Abstract：
:The neural mechanisms that mediate the transition from a drug-naive state to a state of drug dependence and addiction are not yet known. Here we show that a discrete population of GABA(A) receptors in the mammalian ventral tegmental area (VTA) serves as a potential addiction switching mechanism by gating reward transmission through one of two neural motivational systems: either a dopamine-independent (opiate-naive) or a dopaminergic (opiate-dependent or opiate-withdrawn) system. Bi-directional transmission of reward signals through this GABA(A) receptor substrate is dynamically controlled by the opiate state of the organism and involves a molecular alteration of the GABA(A) receptor. After opiate exposure and subsequent withdrawal, the functional conductance properties of the rat VTA GABA(A) receptor switch from an inhibitory to an excitatory signaling mode.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Laviolette SR,Gallegos RA,Henriksen SJ,van der Kooy Ddoi
10.1038/nn1182subject
Has Abstractpub_date
2004-02-01 00:00:00pages
160-9issue
2eissn
1097-6256issn
1546-1726pii
nn1182journal_volume
7pub_type
杂志文章abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Nature neuroscience
pub_type： 已发布勘误
doi：10.1038/s41593-019-0570-5
更新日期：2020-02-01 00:00:00
abstract：:Peptides derived from proteolytic processing of the beta-amyloid precursor protein (APP), including the amyloid-beta peptide, are important for the pathogenesis of Alzheimer's dementia. We found that transgenic mice overexpressing APP have a profound and selective impairment in endothelium-dependent regulation of the ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/5715
更新日期：1999-02-01 00:00:00
abstract：:Brain circuitry processes information by rapidly and selectively engaging functional neuronal networks. The dynamic formation of networks is often evident in rhythmically synchronized neuronal activity and tightly correlates with perceptual, cognitive and motor performances. But how synchronized neuronal activity cont...
journal_title：Nature neuroscience
pub_type： 杂志文章,评审
doi：10.1038/nn.3764
更新日期：2014-08-01 00:00:00
abstract：:The weight of synaptic connections, which is controlled not only postsynaptically but also presynaptically, is a key determinant in neuronal network dynamics. The mechanisms controlling synaptic weight, especially on the presynaptic side, remain elusive. Using single-synapse imaging of the neurotransmitter glutamate c...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-017-0041-9
更新日期：2018-01-01 00:00:00
abstract：:Timing is crucial to many aspects of human performance. To better understand its neural underpinnings, we used event-related fMRI to examine the time course of activation associated with different components of a time perception task. We distinguished systems associated with encoding time intervals from those related ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/85191
更新日期：2001-03-01 00:00:00
abstract：:Agonists of GABA(B) receptors exert a bi-directional effect on the activity of dopamine (DA) neurons of the ventral tegmental area, which can be explained by the fact that coupling between GABA(B) receptors and G protein-gated inwardly rectifying potassium (GIRK) channels is significantly weaker in DA neurons than in ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn2006
更新日期：2007-12-01 00:00:00
abstract：:A fundamental assumption in neuroscience is that brain structure determines function. Accordingly, functionally distinct regions of cortex should be structurally distinct in their connections to other areas. We tested this hypothesis in relation to face selectivity in the fusiform gyrus. By using only structural conne...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3001
更新日期：2011-12-25 00:00:00
abstract：:To discover novel genes underlying amyotrophic lateral sclerosis (ALS), we aggregated exomes from 3,864 cases and 7,839 ancestry-matched controls. We observed a significant excess of rare protein-truncating variants among ALS cases, and these variants were concentrated in constrained genes. Through gene level analyses...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-019-0530-0
更新日期：2019-12-01 00:00:00
abstract：:The output of cortical columns is routed to different downstream targets via distinct pathways: cortico-cortical and cortico-subcortical. It is as yet unclear what roles these pathways play in perception, and which cellular and circuit mechanisms regulate their gating. We recently showed that activation of the apical ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-020-0677-8
更新日期：2020-10-01 00:00:00
abstract：:Sharp wave-ripple (SPW-R) complexes in the hippocampus-entorhinal cortex are believed to be important for transferring labile memories from the hippocampus to the neocortex for long-term storage. We found that selective elimination of SPW-Rs during post-training consolidation periods resulted in performance impairment...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2384
更新日期：2009-10-01 00:00:00
abstract：:Humans and other primates sample the visual environment using saccadic eye movements that shift a high-resolution fovea toward regions of interest to create a clear perception of a scene across fixations. Many mammals, however, like mice, lack a fovea, which raises the question of why they make saccades. Here we descr...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-018-0255-5
更新日期：2018-11-01 00:00:00
abstract：:Modeling of human neuropsychiatric disorders in animals is extremely challenging given the subjective nature of many symptoms, the lack of biomarkers and objective diagnostic tests, and the early state of the relevant neurobiology and genetics. Nonetheless, progress in understanding pathophysiology and in treatment de...
journal_title：Nature neuroscience
pub_type： 杂志文章,评审
doi：10.1038/nn.2647
更新日期：2010-10-01 00:00:00
abstract：:Microcircuits composed of principal neuron and interneuron dendrites have an important role in shaping the representation of sensory information in the olfactory bulb. Here we establish the physiological features governing synaptic signaling in dendrodendritic microcircuits of olfactory bulb glomeruli. We show that de...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1403
更新日期：2005-03-01 00:00:00
abstract：:The melanocortin system provides a conceptual blueprint for the central control of energetic state. Defined by four principal molecular components--two antagonistically acting ligands and two cognate receptors--this phylogenetically conserved system serves as a prototype for hierarchical energy balance regulation. Ove...
journal_title：Nature neuroscience
pub_type： 杂志文章,评审
doi：10.1038/nn.4202
更新日期：2016-02-01 00:00:00
abstract：:The basis for differences in activity-dependent trafficking of AMPA receptors (AMPARs) and NMDA receptors (NMDARs) remains unclear. Using single-molecule tracking, we found different lateral mobilities for AMPARs and NMDARs: changes in neuronal activity modified AMPAR but not NMDAR mobility, whereas protein kinase C a...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1270
更新日期：2004-07-01 00:00:00
abstract：:Angelman syndrome (AS) is a severe neurological disorder characterized by mental retardation, motor dysfunction and epilepsy. We show that the molecular and cellular deficits of an AS mouse model can be rescued by introducing an additional mutation at the inhibitory phosphorylation site of alphaCaMKII. Moreover, these...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1845
更新日期：2007-03-01 00:00:00
abstract：:The sensing of circulating nutrients within the mediobasal hypothalamus may be critical for energy homeostasis. To induce a sustained impairment in hypothalamic nutrient sensing, adeno-associated viruses (AAV) expressing malonyl-coenzyme A decarboxylase (MCD; an enzyme involved in the degradation of malonyl coenzyme A...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1626
更新日期：2006-02-01 00:00:00
abstract：:The CNS is protected by the immune system, including cells that reside directly within the CNS and help to ensure proper neural function, as well as cells that traffic into the CNS with disease. The CNS-resident immune system is comprised mainly of innate immune cells and operates under homeostatic conditions. These m...
journal_title：Nature neuroscience
pub_type： 杂志文章,评审
doi：10.1038/nn.4475
更新日期：2017-02-01 00:00:00
abstract：:Here, we characterized behavioral abnormalities induced by prolonged social isolation in adult rodents. Social isolation induced both anxiety- and anhedonia-like symptoms and decreased cAMP response element-binding protein (CREB) activity in the nucleus accumbens shell (NAcSh). All of these abnormalities were reversed...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2257
更新日期：2009-02-01 00:00:00
abstract：:Perturbations of astrocytes trigger neurodegeneration in several diseases, but the glial cell-intrinsic mechanisms that induce neurodegeneration remain poorly understood. We found that a protein complex of α2-Na/K ATPase and α-adducin was enriched in astrocytes expressing mutant superoxide dismutase 1 (SOD1), which ca...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3853
更新日期：2014-12-01 00:00:00
abstract：:The classic 'size principle' of motor control describes how increasingly forceful movements arise by the recruitment of motoneurons of progressively larger size and force output into the active pool. We explored the activity of pools of spinal interneurons in larval zebrafish and found that increases in swimming speed...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2225
更新日期：2008-12-01 00:00:00
abstract：:Axon degeneration is a hallmark of many neurodegenerative disorders. The current assumption is that the decision of injured axons to degenerate is cell-autonomously regulated. Here we show that Schwann cells (SCs), the glia of the peripheral nervous system, protect injured axons by virtue of a dramatic glycolytic upre...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-020-0689-4
更新日期：2020-10-01 00:00:00
abstract：:Ample evidence suggests that primary visual cortex is involved in the perception of form, and there is increasing evidence that it may also be important in the perception of surfaces. Perceptual qualities of surfaces, such as brightness, are based on extensive integration of information throughout the visual field. In...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/2849
更新日期：1998-11-01 00:00:00
abstract：:Replay of hippocampal place cell sequences has been proposed as a fundamental mechanism of learning and memory. However, the standard interpretation of replay has been challenged by reports that similar activity is observed before experience ('preplay'). By the preplay account, pre-existing temporal sequences are mapp...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4151
更新日期：2015-12-01 00:00:00
abstract：:In Huntington's disease (HD), expansion of CAG codons in the huntingtin gene (HTT) leads to the aberrant formation of protein aggregates and the differential degeneration of striatal medium spiny neurons (MSNs). Modeling HD using patient-specific MSNs has been challenging, as neurons differentiated from induced plurip...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-018-0075-7
更新日期：2018-03-01 00:00:00
abstract：:Successfully navigating in physical or semantic space requires a neural representation of allocentric (map-based) vectors to boundaries, objects and goals. Cognitive processes such as path-planning and imagination entail the recall of vector representations, but evidence of neuron-level memory for allocentric vectors ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-020-00761-w
更新日期：2020-12-21 00:00:00
abstract：:The autosomal dominant disorder neurofibromatosis type 2 (NF2) is a hereditary tumor syndrome caused by inactivation of the NF2 tumor suppressor gene, encoding merlin. Apart from tumors affecting the peripheral and central nervous systems, most NF2 patients develop peripheral neuropathies. This peripheral nerve diseas...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3348
更新日期：2013-04-01 00:00:00
abstract：:Activity in the primary auditory cortex (A1) is essential for normal sound localization behavior, but previous studies of the spatial sensitivity of neurons in A1 have found broad spatial tuning. We tested the hypothesis that spatial tuning sharpens when an animal engages in an auditory task. Cats performed a task tha...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2713
更新日期：2011-01-01 00:00:00
abstract：:Long-term synaptic changes, which are essential for learning and memory, are dependent on homeostatic mechanisms that stabilize neural activity. Homeostatic responses have also been implicated in pathological conditions, including nicotine addiction. Although multiple homeostatic pathways have been described, little i...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2969
更新日期：2011-11-13 00:00:00
abstract：:The processing of synaptic potentials by neuronal dendrites depends on both their passive cable properties and active voltage-gated channels, which can generate complex effects as a result of their nonlinear properties. We characterized the actions of HCN (hyperpolarization-activated cyclic nucleotide-gated cation) ch...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2307
更新日期：2009-05-01 00:00:00
