Abstract：
:Several ion channels are thought to be directly modulated by nitric oxide (NO), but the molecular basis of this regulation is unclear. Here we show that the NMDA receptor (NMDAR)-associated ion channel was modulated not only by exogenous NO but also by endogenous NO. Site-directed mutagenesis identified a critical cysteine residue (Cys 399) on the NR2A subunit whose S-nitrosylation (NO+ transfer) under physiological conditions underlies this modulation. In cell systems expressing NMDARs with mutant NR2A subunits in which this single cysteine was replaced by an alanine, the effect of endogenous NO was lost. Thus endogenous S-nitrosylation can regulate ion channel activity.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Choi YB,Tenneti L,Le DA,Ortiz J,Bai G,Chen HS,Lipton SAdoi
10.1038/71090subject
Has Abstractpub_date
2000-01-01 00:00:00pages
15-21issue
1eissn
1097-6256issn
1546-1726journal_volume
3pub_type
杂志文章abstract：:Most neurons receive thousands of synaptic inputs onto widely spread dendrites. Because of dendritic filtering, distant synapses should have less efficacy than proximal ones. To investigate this, we characterized the amplitude and kinetics of excitatory synaptic input across the apical dendrites of CA1 pyramidal neuro...
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