Abstract：
:Histone deacetylases (HDACs) are major epigenetic regulators. We show that HDAC1 and HDAC2 functions are critical for myelination of the peripheral nervous system. Using mouse genetics, we have ablated Hdac1 and Hdac2 specifically in Schwann cells, resulting in massive Schwann cell loss and virtual absence of myelin in mutant sciatic nerves. Expression of Sox10 and Krox20, the main transcriptional regulators of Schwann cell myelination, was greatly reduced. We demonstrate that in Schwann cells, HDAC1 and HDAC2 exert specific primary functions: HDAC2 activates the transcriptional program of myelination in synergy with Sox10, whereas HDAC1 controls Schwann cell survival by regulating the levels of active β-catenin.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Jacob C,Christen CN,Pereira JA,Somandin C,Baggiolini A,Lötscher P,Ozçelik M,Tricaud N,Meijer D,Yamaguchi T,Matthias P,Suter Udoi
10.1038/nn.2762subject
Has Abstractpub_date
2011-04-01 00:00:00pages
429-36issue
4eissn
1097-6256issn
1546-1726pii
nn.2762journal_volume
14pub_type
杂志文章abstract：:Glycine receptors (GlyRs), together with GABA(A) and nicotinic acetylcholine (ACh) receptors, form part of the ligand-activated ion channel superfamily and regulate the excitability of the mammalian brain stem and spinal cord. Here we report that the ability of the neurotransmitter glycine to gate recombinant and nati...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1095
更新日期：2003-08-01 00:00:00
abstract：:Pericytes are perivascular mural cells of brain capillaries. They are positioned centrally in the neurovascular unit between endothelial cells, astrocytes and neurons. This position allows them to regulate key neurovascular functions of the brain. The role of pericytes in the regulation of cerebral blood flow (CBF) an...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4489
更新日期：2017-03-01 00:00:00
abstract：:The mammalian visual system contains an extensive web of feedback connections projecting from higher cortical areas to lower areas, including primary visual cortex. Although multiple theories have been proposed, the role of these connections in perceptual processing is not understood. We found that the pattern of func...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2218
更新日期：2008-12-01 00:00:00
abstract：:Binocular competition is thought to drive eye-specific segregation in the developing visual system, potentially through Hebbian synaptic learning rules that are sensitive to correlations in afferent activity. Altering retinal activity can disrupt eye-specific segregation, but little is known about the temporal feature...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3007
更新日期：2011-11-18 00:00:00
abstract：:Selective serotonin reuptake inhibitors (SSRIs) are widely used antidepressants, but the mechanisms by which they influence behavior are only partially resolved. Adult hippocampal neurogenesis is necessary for some of the responses to SSRIs, but it is not known whether mature dentate gyrus granule cells (DG GCs) also ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4116
更新日期：2015-11-01 00:00:00
abstract：:We used fluorescent in-situ hybridization and confocal microscopy to monitor the subcellular distribution of the immediate-early gene Arc. Arc RNA appeared in discrete intranuclear foci within minutes of neuronal activation and subsequently disappeared from the nucleus and accumulated in the cytoplasm by 30 minutes. T...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/16046
更新日期：1999-12-01 00:00:00
abstract：:Rhythmic movements, such as walking, chewing or scratching, are phylogenetically old motor behaviors found in many organisms, ranging from insects to primates. In contrast, discrete movements, such as reaching, grasping or kicking, are behaviors that have reached sophistication primarily in younger species, particular...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1322
更新日期：2004-10-01 00:00:00
abstract：:Anatomical studies have led to the assertion that intratelencephalic and pyramidal tract cortical neurons innervate different striatal projection neurons. To test this hypothesis, we measured the responses of mouse striatal neurons to optogenetic activation of intratelencephalic and pyramidal tract axons. Contrary to ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3397
更新日期：2013-06-01 00:00:00
abstract：:Polyamines are endogenous molecules involved in cell damage following neurological insults, although it is unclear whether polyamines reduce or exacerbate this damage. We used a developmental seizure model in which we exposed Xenopus laevis tadpoles to pentylenetetrazole (PTZ), a known convulsant. We found that, after...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2777
更新日期：2011-04-01 00:00:00
abstract：:Timing is crucial to many aspects of human performance. To better understand its neural underpinnings, we used event-related fMRI to examine the time course of activation associated with different components of a time perception task. We distinguished systems associated with encoding time intervals from those related ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/85191
更新日期：2001-03-01 00:00:00
abstract：:Transmitter release is triggered by highly localized, transient increases in the presynaptic Ca(2+) concentration ([Ca(2+)]). Rapidly decaying [Ca(2+)] elevations were generated using Ca(2+) uncaging techniques, and [Ca(2+)] was measured with a low-affinity Ca(2+) indicator in a giant presynaptic terminal, the calyx o...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1417
更新日期：2005-04-01 00:00:00
abstract：:Individual behavioral performance during learning is known to be affected by modulatory factors, such as stress and motivation, and by genetic predispositions that influence sensitivity to these factors. Despite numerous studies, no integrative framework is available that could predict how a given animal would perform...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2374
更新日期：2009-09-01 00:00:00
abstract：:Sugar exerts its potent reinforcing effects via both gustatory and post-ingestive pathways. It is, however, unknown whether sweetness and nutritional signals engage segregated brain networks to motivate ingestion. We found in mice that separate basal ganglia circuitries mediated the hedonic and nutritional actions of ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4224
更新日期：2016-03-01 00:00:00
abstract：:Arcuate nucleus (ARC) neurons sense the fed or fasted state and regulate hunger. Agouti-related protein (AgRP) neurons in the ARC (ARCAgRP neurons) are stimulated by fasting and, once activated, they rapidly (within minutes) drive hunger. Pro-opiomelanocortin (ARCPOMC) neurons are viewed as the counterpoint to ARCAgRP...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4442
更新日期：2017-01-01 00:00:00
abstract：:Peptides derived from proteolytic processing of the beta-amyloid precursor protein (APP), including the amyloid-beta peptide, are important for the pathogenesis of Alzheimer's dementia. We found that transgenic mice overexpressing APP have a profound and selective impairment in endothelium-dependent regulation of the ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/5715
更新日期：1999-02-01 00:00:00
abstract：:Neuroscientists increasingly analyze the joint activity of multineuron recordings to identify population-level structures believed to be significant and scientifically novel. Claims of significant population structure support hypotheses in many brain areas. However, these claims require first investigating the possibi...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4617
更新日期：2017-09-01 00:00:00
abstract：:Visual attention enhances the responses of visual neurons that encode the attended location. Several recent studies have shown that attention also decreases correlations between fluctuations in the responses of pairs of neurons (termed spike count correlation or r(SC)). These results are consistent with two hypotheses...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3835
更新日期：2014-11-01 00:00:00
abstract：:We combined psychophysical and transcranial magnetic stimulation studies to investigate the dynamics of action anticipation and its underlying neural correlates in professional basketball players. Athletes predicted the success of free shots at a basket earlier and more accurately than did individuals with comparable ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2182
更新日期：2008-09-01 00:00:00
abstract：:Neural progenitor cells in the developing neocortex change over time to produce different neurons, a phenomenon that is also observed in other regions of the nervous system. Mouse Numb (also known as m-numb) and Numbl (also known as numblike or Nbl) are redundant but essential in maintaining virtually all progenitor c...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1289
更新日期：2004-08-01 00:00:00
abstract：:The projections and odor responses of mammalian olfactory receptor neurons, as well as the physiology of the bulb's principal neurons-the mitral cells (MCs)-are known from studies in slices and anesthetized animals. In behaving rats trained to discriminate between two odors associated with different reinforcers, we ex...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/14801
更新日期：1999-11-01 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Nature neuroscience
pub_type： 已发布勘误
doi：10.1038/s41593-019-0546-5
更新日期：2019-12-01 00:00:00
abstract：:An unknown aspect of behavioral state regulation is how the circadian oscillator of the suprachiasmatic nucleus (SCN) regulates sleep and waking. In this report, we describe the necessary elements for a circuit that provides circadian regulation of arousal. Trans-synaptic retrograde tracing revealed a prominent indire...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/89522
更新日期：2001-07-01 00:00:00
abstract：:Microglia are primary immune sentinels of the CNS. Following injury, these cells migrate or extend processes toward sites of tissue damage. CNS injury is accompanied by release of nucleotides, serving as signals for microglial activation or chemotaxis. Microglia express several purinoceptors, including a G(i)-coupled ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1805
更新日期：2006-12-01 00:00:00
abstract：:Odor stimulation evokes complex spatiotemporal activity in the olfactory bulb, suggesting that both the identity of activated neurons and the timing of their activity convey information about odors. However, whether and how downstream neurons decipher these temporal patterns remains unknown. We addressed this question...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3407
更新日期：2013-07-01 00:00:00
abstract：:The output of cortical columns is routed to different downstream targets via distinct pathways: cortico-cortical and cortico-subcortical. It is as yet unclear what roles these pathways play in perception, and which cellular and circuit mechanisms regulate their gating. We recently showed that activation of the apical ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-020-0677-8
更新日期：2020-10-01 00:00:00
abstract：:EphB receptor tyrosine kinases control multiple steps in nervous system development. However, it remains unclear whether EphBs regulate these different developmental processes directly or indirectly. In addition, given that EphBs signal through multiple mechanisms, it has been challenging to define which signaling fun...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3249
更新日期：2012-12-01 00:00:00
abstract：:The orbitofrontal cortex plays a central role in good-based economic decisions. When subjects make choices, neurons in this region represent the identities and values of offered and chosen goods. Notably, choices in different behavioral contexts may involve a potentially infinite variety of goods. Thus a fundamental q...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4300
更新日期：2016-06-01 00:00:00
abstract：:Agonists of GABA(B) receptors exert a bi-directional effect on the activity of dopamine (DA) neurons of the ventral tegmental area, which can be explained by the fact that coupling between GABA(B) receptors and G protein-gated inwardly rectifying potassium (GIRK) channels is significantly weaker in DA neurons than in ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn2006
更新日期：2007-12-01 00:00:00
abstract：:Grid cells in layer II of the medial entorhinal cortex form a principal component of the mammalian neural representation of space. The firing pattern of a single grid cell has been hypothesized to be generated through attractor dynamics in a network with a specific local connectivity including both excitatory and inhi...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3310
更新日期：2013-03-01 00:00:00
abstract：:Cerebellar abnormalities, particularly in Right Crus I (RCrusI), are consistently reported in autism spectrum disorders (ASD). Although RCrusI is functionally connected with ASD-implicated circuits, the contribution of RCrusI dysfunction to ASD remains unclear. Here neuromodulation of RCrusI in neurotypical humans res...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-017-0004-1
更新日期：2017-12-01 00:00:00
