Abstract：
:The identity of specific cell types in the nervous system is defined by the expression of neuron type-specific gene batteries. How the expression of such batteries is initiated during nervous system development has been under intensive study over the past few decades. However, comparatively little is known about how gene batteries that define the terminally differentiated state of a neuron type are maintained throughout the life of an animal. Here we provide an overview of studies in invertebrate and vertebrate model systems that have carved out the general and not commonly appreciated principle that neuronal identity is maintained in postmitotic neurons by the sustained, and often autoregulated, expression of the same transcription factors that initiate terminal differentiation in a developing organism. Disruption of postmitotic maintenance mechanisms may result in neuropsychiatric and neurodegenerative conditions.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Deneris ES,Hobert Odoi
10.1038/nn.3731subject
Has Abstractpub_date
2014-07-01 00:00:00pages
899-907issue
7eissn
1097-6256issn
1546-1726pii
nn.3731journal_volume
17pub_type
杂志文章,评审abstract：:As we move through the environment, the pattern of visual motion on the retina provides rich information about our movement through the scene. Human subjects can use this information, often termed "optic flow", to accurately estimate their direction of self movement (heading) from relatively sparse displays. Physiolog...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/259
更新日期：1998-05-01 00:00:00
abstract：:Active dendritic integration is thought to enrich the computational power of central neurons. However, a direct role of active dendritic processing in the execution of defined neuronal computations in intact neural networks has not been established. Here we used multi-site electrophysiological recording techniques to ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3565
更新日期：2013-12-01 00:00:00
abstract：:Sensory neural systems use spatiotemporal coding mechanisms to represent stimuli. These time-varying response patterns sometimes outlast the stimulus. Can the temporal structure of a stimulus interfere with, or even disrupt, the spatiotemporal structure of the neural representation? We investigated this potential conf...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1559
更新日期：2005-11-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/6368
更新日期：1999-03-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3001
更新日期：2011-12-25 00:00:00
abstract：:The identification of distinct cell types in the basal ganglia has been critical to our understanding of basal ganglia function and the treatment of neurological disorders. The external globus pallidus (GPe) is a key contributor to motor suppressing pathways in the basal ganglia, yet its neuronal heterogeneity has rem...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4559
更新日期：2017-06-01 00:00:00
abstract：:The molecular basis of CNS myelin regeneration (remyelination) is poorly understood. We generated a comprehensive transcriptional profile of the separate stages of spontaneous remyelination that follow focal demyelination in the rat CNS and found that transcripts that encode the retinoid acid receptor RXR-γ were diffe...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2702
更新日期：2011-01-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/89522
更新日期：2001-07-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4035
更新日期：2015-07-01 00:00:00
abstract：:Intrinsic signal imaging from inferotemporal (IT) cortex, a visual area essential for object perception and recognition, revealed that visually presented objects activated patches in a distributed manner. When visual features of these objects were partially removed, the simplified stimuli activated only a subset of th...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/90547
更新日期：2001-08-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1382
更新日期：2005-02-01 00:00:00
abstract：:Brain circuitry processes information by rapidly and selectively engaging functional neuronal networks. The dynamic formation of networks is often evident in rhythmically synchronized neuronal activity and tightly correlates with perceptual, cognitive and motor performances. But how synchronized neuronal activity cont...
journal_title：Nature neuroscience
pub_type： 杂志文章,评审
doi：10.1038/nn.3764
更新日期：2014-08-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1815
更新日期：2007-01-01 00:00:00
abstract：:Phosphatidylinositol 3-kinase (PI3K) has been shown to enhance native voltage-dependent calcium channel (Ca(v)) currents both in myocytes and in neurons; however, the mechanism(s) responsible for this regulation were not known. Here we show that PI3K promotes the translocation of GFP-tagged Ca(v) channels to the plasm...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1300
更新日期：2004-09-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn971
更新日期：2002-12-01 00:00:00
abstract：:Dopamine signaling is implicated in reinforcement learning, but the neural substrates targeted by dopamine are poorly understood. We bypassed dopamine signaling itself and tested how optogenetic activation of dopamine D1 or D2 receptor–expressing striatal projection neurons influenced reinforcement learning in mice. S...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3100
更新日期：2012-06-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn776
更新日期：2002-01-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2558
更新日期：2010-06-01 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Nature neuroscience
pub_type： 已发布勘误
doi：10.1038/s41593-019-0570-5
更新日期：2020-02-01 00:00:00
abstract：:Axonal injury results in regenerative success or failure, depending on whether the axon lies in the peripheral or the CNS, respectively. The present study addresses whether epigenetic signatures in dorsal root ganglia discriminate between regenerative and non-regenerative axonal injury. Chromatin immunoprecipitation f...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-019-0490-4
更新日期：2019-11-01 00:00:00
abstract：:Sensory systems create neural representations of environmental stimuli and these representations can be associated with other stimuli through learning. Are spike patterns the neural representations that get directly associated with reinforcement during conditioning? In the moth Manduca sexta, we found that odor presen...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2192
更新日期：2008-10-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4589
更新日期：2017-08-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章,评审
doi：10.1038/s41593-018-0235-9
更新日期：2018-10-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2513
更新日期：2010-05-01 00:00:00
abstract：:In humans and many other animals, memory consolidation occurs through multiple temporal phases and usually involves more than one neuroanatomical brain system. Genetic dissection of Pavlovian olfactory learning in Drosophila melanogaster has revealed multiple memory phases, but the predominant view holds that all memo...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn2005
更新日期：2007-12-01 00:00:00
abstract：:The majority of neurons in primary visual cortex are tuned for stimulus orientation, but the factors that account for the range of orientation selectivities exhibited by cortical neurons remain unclear. To address this issue, we used in vivo two-photon calcium imaging to characterize the orientation tuning and spatial...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4323
更新日期：2016-08-01 00:00:00
abstract：:Neuregulin 1 type III is processed following regulated intramembrane proteolysis, which allows communication from the plasma membrane to the nucleus. We found that the intracellular domain of neuregulin 1 type III upregulated the prostaglandin D2 synthase (L-pgds, also known as Ptgds) gene, which, together with the G ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3857
更新日期：2014-12-01 00:00:00
abstract：:We studied how the posterior parietal cortex combines new information with ongoing activity dynamics as mice accumulate evidence during a virtual navigation task. Using new methods to analyze population activity on single trials, we found that activity transitioned rapidly between different sets of active neurons. Eac...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4403
更新日期：2016-12-01 00:00:00
abstract：:By combining computational, morphological, and functional analyses, this study relates latent markers of associative threat learning to overt post-traumatic stress disorder (PTSD) symptoms in combat veterans. Using reversal learning, we found that symptomatic veterans showed greater physiological adjustment to cues th...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-018-0315-x
更新日期：2019-03-01 00:00:00
abstract：:Predatory hunting plays a fundamental role in animal survival. Little is known about the neural circuits that convert sensory cues into neural signals to drive this behavior. Here we identified an excitatory subcortical neural circuit from the superior colliculus to the zona incerta that triggers predatory hunting. Th...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-019-0405-4
更新日期：2019-06-01 00:00:00
