Abstract:
:During development, the mammalian ventral telencephalon is comprised of three major proliferative zones: the medial (MGE), lateral (LGE) and caudal (CGE) ganglionic eminences. Through gene expression studies, in vitro migration assays, genetic mutant analysis and in vivo fate mapping in mice, we found that the CGE is a progenitor region that is distinct from both the MGE and LGE. Notably, CGE cells showed a unique in vivo pattern of migration, and the CGE contributed cells to nuclei distinct from those populated by the MGE and LGE. Moreover, we report that the migratory fate of cells from the CGE is intrinsically determined by embryonic day 13.5 (E13.5). Together, these results provide the first insights into the development and fate of the CGE.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Nery S,Fishell G,Corbin JGdoi
10.1038/nn971subject
Has Abstractpub_date
2002-12-01 00:00:00pages
1279-87issue
12eissn
1097-6256issn
1546-1726pii
nn971journal_volume
5pub_type
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