Retinoid X receptor gamma signaling accelerates CNS remyelination.


:The molecular basis of CNS myelin regeneration (remyelination) is poorly understood. We generated a comprehensive transcriptional profile of the separate stages of spontaneous remyelination that follow focal demyelination in the rat CNS and found that transcripts that encode the retinoid acid receptor RXR-γ were differentially expressed during remyelination. Cells of the oligodendrocyte lineage expressed RXR-γ in rat tissues that were undergoing remyelination and in active and remyelinated multiple sclerosis lesions. Knockdown of RXR-γ by RNA interference or RXR-specific antagonists severely inhibited oligodendrocyte differentiation in culture. In mice that lacked RXR-γ, adult oligodendrocyte precursor cells efficiently repopulated lesions after demyelination, but showed delayed differentiation into mature oligodendrocytes. Administration of the RXR agonist 9-cis-retinoic acid to demyelinated cerebellar slice cultures and to aged rats after demyelination caused an increase in remyelinated axons. Our results indicate that RXR-γ is a positive regulator of endogenous oligodendrocyte precursor cell differentiation and remyelination and might be a pharmacological target for regenerative therapy in the CNS.


Nat Neurosci


Nature neuroscience


Huang JK,Jarjour AA,Nait Oumesmar B,Kerninon C,Williams A,Krezel W,Kagechika H,Bauer J,Zhao C,Baron-Van Evercooren A,Chambon P,Ffrench-Constant C,Franklin RJM




Has Abstract


2011-01-01 00:00:00












  • Specialized neuronal adaptation for preserving input sensitivity.

    abstract::Some neurons in auditory cortex respond to recent stimulus history by adapting their response functions to track stimulus statistics directly, as might be expected. In contrast, some neurons respond to loud sounds by adjusting their response functions away from high intensities and consequently remain sensitive to sof...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: Watkins PV,Barbour DL

    更新日期:2008-11-01 00:00:00

  • XTRPC1-dependent chemotropic guidance of neuronal growth cones.

    abstract::Calcium arising through release from intracellular stores and from influx across the plasma membrane is essential for signalling by specific guidance cues and by factors that inhibit axon regeneration. The mediators of calcium influx in these cases are largely unknown. Transient receptor potential channels (TRPCs) bel...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: Shim S,Goh EL,Ge S,Sailor K,Yuan JP,Roderick HL,Bootman MD,Worley PF,Song H,Ming GL

    更新日期:2005-06-01 00:00:00

  • Area identity shifts in the early cerebral cortex of Emx2-/- mutant mice.

    abstract::The specification of area identities in the cerebral cortex is a complex process, primed by intrinsic cortical cues and refined after the arrival of afferent fibers from the thalamus. Little is known about the genetic control of the early steps of this process, but the distinctive expression pattern of the homeogene E...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: Mallamaci A,Muzio L,Chan CH,Parnavelas J,Boncinelli E

    更新日期:2000-07-01 00:00:00

  • Cortical tracking of hierarchical linguistic structures in connected speech.

    abstract::The most critical attribute of human language is its unbounded combinatorial nature: smaller elements can be combined into larger structures on the basis of a grammatical system, resulting in a hierarchy of linguistic units, such as words, phrases and sentences. Mentally parsing and representing such structures, howev...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: Ding N,Melloni L,Zhang H,Tian X,Poeppel D

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  • Animal models of neuropsychiatric disorders.

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    journal_title:Nature neuroscience

    pub_type: 杂志文章,评审


    authors: Nestler EJ,Hyman SE

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  • The dissociation of color from form and function knowledge.

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    journal_title:Nature neuroscience

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  • Evolving insights into RNA modifications and their functional diversity in the brain.

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    journal_title:Nature neuroscience

    pub_type: 杂志文章


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  • Activity-dependent AIDA-1 nuclear signaling regulates nucleolar numbers and protein synthesis in neurons.

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    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: Jordan BA,Fernholz BD,Khatri L,Ziff EB

    更新日期:2007-04-01 00:00:00

  • Reward expectation differentially modulates attentional behavior and activity in visual area V4.

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    journal_title:Nature neuroscience

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  • L1-associated genomic regions are deleted in somatic cells of the healthy human brain.

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    journal_title:Nature neuroscience

    pub_type: 杂志文章


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    journal_title:Nature neuroscience

    pub_type: 杂志文章


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    journal_title:Nature neuroscience

    pub_type: 杂志文章


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    journal_title:Nature neuroscience

    pub_type: 杂志文章


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  • NR3A-containing NMDARs promote neurotransmitter release and spike timing-dependent plasticity.

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    journal_title:Nature neuroscience

    pub_type: 杂志文章


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  • Rethinking grant review.

    abstract::The US government is re-examining how it funds science, but it remains to be seen whether the administration can overcome tradition and bureaucratic inertia and achieve a substantial renovation of the grants peer-review system. ...

    journal_title:Nature neuroscience

    pub_type: 社论



    更新日期:2008-02-01 00:00:00

  • A subcortical excitatory circuit for sensory-triggered predatory hunting in mice.

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    journal_title:Nature neuroscience

    pub_type: 杂志文章


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  • Olfactory receptor neuron axon targeting: intrinsic transcriptional control and hierarchical interactions.

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    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: Komiyama T,Carlson JR,Luo L

    更新日期:2004-08-01 00:00:00

  • Neural coding during active somatosensation revealed using illusory touch.

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    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: O'Connor DH,Hires SA,Guo ZV,Li N,Yu J,Sun QQ,Huber D,Svoboda K

    更新日期:2013-07-01 00:00:00

  • DeepLabCut: markerless pose estimation of user-defined body parts with deep learning.

    abstract::Quantifying behavior is crucial for many applications in neuroscience. Videography provides easy methods for the observation and recording of animal behavior in diverse settings, yet extracting particular aspects of a behavior for further analysis can be highly time consuming. In motor control studies, humans or other...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: Mathis A,Mamidanna P,Cury KM,Abe T,Murthy VN,Mathis MW,Bethge M

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  • Oligodendrocyte precursor cell specification is regulated by bidirectional neural progenitor-endothelial cell crosstalk.

    abstract::Neural-derived signals are crucial regulators of CNS vascularization. However, whether the vasculature responds to these signals by means of elongating and branching or in addition by building a feedback response to modulate neurodevelopmental processes remains unknown. In this study, we identified bidirectional cross...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: Paredes I,Vieira JR,Shah B,Ramunno CF,Dyckow J,Adler H,Richter M,Schermann G,Giannakouri E,Schirmer L,Augustin HG,Ruiz de Almodóvar C

    更新日期:2021-01-28 00:00:00

  • Regulation of T-type calcium channels by Rho-associated kinase.

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    journal_title:Nature neuroscience

    pub_type: 杂志文章


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    更新日期:2007-07-01 00:00:00

  • Octopamine fuels fighting flies.

    abstract::The neural basis of aggression is poorly understood. A study in this issue used genetic scalpels to dissect the circuitry of the fly brain and identified a small cluster of octopaminergic neurons that can make a fly fighting mad. ...

    journal_title:Nature neuroscience

    pub_type: 评论,杂志文章,评审


    authors: Potter CJ,Luo L

    更新日期:2008-09-01 00:00:00

  • Pharmacological REM sleep suppression paradoxically improves rather than impairs skill memory.

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    journal_title:Nature neuroscience

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Rasch B,Pommer J,Diekelmann S,Born J

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  • GluA1 phosphorylation at serine 831 in the lateral amygdala is required for fear renewal.

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    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: Lee S,Song B,Kim J,Park K,Hong I,An B,Song S,Lee J,Park S,Kim J,Park D,Lee CJ,Kim K,Shin KS,Tsien RW,Choi S

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  • HDAC1 and HDAC2 control the transcriptional program of myelination and the survival of Schwann cells.

    abstract::Histone deacetylases (HDACs) are major epigenetic regulators. We show that HDAC1 and HDAC2 functions are critical for myelination of the peripheral nervous system. Using mouse genetics, we have ablated Hdac1 and Hdac2 specifically in Schwann cells, resulting in massive Schwann cell loss and virtual absence of myelin i...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: Jacob C,Christen CN,Pereira JA,Somandin C,Baggiolini A,Lötscher P,Ozçelik M,Tricaud N,Meijer D,Yamaguchi T,Matthias P,Suter U

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  • Neurobiology of premature brain injury.

    abstract::Every year in the United States, an estimated 500,000 babies are born preterm (before 37 completed weeks of gestation), and this number is rising, along with the recognition of brain injuries due to preterm delivery. A common underlying pathogenesis appears to be perinatal hypoxia induced by immature lung development,...

    journal_title:Nature neuroscience

    pub_type: 杂志文章,评审


    authors: Salmaso N,Jablonska B,Scafidi J,Vaccarino FM,Gallo V

    更新日期:2014-03-01 00:00:00

  • Auditory activity is diverse and widespread throughout the central brain of Drosophila.

    abstract::Sensory pathways are typically studied by starting at receptor neurons and following postsynaptic neurons into the brain. However, this leads to a bias in analyses of activity toward the earliest layers of processing. Here, we present new methods for volumetric neural imaging with precise across-brain registration to ...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: Pacheco DA,Thiberge SY,Pnevmatikakis E,Murthy M

    更新日期:2021-01-01 00:00:00

  • Palmitoylation of δ-catenin by DHHC5 mediates activity-induced synapse plasticity.

    abstract::Synaptic cadherin adhesion complexes are known to be key regulators of synapse plasticity. However, the molecular mechanisms that coordinate activity-induced modifications in cadherin localization and adhesion and the subsequent changes in synapse morphology and efficacy remain unknown. We demonstrate that the intrace...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: Brigidi GS,Sun Y,Beccano-Kelly D,Pitman K,Mobasser M,Borgland SL,Milnerwood AJ,Bamji SX

    更新日期:2014-04-01 00:00:00

  • Maintenance of postmitotic neuronal cell identity.

    abstract::The identity of specific cell types in the nervous system is defined by the expression of neuron type-specific gene batteries. How the expression of such batteries is initiated during nervous system development has been under intensive study over the past few decades. However, comparatively little is known about how g...

    journal_title:Nature neuroscience

    pub_type: 杂志文章,评审


    authors: Deneris ES,Hobert O

    更新日期:2014-07-01 00:00:00

  • Cerebrovascular disorders: molecular insights and therapeutic opportunities.

    abstract::Blood vessels in the nervous system have traditionally been considered neutral bystanders that only passively adapt their structure and function in response to the needs of neural cells. Emerging evidence suggests, however, that vessels and angiogenic molecules actively participate in the pathogenesis of neurological ...

    journal_title:Nature neuroscience

    pub_type: 杂志文章,评审


    authors: Storkebaum E,Quaegebeur A,Vikkula M,Carmeliet P

    更新日期:2011-10-26 00:00:00