Abstract:
:The mammalian visual system contains an extensive web of feedback connections projecting from higher cortical areas to lower areas, including primary visual cortex. Although multiple theories have been proposed, the role of these connections in perceptual processing is not understood. We found that the pattern of functional magnetic resonance imaging response in human foveal retinotopic cortex contained information about objects presented in the periphery, far away from the fovea, which has not been predicted by prior theories of feedback. This information was position invariant, correlated with perceptual discrimination accuracy and was found only in foveal, but not peripheral, retinotopic cortex. Our data cannot be explained by differential eye movements, activation from the fixation cross, or spillover activation from peripheral retinotopic cortex or from lateral occipital complex. Instead, our findings indicate that position-invariant object information from higher cortical areas is fed back to foveal retinotopic cortex, enhancing task performance.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Williams MA,Baker CI,Op de Beeck HP,Shim WM,Dang S,Triantafyllou C,Kanwisher Ndoi
10.1038/nn.2218subject
Has Abstractpub_date
2008-12-01 00:00:00pages
1439-45issue
12eissn
1097-6256issn
1546-1726pii
nn.2218journal_volume
11pub_type
杂志文章abstract::The spinal cord is the initial stage that integrates temperature information from peripheral inputs. Here we used molecular genetics and in vivo calcium imaging to investigate the coding of cutaneous temperature in the spinal cord in mice. We found that heating or cooling the skin evoked robust calcium responses in sp...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.4350
更新日期:2016-09-01 00:00:00
abstract::Cell type-specific expression of optogenetic molecules allows temporally precise manipulation of targeted neuronal activity. Here we present a toolbox of four knock-in mouse lines engineered for strong, Cre-dependent expression of channelrhodopsins ChR2-tdTomato and ChR2-EYFP, halorhodopsin eNpHR3.0 and archaerhodopsi...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3078
更新日期:2012-03-25 00:00:00
abstract::The 'cognitive map' hypothesis proposes that brain builds a unified representation of the spatial environment to support memory and guide future action. Forty years of electrophysiological research in rodents suggest that cognitive maps are neurally instantiated by place, grid, border and head direction cells in the h...
journal_title:Nature neuroscience
pub_type: 杂志文章,评审
doi:10.1038/nn.4656
更新日期:2017-10-26 00:00:00
abstract::Although it has long been known that cultured embryonic stem cells can generate neurons, the lineage relationships with their immediate precursors remain unclear. We report here that selection of highly proliferative stem cells followed by treatment with retinoic acid generated essentially pure precursors that markers...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1301
更新日期:2004-09-01 00:00:00
abstract::Recent evidence suggests that presynaptic-acting NMDA receptors (preNMDARs) are important for neocortical synaptic transmission and plasticity. We found that unique properties of the NR3A subunit enable preNMDARs to enhance spontaneous and evoked glutamate release and that NR3A is required for spike timing-dependent l...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2750
更新日期:2011-03-01 00:00:00
abstract::Many cells in retinotopic brain areas increase their activity when saccades (rapid eye movements) are about to bring stimuli into their receptive fields. Although previous work has attempted to look at the functional correlates of such predictive remapping, no study has explicitly tested for better attentional perform...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2711
更新日期:2011-02-01 00:00:00
abstract::Here we report that synaptic and extrasynaptic NMDA (N-methyl-D-aspartate) receptors have opposite effects on CREB (cAMP response element binding protein) function, gene regulation and neuron survival. Calcium entry through synaptic NMDA receptors induced CREB activity and brain-derived neurotrophic factor (BDNF) gene...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn835
更新日期:2002-05-01 00:00:00
abstract::Fear-inducing memories can be state dependent, meaning that they can best be retrieved if the brain states at encoding and retrieval are similar. Restricted access to such memories can present a risk for psychiatric disorders and hamper their treatment. To better understand the mechanisms underlying state-dependent fe...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.4084
更新日期:2015-09-01 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature neuroscience
pub_type: 已发布勘误
doi:10.1038/s41593-020-00723-2
更新日期:2020-11-01 00:00:00
abstract::The zona limitans intrathalamica (ZLI), a narrow compartment in the vertebrate forebrain that bisects the diencephalon transversely, expresses the secreted factor sonic hedgehog (Shh). Because genetic disruption of Shh in mouse causes severe early developmental defects, this strategy has not been useful in identifying...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1338
更新日期:2004-11-01 00:00:00
abstract::Declarative memory, the conscious recollection of past experiences, is known to involve the hippocampus. Now a study of amnesic patients shows that hippocampus-dependent learning can occur in the absence of conscious awareness. ...
journal_title:Nature neuroscience
pub_type: 评论,新闻
doi:10.1038/12137
更新日期:1999-09-01 00:00:00
abstract::Adult neurogenesis occurs in the hippocampus and the olfactory bulb of the mammalian CNS. Recent studies have demonstrated that newborn granule cells of the adult hippocampus are postsynaptic targets of excitatory and inhibitory neurons, but evidence of synapse formation by the axons of these cells is still lacking. B...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2156
更新日期:2008-08-01 00:00:00
abstract::Dysfunction in sensory information processing is a hallmark of many neurological disorders, including autism spectrum disorders, schizophrenia and Rett syndrome (RTT). Using mouse models of RTT, a monogenic disorder caused by mutations in MECP2, we found that the large-scale loss of MeCP2 from forebrain GABAergic inte...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3710
更新日期:2014-06-01 00:00:00
abstract::Sharp wave-ripple (SPW-R) complexes in the hippocampus-entorhinal cortex are believed to be important for transferring labile memories from the hippocampus to the neocortex for long-term storage. We found that selective elimination of SPW-Rs during post-training consolidation periods resulted in performance impairment...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2384
更新日期:2009-10-01 00:00:00
abstract::Vesicular release of neurotransmitter is the universal output signal of neurons in the brain. It is generally believed that fast transmitter release is restricted to nerve terminals that contact postsynaptic cells in the gray matter. Here we show in the rat brain that the neurotransmitter glutamate is also released at...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1850
更新日期:2007-03-01 00:00:00
abstract::T cells clear virus from the CNS and dynamically regulate brain functions, including spatial learning, through cytokine signaling. Here we determined whether hippocampal T cells that persist after recovery from infection with West Nile virus (WNV) or Zika virus (ZIKV) impact hippocampal-dependent learning and memory. ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/s41593-019-0427-y
更新日期:2019-08-01 00:00:00
abstract::The ability to attribute mental states to others, and therefore to predict others' behavior, is particularly advanced in humans. A controversial but untested idea is that this is achieved by simulating the other person's mental processes in one's own mind. If this is the case, then the same neural systems activated by...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1168
更新日期:2004-01-01 00:00:00
abstract::The sensing of circulating nutrients within the mediobasal hypothalamus may be critical for energy homeostasis. To induce a sustained impairment in hypothalamic nutrient sensing, adeno-associated viruses (AAV) expressing malonyl-coenzyme A decarboxylase (MCD; an enzyme involved in the degradation of malonyl coenzyme A...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1626
更新日期:2006-02-01 00:00:00
abstract::We found that optogenetic burst stimulation of hippocampal dopaminergic fibers from midbrain neurons in mice exploring novel environments enhanced the reactivation of pyramidal cell assemblies during subsequent sleep/rest. When applied during spatial learning of new goal locations, dopaminergic photostimulation improv...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3843
更新日期:2014-12-01 00:00:00
abstract::Many attempts to obtain reliable self-administration behavior by laboratory animals with delta-9-tetrahydrocannabinol (THC), the psychoactive ingredient in marijuana, have been unsuccessful. Because self-administration behavior has been demonstrated in laboratory animals for almost all other psychoactive drugs abused ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/80577
更新日期:2000-11-01 00:00:00
abstract::Axonal degeneration is important during development but has not been thought to function in the intact mature nervous system. Here, we provide evidence that degeneration of adult axons occurs in the intact rodent brain through a p75 neurotrophin receptor (p75NTR)- and myelin-dependent mechanism. Specifically, we show ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2513
更新日期:2010-05-01 00:00:00
abstract::Precise apposition of pre- to postsynaptic specializations is required for optimal function of chemical synapses, but little is known about how it is achieved. At the skeletal neuromuscular junction, active zones (transmitter release sites) in the nerve terminal lie directly opposite junctional folds in the postsynapt...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/88414
更新日期:2001-06-01 00:00:00
abstract::The diseased brain hosts a heterogeneous population of myeloid cells, including parenchymal microglia, perivascular cells, meningeal macrophages and blood-borne monocytes. To date, the different types of brain myeloid cells have been discriminated solely on the basis of their localization, morphology and surface epito...
journal_title:Nature neuroscience
pub_type: 杂志文章,评审
doi:10.1038/nn.2923
更新日期:2011-09-27 00:00:00
abstract::Items held in working memory can be either attended or not, depending on their current behavioral relevance. It has been suggested that unattended contents might be solely retained in an activity-silent form. Instead, we demonstrate here that encoding unattended contents involves a division of labor. While visual cort...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/s41593-018-0094-4
更新日期:2018-04-01 00:00:00
abstract::Human neurodegenerative disorders are among the most difficult to study. In particular, the inability to readily obtain the faulty cell types most relevant to these diseases has impeded progress for decades. Recent advances in pluripotent stem cell technology now grant access to substantial quantities of disease-perti...
journal_title:Nature neuroscience
pub_type: 杂志文章,评审
doi:10.1038/nn.3425
更新日期:2013-07-01 00:00:00
abstract::Learning and memory are associated with the formation and modification of neuronal assemblies: populations of neurons that encode what has been learned and mediate memory retrieval upon recall. Functional studies of neuronal assemblies have progressed dramatically thanks to recent technological advances. Here we discu...
journal_title:Nature neuroscience
pub_type: 杂志文章,评审
doi:10.1038/nn.4418
更新日期:2016-12-01 00:00:00
abstract::Every year in the United States, an estimated 500,000 babies are born preterm (before 37 completed weeks of gestation), and this number is rising, along with the recognition of brain injuries due to preterm delivery. A common underlying pathogenesis appears to be perinatal hypoxia induced by immature lung development,...
journal_title:Nature neuroscience
pub_type: 杂志文章,评审
doi:10.1038/nn.3604
更新日期:2014-03-01 00:00:00
abstract::Understanding the origins and evolution of synapses may provide insight into species diversity and the organization of the brain. Using comparative proteomics and genomics, we examined the evolution of the postsynaptic density (PSD) and membrane-associated guanylate kinase (MAGUK)-associated signaling complexes (MASCs...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2135
更新日期:2008-07-01 00:00:00
abstract::The endocytosis of AMPA receptors is thought to be important in the expression of long-term depression (LTD) triggered by NMDA receptor activation. Although signaling pathways necessary for LTD induction have been identified, those responsible for the regulated internalization of AMPA receptors are unknown. Here we sh...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/81823
更新日期:2000-12-01 00:00:00
abstract::Images are processed in the primary visual cortex by neurons that encode different stimulus orientations and spatial phases. In primates and carnivores, neighboring cortical neurons share similar orientation preferences, but spatial phases were thought to be randomly distributed. We discovered a columnar organization ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3878
更新日期:2015-01-01 00:00:00