Abstract:
:Studies of populations of receptor proteins suggest that their number and location are highly regulated. Single-particle tracking of glycine receptors now reveals the direct movement of receptors between different clusters of the anchoring protein gephyrin.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Craig AM,Lichtman JWdoi
10.1038/85042subject
Has Abstractpub_date
2001-03-01 00:00:00pages
219-20issue
3eissn
1097-6256issn
1546-1726pii
85042journal_volume
4pub_type
评论,杂志文章,评审abstract::Evaluating social others requires processing complex information. Nevertheless, we can rapidly form an opinion of an individual during an initial encounter. Moreover, people can vary in these opinions, even though the same information is provided. We investigated the brain mechanisms that give rise to the impressions ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2278
更新日期:2009-04-01 00:00:00
abstract::Mammalian hearing owes its remarkable sensitivity and frequency selectivity to a local mechanical feedback process within the cochlea. Cochlear outer hair cells (OHCs) function as the key elements in the feedback loop in which the fast somatic motility of OHCs is thought to be the source of cochlear amplification. An ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1509
更新日期:2005-08-01 00:00:00
abstract::The identity of specific cell types in the nervous system is defined by the expression of neuron type-specific gene batteries. How the expression of such batteries is initiated during nervous system development has been under intensive study over the past few decades. However, comparatively little is known about how g...
journal_title:Nature neuroscience
pub_type: 杂志文章,评审
doi:10.1038/nn.3731
更新日期:2014-07-01 00:00:00
abstract::We report a systematic relationship between sound-frequency tuning and sensitivity to interaural time delays for neurons in the midbrain nucleus of the inferior colliculus; neurons with relatively low best frequencies (BFs) showed response peaks at long delays, whereas neurons with relatively high BFs showed response ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/86049
更新日期:2001-04-01 00:00:00
abstract::Stimuli that elicit itch are detected by sensory neurons that innervate the skin. This information is processed by the spinal cord; however, the way in which this occurs is still poorly understood. Here we investigated the neuronal pathways for itch neurotransmission, particularly the contribution of the neuropeptide ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/s41593-018-0119-z
更新日期:2018-05-01 00:00:00
abstract::Synaptic vesicles release neurotransmitter both actively (on stimulation) and spontaneously (at rest). It has been assumed that identical vesicles use both modes of release; however, recent evidence has challenged this view. Using several assays (FM dye imaging, pHluorin imaging and antibody-labeling of synaptotagmin)...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2690
更新日期:2010-12-01 00:00:00
abstract::In the version of this article initially published online, the accession code was given as GSE1000333. The correct code is GSE100033. The error has been corrected in the print, HTML and PDF versions of the article. ...
journal_title:Nature neuroscience
pub_type: 已发布勘误
doi:10.1038/s41593-018-0114-4
更新日期:2018-07-01 00:00:00
abstract::Histone deacetylases (HDACs) are major epigenetic regulators. We show that HDAC1 and HDAC2 functions are critical for myelination of the peripheral nervous system. Using mouse genetics, we have ablated Hdac1 and Hdac2 specifically in Schwann cells, resulting in massive Schwann cell loss and virtual absence of myelin i...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2762
更新日期:2011-04-01 00:00:00
abstract::Two studies in this issue show that the protein MeCP2, which is implicated in Rett syndrome, also critically regulates behavioral responses to psychostimulants. Although the two studies highlight different mechanisms of MeCP2 in regulating these behaviors, both underscore the importance of epigenetic mechanisms in est...
journal_title:Nature neuroscience
pub_type: 评论,新闻
doi:10.1038/nn0910-1039
更新日期:2010-09-01 00:00:00
abstract::In the published version of this article, a data point is missing from Fig. 4f, and the y-axis label reads "RFpre"; it should read "RFpref." The original article has not been corrected. The original and corrected figures are shown in the accompanying Publisher Correction. ...
journal_title:Nature neuroscience
pub_type: 已发布勘误
doi:10.1038/s41593-018-0181-6
更新日期:2018-09-01 00:00:00
abstract::Continuous, predictable events and spontaneous events may coincide in the visual environment. For a continuously moving object, the brain compensates for delays in transmission between a retinal event and neural responses in higher visual areas. Here we show that it similarly compensated for other smoothly changing fe...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/74865
更新日期:2000-05-01 00:00:00
abstract::The growth of neurites (axon and dendrite) should be appropriately regulated by their interactions in the development of nervous systems where a myriad of neurons and their neurites are tightly packed. We show here that mammalian seven-pass transmembrane cadherins Celsr2 and Celsr3 are activated by their homophilic in...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1933
更新日期:2007-08-01 00:00:00
abstract::The hippocampus is thought to be involved in episodic memory formation by reactivating traces of waking experience during sleep. Indeed, the joint firing of spatially tuned pyramidal cells encoding nearby places recur during sleep. We found that the sleep cofiring of rat CA1 pyramidal cells encoding similar places inc...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn2037
更新日期:2008-02-01 00:00:00
abstract::Neuroimaging studies show that the efficacy of long-term memory encoding of a stimulus is indexed by transient neural activity elicited by that stimulus. Here, we show that successful memory encoding is also indexed by neural activity that is tonically maintained throughout a study task. Using functional magnetic reso...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn967
更新日期:2002-12-01 00:00:00
abstract::Pericytes are perivascular mural cells of brain capillaries. They are positioned centrally in the neurovascular unit between endothelial cells, astrocytes and neurons. This position allows them to regulate key neurovascular functions of the brain. The role of pericytes in the regulation of cerebral blood flow (CBF) an...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.4489
更新日期:2017-03-01 00:00:00
abstract::Autism spectrum disorder (ASD) is genetically heterogeneous with convergent symptomatology, suggesting common dysregulated pathways. In this study, we analyzed brain transcriptional changes in five mouse models of Pitt-Hopkins syndrome (PTHS), a syndromic form of ASD caused by mutations in the TCF4 gene, but not the T...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/s41593-019-0578-x
更新日期:2020-03-01 00:00:00
abstract::A hallmark event in neurodegenerative diseases (NDs) is the misfolding, aggregation, and accumulation of proteins, leading to cellular dysfunction, loss of synaptic connections, and brain damage. Despite the involvement of distinct proteins in different NDs, the process of protein misfolding and aggregation is remarka...
journal_title:Nature neuroscience
pub_type: 杂志文章,评审
doi:10.1038/s41593-018-0235-9
更新日期:2018-10-01 00:00:00
abstract::Adult expertise in face processing is mediated largely by neural networks in the right hemisphere. Here we evaluate the contribution of early visual input in establishing this neural substrate. We compared visually normal individuals to patients for whom visual input had been restricted mainly to one hemisphere during...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1121
更新日期:2003-10-01 00:00:00
abstract::Cell type-specific expression of optogenetic molecules allows temporally precise manipulation of targeted neuronal activity. Here we present a toolbox of four knock-in mouse lines engineered for strong, Cre-dependent expression of channelrhodopsins ChR2-tdTomato and ChR2-EYFP, halorhodopsin eNpHR3.0 and archaerhodopsi...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3078
更新日期:2012-03-25 00:00:00
abstract::Over the past two centuries, prevalent models of energy and glucose homeostasis have emerged from careful anatomical descriptions in tandem with an understanding of cellular physiology. More recent technological advances have culminated in the identification of peripheral and central factors that influence neural circ...
journal_title:Nature neuroscience
pub_type: 杂志文章,评审
doi:10.1038/nn.3217
更新日期:2012-10-01 00:00:00
abstract::Individual differences in motor learning ability are widely acknowledged, yet little is known about the factors that underlie them. Here we explore whether movement-to-movement variability in motor output, a ubiquitous if often unwanted characteristic of motor performance, predicts motor learning ability. Surprisingly...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3616
更新日期:2014-02-01 00:00:00
abstract::The classic 'size principle' of motor control describes how increasingly forceful movements arise by the recruitment of motoneurons of progressively larger size and force output into the active pool. We explored the activity of pools of spinal interneurons in larval zebrafish and found that increases in swimming speed...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2225
更新日期:2008-12-01 00:00:00
abstract::Leucine-rich repeat kinase 2 (LRRK2) is enriched in the striatal projection neurons (SPNs). We found that LRRK2 negatively regulates protein kinase A (PKA) activity in the SPNs during synaptogenesis and in response to dopamine receptor Drd1 activation. LRRK2 interacted with PKA regulatory subunit IIβ (PKARIIβ). A lack...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3636
更新日期:2014-03-01 00:00:00
abstract::Three families of ligand-activated ion channels mediate synaptic communication between excitable cells in mammals. For pentameric channels related to nicotinic acetylcholine receptors and tetrameric channels such as glutamate receptors, the pore-forming and gate regions have been studied extensively. In contrast, litt...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2151
更新日期:2008-08-01 00:00:00
abstract::Previous gene knockout studies have shown that the orphan glutamate receptor delta2 (GluRdelta2) is critically involved in synaptogenesis between parallel fibers and Purkinje cells during development. However, the precise function of GluRdelta2 and whether it is functional in the mature cerebellum remain unclear. To a...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1086
更新日期:2003-08-01 00:00:00
abstract::Visual attention enhances the responses of visual neurons that encode the attended location. Several recent studies have shown that attention also decreases correlations between fluctuations in the responses of pairs of neurons (termed spike count correlation or r(SC)). These results are consistent with two hypotheses...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3835
更新日期:2014-11-01 00:00:00
abstract::How tightly tuned are the synaptic and intrinsic properties that give rise to neuron and circuit function? Experimental work shows that these properties vary considerably across identified neurons in different animals. Given this variability in experimental data, this review describes some of the complications of buil...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2735
更新日期:2011-02-01 00:00:00
abstract::The balance between proliferation and apoptosis is critical for proper development of the nervous system. Yet, little is known about molecules that regulate apoptosis of proliferative neurons. Here we identify a soluble, secreted form of CPG15 expressed in embryonic rat brain regions undergoing rapid proliferation and...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1407
更新日期:2005-03-01 00:00:00
abstract::A long-standing debate in neuroscience is whether classical and operant conditioning are mechanistically similar or distinct. The feeding behavior of Aplysia provides a model system suitable for addressing this question. Here we report that classical and operant conditioning of feeding behavior differentially modify t...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1593
更新日期:2006-01-01 00:00:00
abstract::The most critical attribute of human language is its unbounded combinatorial nature: smaller elements can be combined into larger structures on the basis of a grammatical system, resulting in a hierarchy of linguistic units, such as words, phrases and sentences. Mentally parsing and representing such structures, howev...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.4186
更新日期:2016-01-01 00:00:00