Abstract:
:In the version of this article initially published, paragraph 8 mentioned intra-accumbens administration of SB334867. This should have read systemic (intraperitoneal) administration. The error has been corrected in the HTML and PDF versions of the article.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Mahler SVdoi
10.1038/s41593-018-0111-7subject
Has Abstractpub_date
2018-06-01 00:00:00pages
894issue
6eissn
1097-6256issn
1546-1726pii
10.1038/s41593-018-0111-7journal_volume
21pub_type
已发布勘误abstract::Age-related decreases in neural function result in part from alterations in synapses. To identify molecular defects that lead to such changes, we focused on the outer retina, in which synapses are markedly altered in old rodents and humans. We found that the serine/threonine kinase LKB1 and one of its substrates, AMPK...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3772
更新日期:2014-09-01 00:00:00
abstract::Cue-triggered recall of learned temporal sequences is an important cognitive function that has been attributed to higher brain areas. Here recordings in both anesthetized and awake rats demonstrate that after repeated stimulation with a moving spot that evoked sequential firing of an ensemble of primary visual cortex ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3036
更新日期:2012-01-22 00:00:00
abstract::The healthy human brain is a mosaic of varied genomes. Long interspersed element-1 (LINE-1 or L1) retrotransposition is known to create mosaicism by inserting L1 sequences into new locations of somatic cell genomes. Using a machine learning-based, single-cell sequencing approach, we discovered that somatic L1-associat...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.4388
更新日期:2016-12-01 00:00:00
abstract::Learning to adapt to a complex and fluctuating environment requires the ability to adjust neural representations of sensory stimuli. Through pattern completion processes, cortical networks can reconstruct familiar patterns from degraded input patterns, whereas pattern separation processes allow discrimination of even ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2966
更新日期:2011-11-20 00:00:00
abstract::The painful sensations produced by a laceration, freeze, burn, muscle strain or internal injury are readily distinguishable because each is characterized by a particular sensory quality such as sharp, aching, burning or prickling. We propose that there are specific neural correlates of each pain quality, and here we u...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn955
更新日期:2002-11-01 00:00:00
abstract::A central neuroscientific pursuit is understanding neuronal interactions that support computations underlying cognition and behavior. Although neurons interact across disparate scales, from cortical columns to whole-brain networks, research has been restricted to one scale at a time. We measured local interactions thr...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3979
更新日期:2015-05-01 00:00:00
abstract::Synaptic strength can be altered by a variety of pre- or postsynaptic modifications. Here we test the hypothesis that long-term depression (LTD) involves a decrease in the number of glutamate receptors that are clustered at individual synapses in primary cultures of hippocampal neurons. Similar to a prominent form of ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/8123
更新日期:1999-05-01 00:00:00
abstract::Neurons in thalamorecipient layers of sensory cortices integrate thalamocortical and intracortical inputs. Although we know that their functional properties can arise from the convergence of thalamic inputs, intracortical circuits could also be involved in thalamocortical transformations of sensory information. We sil...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3494
更新日期:2013-09-01 00:00:00
abstract::Cocaine is a widely abused substance with psychostimulant effects that are attributed to inhibition of the dopamine transporter (DAT). We present molecular models for DAT binding of cocaine and cocaine analogs constructed from the high-resolution structure of the bacterial transporter homolog LeuT. Our models suggest ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2146
更新日期:2008-07-01 00:00:00
abstract::Understanding a sensory system implies the ability to predict responses to a variety of inputs from a common model. In the retina, this includes predicting how the integration of signals across visual space shapes the outputs of retinal ganglion cells. Existing models of this process generalize poorly to predict respo...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3225
更新日期:2012-11-01 00:00:00
abstract::T cells clear virus from the CNS and dynamically regulate brain functions, including spatial learning, through cytokine signaling. Here we determined whether hippocampal T cells that persist after recovery from infection with West Nile virus (WNV) or Zika virus (ZIKV) impact hippocampal-dependent learning and memory. ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/s41593-019-0427-y
更新日期:2019-08-01 00:00:00
abstract::Parvalbumin-positive GABAergic interneurons in cortical circuits are hypothesized to control cognitive function. To test this idea directly, we functionally removed parvalbumin-positive interneurons selectively from hippocampal CA1 in mice. We found that parvalbumin-positive interneurons are dispensable for spatial re...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2751
更新日期:2011-03-01 00:00:00
abstract::Neural-derived signals are crucial regulators of CNS vascularization. However, whether the vasculature responds to these signals by means of elongating and branching or in addition by building a feedback response to modulate neurodevelopmental processes remains unknown. In this study, we identified bidirectional cross...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/s41593-020-00788-z
更新日期:2021-01-28 00:00:00
abstract::Axon guidance cues contributing to the development of eye-specific visual projections to the lateral geniculate nucleus (LGN) have not previously been identified. Here we show that gradients of ephrin-As and their receptors (EphAs) direct retinal ganglion cell (RGC) axons from the two eyes into their stereotyped patte...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1505
更新日期:2005-08-01 00:00:00
abstract::Communication plays an integral role in human social dynamics and is impaired in several neurodevelopmental disorders. Mice are used to study the neurobiology of social behavior; however, the extent to which mouse vocalizations influence social dynamics has remained elusive because it is difficult to identify the voca...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/s41593-020-0584-z
更新日期:2020-03-01 00:00:00
abstract::Lateral and medial parts of entorhinal cortex (EC) convey nonspatial 'what' and spatial 'where' information, respectively, into hippocampal CA1, via both the indirect EC layer 2→ hippocampal dentate gyrus→CA3→CA1 and the direct EC layer 3→CA1 paths. However, it remains elusive how the direct path transfers distinct in...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.4517
更新日期:2017-04-01 00:00:00
abstract::It is widely held that color and motion are processed by separate parallel pathways in the visual system, but this view is difficult to reconcile with the fact that motion can be detected in equiluminant stimuli that are defined by color alone. To examine the relationship between color and motion, we tested three pati...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/688
更新日期:1998-07-01 00:00:00
abstract::Previous studies suggested that MeCP2 competes with linker histone H1, but this hypothesis has never been tested in vivo. Here, we performed chromatin immunoprecipitation followed by sequencing (ChIP-seq) of Flag-tagged-H1.0 in mouse forebrain excitatory neurons. Unexpectedly, Flag-H1.0 and MeCP2 occupied similar geno...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/s41593-018-0155-8
更新日期:2018-06-01 00:00:00
abstract::The efficiency of remyelination decreases with age, but the molecular mechanisms responsible for this decline remain only partially understood. In this study, we show that remyelination is regulated by age-dependent epigenetic control of gene expression. In demyelinated young brains, new myelin synthesis is preceded b...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2172
更新日期:2008-09-01 00:00:00
abstract::Active sensation requires the convergence of external stimuli with representations of body movements. We used mouse behavior, electrophysiology and optogenetics to dissect the temporal interactions among whisker movement, neural activity and sensation of touch. We photostimulated layer 4 activity in single barrels in ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3419
更新日期:2013-07-01 00:00:00
abstract::The control of cell fate in neural progenitor cells is critical for nervous system development. Nevertheless, the processes involved are only partially known. We found that the expression of the tumor suppressor Pml was restricted to neural progenitor cells (NPCs) in the developing neocortex of the mouse. Notably, in ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2251
更新日期:2009-02-01 00:00:00
abstract::Economic choice entails assigning values to the available options and is impaired by lesions to the orbitofrontal cortex (OFC). Recent results show that some neurons in the OFC encode the values that monkeys (Macaca mulatta) assign to different goods when they choose between them. A broad and fundamental question is h...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn2020
更新日期:2008-01-01 00:00:00
abstract::Spinal cord injury (SCI) at high spinal levels (e.g., above thoracic level 5) causes systemic immune suppression; however, the underlying mechanisms are unknown. Here we show that profound plasticity develops within spinal autonomic circuitry below the injury, creating a sympathetic anti-inflammatory reflex, and that ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.4289
更新日期:2016-06-01 00:00:00
abstract::We introduce a deceptively simple behavioral task that robustly identifies two qualitatively different groups within the general population. When presented with an isochronous train of random syllables, some listeners are compelled to align their own concurrent syllable production with the perceived rate, whereas othe...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/s41593-019-0353-z
更新日期:2019-04-01 00:00:00
abstract::Previous gene knockout studies have shown that the orphan glutamate receptor delta2 (GluRdelta2) is critically involved in synaptogenesis between parallel fibers and Purkinje cells during development. However, the precise function of GluRdelta2 and whether it is functional in the mature cerebellum remain unclear. To a...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1086
更新日期:2003-08-01 00:00:00
abstract::Oxytocin is an essential hormone for mammalian labor and lactation. Here, we show a new function of oxytocin in causing plastic changes in hippocampal synapses during motherhood. In oxytocin-perfused hippocampal slices, one-train tetanus stimulation induced long-lasting, long-term potentiation (L-LTP) and phosphorylat...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1023
更新日期:2003-04-01 00:00:00
abstract::In this Perspective, we expand the notion of temporal regulation of RNA in the brain and propose that the qualitative nature of RNA and its metabolism, together with RNA abundance, are essential for the molecular mechanisms underlying experience-dependent plasticity. We discuss emerging concepts in the newly burgeonin...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.4378
更新日期:2016-09-27 00:00:00
abstract::Transposable elements, known colloquially as 'jumping genes', constitute approximately 45% of the human genome. Cells utilize epigenetic defenses to limit transposable element jumping, including formation of silencing heterochromatin and generation of piwi-interacting RNAs (piRNAs), small RNAs that facilitate clearanc...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/s41593-018-0194-1
更新日期:2018-08-01 00:00:00
abstract::The CNS, which consists of the brain and spinal cord, is continuously monitored by resident microglia and blood-borne immune cells such as macrophages, dendritic cells and T cells to detect for damaging agents that would disrupt homeostasis and optimal functioning of these vital organs. Further, the CNS must balance b...
journal_title:Nature neuroscience
pub_type: 杂志文章,评审
doi:10.1038/nn.3161
更新日期:2012-07-26 00:00:00
abstract::The subunit composition of postsynaptic non-NMDA-type glutamate receptors (GluRs) determines the function and trafficking of the receptor. Changes in GluR composition have been implicated in the homeostasis of neuronal excitability and synaptic plasticity underlying learning. Here, we imaged GluRs in vivo during the f...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2122
更新日期:2008-06-01 00:00:00