Perspective, we expand the notion of temporal regulation of RNA in the brain and propose that the qualitative nature of RNA and its metabolism, together with RNA abundance, are essential for the molecular mechanisms underlying experience-dependent plasticity. We discuss emerging concepts in the newly burgeonin...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4378
更新日期：2016-09-27 00:00:00
abstract：:Most neurons receive thousands of synaptic inputs onto widely spread dendrites. Because of dendritic filtering, distant synapses should have less efficacy than proximal ones. To investigate this, we characterized the amplitude and kinetics of excitatory synaptic input across the apical dendrites of CA1 pyramidal neuro...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/78800
更新日期：2000-09-01 00:00:00
abstract：:The amygdala is essential for fear learning and expression. The central amygdala (CeA), once viewed as a passive relay between the amygdala complex and downstream fear effectors, has emerged as an active participant in fear conditioning. However, the mechanism by which CeA contributes to the learning and expression of...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3322
更新日期：2013-03-01 00:00:00
abstract：:Basal dendrites receive the majority of synapses that contact neocortical pyramidal neurons, yet our knowledge of synaptic processing in these dendrites has been hampered by their inaccessibility for electrical recordings. A new approach to patch-clamp recordings enabled us to characterize the integrative properties o...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1826
更新日期：2007-02-01 00:00:00
abstract：:The growth of neurites (axon and dendrite) should be appropriately regulated by their interactions in the development of nervous systems where a myriad of neurons and their neurites are tightly packed. We show here that mammalian seven-pass transmembrane cadherins Celsr2 and Celsr3 are activated by their homophilic in...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1933
更新日期：2007-08-01 00:00:00
abstract：:Glycine receptors (GlyRs), together with GABA(A) and nicotinic acetylcholine (ACh) receptors, form part of the ligand-activated ion channel superfamily and regulate the excitability of the mammalian brain stem and spinal cord. Here we report that the ability of the neurotransmitter glycine to gate recombinant and nati...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1095
更新日期：2003-08-01 00:00:00
abstract：:Fast desensitization is an important regulatory mechanism of neuronal NMDA receptor function. Only recombinant NMDA receptors composed of NR1/NR2A exhibit a fast component of desensitization similar to neuronal NMDA receptors. Here we report that the fast desensitization of NR1/NR2A receptors is caused by ambient zinc...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn0901-894
更新日期：2001-09-01 00:00:00
abstract：:Human observers adapted to complex biological motions that distinguish males from females: viewing the gait of one gender biased judgments of subsequent gaits toward the opposite gender. This adaptation was not simply due to local features of the stimuli but instead relied upon the global motion of the figures. These ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1710
更新日期：2006-06-01 00:00:00
abstract：:The output of cortical columns is routed to different downstream targets via distinct pathways: cortico-cortical and cortico-subcortical. It is as yet unclear what roles these pathways play in perception, and which cellular and circuit mechanisms regulate their gating. We recently showed that activation of the apical ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-020-0677-8
更新日期：2020-10-01 00:00:00
