Activity-dependent site-specific changes of glutamate receptor composition in vivo.

abstract：:Some neurons in auditory cortex respond to recent stimulus history by adapting their response functions to track stimulus statistics directly, as might be expected. In contrast, some neurons respond to loud sounds by adjusting their response functions away from high intensities and consequently remain sensitive to sof...

journal_title：Nature neuroscience

authors： Watkins PV,Barbour DL

更新日期：2008-11-01 00:00:00

abstract：:Several ion channels are thought to be directly modulated by nitric oxide (NO), but the molecular basis of this regulation is unclear. Here we show that the NMDA receptor (NMDAR)-associated ion channel was modulated not only by exogenous NO but also by endogenous NO. Site-directed mutagenesis identified a critical cys...

journal_title：Nature neuroscience

authors： Choi YB,Tenneti L,Le DA,Ortiz J,Bai G,Chen HS,Lipton SA

更新日期：2000-01-01 00:00:00

abstract：:It has been debated whether orientation selectivity in mouse primary visual cortex (V1) is derived from tuned lateral geniculate nucleus (LGN) inputs or computed from untuned LGN inputs. However, few studies have measured orientation tuning of LGN axons projecting to V1. We measured the response properties of mouse LG...

journal_title：Nature neuroscience

authors： Kondo S,Ohki K

更新日期：2016-02-01 00:00:00

abstract：:Humans have ~400 intact odorant receptors, but each individual has a unique set of genetic variations that lead to variation in olfactory perception. We used a heterologous assay to determine how often genetic polymorphisms in odorant receptors alter receptor function. We identified agonists for 18 odorant receptors a...

journal_title：Nature neuroscience

authors： Mainland JD,Keller A,Li YR,Zhou T,Trimmer C,Snyder LL,Moberly AH,Adipietro KA,Liu WL,Zhuang H,Zhan S,Lee SS,Lin A,Matsunami H

更新日期：2014-01-01 00:00:00

abstract：:Uncovering the functional relationship between temporal lobe amnesia and diencephalic amnesia depends on determining the role of the fornix, the major interlinking fiber tract. In this study relating fornix volume with memory, we made magnetic resonance imaging-based volume estimates of 13 brain structures in 38 indiv...

journal_title：Nature neuroscience

authors： Tsivilis D,Vann SD,Denby C,Roberts N,Mayes AR,Montaldi D,Aggleton JP

更新日期：2008-07-01 00:00:00

abstract：:An ion channel's function depends largely on its location and density on neurons. Here we used high-resolution immunolocalization to determine the subcellular distribution of the hyperpolarization-activated and cyclic-nucleotide-gated channel subunit 1 (HCN1) in rat brain. Light microscopy revealed graded HCN1 immunor...

journal_title：Nature neuroscience

authors： Lörincz A,Notomi T,Tamás G,Shigemoto R,Nusser Z

更新日期：2002-11-01 00:00:00

abstract：:In neocortical circuits, repetitively active neurons evoke unitary postsynaptic potentials (PSPs) whose peak amplitudes either increase (facilitate) or decrease (depress) progressively. To examine the basis for these different synaptic responses, we made simultaneous recordings from three classes of neurons in cortica...

journal_title：Nature neuroscience

authors： Reyes A,Lujan R,Rozov A,Burnashev N,Somogyi P,Sakmann B

更新日期：1998-08-01 00:00:00

abstract：:Leucine-rich repeat kinase 2 (LRRK2) is enriched in the striatal projection neurons (SPNs). We found that LRRK2 negatively regulates protein kinase A (PKA) activity in the SPNs during synaptogenesis and in response to dopamine receptor Drd1 activation. LRRK2 interacted with PKA regulatory subunit IIβ (PKARIIβ). A lack...

journal_title：Nature neuroscience

authors： Parisiadou L,Yu J,Sgobio C,Xie C,Liu G,Sun L,Gu XL,Lin X,Crowley NA,Lovinger DM,Cai H

更新日期：2014-03-01 00:00:00

abstract：:Phasic activation of the dopamine (DA) midbrain system in response to unexpected reward or novelty is critical for adaptive behavioral strategies. This activation of DA midbrain neurons occurs via a synaptically triggered switch from low-frequency background spiking to transient high-frequency burst firing. We found t...

journal_title：Nature neuroscience

authors： Schiemann J,Schlaudraff F,Klose V,Bingmer M,Seino S,Magill PJ,Zaghloul KA,Schneider G,Liss B,Roeper J

更新日期：2012-09-01 00:00:00

abstract：:Entorhinal grid cells in mammals fire as a function of animal location, with spatially periodic response patterns. This nonlocal periodic representation of location, a local variable, is unlike other neural codes. There is no theoretical explanation for why such a code should exist. We examined how accurately the grid...

journal_title：Nature neuroscience

authors： Sreenivasan S,Fiete I

更新日期：2011-09-11 00:00:00

abstract：:Synaptic cadherin adhesion complexes are known to be key regulators of synapse plasticity. However, the molecular mechanisms that coordinate activity-induced modifications in cadherin localization and adhesion and the subsequent changes in synapse morphology and efficacy remain unknown. We demonstrate that the intrace...

journal_title：Nature neuroscience

authors： Brigidi GS,Sun Y,Beccano-Kelly D,Pitman K,Mobasser M,Borgland SL,Milnerwood AJ,Bamji SX

更新日期：2014-04-01 00:00:00

abstract：:Most neurons receive thousands of synaptic inputs onto widely spread dendrites. Because of dendritic filtering, distant synapses should have less efficacy than proximal ones. To investigate this, we characterized the amplitude and kinetics of excitatory synaptic input across the apical dendrites of CA1 pyramidal neuro...

journal_title：Nature neuroscience

authors： Magee JC,Cook EP

更新日期：2000-09-01 00:00:00

abstract：:The specification of area identities in the cerebral cortex is a complex process, primed by intrinsic cortical cues and refined after the arrival of afferent fibers from the thalamus. Little is known about the genetic control of the early steps of this process, but the distinctive expression pattern of the homeogene E...

journal_title：Nature neuroscience

authors： Mallamaci A,Muzio L,Chan CH,Parnavelas J,Boncinelli E

更新日期：2000-07-01 00:00:00

abstract：:Brain-derived neurotrophic factor (BDNF) acting through the tyrosine kinase B receptor (TrkB) is thought to be a critical mediator of learning. As there are no available selective antagonists of TrkB, we used a lentivirus encoding a dominant-negative TrkB (TrkB.t1) to antagonize BDNF signaling during extinction of con...

journal_title：Nature neuroscience

authors： Chhatwal JP,Stanek-Rattiner L,Davis M,Ressler KJ

更新日期：2006-07-01 00:00:00

abstract：:A picture viewed from its center of projection generates the same retinal image as the original scene, so the viewer perceives the scene correctly. When a picture is viewed from other locations, the retinal image specifies a different scene, but we normally do not notice the changes. We investigated the mechanism unde...

journal_title：Nature neuroscience

authors： Vishwanath D,Girshick AR,Banks MS

更新日期：2005-10-01 00:00:00

abstract：:Striatal parvalbumin (PV) and cholinergic interneurons (CHIs) are poised to play major roles in behavior by coordinating the networks of medium spiny cells that relay motor output. However, the small numbers and scattered distribution of these cells have hindered direct assessment of their contribution to activity in ...

journal_title：Nature neuroscience

authors： Gritton HJ,Howe WM,Romano MF,DiFeliceantonio AG,Kramer MA,Saligrama V,Bucklin ME,Zemel D,Han X

更新日期：2019-04-01 00:00:00

abstract：:Hippocampal long-term potentiation (LTP) induced by theta-burst pairing of Schaffer collateral inputs and postsynaptic firing is associated with localized increases in synaptic strength and dendritic excitability. Using the same protocol, we now demonstrate a decrease in cellular excitability that was blocked by the h...

journal_title：Nature neuroscience

authors： Fan Y,Fricker D,Brager DH,Chen X,Lu HC,Chitwood RA,Johnston D

更新日期：2005-11-01 00:00:00

abstract：:Independent evidence associates β-amyloid pathology with both non-rapid eye movement (NREM) sleep disruption and memory impairment in older adults. However, whether the influence of β-amyloid pathology on hippocampus-dependent memory is, in part, driven by impairments of NREM slow wave activity (SWA) and associated ov...

journal_title：Nature neuroscience

authors： Mander BA,Marks SM,Vogel JW,Rao V,Lu B,Saletin JM,Ancoli-Israel S,Jagust WJ,Walker MP

更新日期：2015-07-01 00:00:00

abstract：:A decade after speech was first decoded from human brain signals, accuracy and speed remain far below that of natural speech. Here we show how to decode the electrocorticogram with high accuracy and at natural-speech rates. Taking a cue from recent advances in machine translation, we train a recurrent neural network t...

journal_title：Nature neuroscience

authors： Makin JG,Moses DA,Chang EF

更新日期：2020-04-01 00:00:00

abstract：:Huntington's disease (HD) is caused by an expansion of exonic CAG triplet repeats in the gene encoding huntingtin protein (Htt), but the mechanisms by which this mutant protein causes neurodegeneration remain unknown. Here we show that lymphoblast mitochondria from patients with HD have a lower membrane potential and ...

journal_title：Nature neuroscience

authors： Panov AV,Gutekunst CA,Leavitt BR,Hayden MR,Burke JR,Strittmatter WJ,Greenamyre JT

更新日期：2002-08-01 00:00:00

abstract：:Every year in the United States, an estimated 500,000 babies are born preterm (before 37 completed weeks of gestation), and this number is rising, along with the recognition of brain injuries due to preterm delivery. A common underlying pathogenesis appears to be perinatal hypoxia induced by immature lung development,...

journal_title：Nature neuroscience

authors： Salmaso N,Jablonska B,Scafidi J,Vaccarino FM,Gallo V

更新日期：2014-03-01 00:00:00

abstract：:Exposure to an enriched environment increases neurogenesis in the dentate gyrus of adult rodents. Environmental enrichment, however, typically consists of many components, such as expanded learning opportunities, increased social interaction, more physical activity and larger housing. We attempted to separate componen...

journal_title：Nature neuroscience

authors： van Praag H,Kempermann G,Gage FH

更新日期：1999-03-01 00:00:00

abstract：:Nucleus accumbens (NAc) dopamine is widely implicated in mediating the reinforcing effects of drugs of abuse. However, the precise function of the NAc itself in drug self-administration has been difficult to establish. Here we show a neural double-dissociation of the behavioral processes that underlie cocaine self-adm...

journal_title：Nature neuroscience

authors： Ito R,Robbins TW,Everitt BJ

更新日期：2004-04-01 00:00:00

abstract：:How different are the neuronal circuits for a given behavior across individual animals? To address this question, we measured multiple cellular and synaptic parameters in individual preparations to see how they correlated with circuit function, using neurons and synapses in the pyloric circuit of the stomatogastric ga...

journal_title：Nature neuroscience

authors： Goaillard JM,Taylor AL,Schulz DJ,Marder E

更新日期：2009-11-01 00:00:00

abstract：:Nature Neuroscience presents a special issue of recent advances on shared mechanisms underlying neurodegenerative disease. ...

journal_title：Nature neuroscience

authors：

更新日期：2018-10-01 00:00:00

abstract：:We introduce a deceptively simple behavioral task that robustly identifies two qualitatively different groups within the general population. When presented with an isochronous train of random syllables, some listeners are compelled to align their own concurrent syllable production with the perceived rate, whereas othe...

journal_title：Nature neuroscience

authors： Assaneo MF,Ripollés P,Orpella J,Lin WM,de Diego-Balaguer R,Poeppel D

更新日期：2019-04-01 00:00:00

abstract：:Recent imaging studies show that the formation of neural connections in the central nervous system is a highly dynamic process. The iterative formation and elimination of synapses and neuronal branches result in the formation of a much larger number of trial connections than is maintained in the mature brain. Neural a...

journal_title：Nature neuroscience

authors： Hua JY,Smith SJ

更新日期：2004-04-01 00:00:00

abstract：:We examined the contribution of 5-HT1A autoreceptors (with [11C]WAY100635 positron emission tomography) to amygdala reactivity (with blood oxygenation level-dependent functional magnetic resonance imaging) in 20 healthy adult volunteers. We found a significant inverse relationship wherein 5-HT1A autoreceptor density p...

journal_title：Nature neuroscience

authors： Fisher PM,Meltzer CC,Ziolko SK,Price JC,Moses-Kolko EL,Berga SL,Hariri AR

更新日期：2006-11-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease whose causes are still poorly understood. To identify additional genetic risk factors, we assessed the role of de novo mutations in ALS by sequencing the exomes of 47 ALS patients and both of their unaffected parents (n = 141 exomes). We fo...

journal_title：Nature neuroscience

authors： Chesi A,Staahl BT,Jovičić A,Couthouis J,Fasolino M,Raphael AR,Yamazaki T,Elias L,Polak M,Kelly C,Williams KL,Fifita JA,Maragakis NJ,Nicholson GA,King OD,Reed R,Crabtree GR,Blair IP,Glass JD,Gitler AD

更新日期：2013-07-01 00:00:00

abstract：:Over the last 10 years, optogenetics has become widespread in neuroscience for the study of how specific cell types contribute to brain functions and brain disorder states. The full impact of optogenetics will emerge only when other toolsets mature, including neural connectivity and cell phenotyping tools and neural r...

journal_title：Nature neuroscience

authors： Boyden ES

更新日期：2015-09-01 00:00:00