Abstract：
:Brain-derived neurotrophic factor (BDNF) acting through the tyrosine kinase B receptor (TrkB) is thought to be a critical mediator of learning. As there are no available selective antagonists of TrkB, we used a lentivirus encoding a dominant-negative TrkB (TrkB.t1) to antagonize BDNF signaling during extinction of conditioned fear. Whereas TrkB.t1-infected rats showed normal within-session extinction, their retention of extinction was impaired, suggesting that amygdala TrkB activation is required for the consolidation of stable extinction memories.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Chhatwal JP,Stanek-Rattiner L,Davis M,Ressler KJdoi
10.1038/nn1718subject
Has Abstractpub_date
2006-07-01 00:00:00pages
870-2issue
7eissn
1097-6256issn
1546-1726pii
nn1718journal_volume
9pub_type
杂志文章abstract：:Neuroinflammatory diseases, such as multiple sclerosis, are characterized by invasion of the brain by autoreactive T cells. The mechanism for how T cells acquire their encephalitogenic phenotype and trigger disease remains, however, unclear. The existence of lymphatic vessels in the meninges indicates a relevant link ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-018-0227-9
更新日期：2018-10-01 00:00:00
abstract：:We introduce a deceptively simple behavioral task that robustly identifies two qualitatively different groups within the general population. When presented with an isochronous train of random syllables, some listeners are compelled to align their own concurrent syllable production with the perceived rate, whereas othe...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-019-0353-z
更新日期：2019-04-01 00:00:00
abstract：:An unresolved question in neuroscience relates to the extent to which corticothalamocortical circuits emanating from layer 5B are involved in information transfer through the cortical hierarchy. Using a new form of optical imaging in a brain slice preparation, we found that the corticothalamocortical pathway drove rob...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2449
更新日期：2010-01-01 00:00:00
abstract：:We report two functional magnetic resonance imaging experiments showing enhanced responses in human middle superior temporal sulcus for angry relative to neutral prosody. This emotional enhancement was voice specific, unrelated to isolated acoustic amplitude or frequency cues in angry prosody, and distinct from any co...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1392
更新日期：2005-02-01 00:00:00
abstract：:The deposition of aggregated amyloid-β peptides derived from the pro-amyloidogenic processing of the amyloid precurson protein (APP) into characteristic amyloid plaques (APs) is distinctive to Alzheimer's disease (AD). Alternative APP processing via the metalloprotease ADAM10 prevents amyloid-β formation. We tested wh...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-019-0432-1
更新日期：2019-08-01 00:00:00
abstract：:It is unclear how knowledge of one's actions and one's body contribute to the understanding of others' actions. Here we show that two subjects lacking cutaneous touch and sense of movement and position show a selective deficit in interpreting another person's anticipation of weight when seeing him lifting boxes. We su...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1535
更新日期：2005-10-01 00:00:00
abstract：:Exposure to an enriched environment increases neurogenesis in the dentate gyrus of adult rodents. Environmental enrichment, however, typically consists of many components, such as expanded learning opportunities, increased social interaction, more physical activity and larger housing. We attempted to separate componen...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/6368
更新日期：1999-03-01 00:00:00
abstract：:Robust form perception and underlying neuronal mechanisms require generalized representation of object boundaries, independent of how they are defined. One visual ability essential for form perception is reconstruction of contours absent from the retinal image. Here we show that barn owls perceive subjective contours ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/10217
更新日期：1999-07-01 00:00:00
abstract：:TDP-43 is a predominantly nuclear RNA-binding protein that forms inclusion bodies in frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). The mRNA targets of TDP-43 in the human brain and its role in RNA processing are largely unknown. Using individual nucleotide-resolution ultraviolet cro...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2778
更新日期：2011-04-01 00:00:00
abstract：:Sleep can strengthen memory for emotional information, but whether emotional memories can be specifically targeted and modified during sleep is unknown. In human subjects who underwent olfactory contextual fear conditioning, re-exposure to the odorant context in slow-wave sleep promoted stimulus-specific fear extincti...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3527
更新日期：2013-11-01 00:00:00
abstract：:Neurotransmitter transporters can affect neuronal excitability indirectly via modulation of neurotransmitter concentrations or directly via transporter currents. A physiological or pathophysiological role for transporter currents has not been described. We found that GABA transporter 1 (GAT-1) cation currents directly...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2940
更新日期：2011-10-30 00:00:00
abstract：:Phasic activation of the dopamine (DA) midbrain system in response to unexpected reward or novelty is critical for adaptive behavioral strategies. This activation of DA midbrain neurons occurs via a synaptically triggered switch from low-frequency background spiking to transient high-frequency burst firing. We found t...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3185
更新日期：2012-09-01 00:00:00
abstract：:A central question in the study of human behavior is the origin of willed action. EEG recordings of surface brain activity from human subjects performing a self-initiated movement show that the subjective experience of wanting to move follows, rather than precedes, the 'readiness potential'--an electrophysiological ma...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1160
更新日期：2004-01-01 00:00:00
abstract：:By combining computational, morphological, and functional analyses, this study relates latent markers of associative threat learning to overt post-traumatic stress disorder (PTSD) symptoms in combat veterans. Using reversal learning, we found that symptomatic veterans showed greater physiological adjustment to cues th...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-018-0315-x
更新日期：2019-03-01 00:00:00
abstract：:Neuronal activity-induced gene expression modulates the function and plasticity of the nervous system. It is unknown whether and to what extent neuronal activity may trigger changes in chromatin accessibility, a major mode of epigenetic regulation of gene expression. Here we compared chromatin accessibility landscapes...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4494
更新日期：2017-03-01 00:00:00
abstract：:Differentiation of CNS glia is regulated by Notch signaling through neuron-glia interaction. Here, we identified Delta/Notch-like EGF-related receptor (DNER), a neuron-specific transmembrane protein, as a previously unknown ligand of Notch during cellular morphogenesis of Bergmann glia in the mouse cerebellum. DNER bi...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1492
更新日期：2005-07-01 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Nature neuroscience
pub_type： 已发布勘误
doi：10.1038/s41593-020-0595-9
更新日期：2020-02-01 00:00:00
abstract：:Neuregulin 1 type III is processed following regulated intramembrane proteolysis, which allows communication from the plasma membrane to the nucleus. We found that the intracellular domain of neuregulin 1 type III upregulated the prostaglandin D2 synthase (L-pgds, also known as Ptgds) gene, which, together with the G ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3857
更新日期：2014-12-01 00:00:00
abstract：:We argue that there will be no single (genetic or cognitive) cause for the diverse symptoms defining autism. We present recent evidence of behavioral fractionation of social impairment, communication difficulties and rigid and repetitive behaviors. Twin data suggest largely nonoverlapping genes acting on each of these...
journal_title：Nature neuroscience
pub_type： 杂志文章,评审
doi：10.1038/nn1770
更新日期：2006-10-01 00:00:00
abstract：:Bone morphogenetic proteins (BMPs), negative regulators of neural determination in the early embryo, were found to be potent inhibitors of neurogenesis in olfactory epithelium (OE) cultures. BMPs 2, 4 or 7 decreased the number of proliferating progenitor cells and blocked production of olfactory receptor neurons (ORNs...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/7251
更新日期：1999-04-01 00:00:00
abstract：:Intrinsic signal imaging from inferotemporal (IT) cortex, a visual area essential for object perception and recognition, revealed that visually presented objects activated patches in a distributed manner. When visual features of these objects were partially removed, the simplified stimuli activated only a subset of th...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/90547
更新日期：2001-08-01 00:00:00
abstract：:The diseased brain hosts a heterogeneous population of myeloid cells, including parenchymal microglia, perivascular cells, meningeal macrophages and blood-borne monocytes. To date, the different types of brain myeloid cells have been discriminated solely on the basis of their localization, morphology and surface epito...
journal_title：Nature neuroscience
pub_type： 杂志文章,评审
doi：10.1038/nn.2923
更新日期：2011-09-27 00:00:00
abstract：:In the version of this article initially published, paragraph 8 mentioned intra-accumbens administration of SB334867. This should have read systemic (intraperitoneal) administration. The error has been corrected in the HTML and PDF versions of the article. ...
journal_title：Nature neuroscience
pub_type： 已发布勘误
doi：10.1038/s41593-018-0111-7
更新日期：2018-06-01 00:00:00
abstract：:As we move through the environment, the pattern of visual motion on the retina provides rich information about our movement through the scene. Human subjects can use this information, often termed "optic flow", to accurately estimate their direction of self movement (heading) from relatively sparse displays. Physiolog...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/259
更新日期：1998-05-01 00:00:00
abstract：:In Huntington's disease (HD), whether transneuronal spreading of mutant huntingtin (mHTT) occurs and its contribution to non-cell autonomous damage in brain networks is largely unknown. We found mHTT spreading in three different neural network models: human neurons integrated in the neural network of organotypic brain...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3761
更新日期：2014-08-01 00:00:00
abstract：:Accumulation of abnormally phosphorylated TDP-43 (pTDP-43) is the main pathology in affected neurons of people with amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Morphological diversity and neuroanatomical distribution of pTDP-43 accumulations allowed classification of FTLD cases in...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-018-0294-y
更新日期：2019-01-01 00:00:00
abstract：:In the version of this article initially published, the traces in Fig. 1j and in Fig. 1k, right, were duplicated from the corresponding traces in Fig. 1c, bottom, and Fig. 1d, bottom right. The error has been corrected in the HTML and PDF versions of the article. ...
journal_title：Nature neuroscience
pub_type： 已发布勘误
doi：10.1038/s41593-018-0183-4
更新日期：2018-09-01 00:00:00
abstract：:A long-standing debate in neuroscience is whether classical and operant conditioning are mechanistically similar or distinct. The feeding behavior of Aplysia provides a model system suitable for addressing this question. Here we report that classical and operant conditioning of feeding behavior differentially modify t...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1593
更新日期：2006-01-01 00:00:00
abstract：:From insects to mammals, olfactory receptor neurons (ORNs) expressing a common olfactory receptor target their axons to specific glomeruli with high precision. Here we show in Drosophila that the POU transcription factor Acj6 controls the axon targeting specificity of a subset of ORN classes, as defined by the olfacto...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1284
更新日期：2004-08-01 00:00:00
abstract：:Illusions that produce perceptual suppression despite constant retinal input are used to manipulate visual consciousness. Here we report on a powerful variant of existing techniques, continuous flash suppression. Distinct images flashed successively at approximately 10 Hz into one eye reliably suppress an image presen...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1500
更新日期：2005-08-01 00:00:00
