Abstract：
:In mammals, many daily cycles are driven by a central circadian clock, which is based on the cell-autonomous rhythmic expression of clock genes. It is not clear, however, how peripheral cells are able to interpret the rhythmic signals disseminated from this central oscillator. Here we show that cycling expression of the clock gene Period1 in rodent pituitary cells depends on the heterologous sensitization of the adenosine A2b receptor, which occurs through the nocturnal activation of melatonin mt1 receptors. Eliminating the impact of the neurohormone melatonin simultaneously suppresses the expression of Period1 and evokes an increase in the release of pituitary prolactin. Our findings expose a mechanism by which two convergent signals interact within a temporal dimension to establish high-amplitude, precise and robust cycles of gene expression.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
von Gall C,Garabette ML,Kell CA,Frenzel S,Dehghani F,Schumm-Draeger PM,Weaver DR,Korf HW,Hastings MH,Stehle JHdoi
10.1038/nn806subject
Has Abstractpub_date
2002-03-01 00:00:00pages
234-8issue
3eissn
1097-6256issn
1546-1726pii
nn806journal_volume
5pub_type
杂志文章abstract：:Hippocampal CA1 pyramidal neurons have frequently been regarded as a homogeneous cell population in biophysical, pharmacological and modeling studies. We found robust differences between pyramidal neurons residing in the deep and superficial CA1 sublayers in rats. Compared with their superficial peers, deep pyramidal ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2894
更新日期：2011-08-07 00:00:00
abstract：:Chondroitinase ABC treatment promotes spinal cord plasticity. We investigated whether chondroitinase-induced plasticity combined with physical rehabilitation promotes recovery of manual dexterity in rats with cervical spinal cord injuries. Rats received a C4 dorsal funiculus cut followed by chondroitinase ABC or penic...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2377
更新日期：2009-09-01 00:00:00
abstract：:Illusions that produce perceptual suppression despite constant retinal input are used to manipulate visual consciousness. Here we report on a powerful variant of existing techniques, continuous flash suppression. Distinct images flashed successively at approximately 10 Hz into one eye reliably suppress an image presen...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1500
更新日期：2005-08-01 00:00:00
abstract：:Neural progenitor cells in the developing neocortex change over time to produce different neurons, a phenomenon that is also observed in other regions of the nervous system. Mouse Numb (also known as m-numb) and Numbl (also known as numblike or Nbl) are redundant but essential in maintaining virtually all progenitor c...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1289
更新日期：2004-08-01 00:00:00
abstract：:The subunit composition of postsynaptic non-NMDA-type glutamate receptors (GluRs) determines the function and trafficking of the receptor. Changes in GluR composition have been implicated in the homeostasis of neuronal excitability and synaptic plasticity underlying learning. Here, we imaged GluRs in vivo during the f...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2122
更新日期：2008-06-01 00:00:00
abstract：:We found that K(+)/Cl(-) co-transporter 2 (KCC2) activity, monitored with wide-field fluorescence, was inhibited by intracellular Zn(2+), a major component of neuronal injury. Zn(2+)-mediated KCC2 inhibition produced a depolarizing shift of GABA(A) reversal potentials in rat cortical neurons. Moreover, oxygen-glucose ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2316
更新日期：2009-06-01 00:00:00
abstract：:The launch of the US BRAIN and European Human Brain Projects coincides with growing international efforts toward transparency and increased access to publicly funded research in the neurosciences. The need for data-sharing standards and neuroinformatics infrastructure is more pressing than ever. However, 'big science'...
journal_title：Nature neuroscience
pub_type： 杂志文章,评审
doi：10.1038/nn.3838
更新日期：2014-11-01 00:00:00
abstract：:Understanding a sensory system implies the ability to predict responses to a variety of inputs from a common model. In the retina, this includes predicting how the integration of signals across visual space shapes the outputs of retinal ganglion cells. Existing models of this process generalize poorly to predict respo...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3225
更新日期：2012-11-01 00:00:00
abstract：:The identity of specific cell types in the nervous system is defined by the expression of neuron type-specific gene batteries. How the expression of such batteries is initiated during nervous system development has been under intensive study over the past few decades. However, comparatively little is known about how g...
journal_title：Nature neuroscience
pub_type： 杂志文章,评审
doi：10.1038/nn.3731
更新日期：2014-07-01 00:00:00
abstract：:Declarative memory, the conscious recollection of past experiences, is known to involve the hippocampus. Now a study of amnesic patients shows that hippocampus-dependent learning can occur in the absence of conscious awareness. ...
journal_title：Nature neuroscience
pub_type： 评论,新闻
doi：10.1038/12137
更新日期：1999-09-01 00:00:00
abstract：:It is unclear how knowledge of one's actions and one's body contribute to the understanding of others' actions. Here we show that two subjects lacking cutaneous touch and sense of movement and position show a selective deficit in interpreting another person's anticipation of weight when seeing him lifting boxes. We su...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1535
更新日期：2005-10-01 00:00:00
abstract：:Phosphoinositide 3 kinase enhancer (PIKE) is a recently identified nuclear GTPase that activates nuclear phosphoinositide 3-kinase (PI3 kinase). We have identified, cloned and characterized a new form of PIKE, designated PIKE-L, which, unlike the nuclear PIKE-S, localizes to both the cytoplasm and the nucleus. We demo...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1134
更新日期：2003-11-01 00:00:00
abstract：:Quantifying behavior is crucial for many applications in neuroscience. Videography provides easy methods for the observation and recording of animal behavior in diverse settings, yet extracting particular aspects of a behavior for further analysis can be highly time consuming. In motor control studies, humans or other...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-018-0209-y
更新日期：2018-09-01 00:00:00
abstract：:In this Perspective, we expand the notion of temporal regulation of RNA in the brain and propose that the qualitative nature of RNA and its metabolism, together with RNA abundance, are essential for the molecular mechanisms underlying experience-dependent plasticity. We discuss emerging concepts in the newly burgeonin...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4378
更新日期：2016-09-27 00:00:00
abstract：:Tumor-associated macrophages (TAMs) play an important role in the immune response to cancer, but the mechanisms by which the tumor microenvironment controls TAMs and T cell immunity are not completely understood. Here we report that kynurenine produced by glioblastoma cells activates aryl hydrocarbon receptor (AHR) in...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-019-0370-y
更新日期：2019-05-01 00:00:00
abstract：:Brain-derived neurotrophic factor (BDNF) acting through the tyrosine kinase B receptor (TrkB) is thought to be a critical mediator of learning. As there are no available selective antagonists of TrkB, we used a lentivirus encoding a dominant-negative TrkB (TrkB.t1) to antagonize BDNF signaling during extinction of con...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1718
更新日期：2006-07-01 00:00:00
abstract：:Aggression is a social behavior essential for securing resources and defending oneself and family. Thanks to its indispensable function in competition and thus survival, aggression exists widely across animal species, including humans. Classical works from Tinbergen and Lorenz concluded that instinctive behaviors incl...
journal_title：Nature neuroscience
pub_type： 杂志文章,评审
doi：10.1038/s41593-020-00715-2
更新日期：2020-11-01 00:00:00
abstract：:The spinal cord is the initial stage that integrates temperature information from peripheral inputs. Here we used molecular genetics and in vivo calcium imaging to investigate the coding of cutaneous temperature in the spinal cord in mice. We found that heating or cooling the skin evoked robust calcium responses in sp...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4350
更新日期：2016-09-01 00:00:00
abstract：:Although long-term potentiation (LTP) is long-lasting, it is not permanent and decays within weeks after its induction. Little is known about the processes underlying this decay. Here we assessed the contribution of synaptic activity to LTP decay by determining the effect of the competitive NMDA receptor antagonist CP...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn776
更新日期：2002-01-01 00:00:00
abstract：:Individuals' risk attitudes are known to guide choices about uncertain options. However, in the presence of others' decisions, these choices can be swayed and manifest as riskier or safer behavior than one would express alone. To test the mechanisms underlying effective social 'nudges' in human decision-making, we use...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4022
更新日期：2015-06-01 00:00:00
abstract：:Microglia, the brain's intrinsic immune cells, rapidly sense brain injury and help clear cellular debris. Haynes et al. now show that P2Y12 receptors are critical for activating microglia and directing them to the site of injury. ...
journal_title：Nature neuroscience
pub_type： 评论,杂志文章
doi：10.1038/nn1206-1463
更新日期：2006-12-01 00:00:00
abstract：:Neurotransmitters are released continuously at ribbon synapses in the retina and cochlea. Notably, a single ribbon synapse of inner hair cells provides the entire input to each cochlear afferent fiber. We investigated hair cell transmitter release in the postnatal rat cochlea by recording excitatory postsynaptic curre...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn796
更新日期：2002-02-01 00:00:00
abstract：:Repeated cocaine administration increases the dendritic arborization of nucleus accumbens neurons, but the underlying signaling events remain unknown. Here we show that repeated exposure to cocaine negatively regulates the active form of Rac1, a small GTPase that controls actin remodeling in other systems. Further, we...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3094
更新日期：2012-06-01 00:00:00
abstract：:Many cells in retinotopic brain areas increase their activity when saccades (rapid eye movements) are about to bring stimuli into their receptive fields. Although previous work has attempted to look at the functional correlates of such predictive remapping, no study has explicitly tested for better attentional perform...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2711
更新日期：2011-02-01 00:00:00
abstract：:Previous gene knockout studies have shown that the orphan glutamate receptor delta2 (GluRdelta2) is critically involved in synaptogenesis between parallel fibers and Purkinje cells during development. However, the precise function of GluRdelta2 and whether it is functional in the mature cerebellum remain unclear. To a...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1086
更新日期：2003-08-01 00:00:00
abstract：:A moving grating elicits innate optomotor behavior in zebrafish larvae; they swim in the direction of perceived motion. We took advantage of this behavior, using computer-animated displays, to determine what attributes of motion are extracted by the fish visual system. As in humans, first-order (luminance-defined or F...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/80649
更新日期：2000-11-01 00:00:00
abstract：:Selective serotonin reuptake inhibitors (SSRIs) are widely used antidepressants, but the mechanisms by which they influence behavior are only partially resolved. Adult hippocampal neurogenesis is necessary for some of the responses to SSRIs, but it is not known whether mature dentate gyrus granule cells (DG GCs) also ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4116
更新日期：2015-11-01 00:00:00
abstract：:Brain neural stem cells (radial glial progenitors, RGPs) undergo a mysterious form of cell cycle-entrained interkinetic nuclear migration (INM) that is driven apically by cytoplasmic dynein and basally by the kinesin KIF1A, which has recently been implicated in human brain developmental disease. To understand the cons...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4213
更新日期：2016-02-01 00:00:00
abstract：:Nucleus HVc of the avian song system is a forebrain structure critical in song production, perception and learning. Here we show that most HVc neurons that respond to auditory stimuli under anesthesia show no responses to the same stimulus in the awake, unrestrained bird. This suppression of auditory responses in awak...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/2232
更新日期：1998-10-01 00:00:00
abstract：:Experience-dependent plasticity in adult visual cortex is believed to have important roles in visual coding and perceptual learning. Here we show that repeated stimulation with movies of natural scenes induces a rapid improvement in response reliability in cat visual cortex, whereas stimulation with white noise or fla...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1895
更新日期：2007-06-01 00:00:00
