Abstract:
:Differentiation of CNS glia is regulated by Notch signaling through neuron-glia interaction. Here, we identified Delta/Notch-like EGF-related receptor (DNER), a neuron-specific transmembrane protein, as a previously unknown ligand of Notch during cellular morphogenesis of Bergmann glia in the mouse cerebellum. DNER binds to Notch1 at cell-cell contacts and activates Notch signaling in vitro. In the developing cerebellum, DNER is highly expressed in Purkinje cell dendrites, which are tightly associated with radial fibers of Bergmann glia expressing Notch. DNER specifically binds to Bergmann glia in culture and induces process extension by activating gamma-secretase- and Deltex-dependent Notch signaling. Inhibition of Deltex-dependent, but not RBP-J-dependent, Notch signaling in Bergmann glia suppresses formation and maturation of radial fibers in organotypic slice cultures. Additionally, deficiency of DNER retards the formation of radial fibers and results in abnormal arrangement of Bergmann glia. Thus, DNER mediates neuron-glia interaction and promotes morphological differentiation of Bergmann glia through Deltex-dependent Notch signaling.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Eiraku M,Tohgo A,Ono K,Kaneko M,Fujishima K,Hirano T,Kengaku Mdoi
10.1038/nn1492subject
Has Abstractpub_date
2005-07-01 00:00:00pages
873-80issue
7eissn
1097-6256issn
1546-1726pii
nn1492journal_volume
8pub_type
杂志文章abstract::Nucleus HVc of the avian song system is a forebrain structure critical in song production, perception and learning. Here we show that most HVc neurons that respond to auditory stimuli under anesthesia show no responses to the same stimulus in the awake, unrestrained bird. This suppression of auditory responses in awak...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/2232
更新日期:1998-10-01 00:00:00
abstract::Cocaine is a widely abused substance with psychostimulant effects that are attributed to inhibition of the dopamine transporter (DAT). We present molecular models for DAT binding of cocaine and cocaine analogs constructed from the high-resolution structure of the bacterial transporter homolog LeuT. Our models suggest ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2146
更新日期:2008-07-01 00:00:00
abstract::UTX is a chromatin modifier required for development and neural lineage specification, but how it controls these biological processes is unclear. To determine the molecular mechanisms of UTX, we identified novel UTX protein interaction partners. Here we show that UTX and 53BP1 directly interact and co-occupy promoters...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/s41593-018-0328-5
更新日期:2019-03-01 00:00:00
abstract::Parkinson disease is a neurodegenerative disorder whose symptoms are caused by the loss of dopaminergic neurons innervating the striatum. As striatal dopamine levels fall, striatal acetylcholine release rises, exacerbating motor symptoms. This adaptation is commonly attributed to the loss of interneuronal regulation b...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1700
更新日期:2006-06-01 00:00:00
abstract::Sharp wave-ripple (SPW-R) complexes in the hippocampus-entorhinal cortex are believed to be important for transferring labile memories from the hippocampus to the neocortex for long-term storage. We found that selective elimination of SPW-Rs during post-training consolidation periods resulted in performance impairment...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2384
更新日期:2009-10-01 00:00:00
abstract::Cuing covert spatial attention can increase spatial resolution. Here we pinpointed the specific locus of this effect using texture segmentation. At the level of visual cortex, texture segmentation theoretically involves passage of visual input through two layers of spatial linear filters separated by a pointwise nonli...
journal_title:Nature neuroscience
pub_type: 临床试验,杂志文章
doi:10.1038/75804
更新日期:2000-06-01 00:00:00
abstract::Dendritic spines are motile structures that contain high concentrations of filamentous actin. Using hippocampal neurons expressing fluorescent actin and the method of fluorescence recovery after photobleaching, we found that 85 +/- 2% of actin in the spine was dynamic, with a turnover time of 44.2 +/- 4.0 s. The rapid...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn811
更新日期:2002-03-01 00:00:00
abstract::TDP-43 is a predominantly nuclear RNA-binding protein that forms inclusion bodies in frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). The mRNA targets of TDP-43 in the human brain and its role in RNA processing are largely unknown. Using individual nucleotide-resolution ultraviolet cro...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2778
更新日期:2011-04-01 00:00:00
abstract::Memory reconsolidation has been demonstrated in various tasks and species, suggesting it is a fundamental process. However, there are experimental parameters that can inhibit reconsolidation from occurring (boundary conditions). These conditions and their mechanisms remain poorly defined. Here, we characterize the abi...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2350
更新日期:2009-07-01 00:00:00
abstract::Huntington's disease (HD) is caused by an expansion of exonic CAG triplet repeats in the gene encoding huntingtin protein (Htt), but the mechanisms by which this mutant protein causes neurodegeneration remain unknown. Here we show that lymphoblast mitochondria from patients with HD have a lower membrane potential and ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn884
更新日期:2002-08-01 00:00:00
abstract::Peptides derived from proteolytic processing of the beta-amyloid precursor protein (APP), including the amyloid-beta peptide, are important for the pathogenesis of Alzheimer's dementia. We found that transgenic mice overexpressing APP have a profound and selective impairment in endothelium-dependent regulation of the ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/5715
更新日期:1999-02-01 00:00:00
abstract::Successfully navigating in physical or semantic space requires a neural representation of allocentric (map-based) vectors to boundaries, objects and goals. Cognitive processes such as path-planning and imagination entail the recall of vector representations, but evidence of neuron-level memory for allocentric vectors ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/s41593-020-00761-w
更新日期:2020-12-21 00:00:00
abstract::Midbrain ventral tegmental neurons project to the prefrontal cortex and modulate cognitive functions. Using viral tracing, optogenetics and electrophysiology, we found that mesocortical neurons in the mouse ventrotegmental area provide fast glutamatergic excitation of GABAergic interneurons in the prefrontal cortex an...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.4020
更新日期:2015-06-01 00:00:00
abstract::Attention powerfully influences auditory perception, but little is understood about the mechanisms whereby attention sharpens responses to unattended sounds. We used high-resolution surface mapping techniques (using functional magnetic resonance imaging, fMRI) to examine activity in human auditory cortex during an int...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1256
更新日期:2004-06-01 00:00:00
abstract::The weight of synaptic connections, which is controlled not only postsynaptically but also presynaptically, is a key determinant in neuronal network dynamics. The mechanisms controlling synaptic weight, especially on the presynaptic side, remain elusive. Using single-synapse imaging of the neurotransmitter glutamate c...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/s41593-017-0041-9
更新日期:2018-01-01 00:00:00
abstract::The structure and function of presynaptic and postsynaptic compartments varies markedly in neurons, but little is known about how they are functionally arranged with respect to each other. In rat hippocampal neurons, we found that, although they are structurally correlated from the early moments of formation, synapses...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2826
更新日期:2011-06-01 00:00:00
abstract::Many attempts to obtain reliable self-administration behavior by laboratory animals with delta-9-tetrahydrocannabinol (THC), the psychoactive ingredient in marijuana, have been unsuccessful. Because self-administration behavior has been demonstrated in laboratory animals for almost all other psychoactive drugs abused ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/80577
更新日期:2000-11-01 00:00:00
abstract::Histone deacetylases (HDACs) are major epigenetic regulators. We show that HDAC1 and HDAC2 functions are critical for myelination of the peripheral nervous system. Using mouse genetics, we have ablated Hdac1 and Hdac2 specifically in Schwann cells, resulting in massive Schwann cell loss and virtual absence of myelin i...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2762
更新日期:2011-04-01 00:00:00
abstract::Neural activity exhibits complex dynamics related to various brain functions, internal states and behaviors. Understanding how neural dynamics explain specific measured behaviors requires dissociating behaviorally relevant and irrelevant dynamics, which is not achieved with current neural dynamic models as they are le...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/s41593-020-00733-0
更新日期:2021-01-01 00:00:00
abstract::We elucidated the intrinsic circuitry of the medial prefrontal cortex and its role in regulating fear extinction, using neuronal tracing and optogenetic stimulation in vitro and in vivo. We show that pyramidal neurons in layer 5/6 of the prelimbic medial prefrontal cortex project to pyramidal cells in layer 5/6 of the...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/s41593-018-0137-x
更新日期:2018-05-01 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature neuroscience
pub_type: 已发布勘误
doi:10.1038/s41593-019-0570-5
更新日期:2020-02-01 00:00:00
abstract::Transformation of mechanical energy into ionic currents is essential for touch, hearing and nociception. Although DEG/ENaC proteins are believed to form sensory mechanotransduction channels, the evidence for this role remains indirect. By recording from C. elegans touch receptor neurons in vivo, we found that external...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1362
更新日期:2005-01-01 00:00:00
abstract::The structure and function of the human brain are highly stereotyped, implying a conserved molecular program responsible for its development, cellular structure and function. We applied a correlation-based metric called differential stability to assess reproducibility of gene expression patterning across 132 structure...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.4171
更新日期:2015-12-01 00:00:00
abstract::It is widely believed that attention selects locations at an earlier stage than it selects nonspatial features, but this has been tested only under conditions of minimal competition. We found that, when competition was increased, color-based attention was able to influence the feedforward flow of information in humans...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2223
更新日期:2009-01-01 00:00:00
abstract::Ability to integrate diverse forms of information in current thought, or working memory, is essential for human reasoning and problem solving. We used functional imaging to identify brain regions preferentially involved in maintaining integrated versus unintegrated information in working memory. For equal amounts of v...
journal_title:Nature neuroscience
pub_type: 临床试验,杂志文章
doi:10.1038/71156
更新日期:2000-01-01 00:00:00
abstract::The sensing of circulating nutrients within the mediobasal hypothalamus may be critical for energy homeostasis. To induce a sustained impairment in hypothalamic nutrient sensing, adeno-associated viruses (AAV) expressing malonyl-coenzyme A decarboxylase (MCD; an enzyme involved in the degradation of malonyl coenzyme A...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1626
更新日期:2006-02-01 00:00:00
abstract::Despite the numerous examples of anticipatory cognitive processes at micro and macro levels in many animal species, the idea that anticipation of specific words plays an integral role in real-time language processing has been contentious. Here we exploited a phonological regularity of English indefinite articles ('an'...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1504
更新日期:2005-08-01 00:00:00
abstract::Many cells in retinotopic brain areas increase their activity when saccades (rapid eye movements) are about to bring stimuli into their receptive fields. Although previous work has attempted to look at the functional correlates of such predictive remapping, no study has explicitly tested for better attentional perform...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2711
更新日期:2011-02-01 00:00:00
abstract::We used fluorescent in-situ hybridization and confocal microscopy to monitor the subcellular distribution of the immediate-early gene Arc. Arc RNA appeared in discrete intranuclear foci within minutes of neuronal activation and subsequently disappeared from the nucleus and accumulated in the cytoplasm by 30 minutes. T...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/16046
更新日期:1999-12-01 00:00:00
abstract::Communication between glia cells and neurons is crucial for brain functions, but the molecular mechanisms and functional consequences of gliotransmission remain enigmatic. Here we report that astrocytes express synaptobrevin II and cellubrevin as functionally non-overlapping vesicular SNARE proteins on glutamatergic v...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.4647
更新日期:2017-11-01 00:00:00